|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
84-331 |
3.97e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 111.56 E-value: 3.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 84 TTLYLQNNQINNagIPQDLKTKVKVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 161
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 162 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 239
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 240 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
|
250
....*....|...
gi 569007457 319 NLAQLLLRNNPWF 331
Cdd:COG4886 343 SLSLLALLTLLLL 355
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
58-329 |
1.12e-22 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 103.24 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 58 CRCDNGFIYCNDR-GLTSIPSDIPDDATTLYLQNNQINNagIPQDLKTKVKvqVIYLYENDLDEFPINLPRSLRELHLQD 136
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQGNIK--TLYANSNQLTSIPATLPDTIQEMELSI 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 137 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 215
Cdd:PRK15370 251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 216 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 295
Cdd:PRK15370 322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392
|
250 260 270
....*....|....*....|....*....|....*..
gi 569007457 296 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 329
Cdd:PRK15370 393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
65-311 |
3.41e-16 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.90 E-value: 3.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 65 IYCNDRGLTSIPSDIP-DDATTLYLQNNQINNagIPqdlktkvkvqviylyenDLDefpiNLPRsLRELHLQDNNVRTIa 143
Cdd:cd21340 7 LYLNDKNITKIDNLSLcKNLKVLYLYDNKITK--IE-----------------NLE----FLTN-LTHLYLQNNQIEKI- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 144 rDSLARIPLLEKLHLDDNSVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNS 223
Cdd:cd21340 62 -ENLENLVNLKKLYLGGNRISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNS 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 224 LRRLVLDGNllanqriaddtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDL 301
Cdd:cd21340 122 LRVLNISGN-------------NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDL 175
|
250
....*....|
gi 569007457 302 SNNNLTTLPR 311
Cdd:cd21340 176 TGNPVCKKPK 185
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
271-329 |
2.13e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.46 E-value: 2.13e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 569007457 271 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 329
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
300-406 |
3.33e-11 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 67.03 E-value: 3.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 300 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 375
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 569007457 376 DE----CF-EAGSQGGAANAAAKTTVSNHASATTPQ 406
Cdd:TIGR00864 81 DEeyvaCLkDNSSGGGAARSELVIFSAAHEGLFQPE 116
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
328-378 |
7.02e-09 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 52.05 E-value: 7.02e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 569007457 328 NPWFCGCNLMWLRDWVRARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 378
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
54-84 |
8.60e-07 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 45.77 E-value: 8.60e-07
10 20 30
....*....|....*....|....*....|.
gi 569007457 54 CPSVCRCDNGFIYCNDRGLTSIPSDIPDDAT 84
Cdd:smart00013 2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
54-80 |
3.08e-06 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 44.16 E-value: 3.08e-06
10 20
....*....|....*....|....*..
gi 569007457 54 CPSVCRCDNGFIYCNDRGLTSIPSDIP 80
Cdd:pfam01462 2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
293-316 |
1.31e-04 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 39.26 E-value: 1.31e-04
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
441-505 |
1.44e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 41.06 E-value: 1.44e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569007457 441 IQVKPLTADSIRITWKAMLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
441-505 |
4.60e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.79 E-value: 4.60e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007457 441 IQVKPLTADSIRITWKAML----PASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEddggPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
441-509 |
1.15e-03 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 38.55 E-value: 1.15e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007457 441 IQVKPLTADSIRITWKAMLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 509
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
84-331 |
3.97e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 111.56 E-value: 3.97e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 84 TTLYLQNNQINNagIPQDLKTKVKVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArDSLARIPLLEKLHLDDN 161
Cdd:COG4886 116 ESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNN 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 162 SVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPlhAFKGLNSLRRLVLDGNllanqRI 239
Cdd:COG4886 193 QITDLP---EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNN-----QL 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 240 AD-DTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLG 318
Cdd:COG4886 263 TDlPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342
|
250
....*....|...
