|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
1-1178 |
0e+00 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 1399.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1 MGKLIRIGTQERRLFRrPKRLHWSRLLFLLGMLIIGSTYQHLRRPQNSPSMWTKVSSQQLIKLASRDLPSDEMTVVGSDP 80
Cdd:TIGR00927 1 MGKLIRMGTQERRLLR-PKRLHWSRLLFLLGMLIIGSTYQHLRRPQGLPSLWAAVSSQQPIKLASRDLSNDEMMMVSSDP 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 81 PEGSSEVDGEMLAPQNTVIRDEATPSLTMEDTPNPPR-TTEITPISPKNNYSPIAAGTS----------SRASNHFISMS 149
Cdd:TIGR00927 80 PKSSSEMEGEMLAPQATVGRDEATPSIAMENTPSPPRrTAKITPTTPKNNYSPTAAGTErvkedtpatpSRALNHYISTS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 150 GRERIKNYTPVPRGERRNSTPAHSREKGRKYTPSPAG------APS---------ATTPITTEKDSKTMATYRLLETRPP 214
Cdd:TIGR00927 160 GRQRVKSYTPKPRGEVKSSSPTQTREKVRKYTPSPLGrmvnsyAPStfmtmprshGITPRTTVKDSEITATYKMLETNPS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 215 ERTVEETTAASLKRVVPNTLTFLTREAETSLLSSP-SLVEENTLGSPRREEQNSSTSL------------QGAVSQHTPA 281
Cdd:TIGR00927 240 KRTAGKTTPTPLKGMTDNTPTFLTREVETDLLTSPrSVVEKNTLTTPRRVESNSSTNHwglvgknnlttpQGTVLEHTPA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 282 TSEEQVTRRARMGSNPETIGVSTVARRISNPLSRTSAPTIRIASATNRELAKRPSTAHRAPVTSKVKAILTTQVHRCVVM 361
Cdd:TIGR00927 320 TSEGQVTISIMTGSSPAETKASTAAWKIRNPLSRTSAPAVRIASATFRGLEKNPSTAPSTPATPRVRAVLTTQVHHCVVV 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 362 EPVPAVPMSPSPSITNIVFPGAPSPSPSDSPPGWPKLHAKAEYPPDLFSVEDRRQGWVALHIFGMMYVFVALAIVCDEYF 441
Cdd:TIGR00927 400 KPAPAVPTTPSPSLTTALFPEAPSPSPSALPPGQPDLHPKAEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYF 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 442 VPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWP 521
Cdd:TIGR00927 480 VPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWP 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 522 LFRDVSFYILDLSMLIVFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSKpsdgaie 601
Cdd:TIGR00927 560 LFRDVSFYILDLMMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELWVKEQLSRRPVAKVMALGDLSK------- 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 602 enesqdnkklklpsvltrgsssaslhnsiirstiyhlmlhsldplgearpskdkqeslnqEARVHPQTKAESSPDEEEPA 681
Cdd:TIGR00927 633 ------------------------------------------------------------GDVAEAEHTGERTGEEGERP 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 682 qlpavTVTPAPAPDAKGDQEEDPGCQEEVGEADQTGDMTGEEGETQPGERETEAEGKEDEGETEAEGKEDEEGETEVEGK 761
Cdd:TIGR00927 653 -----TEAEGENGEESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTE 727
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 762 DEHKGETEVEGKGDE-EGETEAEGKEDKEgeteaegkedeegegeteveRKGDEQEGEIeaegkedeeegeteaegkgae 840
Cdd:TIGR00927 728 DEGEIETGEEGEEVEdEGEGEAEGKHEVE--------------------TEGDRKETEH--------------------- 766
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 841 egeteaegkgaeegeteaegkgaEEGETEAEGKGDEEGETEAEG----KGDEQE------GETEAEGKEDELEGQAEIQG 910
Cdd:TIGR00927 767 -----------------------EGETEAEGKEDEDEGEIQAGEdgemKGDEGAegkvehEGETEAGEKDEHEGQSETQA 823
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 911 DnNTEVKDGEGETEANAENPCETTQGEKGAGDEG------GSDGGDSGEEEDEEEEEEEEEEEDEEENEEPLSLEWPESR 984
Cdd:TIGR00927 824 D-DTEVKDETGEQELNAENQGEAKQDEKGVDGGGgsdggdSEEEEEEEEEEEEEEEEEEEEEEEEEENEEPLSLEWPETR 902
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 985 QKQAIYLFLLPIVFPLWLTVPDVRRQESRKFFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIP 1064
Cdd:TIGR00927 903 QKQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIP 982
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1065 DLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINTLQPVPVSSNGLFCAIVLLFLMLLFVIFSIASCKWR 1144
Cdd:TIGR00927 983 DLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWR 1062
|
1210 1220 1230
....*....|....*....|....*....|....
