|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07812 |
PRK07812 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
5-440 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236105 Cd Length: 436 Bit Score: 882.17 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 5 SNSTDADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAA 84
Cdd:PRK07812 1 STSTDADPTANWSFETKQIHAGQTPDPATNARALPIYQTTSYTFDDTDHAAALFGLAEPGNIYTRIMNPTQDVVEQRIAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 85 LEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNTKAFF 164
Cdd:PRK07812 81 LEGGVAALLLASGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYTLPKLGIEVSFVEDPDDLDAWRAAVRPNTKAFF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 165 AETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQG 244
Cdd:PRK07812 161 AETISNPQIDVLDIPGVAEVAHEAGVPLIVDNTIATPYLIRPLEHGADIVVHSATKYLGGHGTAIAGVIVDGGTFDWTQG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 245 RFPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDV 324
Cdd:PRK07812 241 RFPGFTTPDPSYHGVVFAELGPPAYALKARVQLLRDLGSAISPFNAFLIAQGLETLSLRIERHVANAQRVAEFLEARDEV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 325 LSVNYAGLPSSPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQL 404
Cdd:PRK07812 321 ASVNYAGLPSSPWYERAKRLAPKGTGAVLSFELAGGVEAGKAFVNALTLHSHVANIGDVRSLVIHPASTTHSQLTPEEQL 400
|
410 420 430
....*....|....*....|....*....|....*.
gi 15610476 405 ATGVSPGLVRLAVGIEGIDDILADLELGFAAARRFS 440
Cdd:PRK07812 401 ATGVTPGLVRLAVGIEGIDDILADLEAGFAAAKAFS 436
|
|
| MET17 |
COG2873 |
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid ... |
16-437 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent [Amino acid transport and metabolism]; O-acetylhomoserine/O-acetylserine sulfhydrylase, pyridoxal phosphate-dependent is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 442120 [Multi-domain] Cd Length: 428 Bit Score: 815.42 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 16 WSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS 95
Cdd:COG2873 6 YGFETLALHAGQEPDPTTGARAVPIYQTTSYVFDDAEHAADLFALKEPGNIYTRIMNPTTDVLEKRIAALEGGVAALATA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 96 SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDL 175
Cdd:COG2873 86 SGQAAITLAILNLAEAGDHIVASSSLYGGTYNLFAHTLPRLGIEVRFVD-PDDPEAFEAAIDPNTKAIFGETIGNPALDV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 176 LDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-GRFPGFTTPDP 254
Cdd:COG2873 165 LDIEAIAEIAHEHGVPLIVDNTFATPYLCRPIEHGADIVVHSATKYIGGHGTSIGGVIVDGGNFDWAAnGKFPELTEPDP 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 255 SYHGVVFAE-LGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLP 333
Cdd:COG2873 245 SYHGLVYTEaFGNAAFITKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLEAHPKVAWVNYPGLP 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 334 SSPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLV 413
Cdd:COG2873 325 SHPYHELAQKYLPKGAGGVLTFGLKGGREAGKKFIDSLKLFSHLANIGDAKSLVIHPASTTHSQLSEEEQAAAGVTPDLI 404
|
410 420
....*....|....*....|....
gi 15610476 414 RLAVGIEGIDDILADLELGFAAAR 437
Cdd:COG2873 405 RLSVGIEDIDDIIADLDQALAAAT 428
|
|
| OAH_OAS_sulfhy |
TIGR01326 |
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism ... |
17-434 |
0e+00 |
|
OAH/OAS sulfhydrylase; This model describes a distinct clade of the Cys/Met metabolism pyridoxal phosphate-dependent enzyme superfamily. Members include examples of OAH/OAS sulfhydrylase, an enzyme with activity both as O-acetylhomoserine (OAH) sulfhydrylase (EC 2.5.1.49) and O-acetylserine (OAS) sulphydrylase (EC 2.5.1.47). An alternate name for OAH sulfhydrylase is homocysteine synthase. This model is designated subfamily because it may or may not have both activities. [Amino acid biosynthesis, Aspartate family, Amino acid biosynthesis, Serine family]
Pssm-ID: 273555 [Multi-domain] Cd Length: 418 Bit Score: 768.83 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 17 SFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSS 96
Cdd:TIGR01326 1 HFETLQLHAGQEPDPTTGSRAVPIYQTTSYVFDSTEHAAALFGLQEPGNIYSRLMNPTTDVLEQRIAALEGGVAALAVAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 97 GQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLL 176
Cdd:TIGR01326 81 GQAAITYAILNLAGAGDNIVSSSYLYGGTYNLFSHTLKRLGIEVRFVD-PDDPESLEKAIDENTKAVFAETIGNPQINVL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 177 DTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQGRFPGFTTPDPSY 256
Cdd:TIGR01326 160 DIEAIAEVAHRHGIPLIVDNTFATPYLCRPIKHGADIVVHSATKYIGGHGTAIGGVIVDGGKFDWNNGRFPLFTTPDPSY 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 257 HGVVFAE-LGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSS 335
Cdd:TIGR01326 240 HGLVFTEtLGNPAFILKARVQLLRDLGAALSPFNAFLLLQGLETLSLRMERHVENALKVAEFLESHPDVAWVNYPGLASH 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 336 PWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRL 415
Cdd:TIGR01326 320 PHHALAKKYLPKGFGAVLSFEIKGGREAGKKFIDALKLASHLANVGDAKSLVIHPASTTHSQLSEEEQLKAGVTPGLIRL 399
|
410
....*....|....*....
gi 15610476 416 AVGIEGIDDILADLELGFA 434
Cdd:TIGR01326 400 SVGIENIDDIIADLEQALE 418
|
|
| PRK08248 |
PRK08248 |
homocysteine synthase; |
15-437 |
0e+00 |
|
homocysteine synthase;
Pssm-ID: 236201 [Multi-domain] Cd Length: 431 Bit Score: 596.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 15 HWSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFL 94
Cdd:PRK08248 6 TFRLETLAIHAGQEIDPTTGSRAVPIYQTTSYGFRDSEHAANLFSLKEFGNIYTRIMNPTTDVFEKRIAALEGGIGALAV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 95 SSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQID 174
Cdd:PRK08248 86 SSGQAAITYSILNIASAGDEIVSSSSLYGGTYNLFAHTLPKLGITVKFVD-PSDPENFEAAITDKTKALFAETIGNPKGD 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 175 LLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-GRFPGFTTPD 253
Cdd:PRK08248 165 VLDIEAVAAIAHEHGIPLIVDNTFASPYLLRPIEHGADIVVHSATKFIGGHGTSIGGVIVDSGKFDWKGsGKFPGLTEPD 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 254 PSYHGVVFAE-LGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGL 332
Cdd:PRK08248 245 PSYHGLVYTDaVGEAAYITKARVQLLRDLGAALSPFNSFLLLQGLETLHLRMERHSENALAVAKFLEEHEAVEWVSYPGL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 333 PSSPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGL 412
Cdd:PRK08248 325 PSHPSYELAKKYLPKGQGAILTFGIKGGVEAGKKLIDSVKLFSHLANVGDSKSLIIHPASTTHQQLSEEEQLAAGVTPGL 404
|
410 420
....*....|....*....|....*
gi 15610476 413 VRLAVGIEGIDDILADLELGFAAAR 437
Cdd:PRK08248 405 VRLSVGTEAIDDILDDLRQAIRQSQ 429
|
|
| PRK05613 |
PRK05613 |
O-acetylhomoserine/O-acetylserine sulfhydrylase; |
9-435 |
0e+00 |
|
O-acetylhomoserine/O-acetylserine sulfhydrylase;
Pssm-ID: 168128 [Multi-domain] Cd Length: 437 Bit Score: 580.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 9 DADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGG 88
Cdd:PRK05613 5 DNSNADQWGFETRSIHAGQSVDSDTSARNLPIYQTTSYVFDSAEHAKQRFALEDLGPIYSRLTNPTVEALENRIASLEGG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 89 VAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNTKAFFAETI 168
Cdd:PRK05613 85 VHAVAFASGQAAETAAILNLAGAGDHIVTSPRLYGGTETLFLVTLNRLGIEVTFVENPDDPESWQAAVQPNTKAFFGETF 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 169 SNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQGR--- 245
Cdd:PRK05613 165 ANPQADVLDIPAVAEVAHRNQVPLIVDNTIATAALVRPLELGADVVVASLTKFYTGNGSGLGGVLIDGGKFDWTVERdgk 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 246 --FPGFTTPDPSYHGVVFAELGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDD 323
Cdd:PRK05613 245 pvFPYFVTPDPAYHGLKYADLGAPAFGLKARAGLLRDTGATLSPFNAWVTAQGLDTLSLRLERHNENAIKVAEFLNNHEK 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 324 VLSVNYAGLPSSPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQ 403
Cdd:PRK05613 325 VAKVNFAGLKDSPWYATKEKLGLKYTGSVLSFDIKGGKDEAWAFIDALKLHSNLANIGDVRSLVVHPATTTHSQSDEAGL 404
|
410 420 430
....*....|....*....|....*....|..
gi 15610476 404 LATGVSPGLVRLAVGIEGIDDILADLELGFAA 435
Cdd:PRK05613 405 ARAGITQATVRLSVGIEDIDDIIADLEGGFAA 436
|
|
| PRK08134 |
PRK08134 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
18-438 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 236159 Cd Length: 433 Bit Score: 552.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:PRK08134 9 FDTLALHAGAAPDPATGARAVPIHLTTSFVFRDSDHAAALFNLERAGHVYSRISNPTVAVLEERVAALEGGVGAIATASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:PRK08134 89 QAALHLAIATLMGAGSHIVASSALYGGSHNLLHYTLRRFGIETTFVK-PGDIDGWRAAIRPNTRLLFGETLGNPGLEVLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-GRFPGFTTPDPSY 256
Cdd:PRK08134 168 IPTVAAIAHEAGVPLLVDSTFTTPYLLRPFEHGADLVYHSATKFLGGHGTAIGGVLVDGGRFDWEAsGKFPELTEPYAGF 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 257 HGVVFAE-LGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSS 335
Cdd:PRK08134 248 HGMVFAEeSTVAAFLLRARREGLRDFGACLSPMNAWQLLQGIETLPLRMERHVANTRKVVAFLASHPAVARVAHPELESH 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 336 PWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRL 415
Cdd:PRK08134 328 PDHALAKRLLPRGAGSVFSFDLKGGRAAGRKFIESLKLFSHLANVGDARSLVIHPASTTHFRMDAAALAAAGIGEGTIRL 407
|
410 420
....*....|....*....|...
gi 15610476 416 AVGIEGIDDILADLELGFAAARR 438
Cdd:PRK08134 408 SIGLEDADDLIDDLKRALKAAEK 430
|
|
| PRK05994 |
PRK05994 |
O-acetylhomoserine aminocarboxypropyltransferase; Validated |
18-436 |
0e+00 |
|
O-acetylhomoserine aminocarboxypropyltransferase; Validated
Pssm-ID: 180344 [Multi-domain] Cd Length: 427 Bit Score: 551.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:PRK05994 8 FATLAVHAGAQPDPTTGARATPIYQTTSFVFNDADHAASLFGLQAFGNIYTRITNPTNAVLEERVAALEGGTAALAVASG 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:PRK05994 88 HAAQFLVFHTLLQPGDEFIAARKLYGGSINQFGHAFKSFGWQVRWAD-ADDPASFERAITPRTKAIFIESIANPGGTVTD 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ-GRFPGFTTPDPSY 256
Cdd:PRK05994 167 IAAIAEVAHRAGLPLIVDNTLASPYLIRPIEHGADIVVHSLTKFLGGHGNSMGGIIVDGGTFDWSKsGKYPMLSEPRPEY 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 257 HGVVFAE-LGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSS 335
Cdd:PRK05994 247 HGLVLHEtFGNFAFAIAARVLGLRDLGPAISPFNAFLILTGIETLPLRMQRHSDNALAVAEWLKGHPKVSWVNYAGLPDD 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 336 PWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRL 415
Cdd:PRK05994 327 PYHALAQKYSPKGAGAVFTFGLKGGYEAGVKLVSSLKLFSHLANIGDTRSLVIHPASTTHRQLTDEQKVAAGAGPDVVRL 406
|
410 420
....*....|....*....|.