gi 569007457 319 NLAQLLLRNNPWF 331
Cdd:COG4886 343 SLSLLALLTLLLL 355
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
60-328 |
5.10e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 111.18 E-value: 5.10e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 60 CDNGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDLDEFPINLPRSLRELHLQDNNV 139
Cdd:COG4886 5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 140 RTIARDSLARIPLLEKLHLDDNsvstvsieeDAFADSKQLKLLFLSRNHLSSIPSGLP--HTLEELRLDDNRISTIPLhA 217
Cdd:COG4886 85 LLLGLTDLGDLTNLTELDLSGN---------EELSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPE-P 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 218 FKGLNSLRRLVLDGNLLANqriADDTFSRLQNLTELSLVRNSLAAPPLNLPS-AHLQKLYLQDNAISHIPyNTLAKMREL 296
Cdd:COG4886 155 LGNLTNLKSLDLSNNQLTD---LPEELGNLTNLKELDLSNNQITDLPEPLGNlTNLEELDLSGNQLTDLP-EPLANLTNL 230
|
250 260 270
....*....|....*....|....*....|..
gi 569007457 297 ERLDLSNNNLTTLPRglFDDLGNLAQLLLRNN 328
Cdd:COG4886 231 ETLDLSNNQLTDLPE--LGNLTNLEELDLSNN 260
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
68-328 |
1.31e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 106.94 E-value: 1.31e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 68 NDRGLTSIPSDIPDDATTLYLQNNQINNAGIPQDLKTKVKVQVIYLYENDLDEFPINLPR--SLRELHLQDNNVRTIArD 145
Cdd:COG4886 75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLP-E 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 146 SLARIPLLEKLHLDDNSVSTVSieeDAFADSKQLKLLFLSRNHLSSIPSGL--PHTLEELRLDDNRISTIPLhAFKGLNS 223
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLTDLP---EELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTN 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 224 LRRLVLDGNllanqRIAD-DTFSRLQNLTElslvrnslaapplnlpsahlqkLYLQDNAISHIPynTLAKMRELERLDLS 302
Cdd:COG4886 230 LETLDLSNN-----QLTDlPELGNLTNLEE----------------------LDLSNNQLTDLP--PLANLTNLKTLDLS 280
|
250 260
....*....|....*....|....*.
gi 569007457 303 NNNLTTLPRGLFDDLGNLAQLLLRNN 328
Cdd:COG4886 281 NNQLTDLKLKELELLLGLNSLLLLLL 306
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
58-329 |
1.12e-22 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 103.24 E-value: 1.12e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 58 CRCDNGFIYCNDR-GLTSIPSDIPDDATTLYLQNNQINNagIPQDLKTKVKvqVIYLYENDLDEFPINLPRSLRELHLQD 136
Cdd:PRK15370 175 CLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKS--LPENLQGNIK--TLYANSNQLTSIPATLPDTIQEMELSI 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 137 NNVRTIARdslaRIP-LLEKLHLDDNSVSTVSieeDAFADskQLKLLFLSRNHLSSIPSGLPHTLEELRLDDNRISTIPL 215
Cdd:PRK15370 251 NRITELPE----RLPsALQSLDLFHNKISCLP---ENLPE--ELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPE 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 216 HAFKGLNSlrrLVLDGNLLANqrIADDTFSRLQNlteLSLVRNSLAAPPLNLPSAhLQKLYLQDNAISHIPYNTLAKMRE 295
Cdd:PRK15370 322 TLPPGLKT---LEAGENALTS--LPASLPPELQV---LDVSKNQITVLPETLPPT-ITTLDVSRNALTNLPENLPAALQI 392
|
250 260 270
....*....|....*....|....*....|....*..
