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Conserved domains on  [gi|2024401417|ref|XP_015131650|]
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pro-epidermal growth factor isoform X2 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 450-492 1.28e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.28e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2024401417   450 RVIASMGLVHPSGIALDYLANKLYWCDAKQSVVESANLDGSGR 492
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 370-405 1.82e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.82e-10
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024401417   370 IDIPEGLAVDWINRKLYWTDRGKACIERSTLNGMQR 405
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA pfam07645
Calcium-binding EGF domain;
738-769 9.25e-08

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.77  E-value: 9.25e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  738 DIDECKMGTHTCGENRTCTNTEGNFTCSCPDG 769
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Ldl_recept_b super family cl44468
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 426-467 4.27e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


The actual alignment was detected with superfamily member pfam00058:

Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 4.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  426 RRLFWTEMGIRPKIASSSLEGMDRRVIASMGLVHPSGIALDY 467
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA smart00179
Calcium-binding EGF-like domain;
696-737 8.01e-07

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 8.01e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024401417   696 DVDECAaNMDHCnRNLSGCINTEGGYVCKCLDGYTgDGLHCE 737
Cdd:smart00179    1 DIDECA-SGNPC-QNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 167-210 1.11e-06

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 50.85  E-value: 1.11e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2024401417  167 KQFCEDINECGFWNHGCTLGCVNIPGSYYCTCPRGFVLLPDRKT 210
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 322-362 2.41e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 2.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024401417   322 LLDGQMGVVLALDSDPVENKIYFAHTALKWIERANLDGSNR 362
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 259-292 5.66e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024401417  259 DNGGCSQICSSlSPFSWECACFPGYKLQRDRKHC 292
Cdd:pfam14670    4 NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 217-252 1.79e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.79e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024401417  217 CLNNDTECSHGCLQTSKGPVCFCPEGSVLKEDGKAC 252
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 561-596 1.31e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024401417  561 CLHMNGGCDQICENNFGVAHCTCRPGFGKTQDGQTC 596
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03099 super family cl31525
epidermal growth factor-like protein (EGF-like protein); Provisional
 771-839 1.51e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


The actual alignment was detected with superfamily member PHA03099:

Pssm-ID: 165381  Cd Length: 139  Bit Score: 40.01  E-value: 1.51e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024401417  771 SGTAMgceSTLSPTVVSneySTRPVPGDSIgCPPAYDSYCLHGgVCNYVSDLQDYACNCVTGYVGERCQ 839
Cdd:PHA03099    21 SGNAI---ETTSPEITN---ATTDIPAIRL-CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQ 81
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 493-534 6.22e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


:

Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.22e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2024401417   493 RILAQNDVGHP--FAVAVFEDHLWLSDWARPSLMRVDkKTGQNR 534
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTNR 43
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 450-492 1.28e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.28e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2024401417   450 RVIASMGLVHPSGIALDYLANKLYWCDAKQSVVESANLDGSGR 492
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 370-405 1.82e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.82e-10
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024401417   370 IDIPEGLAVDWINRKLYWTDRGKACIERSTLNGMQR 405
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 470-510 7.54e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 7.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  470 NKLYWCDAKQS-VVESANLDGSGRRILAQNDVGHPFAVAVFE 510
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA pfam07645
Calcium-binding EGF domain;
738-769 9.25e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.77  E-value: 9.25e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  738 DIDECKMGTHTCGENRTCTNTEGNFTCSCPDG 769
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 426-467 4.27e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 4.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  426 RRLFWTEMGIRPKIASSSLEGMDRRVIASMGLVHPSGIALDY 467
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 406-449 7.00e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 7.00e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2024401417   406 KMIIWEGISQPRGIAIHPFVRRLFWTEMGiRPKIASSSLEGMDR 449
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
696-737 8.01e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 8.01e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024401417   696 DVDECAaNMDHCnRNLSGCINTEGGYVCKCLDGYTgDGLHCE 737
Cdd:smart00179    1 DIDECA-SGNPC-QNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 700-736 8.33e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.44  E-value: 8.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024401417  700 CAANMDHCNRNLSgCINTEGGYVCKCLDGYTGDGLHC 736
Cdd:pfam12947    1 CSDNNGGCHPNAT-CTNTGGSFTCTCNDGYTGDGVTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 167-210 1.11e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.85  E-value: 1.11e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2024401417  167 KQFCEDINECGFWNHGCTLGCVNIPGSYYCTCPRGFVLLPDRKT 210
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 322-362 2.41e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 2.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024401417   322 LLDGQMGVVLALDSDPVENKIYFAHTALKWIERANLDGSNR 362
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
738-769 4.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 4.41e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2024401417   738 DIDECKMGtHTCGENRTCTNTEGNFTCSCPDG 769
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 738-769 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  738 DIDECKMGtHTCGENRTCTNTEGNFTCSCPDG 769
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 180-211 1.83e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 1.83e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  180 NHGCTLGCVNIPGSYYCTCPRGFVLLPDRKTC 211
Cdd:pfam14670    5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 383-423 2.16e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.53  E-value: 2.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  383 RKLYWTDRG-KACIERSTLNGMQRKMIIWEGISQPRGIAIHP 423
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-737 2.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  696 DVDECAaNMDHCnRNLSGCINTEGGYVCKCLDGYTGDglHCE 737
Cdd:cd00054      1 DIDECA-SGNPC-QNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 259-292 5.66e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024401417  259 DNGGCSQICSSlSPFSWECACFPGYKLQRDRKHC 292
Cdd:pfam14670    4 NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
172-211 1.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.48e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2024401417   172 DINECGFWN---HGCTlgCVNIPGSYYCTCPRGFVllpDRKTC 211
Cdd:smart00179    1 DIDECASGNpcqNGGT--CVNTVGSYRCECPPGYT---DGRNC 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 217-252 1.79e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.79e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024401417  217 CLNNDTECSHGCLQTSKGPVCFCPEGSVLKEDGKAC 252
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
304-477 5.17e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024401417  304 ANGQDIRRISFDGTDYASLLDGQMGVVLALDSDPVENKIYFAHTALKWIERANLDGSNREKVIHGAIDiPEGLAVDWINR 383
Cdd:COG3391     44 VVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024401417  384 KLYWTDRGKACIerSTLNGMQRKMI-IWEGISQPRGIAIHPFVRRLFWTEMGiRPKIAS--SSLEGMDRRVIASMGL-VH 459
Cdd:COG3391    123 RLYVADSGNGRV--SVIDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVATIPVgGG 199

                          170
                   ....*....|....*...
gi 2024401417  460 PSGIALDYLANKLYWCDA 477
Cdd:COG3391    200 PVGVAVSPDGRRLYVANR 217
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 340-380 1.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  340 NKIYFAHTALKW-IERANLDGSNREKVIHGAIDIPEGLAVDW 380
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 561-596 1.31e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024401417  561 CLHMNGGCDQICENNFGVAHCTCRPGFGKTQDGQTC 596
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 771-839 1.51e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 40.01  E-value: 1.51e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024401417  771 SGTAMgceSTLSPTVVSneySTRPVPGDSIgCPPAYDSYCLHGgVCNYVSDLQDYACNCVTGYVGERCQ 839
Cdd:PHA03099    21 SGNAI---ETTSPEITN---ATTDIPAIRL-CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQ 81
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 493-534 6.22e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.22e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2024401417   493 RILAQNDVGHP--FAVAVFEDHLWLSDWARPSLMRVDkKTGQNR 534
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTNR 43
 
Name Accession Description Interval E-value
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 450-492 1.28e-11

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 59.92  E-value: 1.28e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2024401417   450 RVIASMGLVHPSGIALDYLANKLYWCDAKQSVVESANLDGSGR 492
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 370-405 1.82e-10

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 56.84  E-value: 1.82e-10
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 2024401417   370 IDIPEGLAVDWINRKLYWTDRGKACIERSTLNGMQR 405
Cdd:smart00135    8 LGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 470-510 7.54e-08

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 49.47  E-value: 7.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  470 NKLYWCDAKQS-VVESANLDGSGRRILAQNDVGHPFAVAVFE 510
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA pfam07645
Calcium-binding EGF domain;
738-769 9.25e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 48.77  E-value: 9.25e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  738 DIDECKMGTHTCGENRTCTNTEGNFTCSCPDG 769
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 426-467 4.27e-07

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 47.15  E-value: 4.27e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  426 RRLFWTEMGIRPKIASSSLEGMDRRVIASMGLVHPSGIALDY 467
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 406-449 7.00e-07