gi 15610476 416 AVGIEGIDDILADLELGFAAA 436
Cdd:PRK05994 407 SIGIEDVDDIIADLEQALAKA 427
|
|
| PRK06084 |
PRK06084 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
19-438 |
4.96e-175 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 180392 [Multi-domain] Cd Length: 425 Bit Score: 496.73 E-value: 4.96e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 19 ETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQ 98
Cdd:PRK06084 4 ETLAIHAGYSPDPTTKAVAVPIYQTTSYAFDDTQHGADLFDLKVPGNIYTRIMNPTNDVLEQRVAALEGGVGALAVASGM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 99 AAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDpDDLDTWQAAVRPNTKAFFAETISNPQIDLLDT 178
Cdd:PRK06084 84 AAITYAIQTIAEAGDNIVSVAKLYGGTYNLLAHTLPRIGIETRFAAH-DDIAALEALIDERTKAVFCESIGNPAGNIIDI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 179 PAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWT--QGRFPGFTTPDPSY 256
Cdd:PRK06084 163 QALADAAHRHGVPLIVDNTVATPVLCRPFEHGADIVVHSLTKYIGGHGTSIGGIVVDSGKFPWAehKERFALLNTPDPSY 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 257 HGVVFAE-LGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSS 335
Cdd:PRK06084 243 HGVTYTEaFGPAAFIGRCRVVPLRNMGAALSPFNAFLILQGLETLALRMERHTENALKVARYLQQHPQVAWVKYAGLPDH 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 336 PWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRL 415
Cdd:PRK06084 323 PEHELARRYMGGKPASILSFGIKGGQAAGARFIDALKLVVRLVNIGDAKSLACHPASTTHRQLNDEELEKAGVSRDMVRL 402
|
410 420
....*....|....*....|...
gi 15610476 416 AVGIEGIDDILADLELGFAAARR 438
Cdd:PRK06084 403 SIGIEHIDDIIADLAQALDASKG 425
|
|
| MetC |
COG0626 |
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; ... |
16-436 |
1.10e-169 |
|
Cystathionine beta-lyase/cystathionine gamma-synthase [Amino acid transport and metabolism]; Cystathionine beta-lyase/cystathionine gamma-synthase is part of the Pathway/BioSystem: Methionine biosynthesis
Pssm-ID: 440391 [Multi-domain] Cd Length: 389 Bit Score: 481.86 E-value: 1.10e-169
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 16 WSFETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS 95
Cdd:COG0626 1 MGPATRAVHAGRDPDPQTGAVSPPIYLTSTFVFPSAEALAARFAGEEGGYIYSRYGNPTRRALEEALAALEGGEAALAFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 96 SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDL 175
Cdd:COG0626 81 SGMAAISAVLLALLKAGDHVVASDDLYGGTRRLLDKVLARFGIEVTFVD-PTDLAAVEAAIRPNTKLVFLETPSNPTLEV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 176 LDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgfttpdps 255
Cdd:COG0626 160 VDIAAIAAIAHAAGALLVVDNTFATPLLQRPLELGADIVVHSATKYLGGHSDVLGGAVV--------------------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 256 yhgvvfaelGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSS 335
Cdd:COG0626 219 ---------GRDEELAERLRFLQNALGAVLSPFDAWLLLRGLKTLALRMERHCENALAVAEWLEAHPAVARVYYPGLPSH 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 336 PWHERAKRLApKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRL 415
Cdd:COG0626 290 PGHELAKRQM-SGFGGMLSFELKGGREAARRFLDALKLFTLAVSLGGVESLITHPATMTHRSLPPEERAALGITDGLVRL 368
|
410 420
....*....|....*....|.
gi 15610476 416 AVGIEGIDDILADLELGFAAA 436
Cdd:COG0626 369 SVGLEDVDDLIADLEQALAAL 389
|
|
| Cys_Met_Meta_PP |
pfam01053 |
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and ... |
19-434 |
1.61e-168 |
|
Cys/Met metabolism PLP-dependent enzyme; This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
Pssm-ID: 395837 [Multi-domain] Cd Length: 376 Bit Score: 478.27 E-value: 1.61e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 19 ETKQIHAGQHPDPTTNARALPIYATTSYTFDdtahaaalFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQ 98
Cdd:pfam01053 1 DTLAVHAGQRPDPQTGAVSVPIYLTSTYVFD--------FAGEEGGYDYSRSGNPTRDVLEERIAALEGGAAALAFSSGM 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 99 AAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDT 178
Cdd:pfam01053 73 AAITAAILALLKAGDHIVATDDLYGGTYRLFNKVLPRFGIEVTFVD-TSDPEDLEAAIKPNTKAVYLETPTNPLLKVVDI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 179 PAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGnfdwtqgrfpgfttpdpsyhg 258
Cdd:pfam01053 152 EAIAKLAKKHGILVVVDNTFASPYLQRPLDLGADIVVHSATKYIGGHSDVVGGVIVVNG--------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 259 vvfaelgppaFALKARVQLL-RDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPW 337
Cdd:pfam01053 211 ----------EELGKELYFLqNATGAVLSPFDAWLLLRGLKTLGLRMEQHQENAQKVAEFLESHPKVEKVYYPGLPSHPG 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 338 HERAKRLApKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAV 417
Cdd:pfam01053 281 HELAKRQM-KGFGGMLSFELKGGLEAAKKFLDNLKLFSLAVSLGGVESLISHPATMTHASIPPEEREAAGITDDLIRLSV 359
|
410
....*....|....*..
gi 15610476 418 GIEGIDDILADLELGFA 434
Cdd:pfam01053 360 GIEDVDDLIADLKQALE 376
|
|
| CGS_like |
cd00614 |
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed ... |
34-434 |
1.98e-168 |
|
CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of antimicrobials and herbicides. This subgroup also includes cystathionine gamma-lyases (CGL), O-acetylhomoserine sulfhydrylases and O-acetylhomoserine thiol lyases. CGL's are very similar to CGS's. Members of this group are widely distributed among all three forms of life.
Pssm-ID: 99738 [Multi-domain] Cd Length: 369 Bit Score: 477.85 E-value: 1.98e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 34 NARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGD 113
Cdd:cd00614 1 GAVAPPIYQTSTFVFPSPAEAADLFALREGGYIYSRIGNPTVDALEKKLAALEGGEAALAFSSGMAAISTVLLALLKAGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 114 HIVSSPRLYGGTYNLFHYSLAKLGIEVSFVdDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLI 193
Cdd:cd00614 81 HVVASDDLYGGTYRLFERLLPKLGIEVTFV-DPDDPEALEAAIKPETKLVYVESPTNPTLKVVDIEAIAELAHEHGALLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 194 VDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNfdwtqgrfpgfttpdpsyhgvvfaelgppAFALKA 273
Cdd:cd00614 160 VDNTFATPYLQRPLELGADIVVHSATKYIGGHSDVIAGVVVGSGE-----------------------------ALIQRL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 274 RVQLLRdYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLaPKGTGAVL 353
Cdd:cd00614 211 RFLRLA-LGTILSPFDAWLLLRGLKTLPLRMERHSENALKVAEFLEKHPKVERVYYPGLPSHPQHELAKKQ-MSGYGGVF 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 354 SFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGF 433
Cdd:cd00614 289 SFELKGGLEAAKKFLNALKLFSLAVSLGGVESLVEHPASMTHSQLPPEERAAAGITPGLVRLSVGIEDVEDLIADLEQAL 368
|
.
gi 15610476 434 A 434
Cdd:cd00614 369 K 369
|
|
| PRK08133 |
PRK08133 |
O-succinylhomoserine sulfhydrylase; Validated |
15-435 |
1.36e-136 |
|
O-succinylhomoserine sulfhydrylase; Validated
Pssm-ID: 181244 [Multi-domain] Cd Length: 390 Bit Score: 397.84 E-value: 1.36e-136
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 15 HWSFETKQIHAGQHPDPTtNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFL 94
Cdd:PRK08133 4 SLGFDTLAVRAGQLRSPF-GEHSEALFLTSSFVFESAAEAAARFAGEEPGNIYSRFTNPTVTMFQERLAALEGAEACVAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 95 SSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQID 174
Cdd:PRK08133 83 ASGMAAILAVVMALLQAGDHVVSSRSLFGSTVSLFEKIFARFGIETTFVD-LTDLDAWRAAVRPNTKLFFLETPSNPLTE 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 175 LLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdgGNFDWTQGRFPgfttpdp 254
Cdd:PRK08133 162 LADIAALAEIAHAAGALLVVDNCFCTPALQQPLKLGADVVIHSATKYLDGQGRVLGGAVV--GSKELMEEVFG------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 255 syhgvvfaelgppafalkarvqLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPS 334
Cdd:PRK08133 233 ----------------------FLRTAGPTLSPFNAWVFLKGLETLSLRMEAHSANALALAEWLEAHPGVERVFYPGLPS 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 335 SPWHERAKRlAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVR 414
Cdd:PRK08133 291 HPQHELAKR-QQKGGGAIVSFEVKGGREAAWRVIDATRLISITANLGDTKTTITHPATTTHGRLSPEARAAAGITEGLIR 369
|
410 420
....*....|....*....|.
gi 15610476 415 LAVGIEGIDDILADLELGFAA 435
Cdd:PRK08133 370 VAVGLEDVADIKADLARGLAA 390
|
|
| PRK06702 |
PRK06702 |
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase; |
16-438 |
6.75e-131 |
|
bifunctional O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase;
Pssm-ID: 102505 [Multi-domain] Cd Length: 432 Bit Score: 384.79 E-value: 6.75e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 16 WSFETKQIHAGQHPDpTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS 95
Cdd:PRK06702 5 WGKGTICVQGGYTPK-NGEPRVLPLYQSTTYKYDTSDDLAALFNLEAEGYIYTRIGNPTLAAFEQKLAELEGGVGAVATA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 96 SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNTKAFFAETISNPQIDL 175
Cdd:PRK06702 84 SGQAAIMLAVLNICSSGDHLLCSSTVYGGTFNLFGVSLRKLGIDVTFFNPNLTADEIVALANDKTKLVYAESLGNPAMNV 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 176 LDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQGRFPGFTTPDPS 255
Cdd:PRK06702 164 LNFKEFSDAAKELEVPFIVDNTLATPYLCQAFEHGANIIVHSTTKYIDGHASSLGGIVIDGGNFDWTNGKYPELVEPDPS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 256 YHGVVFAE-LGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPS 334
Cdd:PRK06702 244 YHGVSYVQnFGAAAYIVKARVQLLRDYGNCMSPFNAYISNIGLETLHLRMERHSENALAVAKWLADHERIEWVNYPGLDS 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 335 SPWHERAKRLAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVR 414
Cdd:PRK06702 324 NENYSLAQKYLKKGASGVLTFGIKGGLEAAKEFIANVKLATLVTHVADARTCVIHPASTTHRQLSAEDQRLAGVTSDLIR 403
|
410 420
....*....|....*....|....