gi 569007457 296 LERldlSNNNLTTLPRGLFDDLGNLAQ---LLLRNNP 329
Cdd:PRK15370 393 MQA---SRNNLVRLPESLPHFRGEGPQptrIIVEYNP 426
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
115-339 |
5.97e-22 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 98.85 E-value: 5.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 115 ENDLDEFPINLPRSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTVSIEEDAFADSKQLKLLFLSRN-HLSSIP 193
Cdd:COG4886 34 LLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeELSNLT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 194 SglphtLEELRLDDNRISTIPlHAFKGLNSLRRLVLDGNLLANqriADDTFSRLQNLTELSLVRN---SLAAPPLNLPsa 270
Cdd:COG4886 114 N-----LESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTD---LPEPLGNLTNLKSLDLSNNqltDLPEELGNLT-- 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569007457 271 HLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLTTLPRGLfDDLGNLAQLLLRNN-----PWFCGC-NLMWL 339
Cdd:COG4886 183 NLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGNLtNLEEL 255
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
65-318 |
1.66e-19 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 91.53 E-value: 1.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 65 IYCNDRGLTSIPSDIPDDA--TTLYLQNNQINNagIPQDLKTKVKVQVIYLYENDLDEFPINL--PRSLRELHLQDNNVR 140
Cdd:COG4886 141 LDLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTD--LPEELGNLTNLKELDLSNNQITDLPEPLgnLTNLEELDLSGNQLT 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 141 TIArDSLARIPLLEKLHLDDNSVSTVSieedAFADSKQLKLLFLSRNHLSSIPSGLPHT-LEELRLDDNRISTIPLHAFK 219
Cdd:COG4886 219 DLP-EPLANLTNLETLDLSNNQLTDLP----ELGNLTNLEELDLSNNQLTDLPPLANLTnLKTLDLSNNQLTDLKLKELE 293
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 220 GLNSLRRLVLDGNLLANQRIADDTFSRLQNLTELSLVRNSLAAPPLNLPSAHLQKLYLQDNAISHIPYNTLAKMRELERL 299
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373
|
250
....*....|....*....
gi 569007457 300 DLSNNNLTTLPRGLFDDLG 318
Cdd:COG4886 374 LLEATLLTLALLLLTLLLL 392
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
65-311 |
3.41e-16 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 77.90 E-value: 3.41e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 65 IYCNDRGLTSIPSDIP-DDATTLYLQNNQINNagIPqdlktkvkvqviylyenDLDefpiNLPRsLRELHLQDNNVRTIa 143
Cdd:cd21340 7 LYLNDKNITKIDNLSLcKNLKVLYLYDNKITK--IE-----------------NLE----FLTN-LTHLYLQNNQIEKI- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 144 rDSLARIPLLEKLHLDDNSVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNS 223
Cdd:cd21340 62 -ENLENLVNLKKLYLGGNRISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNS 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 224 LRRLVLDGNllanqriaddtfsRLQNLTELSLVRNslaapplnlpsahLQKLYLQDNAISHIPY--NTLAKMRELERLDL 301
Cdd:cd21340 122 LRVLNISGN-------------NIDSLEPLAPLRN-------------LEQLDASNNQISDLEEllDLLSSWPSLRELDL 175
|
250
....*....|
gi 569007457 302 SNNNLTTLPR 311
Cdd:cd21340 176 TGNPVCKKPK 185
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
84-329 |
3.75e-14 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 72.13 E-value: 3.75e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 84 TTLYLQNNQINnaGIPqDLKTKVKVQVIYLYENDLDEFPiNLP--RSLRELHLQDNNVRTIarDSLARIPLLEKLHLDDN 161
Cdd:cd21340 5 THLYLNDKNIT--KID-NLSLCKNLKVLYLYDNKITKIE-NLEflTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 162 SVSTVSieedAFADSKQLKLLFLSRNHLssiPSGlphtlEELRLDDNRISTIplhafkgLNSLRRLVLDGNllanqriad 241
Cdd:cd21340 79 RISVVE----GLENLTNLEELHIENQRL---PPG-----EKLTFDPRSLAAL-------SNSLRVLNISGN--------- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 242 dtfsRLQNLTELslvrnslaapplnlpsahlqklylqdnaishipyntlAKMRELERLDLSNNNLTTLpRGLFDDLGNLA 321
Cdd:cd21340 131 ----NIDSLEPL-------------------------------------APLRNLEQLDASNNQISDL-EELLDLLSSWP 168
|
250
....*....|.
