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Conserved domains on  [gi|157868114|ref|XP_001682610|]
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conserved hypothetical protein [Leishmania major strain Friedlin]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-110 2.63e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPYGCSIFVAAAG-EHPITSVRFAADGESFAVGSF-MNVRVCD-KTGW 83
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSSdKTIRLWDlETGE 84

                         90       100
                 ....*....|....*....|....*..
gi 157868114  84 SHSYERTTEGSAMALDWMPDGtQMILG 110
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDG-RILSS 110
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-110 2.63e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPYGCSIFVAAAG-EHPITSVRFAADGESFAVGSF-MNVRVCD-KTGW 83
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSSdKTIRLWDlETGE 84

                         90       100
                 ....*....|....*....|....*..
gi 157868114  84 SHSYERTTEGSAMALDWMPDGtQMILG 110
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDG-RILSS 110
WD40 COG2319
WD40 repeat [General function prediction only];
7-118 1.92e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPY-GCSIFVAAAGEHPITSVRFAADGESFAVGSF-MNVRVCD-KTGW 83
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDlATGK 237

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157868114  84 SHSYERTTEGSAMALDWMPDGTQMILGNGTGALSI 118
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-39 2.39e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.39e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 157868114     7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWD 39
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1-39 2.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157868114    1 MKKQIKWKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWD 39
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-110 2.63e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.42  E-value: 2.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPYGCSIFVAAAG-EHPITSVRFAADGESFAVGSF-MNVRVCD-KTGW 83
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGhTGPVRDVAASADGTYLASGSSdKTIRLWDlETGE 84

                         90       100
                 ....*....|....*....|....*..
gi 157868114  84 SHSYERTTEGSAMALDWMPDGtQMILG 110
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDG-RILSS 110
WD40 COG2319
WD40 repeat [General function prediction only];
7-118 1.92e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 1.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPY-GCSIFVAAAGEHPITSVRFAADGESFAVGSF-MNVRVCD-KTGW 83
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAdGTVRLWDlATGK 237

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157868114  84 SHSYERTTEGSAMALDWMPDGTQMILGNGTGALSI 118
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-114 3.50e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.95  E-value: 3.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWD--PYGCsIFVAAAGEHPITSVRFAADGESFAVGSF-MNVRVCDKTGW 83
Cdd:cd00200   89 LTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDveTGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQdGTIKLWDLRTG 167

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157868114  84 SHSYERTT-EGSAMALDWMPDGTQMILGNGTG 114
Cdd:cd00200  168 KCVATLTGhTGEVNSVAFSPDGEKLLSSSSDG 199
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-104 6.45e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 6.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   2 KKQIKWKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPYGCSIFVAAAG-EHPITSVRFAADGESFAVGSF-MNVRV-- 77
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGhTGEVNSVAFSPDGEKLLSSSSdGTIKLwd 205

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157868114  78 -----CDKTGWSHsyerttEGSAMALDWMPDG 104
Cdd:cd00200  206 lstgkCLGTLRGH------ENGVNSVAFSPDG 231
WD40 COG2319
WD40 repeat [General function prediction only];
7-110 5.93e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 5.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPY-GCSIFVAAAGEHPITSVRFAADGESFAVGSFMN-VRVCD-KTGW 83
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLAtGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGtVRLWDlATGK 321

                         90       100
                 ....*....|....*....|....*..
gi 157868114  84 SHSYERTTEGSAMALDWMPDGTQMILG 110
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
7-72 1.30e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 1.30e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPYGCSIFVAAAG-EHPITSVRFAADGESFAVGSF 72
Cdd:COG2319  326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSA 392
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-108 1.58e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 1.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   8 KAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPYGCSIFVAAAG-EHPITSVRFAADGESFAVGSF--------MNVRVC 78
Cdd:cd00200  174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEdgtirvwdLRTGEC 253

                         90       100       110
                 ....*....|....*....|....*....|
gi 157868114  79 DKTGWSHsyerttEGSAMALDWMPDGTQMI 108
Cdd:cd00200  254 VQTLSGH------TNSVTSLAWSPDGKRLA 277
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 7-39 2.39e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.39e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 157868114     7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWD 39
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
7-118 3.68e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 3.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   7 WKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDP-YGCSIFVAAAGEHPITSVRFAADGESFAVGSFMN-VRVCDKTGWS 84
Cdd:COG2319  284 LTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLaTGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGtVRLWDLATGE 363

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 157868114  85 HSYERTT-EGSAMALDWMPDGTQMILGNGTGALSI 118
Cdd:COG2319  364 LLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-77 2.53e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114   1 MKKQIKW-KAHKGVVLCADWSRMSGMIVTGGEDGVYKVWDPYGCS-IFVAAAGEHPITSVRFAADGESFAVGSF-MNVRV 77
Cdd:cd00200  208 TGKCLGTlRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGEcVQTLSGHTNSVTSLAWSPDGKRLASGSAdGTIRI 287
WD40 pfam00400
WD domain, G-beta repeat;
1-39 2.69e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 2.69e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 157868114    1 MKKQIKWKAHKGVVLCADWSRMSGMIVTGGEDGVYKVWD 39
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
10-118 3.50e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.89  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157868114  10 HKGVVLCADWSRMSGMIVTGGEDGVYKVWD-PYGCSIFVAAAGEHPITSVRFAADGESFAVGSFMN-VRVCDKTGWSHSY 87
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLWDLATGKLLR 156

                         90       100       110
                 ....*....|....*....|....*....|..
gi 157868114  88 E-RTTEGSAMALDWMPDGTQMILGNGTGALSI 118
Cdd:COG2319  157 TlTGHSGAVTSVAFSPDGKLLASGSDDGTVRL 188
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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