gi 354490081 1145 MNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1178
Cdd:TIGR00927 1063 MNKILGFTMFLLYFVFLIISVMLEDRIISCPVSV 1096
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
421-547 |
4.43e-43 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 159.41 E-value: 4.43e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 421 LHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNI 500
Cdd:TIGR00367 1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 354490081 501 LFVIGTCALFSrEILNLTWWpLFRDVSFYILDLSMLIVFFLDSLIAW 547
Cdd:TIGR00367 81 LLILGLSAIFS-PIIVDKDW-LRRDILFYLLVSILLLFFGLDGQISR 125
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
1009-1160 |
1.67e-40 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 152.09 E-value: 1.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1009 RQESRKFFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGS 1088
Cdd:TIGR00367 164 RRPQIFFSLVLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGS 243
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 354490081 1089 NIFDITVGLPVPWLLFSLinTLQPVPVSSNGLFCAiVLLFLMLLFVIFSIASCKWrmnkiLGFTMFLLYFVF 1160
Cdd:TIGR00367 244 NIFNILVGLGVPSLFMPI--PVEPLAYNLDAPVMV-IVTLLLMLFFKTSMKLGRW-----EGILLLALYIAY 307
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
1015-1166 |
2.36e-32 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 123.10 E-value: 2.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1015 FFVITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 1094
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 354490081 1095 VGLPVPWLLFSLINTLQPVPVSSNGLFCAIVLLFLMLLFVIFSIascKWRMNKILGFTMFLLYFVFLIISVM 1166
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL---FGRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
422-550 |
7.47e-31 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 118.86 E-value: 7.47e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 422 HIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 501
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 354490081 502 FVIGTCALFS-----REILNLTwWPLFRDVSFYILDLSMLIVFFLDSLIAWWES 550
Cdd:pfam01699 81 LVLGLSALIGpvkvdSLLLKLD-LGVLLLVALLLLLLLLLLLLPLFGRLSRFEG 133
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
1017-1163 |
1.12e-24 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 105.60 E-value: 1.12e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1017 VITFLGSIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVG 1096
Cdd:COG0530 154 LLLLVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 354490081 1097 LPVPWLlfslintLQPVPVSSN------------GLFCAIvllflmllfvifsIASCKWRMNKILGFTMFLLYFVFLII 1163
Cdd:COG0530 234 LGIGAL-------ITPIPVDPAvlsfdlpvmlaaTLLLLG-------------LLRTGGRIGRWEGLLLLALYLAYLAL 292
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
439-549 |
3.48e-23 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 101.36 E-value: 3.48e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 439 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSReiLNLT 518
Cdd:COG0530 2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
|
90 100 110
....*....|....*....|....*....|.
gi 354490081 519 WWPLFRDVSFYILDLSMLIVFFLDSLIAWWE 549
Cdd:COG0530 80 RRVLRRDLPFLLLASLLLLALLLDGTLSRID 110
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
426-550 |
5.24e-16 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 79.79 E-value: 5.24e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 426 MMYVFVALA--IVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFV 503
Cdd:COG0530 154 LLLLVLGLAllVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLV 233
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 354490081 504 IGTCALFSReiLNLTWWPLFRDVSFYILdLSMLIVFFL--DSLIAWWES 550
Cdd:COG0530 234 LGIGALITP--IPVDPAVLSFDLPVMLA-ATLLLLGLLrtGGRIGRWEG 279
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
1046-1103 |
5.35e-14 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 74.68 E-value: 5.35e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 354490081 1046 GISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLL 1103