gi 15610476 415 LAVGIEGIDDILADLELGFAAARR 438
Cdd:PRK06702 404 LSVGIEDVSDIIADLEAALVGGKQ 427
|
|
| PRK06234 |
PRK06234 |
methionine gamma-lyase; Provisional |
18-432 |
3.59e-126 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 168478 [Multi-domain] Cd Length: 400 Bit Score: 371.47 E-value: 3.59e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:PRK06234 9 FATKAIHGGHIGDKQFGSLATPIYQTSTFIFDSAEQGGRRFAGEESGYIYSRLGNPTSTEVENKLALLEGGEAAVVAASG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVdDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:PRK06234 89 MGAISSSLWSALKAGDHVVASDTLYGCTFALLNHGLTRYGVEVTFV-DTSNLEEVRNALKANTKVVYLETPANPTLKVTD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRN--GVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgfttpdps 255
Cdd:PRK06234 168 IKAISNIAHENnkECLVFVDNTFCTPYIQRPLQLGADVVVHSATKYLNGHGDVIAGFVV--------------------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 256 yhgvvfaelGPPAFALKARVQLLRDY-GSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPS 334
Cdd:PRK06234 227 ---------GKEEFINQVKLFGIKDMtGSVIGPFEAFLIIRGMKTLQIRMEKHCKNAMKVAKFLESHPAVEKVYYPGLES 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 335 SPWHERAKRLApKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVR 414
Cdd:PRK06234 298 FEYYELAKKQM-SLPGAMISFELKGGVEEGKVVMNNVKLATLAVSLGDAETLIQHPASMTHSPYTAEERKEAGISDGLVR 376
|
410
....*....|....*...
gi 15610476 415 LAVGIEGIDDILADLELG 432
Cdd:PRK06234 377 LSVGLEDVDDIIADLKQA 394
|
|
| O_suc_HS_sulf |
TIGR01325 |
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, ... |
19-429 |
3.53e-118 |
|
O-succinylhomoserine sulfhydrylase; This model describes O-succinylhomoserine sulfhydrylase, one of several related pyridoxal phosphate-dependent enzymes of cysteine and methionine metabolism. This enzyme is part of an alternative pathway of homocysteine biosynthesis, a step in methionine biosynthesis. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 188131 Cd Length: 381 Bit Score: 350.30 E-value: 3.53e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 19 ETKQIHAGQHPDP-TTNARALpiYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:TIGR01325 1 ATLAVRGGMLRSGfEETAEAL--YLTSGYVYDSAAVAAKRFAGELPGFVYSRYGNPTVSVFEERLALLEGAEAAVATASG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:TIGR01325 79 MAAIFAALMALLGAGDHVVASRSLFGSCFVVCSEILPRFGVQTVFVD-GTDLSAWEAALKPNTKAVFVETPSNPLQELVD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIvdggnfdwtqgrfpgfttpdpsyh 257
Cdd:TIGR01325 158 IAAVAELAHAAGAKVVVDNVFATPLLQQPLKLGADVVVYSATKHIDGQGRVLGGAI------------------------ 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 258 gvvfaeLGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPW 337
Cdd:TIGR01325 214 ------LGSEEYMDEPVQKLLRHTGPAMSPFNAWVLLKGLETLAIRVQHQNASALAIAEWLNGHPSVQWVYYPGLPSHPQ 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 338 HERAKRlAPKGTGAVLSFELAGGiEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAV 417
Cdd:TIGR01325 288 HELAKR-QMSGGGTVVTFDLDCR-QAAFKVLDAMRLVDISNNLGDAKSTITHPATTTHRRMGPEERAAAGIGDGLVRLSV 365
|
410
....*....|..
gi 15610476 418 GIEGIDDILADL 429
Cdd:TIGR01325 366 GLEDVDDLIADI 377
|
|
| PRK07503 |
PRK07503 |
methionine gamma-lyase; Provisional |
18-438 |
5.33e-117 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 181005 [Multi-domain] Cd Length: 403 Bit Score: 348.33 E-value: 5.33e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:PRK07503 10 FSTRAIHHGYDPLDHGGALVPPVYLTATFAFPTAEYGAECFAGEEEGHFYSRISNPTLALLEQRMASLEGGEAAVALASG 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVdDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:PRK07503 90 MGAITATLWTLLRPGDEVIVDQTLYGCTFAFLHHGLGEFGVTVRHV-DLTDPAALKAAISDKTRMVYFETPANPNMRLVD 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgfttpdpsyh 257
Cdd:PRK07503 169 IAAVAEIAHGAGAKVVVDNTYCTPYLQRPLELGADLVVHSATKYLGGHGDITAGLVV----------------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 258 gvvfaelGPPAFALKARVQLLRDY-GSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSP 336
Cdd:PRK07503 226 -------GGKALADRIRLEGLKDMtGAVMSPFDAFLLMRGLKTLALRMDRHCASAQAVAEWLARHPAVELVHYPGLPSFA 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 337 WHERAKRLAPKGtGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLA 416
Cdd:PRK07503 299 QHALAQRQMALP-GGMIAFELKGGIAAGRRFMNALQLFARAVSLGDAESLAQHPASMTHSTYTPEERAEHGISEGLVRLS 377
|
410 420
....*....|....*....|..
gi 15610476 417 VGIEGIDDILADLELGFAAARR 438
Cdd:PRK07503 378 VGLEDVADILADLAQALDACAV 399
|
|
| met_gam_lyase |
TIGR01328 |
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of ... |
18-435 |
7.45e-109 |
|
methionine gamma-lyase; This model describes a methionine gamma-lyase subset of a family of PLP-dependent trans-sulfuration enzymes. The member from the parasite Trichomonas vaginalis is described as catalyzing alpha gamma- and alpha-beta eliminations and gamma-replacement reactions on methionine, cysteine, and some derivatives. Likewise, the enzyme from Pseudomonas degrades cysteine as well as methionine. [Energy metabolism, Amino acids and amines]
Pssm-ID: 130395 [Multi-domain] Cd Length: 391 Bit Score: 326.85 E-value: 7.45e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:TIGR01328 4 FATRAIHAGYPPKDQFGALTPPIYQTSTFVFDSCEQGGNRFAGQESGYIYSRLGNPTVSNLEGRIAFLEGTEAAVATSSG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVdDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:TIGR01328 84 MGAIAATLLTILKAGDHLISDECLYGCTFALLEHALTKFGIQVDFI-NMAIPEEVKAHIKDNTKIVYFETPANPTMKLID 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdGGNFDWTQGRFPGfttpdpsyh 257
Cdd:TIGR01328 163 MERVCRDAHSQGVKVIVDNTFATPMLTNPVALGVDVVVHSATKYIGGHGDVVAGLIC-GKAELLQQIRMVG--------- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 258 gvvfaelgppafalkarvqlLRDY-GSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSP 336
Cdd:TIGR01328 233 --------------------IKDMtGSVISPFDAWLILRGLKTLNIRMKRHSENAMKVAEYLKSHPAVEKVYYPGFEDHP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 337 WHERAKRLAPKGtGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLA 416
Cdd:TIGR01328 293 GHDIAAKQMRMG-GGMITFELKGGFAGAKKLLNNLKLIRLAVSLGDAETLIQHPASMTHAVVPKEEREAAGITDGMIRLS 371
|
410
....*....|....*....
gi 15610476 417 VGIEGIDDILADLELGFAA 435
Cdd:TIGR01328 372 VGLEDADDLIADLKQALDA 390
|
|
| PRK07811 |
PRK07811 |
cystathionine gamma-synthase; Provisional |
10-430 |
1.39e-108 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 236104 [Multi-domain] Cd Length: 388 Bit Score: 326.22 E-value: 1.39e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 10 ADPTAHWSFETKQIHAGQHPDPTTNARALPIYATTSYTFDdtahaaALFGLEiPGNIYTRIGNPTTDVVEQRIAALEGGV 89
Cdd:PRK07811 5 SDHHANQGFATRAIHAGYEPDPATGAVNPPIYASSTFAQD------GVGGLR-GGYEYARTGNPTRTALEEQLAALEGGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 90 AALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETIS 169
Cdd:PRK07811 78 YGRAFSSGMAATDCLLRAVLRPGDHIVIPNDAYGGTFRLIDKVFTRWGVEYTPVD-LSDLDAVRAAITPRTKLIWVETPT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 170 NPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgf 249
Cdd:PRK07811 157 NPLLSITDIAALAELAHDAGAKVVVDNTFASPYLQQPLALGADVVVHSTTKYIGGHSDVVGGALV--------------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 250 tTPDPsyhgvvfaELGpPAFALkarvqLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNY 329
Cdd:PRK07811 222 -TNDE--------ELD-EAFAF-----LQNGAGAVPGPFDAYLTLRGLKTLAVRMDRHSENAEAVAEFLAGHPEVSTVLY 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 330 AGLPSSPWHERAKRLApKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSpAEQLAtgVS 409
Cdd:PRK07811 287 PGLPSHPGHEVAARQM-RGFGGMVSVRLAGGEEAARDFCARTKVFTLAESLGGVESLIEHPSAMTHASTA-GSQLE--VP 362
|
410 420
....*....|....*....|.
gi 15610476 410 PGLVRLAVGIEGIDDILADLE 430
Cdd:PRK07811 363 DDLVRLSVGIEDVADLLADLE 383
|
|
| PRK06767 |
PRK06767 |
methionine gamma-lyase; Provisional |
18-430 |
1.25e-105 |
|
methionine gamma-lyase; Provisional
Pssm-ID: 180685 [Multi-domain] Cd Length: 386 Bit Score: 318.71 E-value: 1.25e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:PRK06767 6 METALIHHGYTSEEHKGSLTPPLFQTSTFTFETAQQGEASFAGVDPSYIYSRLGNPTVKLFEERMAVLEGGEEALAFGSG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTwQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:PRK06767 86 MAAISATLIGFLKAGDHIICSNGLYGCTYGFLEVLEEKFMITHSFCDMETEADI-ENKIRPNTKLIFVETPINPTMKLID 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdgGNFDwtqgrfpgfttpdpsyh 257
Cdd:PRK06767 165 LKQVIRVAKRNGLLVIVDNTFCSPYLQRPLELGCDAVVHSATKYIGGHGDVVAGVTI--CKTR----------------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 258 gvvfaelgppAFALKARVqLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYaglpssPW 337
Cdd:PRK06767 226 ----------ALAEKIRP-MRKDIGGIMAPFDAWLLLRGLKTLAVRMDRHCDNAEKIVSFLKNHDAVEGVWY------PE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 338 HERAKRLAPKGtGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAV 417
Cdd:PRK06767 289 GELASRQMKRG-GGVISFSIKGGKEETQAFINDLHFITIAVSLGDTETLIQHPATMTHAAIPAELRQEMGIYDNLIRLSV 367
|
410
....*....|...
