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Conserved domains on  [gi|88900515|ref|NP_082185|]
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phospholipid transfer protein C2CD2L isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SMP_C2CD2L cd21683
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 ...
84-260 6.74e-110

synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 domain-containing protein 2-like (C2CD2L); C2CD2L, also called phospholipid transfer protein C2CD2L, or C2CD2-like, or transmembrane protein 24 (TMEM24), is a lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It is a Ca2+-regulated component of endoplasmic reticulum (ER)-plasma membrane contacts in mammalian neurons. This model corresponds to the SMP domain of C2CD2L, which may be implicated in lipid transport.


:

Pssm-ID: 439239  Cd Length: 177  Bit Score: 330.13  E-value: 6.74e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515  84 GVRGLLASLFAFKSFRENWQRAWVRALNEQACRDGSSIQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEEVRF 163
Cdd:cd21683   1 GAKGLLTSLFAFKSFRENWQRAWVRALNEQACRNGSSLQITFEESPQLPASASISHVTCTDQSDHSMVLHCNLSADAVKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 164 PISVTQQSPAAVSMETYHVTLTLPPTQLEVSLEEIPDEGLLVSWAFTDRPELSLKVLPKLQTRERDEEQPELSTVEELIK 243
Cdd:cd21683  81 PVSVTQQSPAAVSMDTYQVTLAPLQAQVEVCLEEVENEGLLVSWTFKDRPDLSLTVTPRQQQQEGNEGKADLSTIQDLIE 160
                       170
                ....*....|....*..
gi 88900515 244 DAIVSTQPAMMVNLRAC 260
Cdd:cd21683 161 DTLVSTQPAMILNLKAC 177
C2 super family cl14603
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
288-412 1.90e-12

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


The actual alignment was detected with superfamily member cd08678:

Pssm-ID: 472691 [Multi-domain]  Cd Length: 126  Bit Score: 64.70  E-value: 1.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 288 LFLRQLRASHLGSELGGTEeLCCAAELDNPMQQKWTKPMRAGPEVEWTEDLALDLGPQSRELTLKVLRSSSCGDAELLGQ 367
Cdd:cd08678   1 LLVKNIKANGLSEAAGSSN-PYCVLEMDEPPQKYQSSTQKNTSNPFWDEHFLFELSPNSKELLFEVYDNGKKSDSKFLGL 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 88900515 368 ATLPVGSPSRPMSRRQVCPLTPGPGKSLSPAATVTAELHYEQGSP 412
Cdd:cd08678  80 AIVPFDELRKNPSGRQIFPLQGRPYEGDSVSGSITVEFLFMEPAE 124
 
Name Accession Description Interval E-value
SMP_C2CD2L cd21683
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 ...
84-260 6.74e-110

synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 domain-containing protein 2-like (C2CD2L); C2CD2L, also called phospholipid transfer protein C2CD2L, or C2CD2-like, or transmembrane protein 24 (TMEM24), is a lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It is a Ca2+-regulated component of endoplasmic reticulum (ER)-plasma membrane contacts in mammalian neurons. This model corresponds to the SMP domain of C2CD2L, which may be implicated in lipid transport.


Pssm-ID: 439239  Cd Length: 177  Bit Score: 330.13  E-value: 6.74e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515  84 GVRGLLASLFAFKSFRENWQRAWVRALNEQACRDGSSIQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEEVRF 163
Cdd:cd21683   1 GAKGLLTSLFAFKSFRENWQRAWVRALNEQACRNGSSLQITFEESPQLPASASISHVTCTDQSDHSMVLHCNLSADAVKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 164 PISVTQQSPAAVSMETYHVTLTLPPTQLEVSLEEIPDEGLLVSWAFTDRPELSLKVLPKLQTRERDEEQPELSTVEELIK 243
Cdd:cd21683  81 PVSVTQQSPAAVSMDTYQVTLAPLQAQVEVCLEEVENEGLLVSWTFKDRPDLSLTVTPRQQQQEGNEGKADLSTIQDLIE 160
                       170
                ....*....|....*..
gi 88900515 244 DAIVSTQPAMMVNLRAC 260
Cdd:cd21683 161 DTLVSTQPAMILNLKAC 177
SMP_C2CD2L pfam18696
Synaptotagmin-like, mitochondrial and lipid-binding domain; This is a lipid transport domain ...
102-253 3.42e-64