gi 569007457 322 QLL---LRNNP 329
Cdd:cd21340 169 SLReldLTGNP 179
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
271-329 |
2.13e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 59.46 E-value: 2.13e-11
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 569007457 271 HLQKLYLQDNAISHIPYNTLAKMRELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNNP 329
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
300-406 |
3.33e-11 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 67.03 E-value: 3.33e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 300 DLSNNNLTTLPRGLFDDLGNLAQLLLRNNPWFCGCNLMWLRDWVRARAA-VVNVRGLMCQGPEKVRG---MAIKDITSEM 375
Cdd:TIGR00864 1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVkVRQPEAALCAGPGALAGqplLGIPLLDSGC 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 569007457 376 DE----CF-EAGSQGGAANAAAKTTVSNHASATTPQ 406
Cdd:TIGR00864 81 DEeyvaCLkDNSSGGGAARSELVIFSAAHEGLFQPE 116
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
178-234 |
2.74e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.38 E-value: 2.74e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007457 178 QLKLLFLSRNHLSSIP----SGLPHtLEELRLDDNRISTIPLHAFKGLNSLRRLVLDGNLL 234
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDdgafKGLSN-LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
127-332 |
5.35e-10 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 61.22 E-value: 5.35e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 127 RSLRELHLQDNNVRTIA----RDSLARIPLLEKLHLDDN----SVSTVSIEEDAFADSKQLKLLFLSRNHLSSIPSGL-- 196
Cdd:cd00116 23 LCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNetgrIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVle 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 197 ----PHTLEELRLDDNRISTIPL-HAFKGLNS----LRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAAPPL 265
Cdd:cd00116 103 sllrSSSLQELKLNNNGLGDRGLrLLAKGLKDlppaLEKLVLGRNRLEGASCEAlaKALRANRDLKELNLANNGIGDAGI 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569007457 266 NL------PSAHLQKLYLQDNAISHIPY----NTLAKMRELERLDLSNNNLTTLP-RGLFDDLGNLAQLLLRNNPWFC 332
Cdd:cd00116 183 RAlaeglkANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGaAALASALLSPNISLLTLSLSCN 260
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
75-327 |
8.01e-10 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 62.17 E-value: 8.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 75 IPSDI--PDDATTLYLQNNQINNAgIPQDLKTKVKVQVIYLYENDLD-EFPINLP--RSLRELHLQDNNVRTIARDSLAR 149
Cdd:PLN00113 348 IPKNLgkHNNLTVLDLSTNNLTGE-IPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVRLQDNSFSGELPSEFTK 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 150 IPLLEKLHLDDNSVSTvSIEEDAFaDSKQLKLLFLSRNHLSSipsGLPHT-----LEELRLDDNRIS-TIPLhAFKGLNS 223
Cdd:PLN00113 427 LPLVYFLDISNNNLQG-RINSRKW-DMPSLQMLSLARNKFFG---GLPDSfgskrLENLDLSRNQFSgAVPR-KLGSLSE 500
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 224 LRRLVLDGNLLANQriADDTFSRLQNLTELSLVRNSLAApplnlpsahlqklylqdnaisHIPyNTLAKMRELERLDLSN 303
Cdd:PLN00113 501 LMQLKLSENKLSGE--IPDELSSCKKLVSLDLSHNQLSG---------------------QIP-ASFSEMPVLSQLDLSQ 556
|
250 260
....*....|....*....|....*
gi 569007457 304 NNLT-TLPRglfdDLGNLAQLLLRN 327
Cdd:PLN00113 557 NQLSgEIPK----NLGNVESLVQVN 577