gi 15610476 418 GIEGIDDILADLE 430
Cdd:PRK06767 368 GLESWEDIVSDLE 380
|
|
| PRK05939 |
PRK05939 |
cystathionine gamma-synthase family protein; |
39-436 |
3.78e-103 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 235650 [Multi-domain] Cd Length: 397 Bit Score: 312.78 E-value: 3.78e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 39 PIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSS 118
Cdd:PRK05939 13 PIHTSVTYGYEDARDLIDVFQGKKPGFTYARQGTPTTAALEAKITKMEGGVGTVCFATGMAAIAAVFLTLLRAGDHLVSS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 119 PRLYGGTYNLFHySLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTI 198
Cdd:PRK05939 93 QFLFGNTNSLFG-TLRGLGVEVTMVD-ATDVQNVAAAIRPNTRMVFVETIANPGTQVADLAGIGALCRERGLLYVVDNTM 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 199 ATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFDWTQ--GRFPGFTTPDPSYHGVvfaelgppafaLKARVQ 276
Cdd:PRK05939 171 TSPWLFRPKDVGASLVINSLSKYIAGHGNALGGAVTDTGLFDWSAypNIFPAYRKGDPQQWGL-----------TQIRKK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 277 LLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLApKGTGAVLSFE 356
Cdd:PRK05939 240 GLRDMGATLSSEAAHRIAIGAETLALRVDRSCSNALALAQFLEAHPKVARVYYPGLASHPQHARATELF-RHYGGLLSFE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 357 LAGGIEAgKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAA 436
Cdd:PRK05939 319 LADGIDC-FDFLNRLKLVIKATHLGDTRTLVIPVAPTIYYEMGAERRASMGIADSLIRVSVGIEDEADLIADFEQALDAT 397
|
|
| PRK07504 |
PRK07504 |
O-succinylhomoserine sulfhydrylase; Reviewed |
10-437 |
2.24e-99 |
|
O-succinylhomoserine sulfhydrylase; Reviewed
Pssm-ID: 168979 [Multi-domain] Cd Length: 398 Bit Score: 302.83 E-value: 2.24e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 10 ADPTAHWSFETKQIHAGQHPDP---TTNAralpIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALE 86
Cdd:PRK07504 3 TEMARKWRPATRLVHSGTLRSQfgeTSEA----LFLTQGFVYDTAEAAEARFKGEDPGFIYSRYSNPTVDMFEKRMCALE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 87 GGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDpDDLDTWQAAVRPNTKAFFAE 166
Cdd:PRK07504 79 GAEDARATASGMAAVTAAILCQVKAGDHVVAARALFGSCRYVVETLLPRYGIESTLVDG-LDLDNWEKAVRPNTKVFFLE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 167 TISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIvdggnfdwtqgrf 246
Cdd:PRK07504 158 SPTNPTLEVIDIAAVAKIANQAGAKLVVDNVFATPLFQKPLELGAHIVVYSATKHIDGQGRCLGGVV------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 247 pgfttpdpsyhgvvfaeLGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLS 326
Cdd:PRK07504 225 -----------------LSDKAWIEEHLQDYFRHTGPSLSPFNAWTLLKGLETLPVRVRQQTESAAAIADFLAGHPKVAR 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 327 VNYAGLPSSPWHERAKRLApKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLAT 406
Cdd:PRK07504 288 VIYPGRADHPQADIIAKQM-TGGSTLVAFELKGGKEAAFRFLNALKIVRISNNLGDAKSLITHPATTTHKNLSPEARAEL 366
|
410 420 430
....*....|....*....|....*....|.
gi 15610476 407 GVSPGLVRLAVGIEGIDDILADLELGFAAAR 437
Cdd:PRK07504 367 GISEGFLRLSAGLEDTDDLIEDLAAALKKVR 397
|
|
| PRK07810 |
PRK07810 |
O-succinylhomoserine sulfhydrylase; Provisional |
39-430 |
7.86e-94 |
|
O-succinylhomoserine sulfhydrylase; Provisional
Pssm-ID: 236103 [Multi-domain] Cd Length: 403 Bit Score: 288.94 E-value: 7.86e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 39 PIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSS 118
Cdd:PRK07810 36 ALYLTSGYVYESAAAAEAAFTGELDRFVYSRYGNPTVSMFEERLRLIEGAEACFATASGMSAVFTALGALLGAGDRLVAA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 119 PRLYGGTYNLFHYSLAKLGIEVSFVDDpDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTI 198
Cdd:PRK07810 116 RSLFGSCFVVCNEILPRWGVETVFVDG-EDLSQWEEALSVPTQAVFFETPSNPMQSLVDIAAVSELAHAAGAKVVLDNVF 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 199 ATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdgGNFDWTQGRFPgfttpdpsyhgvvfaelgppafalkarvQLL 278
Cdd:PRK07810 195 ATPLLQRGLPLGADVVVYSGTKHIDGQGRVLGGAIL--GDREYIDGPVQ----------------------------KLM 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 279 RDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRlAPKGTGAVLSFELA 358
Cdd:PRK07810 245 RHTGPALSAFNAWVLLKGLETLALRVRHSNASALRIAEFLEGHPAVRWVRYPFLPSHPQYDLAKR-QMSGGGTVVTFELD 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 15610476 359 GGIEAGK----AFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLE 430
Cdd:PRK07810 324 APEDAAKkrafEVLDKLRVIDISNNLGDAKSLITHPATTTHRAMGPEGRAAIGLGDGVVRLSVGLEDTDDLIADLD 399
|
|
| PRK08247 |
PRK08247 |
methionine biosynthesis PLP-dependent protein; |
19-437 |
1.43e-93 |
|
methionine biosynthesis PLP-dependent protein;
Pssm-ID: 181320 [Multi-domain] Cd Length: 366 Bit Score: 286.98 E-value: 1.43e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 19 ETKQIHAGQHPDPTTNARALPIYATTSYtfddtAHAaalfGL-EIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:PRK08247 6 ETKLAQIGNRSDERTGTVNPPVYFSTAY-----RHE----GIgESTGFDYSRTGNPTRGVLEQAIADLEGGDQGFACSSG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAeTFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:PRK08247 77 MAA-IQLVMSLFRSGDELIVSSDLYGGTYRLFEEHWKKWNVRFVYVN-TASLKAIEQAITPNTKAIFIETPTNPLMQETD 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGnfdwtqgrfpgfttpdpsyh 257
Cdd:PRK08247 155 IAAIAKIAKKHGLLLIVDNTFYTPVLQRPLEEGADIVIHSATKYLGGHNDVLAGLVVAKG-------------------- 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 258 gvvfAELGPPAFalkarvQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAglpsspw 337
Cdd:PRK08247 215 ----QELCERLA------YYQNAAGAVLSPFDSWLLIRGMKTLALRMRQHEENAKAIAAFLNEQPGVTDVLYP------- 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 338 herakrlapkGTGAVLSFELAGGiEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAV 417
Cdd:PRK08247 278 ----------GRGGMLSFRLQDE-EWVNPFLKSLKLITFAESLGGVESFITYPATQTHADIPEEIRIANGVCNRLLRFSV 346
|
410 420
....*....|....*....|
gi 15610476 418 GIEGIDDILADLELGFAAAR 437
Cdd:PRK08247 347 GIENVEDLIADLKQAFKQVK 366
|
|
| PRK08249 |
PRK08249 |
cystathionine gamma-synthase family protein; |
18-437 |
9.64e-93 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236202 [Multi-domain] Cd Length: 398 Bit Score: 285.87 E-value: 9.64e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTA--HAAALFglEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLS 95
Cdd:PRK08249 9 VGTKAVWAGEKEYLPYGATQVPVVLSVAYGYDDIDewYDVALG--KKPGHIYSRNTNPTVQAFEEKVRILEGAEAATAFS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 96 SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDpDDLDTWQAAVRPNTKAFFAETISNPQIDL 175
Cdd:PRK08249 87 TGMAAISNTLYTFLKPGDRVVSIKDTYGGTNKIFTEFLPRMGVDVTLCET-GDHEQIEAEIAKGCDLLYLETPTNPTLKI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 176 LDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgfttpdps 255
Cdd:PRK08249 166 VDIERLAAAAKKVGALVVVDNTFATPINQNPLALGADLVIHSATKFLSGHADALGGVVC--------------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 256 yhgvvfaelGPpafalKARVQLLRDY----GSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAG 331
Cdd:PRK08249 225 ---------GS-----KELMEQVYHYreinGATMDPMSAYLILRGMKTLKLRVRQQQESAMALAKYLQTHPKVEAVYYPG 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 332 LPSSPWHERAKRLApKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPG 411
Cdd:PRK08249 291 LETHPNHEIAKAQM-RGFGGILSFVLKGGMDTVKRLLPKLRYAHRAANLGAVETIYGPARTTSHVENTLEERAALGIPEG 369
|
410 420
....*....|....*....|....*.
gi 15610476 412 LVRLAVGIEGIDDILADLELGFAAAR 437
Cdd:PRK08249 370 LVRISVGIEDTEDLIADLEQAFAHLE 395
|
|
| PRK06176 |
PRK06176 |
cystathionine gamma-synthase; |
17-435 |
2.64e-91 |
|
cystathionine gamma-synthase;
Pssm-ID: 180443 [Multi-domain] Cd Length: 380 Bit Score: 281.79 E-value: 2.64e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 17 SFETKQIHAGQHPDPTTNARALPIYATTSYTFDdtahaaalfGLEIP-GNIYTRIGNPTTDVVEQRIAALEGGVAALFLS 95
Cdd:PRK06176 2 RMQTKLIHGGISEDTTTGAVSVPIYQTSTYRQD---------AIGRPkGYEYSRSGNPTRFALEELIADLEGGVKGFAFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 96 SGQAAeTFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDL 175
Cdd:PRK06176 73 SGLAG-IHAVFSLFQSGDHVLLGDDVYGGTFRLFDKVLVKNGLSCTIID-TSDLSQIKKAIKPNTKALYLETPSNPLLKI 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 176 LDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNfdwtqgrfpgfttpdps 255
Cdd:PRK06176 151 TDLAQCASVAKDHGLLTIVDNTFATPYYQNPLLLGADIVVHSGTKYLGGHSDVVAGLVTTNNE----------------- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 256 yhgvvfaelgppafALKARVQLLRD-YGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPS 334
Cdd:PRK06176 214 --------------ALAQEIAFFQNaIGGVLGPQDSWLLQRGIKTLGLRMEAHQKNALCVAEFLEKHPKVEKVYYPGLPT 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 335 SPWHERAKRLApKGTGAVLSFELAGGIEAgKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVR 414
Cdd:PRK06176 280 HPNHELAKKQM-RGFSGMLSFTLKNDSEA-VAFVESLKLFILGESLGGVESLVGIPAFMTHACIPKEQREAAGIRDGLVR 357
|
410 420
....*....|....*....|.
gi 15610476 415 LAVGIEGIDDILADLELGFAA 435
Cdd:PRK06176 358 LSVGIEHEQDLLEDLEQAFAK 378
|
|
| PRK07671 |
PRK07671 |
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase; |
19-434 |
7.99e-91 |
|
bifunctional cystathionine gamma-lyase/homocysteine desulfhydrase;
Pssm-ID: 181076 [Multi-domain] Cd Length: 377 Bit Score: 280.46 E-value: 7.99e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 19 ETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAhaaalfglEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQ 98
Cdd:PRK07671 4 KTKLIHGGIIGDPSTGAVSVPIYQVSTYKQEAVG--------KHQGYEYSRTGNPTRAALEELIAVLEGGHAGFAFGSGM 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 99 AAETfAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDpDDLDTWQAAVRPNTKAFFAETISNPQIDLLDT 178
Cdd:PRK07671 76 AAIT-AVMMLFSSGDHVILTDDVYGGTYRVMTKVLNRFGIEHTFVDT-SNLEEVEEAIRPNTKAIYVETPTNPLLKITDI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 179 PAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgfttpdpsyhg 258
Cdd:PRK07671 154 KKISTIAKEKGLLTIVDNTFMTPYWQSPISLGADIVLHSATKYLGGHSDVVAGLVV------------------------ 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 259 VVFAELGPPAFALKARVqllrdyGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWH 338
Cdd:PRK07671 210 VNSPELAEDLHFVQNST------GGILGPQDSWLLLRGLKTLGIRMEEHETNSRAIAEFLNNHPAVNKVYYPGLPSHPNH 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 339 ERAKRLApKGTGAVLSFELaGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVG 418
Cdd:PRK07671 284 ELAKEQA-NGFGGMISFDV-GSEETANKVLERLQYFTLAESLGAVESLISIPSQMTHASIPADRRKELGITDGLIRISVG 361
|
410
....*....|....*.
