NCBI
National Center for
Biotechnology Information
Search
4WUY:
Crystal Structure of Protein Lysine Methyltransferase SMYD2 in complex with LLY-507, a Cell-Active, Potent and Selective Inhibitor
PDB ID:
4WUY
Download
MMDB ID:
128465
PDB Deposition Date:
2014/11/4
Updated in MMDB:
2023/12
Experimental Method:
x-ray diffraction
Resolution:
1.63 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4WUY: monomeric; determined by author and by software (PISA)
Molecular Components in 4WUY
Label
Count
Molecule
Protein (1 molecule)
A
1
N-lysine Methyltransferase Smyd2
(Gene symbol:
SMYD2
)
Chemicals and Non-standard biopolymers (9 molecules)
1
1
5-cyano-2'-{4-[2-(3-methyl-1H-indol-1-yl)ethyl]piperazin-1-yl}-N-[3-(pyrrolidin-1-yl)propyl]biphenyl-3-carboxamide
2
1
S-ADENOSYL-L-HOMOCYSTEINE
3
3
GLYCEROL
4
4
ZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303