Cdd:PRK10734 205 AISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI 262
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
1038-1170 |
1.86e-13 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 72.47 E-value: 1.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1038 AHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWL--------------- 1102
Cdd:COG0530 8 ADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALirplavdrrvlrrdl 87
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 354490081 1103 LFSLINTLQPVPVSSNGlfcaivllflmllfvifsiasckwRMNKILGFTMFLLYFVFLIISVMLEDR 1170
Cdd:COG0530 88 PFLLLASLLLLALLLDG------------------------TLSRIDGVILLLLYVLYLYYLIRRARK 131
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
429-547 |
2.64e-12 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 69.27 E-value: 2.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 429 VFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCA 508
Cdd:TIGR00367 177 IGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPS 256
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 354490081 509 LFSreilnltwwPLFRDVSFYILDLS-MLIVFFLDSLIAW 547
Cdd:TIGR00367 257 LFM---------PIPVEPLAYNLDAPvMVIVTLLLMLFFK 287
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
1015-1168 |
2.30e-11 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 66.19 E-value: 2.30e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1015 FFVITFLGSIIWIAMFsylMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDIT 1094
Cdd:TIGR00367 5 GYLILGLILLIYGADL---FVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNIL 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 354490081 1095 VGLPVPWLlfslintLQPVPVSSNGLFcaIVLLFLMLLFVIFSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1168
Cdd:TIGR00367 82 LILGLSAI-------FSPIIVDKDWLR--RDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVYLLFLVKNE 146
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
426-549 |
1.56e-09 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 62.50 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 426 MMYVFVALAIVCDEyFVPALGVITDK-----------------LQI-SEDVAGATFMAAGGSAPELFTSLIGV----FIS 483
Cdd:TIGR00845 82 MVYMFLGVSIIADR-FMASIEVITSQekeitikkpngettvttVRIwNETVSNLTLMALGSSAPEILLSVIEVcghnFEA 160
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 354490081 484 hSNVGIGTIVGSAVFNILFVIGTCALF-----SREILNL------TWWPLFRDVSFYildlsMLIVFFLDSLIAWWE 549
Cdd:TIGR00845 161 -GDLGPSTIVGSAAFNMFIIIAICVYVipdgeTRKIKHLrvffvtAAWSVFAYVWLY-----LILAVFSPGVVEVWE 231
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
447-511 |
1.90e-08 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 57.35 E-value: 1.90e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 354490081 447 VITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFS 511
Cdd:PRK10734 199 VLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALIS 263
|
|
| PLN03151 |
PLN03151 |
cation/calcium exchanger; Provisional |
1003-1165 |
6.30e-08 |
|
cation/calcium exchanger; Provisional
Pssm-ID: 215604 [Multi-domain] Cd Length: 650 Bit Score: 57.08 E-value: 6.30e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1003 TVPDvrrQESRKFFVITFLG----SIIWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGlG 1078
Cdd:PLN03151 471 TEPD---RPPRRFLIPWVLGgfimSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-G 546
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1079 D---MAVSSSVGSNIFDITVGLPVPWLLFSLINTLQP--VPvSSNGLFCAIVLLFLMLLFVIFSIASCKWRMNKILGFTM 1153
Cdd:PLN03151 547 DgvqIAMSGCYAGPMFNTLVGLGMSMLLGAWSKSPESymLP-EDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGL 625
|
170
....*....|..
gi 354490081 1154 FLLYFVFLIISV 1165
Cdd:PLN03151 626 IALYLIFLTFRV 637
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
1034-1120 |
2.09e-07 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 54.27 E-value: 2.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 1034 MVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITvglpvpwLLFSLINTLQPV 1113
Cdd:PRK10734 22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNIL-------LILGLAALIRPF 94
|
....*..