|
|
| PRK15387 |
PRK15387 |
type III secretion system effector E3 ubiquitin transferase SspH2; |
62-307 |
3.01e-09 |
|
type III secretion system effector E3 ubiquitin transferase SspH2;
Pssm-ID: 185285 [Multi-domain] Cd Length: 788 Bit Score: 60.18 E-value: 3.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 62 NGFIYCNDRGLTSIPSDIPDDATTLYLQNNQINN-AGIPQDLKTkvkvqvIYLYENDLDEFPInLPRSLRELHLQDNNVR 140
Cdd:PRK15387 203 NAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSlPALPPELRT------LEVSGNQLTSLPV-LPPGLLELSIFSNPLT 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 141 T------------IARDSLARIPL----LEKLHLDDNSVSTVSieedafADSKQLKLLFLSRNHLSSIPSgLPHTLEELR 204
Cdd:PRK15387 276 HlpalpsglcklwIFGNQLTSLPVlppgLQELSVSDNQLASLP------ALPSELCKLWAYNNQLTSLPT-LPSGLQELS 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 205 LDDNRISTIP---------------LHAFKGLNS-LRRLVLDGNLLANQRIADdtfsrlQNLTELSLVRNSLAAPPLnLP 268
Cdd:PRK15387 349 VSDNQLASLPtlpselyklwaynnrLTSLPALPSgLKELIVSGNRLTSLPVLP------SELKELMVSGNRLTSLPM-LP 421
|
250 260 270
....*....|....*....|....*....|....*....
gi 569007457 269 SAhLQKLYLQDNAISHIPyNTLAKMRELERLDLSNNNLT 307
Cdd:PRK15387 422 SG-LLSLSVYRNQLTRLP-ESLIHLSSETTVNLEGNPLS 458
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
328-378 |
7.02e-09 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 52.05 E-value: 7.02e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 569007457 328 NPWFCGCNLMWLRDWVRARAAVVNVRGLMCQGPEKVRGmAIKDITSEMDEC 378
Cdd:smart00082 1 NPFICDCELRWLLRWLQANEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
127-189 |
3.03e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 3.03e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007457 127 RSLRELHLQDNNVRTIARDSLARIPLLEKLHLDDNSVSTvsIEEDAFADSKQLKLLFLSRNHL 189
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
223-306 |
5.73e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.83 E-value: 5.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 223 SLRRLVLDGNLLanQRIADDTFSRLQNLTELslvrnslaapplnlpsahlqklYLQDNAISHIPYNTLAKMRELERLDLS 302
Cdd:pfam13855 2 NLRSLDLSNNRL--TSLDDGAFKGLSNLKVL----------------------DLSNNLLTTLSPGAFSGLPSLRYLDLS 57
|
....
gi 569007457 303 NNNL 306
Cdd:pfam13855 58 GNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
129-315 |
6.82e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 6.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 129 LRELHLQDN-----NVRTIArdSLARIPLLEKLHLDDNSVST--VSIEEDAFADSK-QLKLLFLSRNHLSSIPS-----G 195
Cdd:cd00116 83 LQELDLSDNalgpdGCGVLE--SLLRSSSLQELKLNNNGLGDrgLRLLAKGLKDLPpALEKLVLGRNRLEGASCealakA 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 196 LPH--TLEELRLDDNRIST--IPL--HAFKGLNSLRRLVLDGNLLANQRIAD--DTFSRLQNLTELSLVRNSLAapplNL 267
Cdd:cd00116 161 LRAnrDLKELNLANNGIGDagIRAlaEGLKANCNLEVLDLNNNGLTDEGASAlaETLASLKSLEVLNLGDNNLT----DA 236
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 569007457 268 PSAHLQKLYLQDNaishipyntlakmRELERLDLSNNNLT-----TLPRGLFD 315
Cdd:cd00116 237 GAAALASALLSPN-------------ISLLTLSLSCNDITddgakDLAEVLAE 276
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
54-84 |
8.60e-07 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 45.77 E-value: 8.60e-07
10 20 30
....*....|....*....|....*....|.
