6O3C: Crystal structure of active Smoothened bound to SAG21k, cholesterol, and NbSmo8

PDB ID: 6O3CDownload
MMDB ID: 177024
PDB Deposition Date: 2019/2/26
Updated in MMDB: 2024/10
Experimental Method:
x-ray diffraction
Resolution: 2.8  Å
Source Organism:
Mus musculus▼
Similar Structures:
Biological Unit for 6O3C: dimeric; determined by author and by software (PISA)
Molecular Components in 6O3C
Label Count Molecule
Proteins (2 molecules)
1
Smoothened Homolog
Molecule annotation
1
Nbsmo8
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
1
PHOSPHATE IONPHOSPHATE ION
2
1
SODIUM IONSODIUM ION
3
6
(2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate(2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate
4
2
2-acetamido-2-deoxy-beta-D-glucopyranose2-acetamido-2-deoxy-beta-D-glucopyranose
5
1
3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide3-chloro-4,7-difluoro-N-{[2-methoxy-5-(pyridin-4-yl)phenyl]methyl}-N-[trans-4-(methylamino)cyclohexyl]-1-benzothiophene-2-carboxamide
6
2
CHOLESTEROLCHOLESTEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303