gi 354490081 1114 PVSSNGL 1120
Cdd:PRK10734 95 TVHSDVL 101
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
83-376 |
1.06e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.91 E-value: 1.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 83 GSSEVDGEMLAPQNTVIRDEATPSLTMedtpnPPRTTEITPISPKNNYSpIAAGTSSRASNHFISMSGRERIKNYTPV-- 160
Cdd:pfam05109 289 GPKASGGDYCIQSNIVFSDEIPASQDM-----PTNTTDITYVGDNATYS-VPMVTSEDANSPNVTVTAFWAWPNNTETdf 362
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 161 ----------PRGeRRNSTPAHSREKGRKYTPSPAGAPSATTPITTEKDSKTMATYRLLETRPPERTVEETTAASLKRVV 230
Cdd:pfam05109 363 kckwtltsgtPSG-CENISGAFASNRTFDITVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAA 441
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 231 PNTLTFLTREAET-SLLSSPSlveenTLGSPRREEQNSSTSLQGAVSQHTPATSEeqvtrrarmgSNPETIGVSTVARRI 309
Cdd:pfam05109 442 PNTTTGLPSSTHVpTNLTAPA-----STGPTVSTADVTSPTPAGTTSGASPVTPS----------PSPRDNGTESKAPDM 506
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 354490081 310 SNPLSRTSAPTIRIASATNRELAKRP-STAHRAPVTSKVKAILTTQVHrcvVMEPVPAVpMSPSPSIT 376
Cdd:pfam05109 507 TSPTSAVTTPTPNATSPTPAVTTPTPnATSPTLGKTSPTSAVTTPTPN---ATSPTPAV-TTPTPNAT 570
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
647-791 |
3.93e-05 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 47.66 E-value: 3.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 647 GEARPSKDKQE-----SLNQEARVHPQTKAESSPDEEEPAQlpAVTVTPAPAPDAKGDQEEDPgcQEEVGEADQTGDMTG 721
Cdd:PHA03169 103 PTPSPSGSAEElasglSPENTSGSSPESPASHSPPPSPPSH--PGPHEPAPPESHNPSPNQQP--SSFLQPSHEDSPEEP 178
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 722 EEGETQPGERETEAEGKEDEGETEAEGKedeegeteveGKDEHKGETEVEGKGDEEGETEAEGKEDKEGE 791
Cdd:PHA03169 179 EPPTSEPEPDSPGPPQSETPTSSPPPQS----------PPDEPGEPQSPTPQQAPSPNTQQAVEHEDEPT 238
|
|
| PLN03151 |
PLN03151 |
cation/calcium exchanger; Provisional |
439-547 |
4.24e-04 |
|
cation/calcium exchanger; Provisional
Pssm-ID: 215604 [Multi-domain] Cd Length: 650 Bit Score: 44.37 E-value: 4.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 439 EYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFTSlIGVFISHS--NVGIGTIVGSAVFNILFVIGTCAL-FSREIL 515
Cdd:PLN03151 160 DYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKDagEVGLNSVLGGAVFVTCVVVGIVSLcVADKEV 238
|
90 100 110
....*....|....*....|....*....|...
gi 354490081 516 NLTWWPLFRDVSFYILDL-SMLIVFFLDSLIAW 547
Cdd:PLN03151 239 QIDKRCFIRDLCFFLFTLvSLLVILMVGKVTVG 271
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
647-748 |
2.93e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.49 E-value: 2.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 647 GEARPSKDKQESLNQEARVHPQTKAESSPDEEEPAqlpavtvTPAPAPDAKG-DQEEDPGCQEEVGE-ADQTGDMTGEEG 724
Cdd:PHA03169 147 HEPAPPESHNPSPNQQPSSFLQPSHEDSPEEPEPP-------TSEPEPDSPGpPQSETPTSSPPPQSpPDEPGEPQSPTP 219
|
90 100
....*....|....*....|....*
gi 354490081 725 ETQP-GERETEAEGKEDEGETEAEG 748
Cdd:PHA03169 220 QQAPsPNTQQAVEHEDEPTEPEREG 244
|
|
| MDN1 |
COG5271 |
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
642-792 |
3.19e-03 |
|
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 41.92 E-value: 3.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 642 SLDPLGEARPSKDKQESLNQEARVHPQTKAESSPDEEEPAQLPAVTVTPAPAPDAKGDQEEDPGCQEEVG-EADQTGDMT 720
Cdd:COG5271 590 SADESEEAEASEDEAAEEEEADDDEADADADGAADEEETEEEAAEDEAAEPETDASEAADEDADAETEAEaSADESEEEA 669
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 354490081 721 GEEGETQPGERETEAEG--KEDEGETEAEGKEDEEGETEVEGKDEHKGETEVEGKGDEEGETEAEGKE-DKEGET 792
Cdd:COG5271 670 EDESETSSEDAEEDADAaaAEASDDEEETEEADEDAETASEEADAEEADTEADGTAEEAEEAAEEAESaDEEAAS 744
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
650-952 |