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 46.83  E-value: 7.00e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2024401417   406 KMIIWEGISQPRGIAIHPFVRRLFWTEMGiRPKIASSSLEGMDR 449
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
696-737 8.01e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 8.01e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 2024401417   696 DVDECAaNMDHCnRNLSGCINTEGGYVCKCLDGYTgDGLHCE 737
Cdd:smart00179    1 DIDECA-SGNPC-QNGGTCVNTVGSYRCECPPGYT-DGRNCE 39
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 700-736 8.33e-07

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 46.44  E-value: 8.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 2024401417  700 CAANMDHCNRNLSgCINTEGGYVCKCLDGYTGDGLHC 736
Cdd:pfam12947    1 CSDNNGGCHPNAT-CTNTGGSFTCTCNDGYTGDGVTC 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 167-210 1.11e-06

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 50.85  E-value: 1.11e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 2024401417  167 KQFCEDINECGFWNHGCTLGCVNIPGSYYCTCPRGFVLLPDRKT 210
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 322-362 2.41e-06

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 45.29  E-value: 2.41e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 2024401417   322 LLDGQMGVVLALDSDPVENKIYFAHTALKWIERANLDGSNR 362
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43
EGF_CA smart00179
Calcium-binding EGF-like domain;
738-769 4.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 4.41e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 2024401417   738 DIDECKMGtHTCGENRTCTNTEGNFTCSCPDG 769
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPG 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 742-772 7.49e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 43.74  E-value: 7.49e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 2024401417  742 CKMGTHTCGENRTCTNTEGNFTCSCPDGASG 772
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 738-769 1.12e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 1.12e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  738 DIDECKMGtHTCGENRTCTNTEGNFTCSCPDG 769
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPG 31
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 180-211 1.83e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 1.83e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  180 NHGCTLGCVNIPGSYYCTCPRGFVLLPDRKTC 211
Cdd:pfam14670    5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 383-423 2.16e-05

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 42.53  E-value: 2.16e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  383 RKLYWTDRG-KACIERSTLNGMQRKMIIWEGISQPRGIAIHP 423
Cdd:pfam00058    1 GRLYWTDSSlRASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
EGF_CA pfam07645
Calcium-binding EGF domain;
696-728 2.75e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.84  E-value: 2.75e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 2024401417  696 DVDECAANMDHCNRNLSgCINTEGGYVCKCLDG 728
Cdd:pfam07645    1 DVDECATGTHNCPANTV-CVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-737 2.98e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 2.98e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  696 DVDECAaNMDHCnRNLSGCINTEGGYVCKCLDGYTGDglHCE 737
Cdd:cd00054      1 DIDECA-SGNPC-QNGGTCVNTVGSYRCSCPPGYTGR--NCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 259-292 5.66e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 41.07  E-value: 5.66e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 2024401417  259 DNGGCSQICSSlSPFSWECACFPGYKLQRDRKHC 292
Cdd:pfam14670    4 NNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
172-211 1.48e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 1.48e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 2024401417   172 DINECGFWN---HGCTlgCVNIPGSYYCTCPRGFVllpDRKTC 211
Cdd:smart00179    1 DIDECASGNpcqNGGT--CVNTVGSYRCECPPGYT---DGRNC 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 217-252 1.79e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 39.53  E-value: 1.79e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024401417  217 CLNNDTECSHGCLQTSKGPVCFCPEGSVLKEDGKAC 252
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 172-204 2.85e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 2.85e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 2024401417  172 DINECGFwNHGCTLG--CVNIPGSYYCTCPRGFVL 204
Cdd:cd00054      1 DIDECAS-GNPCQNGgtCVNTVGSYRCSCPPGYTG 34
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
304-477 5.17e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.76  E-value: 5.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024401417  304 ANGQDIRRISFDGTDYASLLDGQMGVVLALDSDPVENKIYFAHTALKWIERANLDGSNREKVIHGAIDiPEGLAVDWINR 383
Cdd:COG3391     44 VVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIPVGGG-PRGLAVDPDGG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024401417  384 KLYWTDRGKACIerSTLNGMQRKMI-IWEGISQPRGIAIHPFVRRLFWTEMGiRPKIAS--SSLEGMDRRVIASMGL-VH 459
Cdd:COG3391    123 RLYVADSGNGRV--SVIDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSVIDTATGKVVATIPVgGG 199

                          170
                   ....*....|....*...
gi 2024401417  460 PSGIALDYLANKLYWCDA 477
Cdd:COG3391    200 PVGVAVSPDGRRLYVANR 217
EGF_CA pfam07645
Calcium-binding EGF domain;
172-201 7.82e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 7.82e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 2024401417  172 DINECGFWNHGCTLG--CVNIPGSYYCTCPRG 201
Cdd:pfam07645    1 DVDECATGTHNCPANtvCVNTIGSFECRCPDG 32
Ldl_recept_b pfam00058
Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...
 340-380 1.02e-03

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.


