Format

Send to:

Choose Destination

SMYD2 SET and MYND domain containing 2 [ Homo sapiens (human) ]

Gene ID: 56950, updated on 24-Nov-2020

Summary

Official Symbol
SMYD2provided by HGNC
Official Full Name
SET and MYND domain containing 2provided by HGNC
Primary source
HGNC:HGNC:20982
See related
Ensembl:ENSG00000143499 MIM:610663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KMT3C; HSKM-B; ZMYND14
Summary
SET domain-containing proteins, such as SMYD2, catalyze lysine methylation (Brown et al., 2006 [PubMed 16805913]).[supplied by OMIM, Nov 2008]
Expression
Broad expression in heart (RPKM 86.3), testis (RPKM 19.8) and 22 other tissues See more
Orthologs

Genomic context

See SMYD2 in Genome Data Viewer
Location:
1q32.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (214281159..214337136)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (214454565..214510477)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PROX1 antisense RNA 1 Neighboring gene prospero homeobox 1 Neighboring gene long intergenic non-protein coding RNA 2775 Neighboring gene VISTA enhancer hs2357 Neighboring gene uncharacterized LOC107985263 Neighboring gene protein tyrosine phosphatase non-receptor type 14 Neighboring gene adaptor related protein complex 3 sigma 1 subunit pseudogene Neighboring gene keratin 18 pseudogene 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119305

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone methyltransferase activity (H3-K36 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
histone-lysine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysine N-methyltransferase activity TAS
Traceable Author Statement
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-lysine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
heart development IEA
Inferred from Electronic Annotation
more info
 
histone H3-K36 methylation IEA
Inferred from Electronic Annotation
more info
 
histone lysine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine dimethylation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-lysine monomethylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of DNA damage response, signal transduction by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
N-lysine methyltransferase SMYD2
Names
SET and MYND domain-containing protein 2
histone methyltransferase SMYD2
lysine N-methyltransferase 3C
zinc finger, MYND domain containing 14
NP_064582.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020197.3NP_064582.2  N-lysine methyltransferase SMYD2

    See identical proteins and their annotated locations for NP_064582.2

    Status: VALIDATED

    Source sequence(s)
    AL929236, AW474469, BC098276, BG723585
    Consensus CDS
    CCDS31022.1
    UniProtKB/Swiss-Prot
    Q9NRG4
    Related
    ENSP00000355924.5, ENST00000366957.10
    Conserved Domains (3) summary
    pfam00856
    Location:204240
    SET; SET domain
    pfam01753
    Location:5290
    zf-MYND; MYND finger
    pfam13424
    Location:338413
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    214281159..214337136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_426790.4 RNA Sequence

Support Center