gi 15610476 419 IEGIDDILADLELGFA 434
Cdd:PRK07671 362 IEDGEDLIEDLAQALA 377
|
|
| PRK08064 |
PRK08064 |
cystathionine beta-lyase MetC; |
15-430 |
1.02e-86 |
|
cystathionine beta-lyase MetC;
Pssm-ID: 236146 [Multi-domain] Cd Length: 390 Bit Score: 270.10 E-value: 1.02e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 15 HWSFETKQIHAGQHPDPTTNARALPIY-ATTSYTFD-DTAHAAAlfgleipgniYTRIGNPTTDVVEQRIAALEGGVAAL 92
Cdd:PRK08064 4 SYSIDTLLLHNQYKHDKQTGAVNVPIYhASTFHQFDfDTFGKYD----------YSRSGNPTREALEDIIAELEGGTKGF 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 93 FLSSGQAAETFAILNLAgAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQ 172
Cdd:PRK08064 74 AFASGMAAISTAFLLLS-KGDHVLISEDVYGGTYRMITEVLSRFGIEHTFVD-MTNLEEVAQNIKPNTKLFYVETPSNPL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 173 IDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgftTP 252
Cdd:PRK08064 152 LKVTDIRGVVKLAKAIGCLTFVDNTFLTPLLQKPLDLGADVVLHSATKFLAGHSDVLAGLAV----------------VK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 253 DPsyhgvvfaELGppafalKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGL 332
Cdd:PRK08064 216 DE--------ELA------QKLYFLQNSFGAVLGVQDCWLVLRGLKTLHVRLEHSSETANKIALYLQEHPKVQNVYYPGL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 333 PSSPWHERAKRLApKGTGAVLSFELAGGiEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGL 412
Cdd:PRK08064 282 QTHLGFDIQQSQA-TSAGAVLSFTLQSE-EAVRQFVSHVKLPVFAVSLGAVESILSYPAKMSHAAMPKEERDERGITDGL 359
|
410
....*....|....*...
gi 15610476 413 VRLAVGIEGIDDILADLE 430
Cdd:PRK08064 360 LRLSVGLENVDDLIADFE 377
|
|
| PRK08574 |
PRK08574 |
cystathionine gamma-synthase family protein; |
20-429 |
1.92e-85 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 236298 [Multi-domain] Cd Length: 385 Bit Score: 266.55 E-value: 1.92e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 20 TKQIHAGQHPDPTtnaRAL--PIYATTSYTFDDTAhaaalfGLEIPGNI--YTRIGNPTTDVVEQRIAALEGGVAALFLS 95
Cdd:PRK08574 5 TDAVRGYRGSDPY---GSLqpPIYLTALFRQEGEA------YPSDRGFDlkYSREENPTLRPLEEALAKLEGGVDALAFN 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 96 SGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHySLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDL 175
Cdd:PRK08574 76 SGMAAISTLFFSLLKAGDRVVLPMEAYGTTLRLLK-SLEKFGVKVVLAY-PSTEDIIEAIKEGRTKLVFIETMTNPTLKV 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 176 LDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGnfdwtqgrfpgfttpdps 255
Cdd:PRK08574 154 IDVPEVAKAAKELGAILVVDNTFATPLLYRPLRHGADFVVHSLTKYIAGHNDVVGGVAVAWS------------------ 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 256 yhGVVFAELgppaFALKARVqllrdyGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSS 335
Cdd:PRK08574 216 --GEFLEEL----WEWRRRL------GTIMQPFEAYLVLRGLKTLEVRFERQCRNAMAIAEFLSEHPKVAEVYYPGLPSD 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 336 PWHERAKRLAPKGT-GAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVR 414
Cdd:PRK08574 284 PYHGVAKRLFGKDLyGGVVSFRVKGGRDAVLKFLRSLKLIKPSPSLGGVESLATYPVKSAASPIPEEDRKALGITEDLVR 363
|
410
....*....|....*
gi 15610476 415 LAVGIEGIDDILADL 429
Cdd:PRK08574 364 LSVGLEDVEDLIEDL 378
|
|
| cysta_beta_ly_E |
TIGR01329 |
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase ... |
35-436 |
4.36e-81 |
|
cystathionine beta-lyase, eukaryotic; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys.
Pssm-ID: 273557 [Multi-domain] Cd Length: 378 Bit Score: 255.14 E-value: 4.36e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 35 ARALPIYATTSYTFDDTAHAAALfgleipgnIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETfAILNLAGAGDH 114
Cdd:TIGR01329 17 ASSMPIYQTATFKQPLAIENGPY--------DYTRSGNPTRTALESLLAKLDKADRAFAFSSGMAALD-VITRLLNNGDE 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 115 IVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIV 194
Cdd:TIGR01329 88 IIAGDDLYGGTDRLLTQVVPRSGVVVVHVD-TTDLDKVKAALGPKTKLVLLESPTNPLQKIVDIRKISEMAHAQNALVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 195 DNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgFTTPdpsyhgvvfaelgppafALKAR 274
Cdd:TIGR01329 167 DNTMMSPLLCNPLELGADIVYHSATKFLAGHSDVMAGVLA--------------VKGE-----------------EIAKK 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 275 VQLLRD-YGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLApKGTGAVL 353
Cdd:TIGR01329 216 VYFLQNsTGSGLAPFDCWLLLRGIKTLAIRIEKQQENARAIAMFLSTHPRVKKVRYAGLPSHPGFHLHFSQA-KGAGSVL 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 354 SFElAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGF 433
Cdd:TIGR01329 295 SFE-TGSVALSKRLVEATKLFSITVSFGSVNSLISMPCFMSHASIPAEVREERGLPEDLVRLSVGIEDVDDLISDLDIAF 373
|
...
gi 15610476 434 AAA 436
Cdd:TIGR01329 374 VTA 376
|
|
| PRK06434 |
PRK06434 |
cystathionine gamma-lyase; Validated |
18-430 |
6.14e-78 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 102374 [Multi-domain] Cd Length: 384 Bit Score: 247.51 E-value: 6.14e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 18 FETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSG 97
Cdd:PRK06434 9 FNTRAVQSGELRDPRFGNVTTPIFETSTFVYPNSEKEAYMDSTRGMPYIYTRWGNPTVQAFEEKYAVLENAEHALSFSSG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 98 QAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVD---------DPDDLDtwqaavrpntkAFFAETI 168
Cdd:PRK06434 89 MGAITSAILSLIKKGKRILSISDLYGQTFYFFNKVLKTLGIHVDYIDtdrlnsldfDPSNYD-----------LIYAESI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 169 SNPQIDLLDTPAVSEVAHRNGVplIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVivdggnfdwtqgrfpg 248
Cdd:PRK06434 158 TNPTLKVPDIKNVSSFCHENDV--IVDATFASPYNQNPLDLGADVVIHSATKYISGHSDVVMGV---------------- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 249 FTTPDPSYHGVVfaelgppafalkarVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVN 328
Cdd:PRK06434 220 AGTNNKSIFNNL--------------VERRKTLGSNPDPIQAYLALRGLKTLGLRMEKHNKNGMELARFLRDSKKISNVY 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 329 YAGLpsspwhERAKRLApKGTGAVLSFELAGGIEAGKaFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGV 408
Cdd:PRK06434 286 YPDT------EIGKKVL-RGFGGMLSFELRSMEDVHK-FIRNLEIPMVAASLGGVESLITLPVETSHSSLSPEERERLGI 357
|
410 420
....*....|....*....|..
gi 15610476 409 SPGLVRLAVGIEGIDDILADLE 430
Cdd:PRK06434 358 SDNLVRFSIGIEDIDDLIKDIE 379
|
|
| PRK06460 |
PRK06460 |
hypothetical protein; Provisional |
30-430 |
1.36e-77 |
|
hypothetical protein; Provisional
Pssm-ID: 235807 [Multi-domain] Cd Length: 376 Bit Score: 246.28 E-value: 1.36e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 30 DPTTNARALPIYATTSYtfddtahaaalfglEIPGN---IYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAIL 106
Cdd:PRK06460 13 DEATGAITTPIYQTTAY--------------HYPEGekyRYSREANPTVLELTKKIVELENAEMGVAFSSGMGAISTTAL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 107 NLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSfVDDPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAH 186
Cdd:PRK06460 79 ALLKPGNSVLVHRDMFGRSYRFFTDYLKNWGVNVD-ASNPGSDNIIEKAKSKRYDVVFVENITNPLLRVVDITELSKVCK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 187 RNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIvdGGNFDWtqgrfpgfttpdpsyhgvvfaelgp 266
Cdd:PRK06460 158 ENGSILIVDATFSTPINQKPLELGADIVVHSASKFLAGHNDVIAGLA--AGYGKL------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 267 pafaLKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLAp 346
Cdd:PRK06460 211 ----LNVIDQMRRTLGTSLDPHAAYLTLRGIKTLKIRMDVINRNAEQIAEFLEGHPKVVKVYYPGLKSHVDYEIARRVL- 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 347 KGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDIL 426
Cdd:PRK06460 286 KGFGGVLSFEVNGGQESALKVMKSLKLIIPAQTLGGVNSVISHPATMSHRTLSLEERKIVGITDSLLRLSVGIEDVNDLI 365
|
....
gi 15610476 427 ADLE 430
Cdd:PRK06460 366 EDLD 369
|
|
| PRK08861 |
PRK08861 |
O-succinylhomoserine (thiol)-lyase; |
20-439 |
2.41e-73 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181567 [Multi-domain] Cd Length: 388 Bit Score: 235.56 E-value: 2.41e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 20 TKQIHAGQHPDPTTNARALPIYATTSYTFDDtahaaalFGlEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQA 99
Cdd:PRK08861 8 TIAVRTGIESDSQYHAVVPPIYLSTNYGFPA-------FG-EVPKYDYTRSGNPNRGLLEQTLSELESGKGAVVTNCGTS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 100 AETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVD--DPDDLDtwqAAVRPNTKAFFAETISNPQIDLLD 177
Cdd:PRK08861 80 ALNLWVSALLGPDDLIVAPHDCYGGTYRLFNTRANKGDFKVQFVDqsDAAALD---AALAKKPKLILLETPSNPLVRVVD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 178 TPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDggnfdwtqgrfpgfttpDPSYH 257
Cdd:PRK08861 157 IAELCQKAKAVGALVAVDNTFLTPVLQKPLELGADFVIHSTTKYINGHSDVIGGVLIT-----------------KTKEH 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 258 GVVFAELGppafalkarvqllRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPW 337
Cdd:PRK08861 220 AEELAWWG-------------NCIGATGTPFDSYMTLRGIRTLGARMRVHEESAQQILAYLQTQSLVGTIYHPSLPEHPG 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 338 HERAKRlAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAV 417
Cdd:PRK08861 287 HEIAKK-QQSGFGSMLSFEFAGSFEQLKVFVKALALFSLAESLGGVESLICHPASMTHRAMGEEALAEAGVSQQLLRLSV 365
|
410 420
....*....|....*....|..