Pssm-ID: 459654  Cd Length: 42  Bit Score: 37.52  E-value: 1.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 2024401417  340 NKIYFAHTALKW-IERANLDGSNREKVIHGAIDIPEGLAVDW 380
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 561-596 1.31e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.22  E-value: 1.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2024401417  561 CLHMNGGCDQICENNFGVAHCTCRPGFGKTQDGQTC 596
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03099 PHA03099
epidermal growth factor-like protein (EGF-like protein); Provisional
 771-839 1.51e-03

epidermal growth factor-like protein (EGF-like protein); Provisional


Pssm-ID: 165381  Cd Length: 139  Bit Score: 40.01  E-value: 1.51e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024401417  771 SGTAMgceSTLSPTVVSneySTRPVPGDSIgCPPAYDSYCLHGgVCNYVSDLQDYACNCVTGYVGERCQ 839
Cdd:PHA03099    21 SGNAI---ETTSPEITN---ATTDIPAIRL-CGPEGDGYCLHG-DCIHARDIDGMYCRCSHGYTGIRCQ 81
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
294-537 2.00e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 41.16  E-value: 2.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024401417  294 AIGPRPFLLFA--NGQDIRRIS-FDG--TDYAsLLDGQMGVVLALDSDpveNKIYFAHTALKWIERANL-DGSNREKVIH 367
Cdd:COG4257     23 AVDPDGAVWFTdqGGGRIGRLDpATGefTEYP-LGGGSGPHGIAVDPD---GNLWFTDNGNNRIGRIDPkTGEITTFALP 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024401417  368 GAIDIPEGLAVDwINRKLYWTDRGKACIERstLNGMQRKMIIWE---GISQPRGIAIHPfVRRLFWTEMGIRpKIASSSL 444
Cdd:COG4257     99 GGGSNPHGIAFD-PDGNLWFTDQGGNRIGR--LDPATGEVTEFPlptGGAGPYGIAVDP-DGNLWVTDFGAN-AIGRIDP 173

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024401417  445 EGMDRRVIASM-GLVHPSGIALDYlANKLYwcdakqsVVESAN--------LDGSGRRILAQNDVGHPFAVAV-FEDHLW 514
Cdd:COG4257    174 DTGTLTEYALPtPGAGPRGLAVDP-DGNLW-------VADTGSgrigrfdpKTGTVTEYPLPGGGARPYGVAVdGDGRVW 245

                          250       260
                   ....*....|....*....|...
gi 2024401417  515 LSDWARPSLMRVDKKTGQNRVRL 537
Cdd:COG4257    246 FAESGANRIVRFDPDTELTEYVL 268
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 699-737 5.35e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 5.35e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 2024401417  699 ECAANMDHcnRNLSGCINTEGGYVCKCLDGYTGDGlHCE 737
Cdd:cd00053      1 ECAASNPC--SNGGTCVNTPGSYRCVCPPGYTGDR-SCE 36
LY smart00135
Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...
 493-534 6.22e-03

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.


Pssm-ID: 214531 [Multi-domain]  Cd Length: 43  Bit Score: 35.66  E-value: 6.22e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 2024401417   493 RILAQNDVGHP--FAVAVFEDHLWLSDWARPSLMRVDkKTGQNR 534
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN-LDGTNR 43
PHA02887 PHA02887
EGF-like protein; Provisional
 802-839 8.26e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 37.60  E-value: 8.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024401417  802 CPPAYDSYCLHGgVCNYVSDLQDYACNCVTGYVGERCQ 839
Cdd:PHA02887    86 CKNDFNDFCING-ECMNIIDLDEKFCICNKGYTGIRCD 122
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 561-596 9.42e-03

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 34.88  E-value: 9.42e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 2024401417  561 CLHMNGGCDQ--ICENNFGVAHCTCRPGFgkTQDGQTC 596
Cdd:pfam12947    1 CSDNNGGCHPnaTCTNTGGSFTCTCNDGY--TGDGVTC 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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