Conserved Protein Domain Family
PAS

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cd00130: PAS 
Click on image for an interactive view with Cn3D
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Statistics
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PSSM-Id: 238075
View PSSM: cd00130
Aligned: 183 rows
Threshold Bit Score: 29.1384
Threshold Setting Gi: 2120409
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
putative activeheme pocket
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:putative active site [active site]
Evidence:
  • Comment:putative active site of photoactive yellow protein (PYP)
  • Citation:PMID 9600888
  • Structure:chromophore covalently bound to the side chain of Cys .
    View structure with Cn3D
  • Structure:hydrophobic pocket formed by three aromatic side chains and the aromatic ring of the chromophore.
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                       #   #      #             ####                                   
3PYP         26 LAFGAIQLDGDGNILQYNAAEGd-iTGRDPKQVIGKNFfkDVAPCTDsp---eFYGKFKEGvas---------gnlNTMF 92
gi 2499558   29 HGLVVVLQEPDLTISQISANCTg-iLGRSPEDLLGRTLg-EVFDSFQid---pIQSRLTAGqi-----------ssLNPS 92
gi 1240049   24 DGADILIHRFDGTITHWSIGCEn-mYGWAREEAVGEKVh-DLLATQFpe---pVENIRDQLks-----------rgSWQG 87
gi 7470857  173 VRNPQTGDIEDFRCLVINPILSk-aFNRSREDLIGRVLlkRFLQRLDp----qLFDQFVNLvet----------gtFLTQ 237
gi 1075570  153 LPAPWILVASDGRVLMMNHPARqvvAGLPEPLLEGQPVa-SLHHDLArawpdrTGRTMSLAiggrqyqvtrapvgaTGAE 231
gi 2494692  704 DSEIWTKVSTSGMFLFVSSNVRs-lLDLLPENLQGTSMq-DLMRKESra---eFGRTIEKArk------------gKIVV 766
gi 282166    74 VSDALIVVSRAGEVLGTSASVEa-lTGQGAGVWQGRPLa-ALFDPASgp---rLDRVLAEAanr----------raPVTV 138
gi 1145263   35 LPDPSYVLDDTGRVLVCSQAGAr-tVGRLPEELVGRHWg-ELGFPPEel--arLETARARVmli----------qdTCEL 100
gi 7340817   63 VSDILIVVSRAGLIEEVSASVPa-rTRLPRAALCGRPAs-DLFAEADrp---aLQEAMRRAtda----------rsALTL 127
gi 481880   450 ASDWFWETGPDHRITKISEHSDp--ASAAPTALIGLTRw-DIPPDAEle--pgKWEQHRATlda---------hlpFRDL 515
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
Feature 1          #    #                                 
3PYP         93 EYTFDYQ-MTPTKVKVHMKKals--------gdsYWVFVKRV 125
gi 2499558   93 KLWARVM-GDDFVIFDGVFHrns--------dglLVCELEPA 125
gi 1240049   88 EIIHRHKsGHDIHIASRCVLvnlpegdfaviqtnIDVSALRR 129
gi 7470857  238 DIYFPIA-NSDWYHFVAVKLgdgfavtvrditdrKRMELELQ 278
gi 1075570  232 VLSFTDR-TEETQLDLLLQGvi----------reAIAATYDI 262
gi 2494692  767 AASMRCK-TSVARCSRPIQHst----------peMVVRVKGQ 797
gi 282166   139 EAALLGP-GGPAPLELSVSPrlderdr-ligyvlTGRPLGEL 178
gi 1145263  101 EAPWTTQtGLRRHALMLSPLpsedgg--accvlvTARPLTDA 140
gi 7340817  128 EAGLETPeGPSAVELSLSPRfdergr--aaglvlTGRSVAEL 167
gi 481880   516 VYRGRDRnGSPIYVRTSGKPlhd--------adgHFLGYRGV 549

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