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6DUK:
EGFR with an allosteric inhibitor
PDB ID:
6DUK
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MMDB ID:
176250
PDB Deposition Date:
2018/6/21
Updated in MMDB:
2019/12
Experimental Method:
x-ray diffraction
Resolution:
2.2 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 6DUK: dimeric; determined by author and by software (PISA)
Molecular Components in 6DUK
Label
Count
Molecule
Proteins (2 molecules)
A
B
2
Epidermal Growth Factor Receptor
(Gene symbol:
EGFR
)
Chemicals and Non-standard biopolymers (6 molecules)
1
2
MAGNESIUM ION
2
2
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
3
2
(2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{1-oxo-6-[4-(piperazin-1-yl)phenyl]-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303