gi 569007457 54 CPSVCRCDNGFIYCNDRGLTSIPSDIPDDAT 84
Cdd:smart00013 2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
74-328 |
1.66e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.39 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 74 SIPSDIPDdaTTLYLQNNQI-----NN--AGIPQDLKTKVKVQVIYLYENDLD-EFPINLPR--SLRELHLQDNNVRtia 143
Cdd:PLN00113 295 SLSGEIPE--LVIQLQNLEIlhlfsNNftGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKhnNLTVLDLSTNNLT--- 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 144 rdslARIPlleklhlddnsvstvsieeDAFADSKQLKLLFLSRNHL-SSIPSGLP--HTLEELRLDDNRISTIPLHAFKG 220
Cdd:PLN00113 370 ----GEIP-------------------EGLCSSGNLFKLILFSNSLeGEIPKSLGacRSLRRVRLQDNSFSGELPSEFTK 426
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 221 LNSLRRLVLDGNLLANqRIADDTFSrLQNLTELSLVRNSLAApplNLP----SAHLQKLYLQDNAISHIPYNTLAKMREL 296
Cdd:PLN00113 427 LPLVYFLDISNNNLQG-RINSRKWD-MPSLQMLSLARNKFFG---GLPdsfgSKRLENLDLSRNQFSGAVPRKLGSLSEL 501
|
250 260 270
....*....|....*....|....*....|...
gi 569007457 297 ERLDLSNNNLT-TLPRGLfDDLGNLAQLLLRNN 328
Cdd:PLN00113 502 MQLKLSENKLSgEIPDEL-SSCKKLVSLDLSHN 533
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
85-328 |
2.17e-06 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 51.00 E-value: 2.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 85 TLYLQNNQINnAGIPQDLKTkvkvqviylyendldefpinLPRSLRELHLQDNNVR-TIARDSlarIPLLEKLHLDDNSV 163
Cdd:PLN00113 97 TINLSNNQLS-GPIPDDIFT--------------------TSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDLSNNML 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 164 STVSIEEDAFADSkqLKLLFLSRNHLSS-IPSGLPH--TLEELRLDDNR-ISTIPlHAFKGLNSLRRLVLDGNLLANQri 239
Cdd:PLN00113 153 SGEIPNDIGSFSS--LKVLDLGGNVLVGkIPNSLTNltSLEFLTLASNQlVGQIP-RELGQMKSLKWIYLGYNNLSGE-- 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 240 ADDTFSRLQNLTELSLVRNSLAAPplnLPSA-----HLQKLYLQDNAIS-HIPyNTLAKMRELERLDLSNNNLTTLPRGL 313
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLVYNNLTGP---IPSSlgnlkNLQYLFLYQNKLSgPIP-PSIFSLQKLISLDLSDNSLSGEIPEL 303
|
250
....*....|....*
gi 569007457 314 FDDLGNLAQLLLRNN 328
Cdd:PLN00113 304 VIQLQNLEILHLFSN 318
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
54-80 |
3.08e-06 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 44.16 E-value: 3.08e-06
10 20
....*....|....*....|....*..
gi 569007457 54 CPSVCRCDNGFIYCNDRGLTSIPSDIP 80
Cdd:pfam01462 2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
|
|
| LRR |
smart00370 |
Leucine-rich repeats, outliers; |
293-316 |
1.31e-04 |
|
Leucine-rich repeats, outliers;
Pssm-ID: 197688 [Multi-domain] Cd Length: 24 Bit Score: 39.26 E-value: 1.31e-04
|
| LRR_TYP |
smart00369 |
Leucine-rich repeats, typical (most populated) subfamily; |
293-316 |
1.31e-04 |
|
Leucine-rich repeats, typical (most populated) subfamily;
Pssm-ID: 197687 [Multi-domain] Cd Length: 24 Bit Score: 39.26 E-value: 1.31e-04
|
| FN3 |
smart00060 |
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ... |
441-505 |
1.44e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.