Synaptotagmin-like, mitochondrial and lipid-binding domain; This is a lipid transport domain found in phospholipid transfer proteins such as C2CD2L-like (also known as TMEM24). The TMEM24-SMP domain is shown to bind glycerolipids with a preference for phosphatidylinositol (PI).The bound PI is then transferred to the plasma membrane (PM) where it is converted to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to replenish pools of this lipid hydrolyzed during glucose-stimulated signaling. PI(4,5)P2 is required for Ca2+-dependent exocytosis hence, the SMP domain of TMEM24 is essential for sustaining the intracellular Ca2+ oscillations that trigger bursts of insulin granule release and hence insulin secretion. The SMP domain belongs to a superfamily of lipid/hydrophobic ligand-binding domains called TULIP for (tubular lipid-binding proteins) it adopts TULIP fold with two alpha helices and a highly curved antiparallel beta sheet forming a cornucopia-like structure.


Pssm-ID: 465835  Cd Length: 152  Bit Score: 209.82  E-value: 3.42e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515   102 WQRAWVRALNEQACRDGSSIQIAFEEIP-QLPPRASISHVTCVDQSERTMVLHCQLSAEEVRFPISVTQQSPAAVSMETY 180
Cdd:pfam18696   1 WQRAWVRALNEEACRRGGPLQLTFEEDGlQQPLELAVSQVSSFDKSAQEKVVSCHVVGEALQFPVSVTQQSPAAVSPQTY 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 88900515   181 HVTLTLPPTQLEVSLEEIPDeGLLVSWAFTDRPELSLKVLPKLQTRERDEEQPELSTVEELIKDAIVSTQPAM 253
Cdd:pfam18696  81 QVTLSPLHLQLELHMEEKEE-DIQISWSFSHLPELSLQVTPKAQQEQVNETAAVSETLKDLLKDLLSSASPSV 152
C2_C21orf25-like cd08678
C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein; The ...
288-412 1.90e-12

C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein; The members in this cd are named after the Human C21orf25 which contains a single C2 domain. Several other members contain a C1 domain downstream of the C2 domain. No other information on this protein is currently known. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176060 [Multi-domain]  Cd Length: 126  Bit Score: 64.70  E-value: 1.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 288 LFLRQLRASHLGSELGGTEeLCCAAELDNPMQQKWTKPMRAGPEVEWTEDLALDLGPQSRELTLKVLRSSSCGDAELLGQ 367
Cdd:cd08678   1 LLVKNIKANGLSEAAGSSN-PYCVLEMDEPPQKYQSSTQKNTSNPFWDEHFLFELSPNSKELLFEVYDNGKKSDSKFLGL 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 88900515 368 ATLPVGSPSRPMSRRQVCPLTPGPGKSLSPAATVTAELHYEQGSP 412
Cdd:cd08678  80 AIVPFDELRKNPSGRQIFPLQGRPYEGDSVSGSITVEFLFMEPAE 124
 
Name Accession Description Interval E-value
SMP_C2CD2L cd21683
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 ...
84-260 6.74e-110

synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 domain-containing protein 2-like (C2CD2L); C2CD2L, also called phospholipid transfer protein C2CD2L, or C2CD2-like, or transmembrane protein 24 (TMEM24), is a lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It is a Ca2+-regulated component of endoplasmic reticulum (ER)-plasma membrane contacts in mammalian neurons. This model corresponds to the SMP domain of C2CD2L, which may be implicated in lipid transport.


Pssm-ID: 439239  Cd Length: 177  Bit Score: 330.13  E-value: 6.74e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515  84 GVRGLLASLFAFKSFRENWQRAWVRALNEQACRDGSSIQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEEVRF 163
Cdd:cd21683   1 GAKGLLTSLFAFKSFRENWQRAWVRALNEQACRNGSSLQITFEESPQLPASASISHVTCTDQSDHSMVLHCNLSADAVKF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 164 PISVTQQSPAAVSMETYHVTLTLPPTQLEVSLEEIPDEGLLVSWAFTDRPELSLKVLPKLQTRERDEEQPELSTVEELIK 243
Cdd:cd21683  81 PVSVTQQSPAAVSMDTYQVTLAPLQAQVEVCLEEVENEGLLVSWTFKDRPDLSLTVTPRQQQQEGNEGKADLSTIQDLIE 160
                       170
                ....*....|....*..
gi 88900515 244 DAIVSTQPAMMVNLRAC 260
Cdd:cd21683 161 DTLVSTQPAMILNLKAC 177
SMP_C2CD2L pfam18696
Synaptotagmin-like, mitochondrial and lipid-binding domain; This is a lipid transport domain ...
102-253 3.42e-64