gi 15610476 418 GIEGIDDILADLELGFAAARRF 439
Cdd:PRK08861 366 GLEDAQDLIADLDQAFAKAAEA 387
|
|
| PRK08776 |
PRK08776 |
O-succinylhomoserine (thiol)-lyase; |
5-437 |
2.64e-73 |
|
O-succinylhomoserine (thiol)-lyase;
Pssm-ID: 181554 [Multi-domain] Cd Length: 405 Bit Score: 236.04 E-value: 2.64e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 5 SNSTDADPTAHWSfeTKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALfgleipgnIYTRIGNPTTDVVEQRIAA 84
Cdd:PRK08776 2 SFRDPTDAPCSAA--TAAVRAGIDRDTAYGAVTPPIVLSSNFSFDGFGNKRQY--------DYTRSGNPTRDLLGEALAE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 85 LEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHySLAKLGIEVSFVDDPDDLDTWQAAVRPNTKAFF 164
Cdd:PRK08776 72 LEGGAGGVITATGMGAINLVLNALLQPGDTLVVPHDAYGGSWRLFN-ALAKKGHFALITADLTDPRSLADALAQSPKLVL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 165 AETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqg 244
Cdd:PRK08776 151 IETPSNPLLRITDLRFVIEAAHKVGALTVVDNTFLSPALQKPLEFGADLVLHSTTKYINGHSDVVGGAVV---------- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 245 rfpgftTPDPSYHgvvfAELGPPAFALkarvqllrdyGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDV 324
Cdd:PRK08776 221 ------ARDAELH----QQLVWWANAL----------GLTGSPFDAFLTLRGLRTLDARLRVHQENADAIAALLDGHAAV 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 325 LSVNYAGLPSSPWHERAKRlAPKGTGAVLSFELAGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQL 404
Cdd:PRK08776 281 NQVYYPGLASHPGHALAAR-QQKGFGAMLSFELEGGEAAVRAFVDGLRYFTLAESLGGVESLIAHPASMTHAAMTAEARA 359
|
410 420 430
....*....|....*....|....*....|...
gi 15610476 405 ATGVSPGLVRLAVGIEGIDDILADLELGFAAAR 437
Cdd:PRK08776 360 AAGISDGLLRLSVGIESAEDLLIDLRAGLARAE 392
|
|
| PLN02509 |
PLN02509 |
cystathionine beta-lyase |
67-433 |
7.05e-73 |
|
cystathionine beta-lyase
Pssm-ID: 178125 [Multi-domain] Cd Length: 464 Bit Score: 236.85 E-value: 7.05e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 67 YTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETfAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDp 146
Cdd:PLN02509 127 YTRSGNPTRDALESLLAKLDKADRAFCFTSGMAALS-AVTHLIKNGEEIVAGDDVYGGSDRLLSQVVPRSGVVVKRVNT- 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 147 DDLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHG 226
Cdd:PLN02509 205 TNLDEVAAAIGPQTKLVWLESPTNPRQQISDIRKIAEMAHAQGALVLVDNSIMSPVLSRPLELGADIVMHSATKFIAGHS 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 227 AAIAGVIVDGGNfdwtqgrfpgfttpdpsyhgvvfaelgppafALKARVQLLRDY-GSAASPFNAFLVAQGLETLSLRIE 305
Cdd:PLN02509 285 DVMAGVLAVKGE-------------------------------KLAKEVYFLQNSeGSGLAPFDCWLCLRGIKTMALRIE 333
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 306 RHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRLApKGTGAVLSFeLAGGIEAGKAFVNALKLHSHVANIGDVRS 385
Cdd:PLN02509 334 KQQENARKIAMYLSSHPRVKKVYYAGLPDHPGHHLHFSQA-KGAGSVFSF-ITGSVALSKHLVETTKYFSIAVSFGSVKS 411
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 15610476 386 LVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGF 433
Cdd:PLN02509 412 LISMPCFMSHASIPAEVREARGLTEDLVRISAGIEDVDDLISDLDIAF 459
|
|
| PRK05968 |
PRK05968 |
hypothetical protein; Provisional |
24-438 |
2.88e-71 |
|
hypothetical protein; Provisional
Pssm-ID: 168320 [Multi-domain] Cd Length: 389 Bit Score: 230.35 E-value: 2.88e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 24 HAGQHPDPTT-NARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAET 102
Cdd:PRK05968 13 LITAHDEGNAfDAVVPPIFQTSLFTFDSYDEMEDVYAGEKVRPIYSRGDNPTVRAFEEMLAKLEGAEDARGFASGMAAIS 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 103 FAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVD--DPDDLdtwqAAVRPNTKAFFAETISNPQIDLLDTPA 180
Cdd:PRK05968 93 STVLSFVEPGDRIVAVRHVYPDAFRLFETILKRMGVEVDYVDgrDEEAV----AKALPGAKLLYLESPTSWVFELQDVAA 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 181 VSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgfttpdpsyhgvv 260
Cdd:PRK05968 169 LAALAKRHGVVTMIDNSWASPVFQRPITLGVDLVIHSASKYLGGHSDTVAGVVA-------------------------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 261 faelGPPAFALKARVQLLRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPwher 340
Cdd:PRK05968 223 ----GSKEHIARINAEAYPYLGAKLSPFEAWLLLRGLRTLPLRMKAHEASALEIARRLKAHPVVERVCHPALANHP---- 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 341 akRLAPKGTGAVLSFELAGGIEAgKAFVNALKLHSHVANIGDVRSLVIhPASTTHAQLSPAEQLAT-GVSPGLVRLAVGI 419
Cdd:PRK05968 295 --PAGLSGTSGLFSFIFREGIDV-RAFADALKLFRLGVSWGGHESLVV-PAEVVLQQKAQPNSAARfGVSPRSVRLHVGL 370
|
410
....*....|....*....
gi 15610476 420 EGIDDILADLELGFAAARR 438
Cdd:PRK05968 371 EGTEALWADLEQALAAASR 389
|
|
| PRK08045 |
PRK08045 |
cystathionine gamma-synthase; Provisional |
39-436 |
2.92e-70 |
|
cystathionine gamma-synthase; Provisional
Pssm-ID: 169194 [Multi-domain] Cd Length: 386 Bit Score: 227.47 E-value: 2.92e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 39 PIYATTSYTFDDTAHAAAlfgleipgNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSS 118
Cdd:PRK08045 26 PIHLSSTYNFTGFNEPRA--------HDYSRRGNPTRDVVQRALAELEGGAGAVLTNTGMSAIHLVTTVFLKPGDLLVAP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 119 PRLYGGTYNLFHySLAKLG-IEVSFVDDPDDlDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNT 197
Cdd:PRK08045 98 HDCYGGSYRLFD-SLAKRGcYRVLFVDQGDE-QALRAALAEKPKLVLVESPSNPLLRVVDIAKICHLAREAGAVSVVDNT 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 198 IATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgftTPDPSyhgvVFAELGPPAfalkarvql 277
Cdd:PRK08045 176 FLSPALQNPLALGADLVLHSCTKYLNGHSDVVAGVVI----------------AKDPD----VVTELAWWA--------- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 278 lRDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRlAPKGTGAVLSFEL 357
Cdd:PRK08045 227 -NNIGVTGGAFDSYLLLRGLRTLVPRMELAQRNAQAIVKYLQTQPLVKKLYHPSLPENQGHEIAAR-QQKGFGAMLSFEL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15610476 358 AGGIEAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAA 436
Cdd:PRK08045 305 DGDEQTLRRFLGGLSLFTLAESLGGVESLISHAATMTHAGMAPEARAAAGISETLLRISTGIEDGEDLIADLENGFRAA 383
|
|
| PRK07049 |
PRK07049 |
cystathionine gamma-synthase family protein; |
20-436 |
1.01e-60 |
|
cystathionine gamma-synthase family protein;
Pssm-ID: 180809 [Multi-domain] Cd Length: 427 Bit Score: 203.75 E-value: 1.01e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 20 TKQIHAGQHP------------DPTTNARAL--PIYATTSYTFDDTAHAAALFGL-----EIP-----GNIYTRIGNPTT 75
Cdd:PRK07049 6 PSKTHIGNRElhpetqmlnygyDPELSEGAVkpPVFLTSTFVFRSAEDGRDFFDYvsgrkEPPagegaGLVYSRFNHPNS 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 76 DVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGieVSFVDDPDDLDTW--- 152
Cdd:PRK07049 86 EIVEDRLAVYEGAESAALFSSGMSAIATTLLAFVRPGDVILHSQPLYGGTETLLAKTFRNFG--VGAVGFADGLSEAaig 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 153 ----QAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNG-----VPLIV-DNTIATPYLIQPLAQGADIVVHSATKYL 222
Cdd:PRK07049 164 aaaeAAAAKGRVSLILIETPANPTNSLVDVAAVRRVADAIEarqghRPIIAcDNTLLGPVFQKPLEHGADLSVYSLTKYV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 223 GGHGAAIAGvivdggnfdwtqgrfpgfttpdpsyhgvvfAELGppAFALKARVQLLRD-YGSAASPFNAFLVAQGLETLS 301
Cdd:PRK07049 244 GGHSDLVAG------------------------------AVLG--RKALIRQVRALRSaIGTQLDPHSCWMLGRSLETLV 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 302 LRIERHVANAQRVAEFLAARDDVLSVNYagLPSSPWHERAKRLAPK---GTGAVLSFELAGGIEAGKAFVNALKLHSHVA 378
Cdd:PRK07049 292 LRMERANRNARAVAEFLRDHPKVEKLHY--LPFLDPDSAYGAVYKRqctGAGSTFSFDIKGGQAAAFRFLNALQIFKLAV 369
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 15610476 379 NIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEGIDDILADLELGFAAA 436
Cdd:PRK07049 370 SLGGTESLASHPASMTHSGVPADVRERIGVLESTIRLSIGIEHPDDLIADLAQALDAA 427
|
|
| PLN02242 |
PLN02242 |
methionine gamma-lyase |
40-421 |
8.70e-60 |
|
methionine gamma-lyase
Pssm-ID: 215134 Cd Length: 418 Bit Score: 201.15 E-value: 8.70e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 40 IYATTSYTFDDTAHAAALFGLEI-PGN---IYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHI 115
Cdd:PLN02242 39 IEASATFTVMEPDTMRRMFSGELgPDRdfyIYSRHFNPTVLNLGRQMAALEGTEAAYCTASGMSAISSVLLQLCSSGGHV 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 116 VSSPRLYGGTYNLF-HYSLAKLGIEVSFVdDPDDLDTWQAAVRPN-TKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLI 193
Cdd:PLN02242 119 VASNTLYGGTHALLaHFLPRKCNITTTFV-DITDLEAVKKAVVPGkTKVLYFESISNPTLTVADIPELARIAHEKGVTVV 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 194 VDNTIAtPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNF-----DWTQGrfpgfttpdpsyhgvVFAELGPpa 268
Cdd:PLN02242 198 VDNTFA-PMVLSPARLGADVVVHSISKFISGGADIIAGAVCGPAELvnsmmDLHHG---------------ALMLLGP-- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 269 fALKARVqllrdygsaaspfnAFLVAQGLETLSLRIERHVANAQRVAEFLaaRDDVLSVNYAGLPSSPWHERAKRLAPK- 347
Cdd:PLN02242 260 -TMNPKV--------------AFELSERLPHLSLRMKEHCRRAMEYAKRM--KELGLKVIYPGLEDHPQHALLKSMANKg 322
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 15610476 348 -GTGAVLSFELaGGIEAGKAFVNALKLHSH----VANIGDVRSLVIHPASTTHAQLSPAEQLATGVSPGLVRLAVGIEG 421
Cdd:PLN02242 323 yGFGGLLCLDM-DTEERANRLMRYLQNSTQfgfmAVSLGYYETLMSCSGSSTSSELDPEEKAAAGISPGLVRMSVGYTG 400
|
|
| PRK07269 |
PRK07269 |
cystathionine gamma-synthase; Reviewed |
24-430 |
8.55e-58 |