Pssm-ID: 214495 [Multi-domain] Cd Length: 83 Bit Score: 41.06 E-value: 1.44e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569007457 441 IQVKPLTADSIRITWKAMLPAS--SFRLSWlRLGHSPAVGSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:smart00060 7 LRVTDVTSTSVTLSWEPPPDDGitGYIVGY-RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEF 72
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
294-328 |
3.26e-04 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 39.04 E-value: 3.26e-04
10 20 30
....*....|....*....|....*....|....*
gi 569007457 294 RELERLDLSNNNLTTLPRGLFDDLGNLAQLLLRNN 328
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN 35
|
|
| FN3 |
cd00063 |
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ... |
441-505 |
4.60e-04 |
|
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.
Pssm-ID: 238020 [Multi-domain] Cd Length: 93 Bit Score: 39.79 E-value: 4.60e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007457 441 IQVKPLTADSIRITWKAML----PASSFRLSWLRLGHSPavgSITETLVQGDKTEYLLTALEPKSTYII 505
Cdd:cd00063 7 LRVTDVTSTSVTLSWTPPEddggPITGYVVEYREKGSGD---WKEVEVTPGSETSYTLTGLKPGTEYEF 72
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
84-210 |
5.48e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 42.85 E-value: 5.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 84 TTLYLQNNQINNAG---IPQDLKTKVKVQVIYLYENDL-DEFPINLPRSLR------ELHLQDNNVRTIARDSLARI--- 150
Cdd:COG5238 267 ETLYLSGNQIGAEGaiaLAKALQGNTTLTSLDLSVNRIgDEGAIALAEGLQgnktlhTLNLAYNGIGAQGAIALAKAlqe 346
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569007457 151 -PLLEKLHLDDNSVSTVSIEE--DAFADSKQLKLLFLSRNHLSS------IPSGLPHTLEELRLDDNRI 210
Cdd:COG5238 347 nTTLHSLDLSDNQIGDEGAIAlaKYLEGNTTLRELNLGKNNIGKqgaealIDALQTNRLHTLILDGNLI 415
|
|
| fn3 |
pfam00041 |
Fibronectin type III domain; |
441-509 |
1.15e-03 |
|
Fibronectin type III domain;
Pssm-ID: 394996 [Multi-domain] Cd Length: 85 Bit Score: 38.55 E-value: 1.15e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007457 441 IQVKPLTADSIRITWKAMLPASS----FRLSWLRLGHSpavGSITETLVQGDKTEYLLTALEPKSTYIICMVT 509
Cdd:pfam00041 6 LTVTDVTSTSLTVSWTPPPDGNGpitgYEVEYRPKNSG---EPWNEITVPGTTTSVTLTGLKPGTEYEVRVQA 75
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
271-308 |
2.76e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.07 E-value: 2.76e-03
10 20 30
....*....|....*....|....*....|....*...
gi 569007457 271 HLQKLYLQDNAISHIPynTLAKMRELERLDLSNNNLTT 308
Cdd:pfam12799 2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
|
|
| LRR_5 |
pfam13306 |
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ... |
153-251 |
5.51e-03 |
|
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.
Pssm-ID: 463839 [Multi-domain] Cd Length: 127 Bit Score: 37.52 E-value: 5.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007457 153 LEKLHLDDNsvsTVSIEEDAFADSKQLKLLFLSRNhLSSIPSglpHT-----LEELRLDDNrISTIPLHAFKGLNSLRRL 227
Cdd:pfam13306 13 LTSITIPSS---LTSIGEYAFSNCTSLKSITLPSS-LTSIGS---YAfyncsLTSITIPSS-LTSIGEYAFSNCSNLKSI 84
|
90 100
....*....|....*....|....*.
gi 569007457 228 VLDGNLlanQRIADDTF--SRLQNLT 251
Cdd:pfam13306 85 TLPSNL---TSIGSYAFsnCSLKSIT 107
|
|
|