4U9M: Structure Of The Dna Duplex D(attaat)2 With Hoogsteen Hydrogen Bonds

The traditional Watson-Crick base pairs in DNA may occasionally adopt a Hoogsteen conformation, with a different organization of hydrogen bonds. Previous crystal structures have shown that the Hoogsteen conformation is favored in alternating AT sequences of DNA. Here we present new data for a different sequence, d(ATTAAT)2, which is also found in the Hoogsteen conformation. Thus we demonstrate that other all-AT sequences of DNA with a different sequence may be found in the Hoogsteen conformation. We conclude that any all-AT sequence might acquire this conformation under appropriate conditions. We also compare the detailed features of DNA in either the Hoogsteen or Watson-Crick conformations.
PDB ID: 4U9MDownload
MMDB ID: 128233
PDB Deposition Date: 2014/8/6
Updated in MMDB: 2015/04
Experimental Method:
x-ray diffraction
Resolution: 3.13  Å
Source Organism:
Biological Unit for 4U9M: dimeric; determined by author and by software (PISA)
Molecular Components in 4U9M
Label Count Molecule
Nucleotide(1 molecule)
DNA (5'-d(*ap*tp*tp*ap*ap*t)-3')
Molecule annotation
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Citing MMDB