Synaptotagmin-like, mitochondrial and lipid-binding domain; This is a lipid transport domain found in phospholipid transfer proteins such as C2CD2L-like (also known as TMEM24). The TMEM24-SMP domain is shown to bind glycerolipids with a preference for phosphatidylinositol (PI).The bound PI is then transferred to the plasma membrane (PM) where it is converted to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to replenish pools of this lipid hydrolyzed during glucose-stimulated signaling. PI(4,5)P2 is required for Ca2+-dependent exocytosis hence, the SMP domain of TMEM24 is essential for sustaining the intracellular Ca2+ oscillations that trigger bursts of insulin granule release and hence insulin secretion. The SMP domain belongs to a superfamily of lipid/hydrophobic ligand-binding domains called TULIP for (tubular lipid-binding proteins) it adopts TULIP fold with two alpha helices and a highly curved antiparallel beta sheet forming a cornucopia-like structure.


Pssm-ID: 465835  Cd Length: 152  Bit Score: 209.82  E-value: 3.42e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515   102 WQRAWVRALNEQACRDGSSIQIAFEEIP-QLPPRASISHVTCVDQSERTMVLHCQLSAEEVRFPISVTQQSPAAVSMETY 180
Cdd:pfam18696   1 WQRAWVRALNEEACRRGGPLQLTFEEDGlQQPLELAVSQVSSFDKSAQEKVVSCHVVGEALQFPVSVTQQSPAAVSPQTY 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 88900515   181 HVTLTLPPTQLEVSLEEIPDeGLLVSWAFTDRPELSLKVLPKLQTRERDEEQPELSTVEELIKDAIVSTQPAM 253
Cdd:pfam18696  81 QVTLSPLHLQLELHMEEKEE-DIQISWSFSHLPELSLQVTPKAQQEQVNETAAVSETLKDLLKDLLSSASPSV 152
SMP_C2CD2-like cd21664
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 ...
85-260 8.82e-60

synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 domain-containing protein 2-like (C2CD2L) and similar proteins; This family includes C2 domain-containing protein 2 (C2CD2) and C2CD2-like (C2CD2L). C2CD2 (also called transmembrane protein 24-like or TMEM24L), may be a lipid-binding protein that shows high sequence similarity with C2 domain-containing protein 2-like (C2CD2L; also called transmembrane protein 24 or TMEM24). C2CD2L is a lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum (ER) to the cell membrane. It is a Ca2+-regulated component of ER-plasma membrane contacts in mammalian neurons. This model corresponds to the SMP domain of C2CD2 and C2CD2L which binds glycerolipids with a preference for phosphatidylinositol (PI). The bound PI is then transferred to the plasma membrane (PM) where it is converted to phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] to replenish pools of this lipid hydrolyzed during glucose-stimulated signaling. PI(4,5)P2 is required for Ca2+-dependent exocytosis; hence, the SMP domain of TMEM24 is essential for sustaining the intracellular Ca2+ oscillations that trigger bursts of insulin granule release and subsequent insulin secretion.


Pssm-ID: 439224  Cd Length: 175  Bit Score: 198.73  E-value: 8.82e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515  85 VRGLLASLFAFK-SFRENWQRAWVRALNEQACRDGSSIQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEEVRF 163
Cdd:cd21664   1 WLNSVLNWIYTQyCNTPELVEAWLKALNEQARRAGSSVQVTFERIQSGSLPPKFTHVSTVAEPNDSLVVTCQVESEGLRF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 164 PISVTQQSPAAVSMETYHVTLTLPPTQLEVSLEEIpDEGLLVSWAFTDRPELSLKVLPKLQTReRDEEQPELSTVEELIK 243
Cdd:cd21664  81 QVFATQQTAQSVKLSNCDVSVTKLSGKLRCHGRTL-GEELQISVSFEDRPDLKLNIKPKNGSP-TAEDSVDLDVVEEIVR 158
                       170
                ....*....|....*..
gi 88900515 244 DAIVSTQPAMMVNLRAC 260
Cdd:cd21664 159 NAIASATTTFVLPTQAT 175
SMP_C2CD2 cd21682
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 ...
87-254 1.83e-28

synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain found in C2 domain-containing protein 2 (C2CD2); C2CD2, also called transmembrane protein 24-like (TMEM24L), may be a lipid-binding protein that shows high sequence similarity with C2 domain-containing protein 2-like (C2CD2L; also transmembrane protein 24 or TMEM24). C2CD2L is a lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane. It is a Ca2+-regulated component of endoplasmic reticulum (ER)-plasma membrane contacts in mammalian neurons. This model corresponds to the SMP domain of C2CD2, which may be implicated in lipid transport.