4.25e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 41.11 E-value: 4.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 650 RPSKDKQESLNQEARVHPQTKAESSPDeeepAQLPAVTVTPAPAPDAKGDQEEDPGCQEEVGEA-DQTGDMTGEEGETQP 728
Cdd:PHA03169 6 RKAKRSRHTLRSSCRGHCKRHGGTREQ----AGRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGhRQTESDTETAEESRH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 729 GERETEAEGKED-EGETEAEGkedeegeteveGKDEHKGETEVEGKGDEEGETEAEGKEDKEGETEAEGKEdeegegete 807
Cdd:PHA03169 82 GEKEERGQGGPSgSGSESVGS-----------PTPSPSGSAEELASGLSPENTSGSSPESPASHSPPPSPP--------- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 808 verkGDEQEGEieaegkedeeegeteaegkgaeegeteaegkgaeegeteaegkgaEEGETEAEGKGDEEGETEAEGKGD 887
Cdd:PHA03169 142 ----SHPGPHE---------------------------------------------PAPPESHNPSPNQQPSSFLQPSHE 172
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 354490081 888 EQEGETEAEGKEDELEGQAEIQGDNNTEVKDGEGETEANAENPCETTQGEKGAGDEGGSDGGDSG 952
Cdd:PHA03169 173 DSPEEPEPPTSEPEPDSPGPPQSETPTSSPPPQSPPDEPGEPQSPTPQQAPSPNTQQAVEHEDEP 237
|
|
| Granin |
pfam01271 |
Granin (chromogranin or secretogranin); |
654-791 |
4.93e-03 |
|
Granin (chromogranin or secretogranin);
Pssm-ID: 279595 [Multi-domain] Cd Length: 584 Bit Score: 41.17 E-value: 4.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 654 DKQESLNQEARVHPQTKAESSPDEEE---------------PAQLPA-VTVTPAPAPDAKGDQEEDPGCQEEVG-EADQT 716
Cdd:pfam01271 209 YRQENIPQEDQVGPEDQEPSEEGEEDatqeevkrsrprthhGRSLPDeSSRGGQLGLEEEASEEEEEYGEESRGlSAVQT 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 717 GDM-------TGEEGETQPGERETEAEGKEDE--GETEAEGKEDEEGETEVEGKDEHKGETEVE-GKGDEEGETEAEGKE 786
Cdd:pfam01271 289 YLLrlvnargRGRSEKRAERERSEESEEEELKraSPYEELEITANLQIPPSEEERMLKKAGRSPrGRVDEAGALEALEAL 368
|
....*
gi 354490081 787 DKEGE 791
Cdd:pfam01271 369 EEKRK 373
|
|
| COG5137 |
COG5137 |
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics] ... |
644-791 |
5.17e-03 |
|
Histone chaperone involved in gene silencing [Transcription / Chromatin structure and dynamics];
Pssm-ID: 227466 [Multi-domain] Cd Length: 279 Bit Score: 40.36 E-value: 5.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 644 DPLGEARPSKDKQESLNQEARVHPQTKAESSPDEEEPAQlPAVtvtPAPAPDAKGDQEEDPGCQEEvgEADQTGDMTGEE 723
Cdd:COG5137 130 EPSEKVDEEDVEREILAEKPRVTRFNIVWDNDEDNDEAP-PAQ---PDVDNEEEERLEESDGREEE--EDEEVGSDSYGE 203
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 354490081 724 GETQPGERETEAEGKEDEGETEAEGKedeegetevegkdehkGETEVEGKGDEEGETEAEGKEDKEGE 791
Cdd:COG5137 204 GNRELNEEEEEEAEGSDDGEDVVDYE----------------GERIDKKQGEEEEMEEEVINLFEIEW 255
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
429-510 |
7.00e-03 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 40.01 E-value: 7.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 429 VFVAlAIVCDEYFVPALgvitdklqisedVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCA 508
Cdd:PRK10734 23 VFAA-SILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAA 89
|
..
gi 354490081 509 LF 510
Cdd:PRK10734 90 LI 91
|
|
| MDN1 |
COG5271 |
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal ... |
641-789 |
9.11e-03 |
|
Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444083 [Multi-domain] Cd Length: 1028 Bit Score: 40.38 E-value: 9.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 354490081 641 HSLDPLGEARPSKDKQESLNQEARVHPQTKAESSPDEEEPAQLPAVTVTPAPAPDAKGDQEEDPGCQEEVGEADQTGDMT 720
Cdd:COG5271 525 AADPEDSDEDALEDETEGEENAPGSDQDADETDEPEATAEEDEPDEAEAETEDATENADADETEESADESEEAEASEDEA 604
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 354490081 721 GEEGETQPGERETEAEGKEDEGETEAEGKEDEEGETEVEGKDEHK----GETEVEGKGDEEGETEAEGKEDKE 789
Cdd:COG5271 605 AEEEEADDDEADADADGAADEEETEEEAAEDEAAEPETDASEAADedadAETEAEASADESEEEAEDESETSS 677
|
|
| |
