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Conserved domains on  [gi|1039796029|ref|XP_017173840|]
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ribose-phosphate pyrophosphokinase 2 isoform X5 [Mus musculus]

Protein Classification

ribose-phosphate pyrophosphokinase-like domain-containing protein( domain architecture ID 10619030)

ribose-phosphate pyrophosphokinase-like domain-containing protein which contains the N-terminal domain of ribose-phosphate pyrophosphokinase and phosphoribosyl pyrophosphate synthetase-associated proteins, which play roles in 5-phospho-ribosyl-1(alpha)-pyrophosphate (PRPP) synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 85-183 7.54e-60

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 184.93  E-value: 7.54e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  85 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 164
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90
                  ....*....|....*....
gi 1039796029 165 RVTAVIPCFPYARQDKKDK 183
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDK 99
 
Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 85-183 7.54e-60

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 184.93  E-value: 7.54e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  85 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 164
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90
                  ....*....|....*....
gi 1039796029 165 RVTAVIPCFPYARQDKKDK 183
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDK 99
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 82-186 4.43e-54

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 176.79  E-value: 4.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  82 MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 161
Cdd:COG0462     1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                          90       100
                  ....*....|....*....|....*
gi 1039796029 162 SSSRVTAVIPCFPYARQDKKDKVGE 186
Cdd:COG0462    81 SARRITAVIPYYGYARQDRKFRPRE 105
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 85-188 5.90e-49

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 163.60  E-value: 5.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  85 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASS 163
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100
                  ....*....|....*....|....*
gi 1039796029 164 SRVTAVIPCFPYARQDKKDKVGEGL 188
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPI 105
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
85-183 2.23e-48

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 162.21  E-value: 2.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  85 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 164
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90
                  ....*....|....*....
gi 1039796029 165 RVTAVIPCFPYARQDKKDK 183
Cdd:PRK01259   81 RITAVIPYFGYARQDRKAR 99
 
Name Accession Description Interval E-value
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 85-183 7.54e-60

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 184.93  E-value: 7.54e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  85 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 164
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90
                  ....*....|....*....
gi 1039796029 165 RVTAVIPCFPYARQDKKDK 183
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDK 99
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 82-186 4.43e-54

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 176.79  E-value: 4.43e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  82 MPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIA 161
Cdd:COG0462     1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                          90       100
                  ....*....|....*....|....*
gi 1039796029 162 SSSRVTAVIPCFPYARQDKKDKVGE 186
Cdd:COG0462    81 SARRITAVIPYYGYARQDRKFRPRE 105
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 85-188 5.90e-49

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 163.60  E-value: 5.90e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  85 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYII-QSGCGEINDNLMELLIMINACKIASS 163
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100
                  ....*....|....*....|....*
gi 1039796029 164 SRVTAVIPCFPYARQDKKDKVGEGL 188
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKKFKSREPI 105
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
85-183 2.23e-48

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 162.21  E-value: 2.23e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  85 IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSS 164
Cdd:PRK01259    1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                          90
                  ....*....|....*....
gi 1039796029 165 RVTAVIPCFPYARQDKKDK 183
Cdd:PRK01259   81 RITAVIPYFGYARQDRKAR 99
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 65-181 9.82e-37

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 134.61  E-value: 9.82e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  65 HRSPFLLLQRAPQSPVTMPNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEI 144
Cdd:PTZ00145  100 FRHPLWRSEEKRPFEKKMENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPV 179

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1039796029 145 NDNLMELLIMINACKIASSSRVTAVIPCFPYARQDKK 181
Cdd:PTZ00145  180 NENLIELLLMISTCRRASAKKITAVIPYYGYARQDRK 216
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 69-181 2.91e-36

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 131.02  E-value: 2.91e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  69 FLLLQRAPQSPVTMPN--IVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEIND 146
Cdd:PRK02812    4 FATAARAEQLPLLSDNnrLRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVND 83

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1039796029 147 NLMELLIMINACKIASSSRVTAVIPCFPYARQDKK 181
Cdd:PRK02812   84 HLMELLIMVDACRRASARQITAVIPYYGYARADRK 118
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 95-181 1.47e-34

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 125.96  E-value: 1.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  95 DLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFP 174
Cdd:PLN02369    2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81


                  ....*..
gi 1039796029 175 YARQDKK 181
Cdd:PLN02369   82 YARADRK 88
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 83-180 9.49e-34

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 124.47  E-value: 9.49e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  83 PNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIAS 162
Cdd:PRK02458    8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87

                          90
                  ....*....|....*...
gi 1039796029 163 SSRVTAVIPCFPYARQDK 180
Cdd:PRK02458   88 ANTVNVVLPYFGYARQDR 105
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
84-186 2.41e-33

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 122.98  E-value: 2.41e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  84 NIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASS 163
Cdd:PRK02269    5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84

                          90       100
                  ....*....|....*....|...
gi 1039796029 164 SRVTAVIPCFPYARQDKKDKVGE 186
Cdd:PRK02269   85 ESINVVMPYYGYARQDRKARSRE 107
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
83-181 5.89e-32

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 119.65  E-value: 5.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  83 PNIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIAS 162
Cdd:PRK04923    5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84

                          90
                  ....*....|....*....
gi 1039796029 163 SSRVTAVIPCFPYARQDKK 181
Cdd:PRK04923   85 AASVTAVIPYFGYSRQDRR 103
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
96-181 2.63e-30

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 114.66  E-value: 2.63e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  96 LSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASSSRVTAVIPCFPY 175
Cdd:PRK03092    1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80


                  ....*.
gi 1039796029 176 ARQDKK 181
Cdd:PRK03092   81 ARQDKK 86
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 84-183 1.25e-27

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 108.08  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  84 NIVLFSGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEINDNLMELLIMINACKIASS 163
Cdd:PRK00553    9 NHVIFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSA 88

                          90       100
                  ....*....|....*....|
gi 1039796029 164 SRVTAVIPCFPYARQDKKDK 183
Cdd:PRK00553   89 KSITAILPYYGYARQDRKTA 108
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 89-186 3.93e-22

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 92.28  E-value: 3.93e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  89 SGSSHQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVYIIQSGCGEiNDNLMELLIMINACKIASSSRVTA 168
Cdd:PRK00934    4 GGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKSITL 82

                          90
                  ....*....|....*...
gi 1039796029 169 VIPCFPYARQDKKDKVGE 186
Cdd:PRK00934   83 VIPYLGYARQDKRFKPGE 100
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 110-188 3.21e-12

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 65.36  E-value: 3.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029 110 KVVTKKFSNQETSVEIGESVRGEDVYIIQ---------SGCGE-----INDNLMELLIMINACKiASSSRVTAVIPCFPY 175
Cdd:PRK06827   56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134

                          90
                  ....*....|...
gi 1039796029 176 ARQDKKDKVgEGL 188
Cdd:PRK06827  135 SRQHKRKGR-ESL 146
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
81-192 1.63e-08

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 54.17  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039796029  81 TMPNIVLFSGSshQDLSQRVADRLGLELGKVVTKKFSNQETSVEIGESVRGEDVyIIQSGCGEINDNLMELLIMINACKI 160
Cdd:PRK07199    1 MQPLLLALPGN--EAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTV-VLVCSLDRPDEKLLPLLFAAEAARE 77

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039796029 161 ASSSRVTAVIPCFPYARQDKKDKVGEGL-QKTF 192
Cdd:PRK07199   78 LGARRVGLVAPYLAYMRQDIAFHPGEAIsQRHF 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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