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SMYD2 SET and MYND domain containing 2 [ Homo sapiens (human) ]

Gene ID: 56950, updated on 17-Oct-2021

Summary

Official Symbol
SMYD2provided by HGNC
Official Full Name
SET and MYND domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20982
See related
Ensembl:ENSG00000143499 MIM:610663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KMT3C; HSKM-B; ZMYND14
Summary
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]
Expression
Broad expression in heart (RPKM 86.3), testis (RPKM 19.8) and 22 other tissues See more
Orthologs
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Genomic context

See SMYD2 in Genome Data Viewer
Location:
1q32.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (214281159..214337136)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (214454502..214510474)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 2293 Neighboring gene prospero homeobox 1 Neighboring gene long intergenic non-protein coding RNA 2775 Neighboring gene VISTA enhancer hs2357 Neighboring gene uncharacterized LOC107985263 Neighboring gene protein tyrosine phosphatase non-receptor type 14 Neighboring gene adaptor related protein complex 3 subunit sigma 1 pseudogene Neighboring gene keratin 18 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone methyltransferase activity (H3-K36 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone-lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
N-lysine methyltransferase SMYD2
Names
SET and MYND domain-containing protein 2
histone methyltransferase SMYD2
lysine N-methyltransferase 3C
zinc finger, MYND domain containing 14
NP_064582.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020197.3NP_064582.2  N-lysine methyltransferase SMYD2

    See identical proteins and their annotated locations for NP_064582.2

    Status: VALIDATED

    Source sequence(s)
    AL929236, AW474469, BC098276, BG723585
    Consensus CDS
    CCDS31022.1
    UniProtKB/Swiss-Prot
    Q9NRG4
    Related
    ENSP00000355924.5, ENST00000366957.10
    Conserved Domains (2) summary
    cd19202
    Location:7269
    SET_SMYD2; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins
    pfam01753
    Location:5290
    zf-MYND; MYND finger

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    214281159..214337136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_426790.4 RNA Sequence

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