Pssm-ID: 439238  Cd Length: 175  Bit Score: 111.96  E-value: 1.83e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515  87 GLLASLFAFKSFRENWQRAWVRALNEQACRDGSSIQIAFEEIPQLPPRASISHVTCVDQSERTMVLHCQLSAEEVRFPIS 166
Cdd:cd21682   4 ALLSWALSLKSWRSQWRRAWVTALNEEARKRGGPLLLTFEEDGLQQLELVVSQVSSFVKSAQEKVVSCQVVGEKLQFSVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 167 VTQQSPAAVSMETYHVTLTLPPTQLEVSLEEIPDEgLLVSWAFTDRPELSLKVLPKLqTRERDEEQPELSTVEELIKDAI 246
Cdd:cd21682  84 AAPASPTAAGPQLYSVKLSPLHLQLELHMKEKRED-IQVSWSFSHLDETNLQVQPKA-TQEVDETSASSEALKDILKQLL 161

                ....*...
gi 88900515 247 VSTQPAMM 254
Cdd:cd21682 162 CSASPSVV 169
C2_C21orf25-like cd08678
C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein; The ...
288-412 1.90e-12

C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein; The members in this cd are named after the Human C21orf25 which contains a single C2 domain. Several other members contain a C1 domain downstream of the C2 domain. No other information on this protein is currently known. The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 176060 [Multi-domain]  Cd Length: 126  Bit Score: 64.70  E-value: 1.90e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 288 LFLRQLRASHLGSELGGTEeLCCAAELDNPMQQKWTKPMRAGPEVEWTEDLALDLGPQSRELTLKVLRSSSCGDAELLGQ 367
Cdd:cd08678   1 LLVKNIKANGLSEAAGSSN-PYCVLEMDEPPQKYQSSTQKNTSNPFWDEHFLFELSPNSKELLFEVYDNGKKSDSKFLGL 79
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 88900515 368 ATLPVGSPSRPMSRRQVCPLTPGPGKSLSPAATVTAELHYEQGSP 412
Cdd:cd08678  80 AIVPFDELRKNPSGRQIFPLQGRPYEGDSVSGSITVEFLFMEPAE 124
SMP_SF cd21669
synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain superfamily; The SMP ...
98-255 1.51e-08

synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain superfamily; The SMP domain is a lipid transport domain found in phospholipid transfer proteins such as synaptotagmin family proteins, tricalbin (TCB) family proteins, maintenance of mitochondrial morphology protein 1 (MMM1), mitochondrial distribution and morphology protein 12 (MDM12), mitochondrial distribution and morphology protein 34 (MDM34), PDZ domain-containing protein 8 (PDZD8), testis-expressed protein 2 (TEX2), meiotically up-regulated gene 190 protein (Mug190), C2 domain-containing protein 2 (C2CD2) and C2 domain-containing protein 2-like (C2CD2L). The SMP domain belongs to a superfamily of lipid/hydrophobic ligand-binding domains called TULIP (tubular lipid-binding proteins). It adopts a TULIP fold with two alpha helices and a highly curved antiparallel beta sheet forming a cornucopia-like structure.


Pssm-ID: 439225  Cd Length: 165  Bit Score: 54.63  E-value: 1.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515  98 FRENWQRAWVRALnEQACRDGSSIQIAFEE--IPQLPPRASISHVTCVDQSERTMVLHCQLS-AEEVRFPISVTQQSPAA 174
Cdd:cd21669   1 LEQLIRESLQELL-EEVKKPSFIESLELTEftLGSNPPRIKSVRVLDSPSSDLQLVLDLDLEyAGDFSVVLSAKLGGGGL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 88900515 175 VSMETYHVTLTLPPTQLEVSLEEIPDEGLL--VSWAFTDRPELSLKVLPKLQTRERdeEQPELST-VEELIKDAIVST-- 249
Cdd:cd21669  80 GLPVPVSVSDLSLEGRLRVRLTLLPEFPYVgaLSISFVEPPDIDFSIRPLGGVDLM--ELPGLSSwLEKLLTDALVELlv 157

                ....*.
gi 88900515 250 QPAMMV 255
Cdd:cd21669 158 EPNRIV 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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