|
cystathionine gamma-synthase; Reviewed
Pssm-ID: 235983 Cd Length: 364 Bit Score: 194.27 E-value: 8.55e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 24 HAGQHPDPTTNARALPIYATTSYTFDDtahaaalFGlEIPGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQAAETF 103
Cdd:PRK07269 13 QAGIKSDEATGALVTPLHFSTTYQHPE-------FG-QSTGFDYTRTKNPTRAKLEETLAAIESADYALATSSGMSAIVL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 104 AiLNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLdtwQAAVRPNTKAFFAETISNPQIDLLDTPAVSE 183
Cdd:PRK07269 85 A-FSVFPVGSKVVAVRDLYGGSFRWFNQQEKEGRFHFTYANTEEEL---IAAIEEDTDIVYIETPTNPLMVEFDIEKVAK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 184 VAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVdggnfdwtqgrfpgftTPDPSYHGVVFAE 263
Cdd:PRK07269 161 LAHAKGAKVIVDNTFYSPIYQRPIELGADIVLHSATKYLSGHNDVLAGVVV----------------TNDLELYEKLFYN 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 264 LGPPafalkarvqllrdyGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLpsspwherakr 343
Cdd:PRK07269 225 LNTT--------------GAVLSPFDSYLLMRGLKTLSLRMERSTANAQEVVAFLKKSPAVKEVLYTGK----------- 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 344 lapkgtGAVLSFELAggiEAGK--AFVNALKLHSHVANIGDVRSLVIHPASTTHAQLsPAE-QLATGVSPGLVRLAVGIE 420
Cdd:PRK07269 280 ------GGMISFKVA---DETRipHILNSLKVFTFAESLGGVESLITYPTTQTHADI-PAEvRHSYGLTDDLLRLSIGIE 349
|
410
....*....|
gi 15610476 421 GIDDILADLE 430
Cdd:PRK07269 350 DARDLIADLK 359
|
|
| PRK07582 |
PRK07582 |
cystathionine gamma-lyase; Validated |
16-436 |
4.34e-57 |
|
cystathionine gamma-lyase; Validated
Pssm-ID: 236061 Cd Length: 366 Bit Score: 192.52 E-value: 4.34e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 16 WSFETKQIHAGQH-PDPTTNARALPIYATTSYTFDDTAHAAalfgleipgNIYTRIGNPTTDVVEQRIAALEGGVAALFl 94
Cdd:PRK07582 2 YGDGTRSVHAGGPeAVPGEPVLPGPVFAAPYHLSPGEPTGP---------DTYGRASNPTWRALEAALGELEGAEALVF- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 95 SSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDDPDDLDTWQAAVRpntkAFFAETISNPQID 174
Cdd:PRK07582 72 PSGMAAITAVLRALLRPGDTVVVPADGYYQVRALAREYLAPLGVTVREAPTAGMAEAALAGAD----LVLAETPSNPGLD 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 175 LLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIvdggnfdwtqgrfpgfTTPDP 254
Cdd:PRK07582 148 VCDLAALAAAAHAAGALLVVDNTTATPLGQRPLELGADLVVASDTKALTGHSDLLLGYV----------------AGRDP 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 255 syhgvvfaelgppafALKARVQLLRDY-GSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLP 333
Cdd:PRK07582 212 ---------------ELMAAVERWRLLaGAIPGPFEAWLAHRSLGTLGLRFARQCANALAVAELLAGHPAVRGVRYPGLP 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 334 SSPWHERAKRLApKGTGAVLSFELAGGiEAGKAFVNALKLHSHVANIGDVRSLVIHPAstthaqlspaeQLATGVSPGLV 413
Cdd:PRK07582 277 GDPAHEVAARQM-RRFGGLVSFELADA-AAAERFVAASRLVVAATSFGGVHTSADRRA-----------RWGDAVPEGFV 343
|
410 420
....*....|....*....|...
gi 15610476 414 RLAVGIEGIDDILADLELGFAAA 436
Cdd:PRK07582 344 RLSCGIEDTDDLVADLERALDAL 366
|
|
| PRK05967 |
PRK05967 |
cystathionine beta-lyase; Provisional |
68-436 |
2.94e-54 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 235657 [Multi-domain] Cd Length: 395 Bit Score: 185.78 E-value: 2.94e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 68 TRiGNPTTDVVEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPD 147
Cdd:PRK05967 60 TR-GTPTTDALCKAIDALEGSAGTILVPSGLAAVTVPFLGFLSPGDHALIVDSVYYPTRHFCDTMLKRLGVEVEYYD-PE 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 148 DLDTWQAAVRPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGA 227
Cdd:PRK05967 138 IGAGIAKLMRPNTKVVHTEAPGSNTFEMQDIPAIAEAAHRHGAIVMMDNTWATPLYFRPLDFGVDISIHAATKYPSGHSD 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 228 AIAGViVDGGNFDWTQgrfpgfttpdpsyhgvvfaelgppafALKARVQLlrdyGSAASPFNAFLVAQGLETLSLRIERH 307
Cdd:PRK05967 218 ILLGT-VSANEKCWPQ--------------------------LLEAHGTL----GLCAGPDDTYQILRGLRTMGIRLEHH 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 308 VANAQRVAEFLAARDDVLSVNYAGLPSSPWHERAKRlAPKGTGAVLSFELAGGIEAGK----AFVNALKLHSHVANIGDV 383
Cdd:PRK05967 267 RKSALEIARWLEGRPDVARVLHPALPSFPGHEIWKR-DFSGASGIFSFVLAAGPEKGKakahAFLDALEIFGLGYSWGGY 345
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 15610476 384 RSLVIhpasttHAQLSPaEQLATGVSPG-LVRLAVGIEGIDDILADLELGFAAA 436
Cdd:PRK05967 346 ESLAL------HVKLGD-RTVAKAPYAGpVIRLQIGLEDVPDLKADLERGFAAA 392
|
|
| cysta_beta_ly_B |
TIGR01324 |
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate ... |
20-436 |
2.95e-50 |
|
cystathionine beta-lyase, bacterial; This model represents cystathionine beta-lyase (alternate name: beta-cystathionase), one of several pyridoxal-dependent enzymes of cysteine, methionine, and homocysteine metabolism. This enzyme is involved in the biosynthesis of Met from Cys. [Amino acid biosynthesis, Aspartate family]
Pssm-ID: 130391 [Multi-domain] Cd Length: 377 Bit Score: 174.68 E-value: 2.95e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 20 TKQIHAGQHPDPTTNARALPIYATTSYTFDDtaHAAALFGLEipGNIYTRIGNPTTDVVEQRIAALEGGVAALFLSSGQA 99
Cdd:TIGR01324 1 TRLIHSGRQPRFSQGSVNPPLQRASTVLFDS--HAAQRRAKG--ELTYGRRGTLTHFALQDAMCELEGGAGCYLYPSGLA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 100 AETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETISNPQIDLLDTP 179
Cdd:TIGR01324 77 AVTNSILAFVKAGDHVLMVDSAYEPTRYFCDIVLKRMGVDITYYD-PLIGEDIATLIQPNTKVLFLEAPSSITFEIQDIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 180 AVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNfDWTQGRfpgfttpDPSYhgv 259
Cdd:TIGR01324 156 AIAKAARNPGIVIMIDNTWAAGLLFKPLEHGVDISIQAGTKYLVGHSDIMIGTVVANAR-TWDQLR-------EHSY--- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 260 vfaelgppafalkarvqllrDYGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNYAGLPSSPWHE 339
Cdd:TIGR01324 225 --------------------LMGQMVDADDAYTTLRGLRTLGVRLKQHQESSLAIAKWLSEQPEVARVLHPALPSCPGHE 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 340 RAKRlAPKGTGAVLSFELAGGI-EAGKAFVNALKLHSHVANIGDVRSLVIhpasTTHAQLSPAEQLATGVSPGLVRLAVG 418
Cdd:TIGR01324 285 FWKR-DFSGSSGLFSFVLQRLTqKQVHAFLDHLQLFGLGYSWGGYESLAL----CNQPELGHRPNIKRNLEGPLIRVHIG 359
|
410
....*....|....*...
gi 15610476 419 IEGIDDILADLELGFAAA 436
Cdd:TIGR01324 360 LENVDDLKADLKAGFEAI 377
|
|
| PRK09028 |
PRK09028 |
cystathionine beta-lyase; Provisional |
19-441 |
6.75e-45 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181615 [Multi-domain] Cd Length: 394 Bit Score: 161.05 E-value: 6.75e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 19 ETKQIHAGQHPDPTTNARALPIYATTSYTFD---DTAHAAA------LFgleipgniYTRIGNPTTDVVEQRIAALEGGV 89
Cdd:PRK09028 6 ATKIVSAGRDKKWTKGVINPPVFRASTVVFDtvaEMRHAAKnrangeMF--------YGRRGTPTHFAFQAAIVELEGGA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 90 AALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAETIS 169
Cdd:PRK09028 78 GTALYPSGAAAISNALLSFLKAGDHLLMVDSCYEPTRDLCDKILKGFGIETTYYD-PMIGEGIRELIRPNTKVLFLESPG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 170 NPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFdWTQGRfpgf 249
Cdd:PRK09028 157 SITMEVQDVPTLSRIAHEHDIVVMLDNTWASPINSRPFEMGVDISIQAATKYIVGHSDVMLGTATANEKH-WDQLR---- 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 250 ttpDPSYhgvvfaelgppafalkarvqLLrdyGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSVNY 329
Cdd:PRK09028 232 ---EHSY--------------------LM---GQCTSPDDVYLAMRGLRTLGVRLAQHEKNALKVANWLATRPEVDHVRH 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 330 AGLPSSPWHERAKRLAPKGTGaVLSFEL-AGGIEAGKAFVNALKLHSHVANIGDVRSLVIhpASTTHAQLSPAEQLATgv 408
Cdd:PRK09028 286 PAFETCPGHEFFKRDFSGSNG-LFSFVLkQGDPKAVTALVEGMQHFKMGFSWGGFESLIL--GVFGINKLRTATNWDF-- 360
|
410 420 430
....*....|....*....|....*....|...
gi 15610476 409 SPGLVRLAVGIEGIDDILADLELGFAaarRFSA 441
Cdd:PRK09028 361 SKPLIRLHIGLEDVDDLIADLEAGFE---RYNA 390
|
|
| PRK07050 |
PRK07050 |
cystathionine beta-lyase; Provisional |
8-438 |
1.51e-44 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 180810 [Multi-domain] Cd Length: 394 Bit Score: 159.89 E-value: 1.51e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 8 TDADPTAHWsfETKQIHAGQHPDPTTNARALPIYATTSYTFDDTAHAAALFGLEIPGNIYTRIGNPTTDVVEQRIAALEG 87
Cdd:PRK07050 2 TASTPKRAL--QTRIVQPDDQIPPGFRSFVTPVARASTVVFPDLATMRALDWRQDVQWRYGLHATPTSLALAQRLAEIEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 88 GVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVDdPDDLDTWQAAVRPNTKAFFAET 167
Cdd:PRK07050 80 GRHALLQPSGLAAISLVYFGLVKAGDDVLIPDNAYGPNRDHGEWLARDFGITVRFYD-PLIGAGIADLIQPNTRLIWLEA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 168 ISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIvdggnfdwtqgrfp 247
Cdd:PRK07050 159 PGSVTMEVPDVPAITAAARARGVVTAIDNTYSAGLAFKPFEHGVDISVQALTKYQSGGSDVLMGAT-------------- 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 248 gfTTPDPSYHgvvfAELGPpafalkARVQLlrdyGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDVLSV 327
Cdd:PRK07050 225 --ITADAELH----AKLKL------ARMRL----GIGVSADDCSLVLRGLPSLQVRLAAHDRSALEVAEWLKARPEIATV 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 328 NYAGLPSSPWHERAKRlAPKGTGAVLSFELAGGIEAGK--AFVNALKLHSHVANIGDVRSLVIhPASTTHAQlsPAEQLA 405
Cdd:PRK07050 289 LHPALPDCPGHAFWMR-DFTGAGGLFSVVFDERYSPAQvdAFVEALELFAIGWSWGGACSLAM-PYDVASMR--TAKWPH 364
|
410 420 430
....*....|....*....|....*....|...
