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GGDEF domain-containing protein

GGDEF domain-containing protein having an EAL domain and one or more PAS sensor or ligand binding domains, similar to E. coli DosP, an oxygen sensor and response regulator.

Arch. IDVersionDate PublishedReview Level
1082206312016-05-13
curated
Arch. ID10822063
Version1
Date Published2016-05-13
Review Level
curated
PAS: PAS domainPASPAS_8: PAS domainPAS_8PAC: Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)PACGGDEF: Diguanylate-cyclase (DGC) or GGDEF domainGGDEFEAL: EAL domainEAL
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Sequences with this architecture
This architecture currently does not link to any protein sequence records.
Name, label and taxonomic scope
Taxonomic scopeNameLabel
All organismsGGDEF domain-containing proteinGGDEF domain-containing protein having an EAL domain and one or more PAS sensor or ligand binding domains, similar to E. coli DosP, an oxygen sensor and response regulator.
Name, label and taxonomic scope
Tax. ExpAll organisms
NameGGDEF domain-containing protein
LabelGGDEF domain-containing protein having an EAL domain and one or more PAS sensor or ligand binding domains, similar to E. coli DosP, an oxygen sensor and response regulator.
Supporting evidence
Comments
  • the EAL domain may function as a cyclic-guanylate-specific phosphodiesterase, some EAL domains may perform a regulatory role via protein-protein interactions; PAS domains play roles in signal transductions by signal sensing and/or by protein?protein interactions
  • GGDEF domain is also called diguanylate-cyclase domain, which is often linked to a regulatory or sensor domain. Its function when catalytically active is to synthesize cyclic di-GMP, which is used as an intracellular signaling molecule in a wide variety of bacteria.
E.C. Number
CDD
Protein Accession
  • P76129: RecName: Full=Oxygen sensor protein DosP; AltName: Full=Direct oxygen-sensing phosphodiesterase; Short=Direct oxygen sensor protein; AltName: Full=Ec DOS; AltName: Full=Heme-regulated cyclic di-GMP phosphodiesterase
  • P77334: RecName: Full=Cyclic di-GMP phosphodiesterase Gmr
  • Q8EJM6: RecName: Full=Cyclic di-GMP phosphodiesterase PdeB; AltName: Full=Phosphodiesterase biofilm protein
  • AAC61684: diguanylate cyclase [Komagataeibacter xylinus]
  • AAC61688: c-di-GMP phosphodiesterase A [Komagataeibacter xylinus]
Conserved domains in this architecture
AccessionShort nameTitle
cd00130PASPAS domain
cd01948EALEAL domain
cd01949GGDEFDiguanylate-cyclase (DGC) or GGDEF domain
pfam13188PAS_8PAS domain
smart00086PACMotif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
Functional sites in this architecture
TitleTypeSource domain
putative active siteactivecd00130
heme pocketchemical bindingcd00130
active siteactivecd01949
metal binding siteion bindingcd01949
I-siteactivecd01949

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