gi 15610476 406 TGvspGLVRLAVGIEGIDDILADLELGFAAARR 438
Cdd:PRK07050 365 RG---TLVRLYIGLEDEADLIADLEQALEAALA 394
|
|
| PRK08114 |
PRK08114 |
cystathionine beta-lyase; Provisional |
17-434 |
1.41e-40 |
|
cystathionine beta-lyase; Provisional
Pssm-ID: 181231 [Multi-domain] Cd Length: 395 Bit Score: 149.47 E-value: 1.41e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 17 SFETKQIHAGQHPDPTTNARALPIYATTSYTFD---DTAHAAA------LFgleipgniYTRIGNPTTDVVEQRIAALEG 87
Cdd:PRK08114 5 KLDTQLVNAGRSKKYTQGSVNSVIQRASSLVFDsveAKKHATRnrangeLF--------YGRRGTLTHFSLQEAMCELEG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 88 GVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFHYSLAKLGIEVSFVdDPDDLDTWQAAVRPNTKAFFAET 167
Cdd:PRK08114 77 GAGCALYPCGAAAVANAILAFVEQGDHVLMTGTAYEPTQDFCSKILSKLGVTTTWF-DPLIGADIAKLIQPNTKVVFLES 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 168 ISNPQIDLLDTPAVSEvAHRNGVPLIV---DNTIATPYLIQPLAQGADIVVHSATKYLGGHGAAIAGVIVDGGNFdWTQG 244
Cdd:PRK08114 156 PGSITMEVHDVPAIVA-AVRSVNPDAVimiDNTWAAGVLFKALDFGIDISIQAGTKYLVGHSDAMIGTAVANARC-WEQL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 245 RfpgfttpDPSYhgvvfaelgppafalkarvqLLrdyGSAASPFNAFLVAQGLETLSLRIERHVANAQRVAEFLAARDDV 324
Cdd:PRK08114 234 R-------ENSY--------------------LM---GQMVDADTAYMTSRGLRTLGVRLRQHEESSLKVAEWLAEHPEV 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 325 LSVNYAGLPSSPWHERAKRlAPKGTGAVLSFELAGGI--EAGKAFVNALKLHSHVANIGDVRSLVIHPASTTHAQLSPAE 402
Cdd:PRK08114 284 ARVNHPALPGCKGHEFWKR-DFTGSSGLFSFVLKKKLtdEQLANYLDNFSLFSMAYSWGGFESLILANQPEEIAAIRPAG 362
|
410 420 430
....*....|....*....|....*....|..
gi 15610476 403 QLatGVSPGLVRLAVGIEGIDDILADLELGFA 434
Cdd:PRK08114 363 EV--DFTGTLIRLHIGLEDVDDLIADLAAGFA 392
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
79-234 |
2.54e-12 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 64.71 E-value: 2.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 79 EQRIAAL--EGGVAALFLSSGQAAETFAILNLAGAGDHIVSSPRLYGGTYNLFhysLAKLGIEVSFVD-DPDDLDTWQAA 155
Cdd:cd01494 6 EEKLARLlqPGNDKAVFVPSGTGANEAALLALLGPGDEVIVDANGHGSRYWVA---AELAGAKPVPVPvDDAGYGGLDVA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 156 V------RPNTKAFFAETISNPQIDLLDTPAVSEVAHRNGVPLIVDNTIATPY----LIQPLAQGADIVVHSATKYLGGh 225
Cdd:cd01494 83 IleelkaKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGAspapGVLIPEGGADVVTFSLHKNLGG- 161
|
....*....
gi 15610476 226 gaAIAGVIV 234
Cdd:cd01494 162 --EGGGVVI 168
|
|
| KBL_like |
cd06454 |
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ... |
78-231 |
9.69e-07 |
|
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.
Pssm-ID: 99747 [Multi-domain] Cd Length: 349 Bit Score: 50.64 E-value: 9.69e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 78 VEQRIAALEGGVAALFLSSGQAAETFAILNLAGAGDHIVSSprlyggtyNLFHYSLAKlGIEVSFVD-------DPDDLD 150
Cdd:cd06454 51 LEEELAEFHGKEAALVFSSGYAANDGVLSTLAGKGDLIISD--------SLNHASIID-GIRLSGAKkrifkhnDMEDLE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 151 T-WQAAVRPNTKAFFA-ETISNPQIDLLDTPAVSEVAHRNGVPLIVD---------NTIATPYLIQPLAQGADIVVHSAT 219
Cdd:cd06454 122 KlLREARRPYGKKLIVtEGVYSMDGDIAPLPELVDLAKKYGAILFVDeahsvgvygPHGRGVEEFGGLTDDVDIIMGTLG 201
|
170
....*....|..
gi 15610476 220 KYLGGHGAAIAG 231
Cdd:cd06454 202 KAFGAVGGYIAG 213
|
|
| WecE |
COG0399 |
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis]; |
79-324 |
2.25e-05 |
|
dTDP-4-amino-4,6-dideoxygalactose transaminase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440168 Cd Length: 364 Bit Score: 46.22 E-value: 2.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 79 EQRIAALEGGVAALFLSSGQAAETFAILNLA-GAGDHIVSSPRLYGGTYNLFHYslakLGIEVSFVD-DPD----DLDTW 152
Cdd:COG0399 36 EEEFAAYLGVKHAVAVSSGTAALHLALRALGiGPGDEVITPAFTFVATANAILY----VGATPVFVDiDPDtyniDPEAL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 153 QAAVRPNTKAFFAetisnpqIDLL----DTPAVSEVAHRNGVPLIVDNtiatpyliqplAQ--GA-----------DIVV 215
Cdd:COG0399 112 EAAITPRTKAIIP-------VHLYgqpaDMDAIMAIAKKHGLKVIEDA-----------AQalGAtykgkkvgtfgDAGC 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 216 HS--ATKYLG-GHGAAIagvivdggnfdwtqgrfpgfTTPDPsyhgvvfaelgppafALKARVQLLRDYGSAASP----- 287
Cdd:COG0399 174 FSfyPTKNLTtGEGGAV--------------------VTNDE---------------ELAERARSLRNHGRDRDAkyehv 218
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 15610476 288 ---FN--------AFLVAQgLETLSLRIERHVANAQRVAEFLAARDDV 324
Cdd:COG0399 219 elgYNyrmdelqaAIGLAQ-LKRLDEFIARRRAIAARYREALADLPGL 265
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
76-327 |
1.51e-04 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 43.87 E-value: 1.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 76 DVVEQRIAALEGGVAALFLssgqaaetfAILNLAGAGDHI-VSSPrlyggTYNLFHYSLAKLGIEVSFV------DDPDD 148
Cdd:cd00609 56 DVPPEEIVVTNGAQEALSL---------LLRALLNPGDEVlVPDP-----TYPGYEAAARLAGAEVVPVpldeegGFLLD 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 149 LDTWQAAVRPNTKAFFAETISNPQIDLLDTP---AVSEVAHRNGVPLIVDNT---IATPYLIQPLAQGAD-----IVVHS 217
Cdd:cd00609 122 LELLEAAKTPKTKLLYLNNPNNPTGAVLSEEeleELAELAKKHGILIISDEAyaeLVYDGEPPPALALLDayervIVLRS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 218 ATKYLGGHGAAIAGVIvdggnfdwtqgrfpgfttpdpsyhgvvfaelGPPAFALKARVQLLRDYGSAASPFNAFLVAQGL 297
Cdd:cd00609 202 FSKTFGLPGLRIGYLI-------------------------------APPEELLERLKKLLPYTTSGPSTLSQAAAAAAL 250
|
250 260 270
....*....|....*....|....*....|....
gi 15610476 298 ET----LSLRIERHVANAQRVAEFLAARDDVLSV 327
Cdd:cd00609 251 DDgeehLEELRERYRRRRDALLEALKELGPLVVV 284
|
|
| SufS_like |
cd06453 |
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ... |
103-226 |
1.89e-04 |
|
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.
Pssm-ID: 99746 [Multi-domain] Cd Length: 373 Bit Score: 43.61 E-value: 1.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 103 FAILNLAGAGDHIVSSPrlyggtynLFHYS-------LAKL-GIEVSFVD-DPD---DLDTWQAAVRPNTKAFFAETISN 170
Cdd:cd06453 79 YGLGRANKPGDEIVTSV--------MEHHSnivpwqqLAERtGAKLKVVPvDDDgqlDLEALEKLLTERTKLVAVTHVSN 150
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 15610476 171 PQIDLLDTPAVSEVAHRNGVPLIVDNTIATPYLiqPL---AQGADIVVHSATKYLGGHG 226
Cdd:cd06453 151 VLGTINPVKEIGEIAHEAGVPVLVDGAQSAGHM--PVdvqDLGCDFLAFSGHKMLGPTG 207
|
|
| SelA |
COG1921 |
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis]; |
176-234 |
2.76e-03 |
|
Seryl-tRNA(Sec) selenium transferase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441524 Cd Length: 399 Bit Score: 39.72 E-value: 2.76e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 15610476 176 LDTPAVSEVAHRNGVPLIVD------------NTIATPYLIQPLAQGADIVVHSATKYLGGhgaAIAGVIV 234
Cdd:COG1921 175 VSLAELAELAHEHGLPVIVDlgsgslvdlskyGLPHEPTVQEYLAAGADLVTFSGDKLLGG---PQAGIIV 242
|
|
| SIS_RpiR |
cd05013 |
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ... |
107-214 |
4.81e-03 |
|
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.
Pssm-ID: 240144 [Multi-domain] Cd Length: 139 Bit Score: 37.21 E-value: 4.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 107 NLAGAGDHIVSSPRLY----GGTYNL---FHYSLAKLGIEVSFVDDPDDLDTWQAAVRPNTkAFFAetISNP--QIDLLD 177
Cdd:cd05013 2 ALEKAVDLLAKARRIYifgvGSSGLVaeyLAYKLLRLGKPVVLLSDPHLQLMSAANLTPGD-VVIA--ISFSgeTKETVE 78
|
90 100 110
....*....|....*....|....*....|....*..
gi 15610476 178 tpaVSEVAHRNGVPLIVdntIaTPYLIQPLAQGADIV 214
Cdd:cd05013 79 ---AAEIAKERGAKVIA---I-TDSANSPLAKLADIV 108
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
47-195 |
6.28e-03 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 38.44 E-value: 6.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 47 TFDDTAHAAALFGLEIPGNIYTRIgnPTTDVVEQRIAALEGG---------VAALFLSSGQAAETFAILNLAGAGDHIVS 117
Cdd:pfam00155 15 TLPAVAKAEKDALAGGTRNLYGPT--DGHPELREALAKFLGRspvlkldreAAVVFGSGAGANIEALIFLLANPGDAILV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 15610476 118 SPRLYGgtynlFHYSLAKL-GIEVSFV--DDPD----DLDTWQAAVRPNTKAFFAETISNPQIDLLDTP---AVSEVAHR 187
Cdd:pfam00155 93 PAPTYA-----SYIRIARLaGGEVVRYplYDSNdfhlDFDALEAALKEKPKVVLHTSPHNPTGTVATLEeleKLLDLAKE 167
|
....*...
gi 15610476 188 NGVPLIVD 195
Cdd:pfam00155 168 HNILLLVD 175
|
|
| |
