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Conserved domains on  [gi|940516954|ref|NP_001303621|]
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putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GGL super family cl00069
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 18-103 5.05e-10

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


The actual alignment was detected with superfamily member smart00224:

Pssm-ID: 469600  Cd Length: 63  Bit Score: 51.12  E-value: 5.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940516954    18 VEQLQMEAGIDQVKVRvgasagggkrwehmgqgtgaclglvwlnqlvcrcpKMAADLLKFCTEQAKNDPFLVGIPAATNS 97
Cdd:smart00224   8 VEQLRKELSRERIKVS-----------------------------------KAAEELLAYCEQHAEEDPLLTGPPPSKNP 52


                   ....*.
gi 940516954    98 FKEKKP 103
Cdd:smart00224  53 FIEDKT 58
 
Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
18-103 5.05e-10

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 51.12  E-value: 5.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940516954    18 VEQLQMEAGIDQVKVRvgasagggkrwehmgqgtgaclglvwlnqlvcrcpKMAADLLKFCTEQAKNDPFLVGIPAATNS 97
Cdd:smart00224   8 VEQLRKELSRERIKVS-----------------------------------KAAEELLAYCEQHAEEDPLLTGPPPSKNP 52


                   ....*.
gi 940516954    98 FKEKKP 103
Cdd:smart00224  53 FIEDKT 58
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 18-102 6.67e-09

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 48.05  E-value: 6.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940516954  18 VEQLQMEAGIDQVKVRvgasagggkrwehmgqgtgaclglvwlnqlvcrcpKMAADLLKFCTEQAKNDPFLVGIPAATNS 97
Cdd:cd00068    8 VEQLRKELSRERLKVS-----------------------------------KAAAELLKYCEQNAENDPLLTGPPSPSNP 52


                 ....*
gi 940516954  98 FKEKK 102
Cdd:cd00068   53 WIEKK 57
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 69-102 2.78e-04

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 36.17  E-value: 2.78e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 940516954   69 KMAADLLKFCTEQAKNDPFLVGI---PAATNSFKEKK 102
Cdd:pfam00631  27 KACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDD 63
 
Name Accession Description Interval E-value
GGL smart00224
G protein gamma subunit-like motifs;
18-103 5.05e-10

G protein gamma subunit-like motifs;


Pssm-ID: 128520  Cd Length: 63  Bit Score: 51.12  E-value: 5.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940516954    18 VEQLQMEAGIDQVKVRvgasagggkrwehmgqgtgaclglvwlnqlvcrcpKMAADLLKFCTEQAKNDPFLVGIPAATNS 97
Cdd:smart00224   8 VEQLRKELSRERIKVS-----------------------------------KAAEELLAYCEQHAEEDPLLTGPPPSKNP 52


                   ....*.
gi 940516954    98 FKEKKP 103
Cdd:smart00224  53 FIEDKT 58
GGL cd00068
G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta ...
 18-102 6.67e-09

G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors


Pssm-ID: 238024  Cd Length: 57  Bit Score: 48.05  E-value: 6.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 940516954  18 VEQLQMEAGIDQVKVRvgasagggkrwehmgqgtgaclglvwlnqlvcrcpKMAADLLKFCTEQAKNDPFLVGIPAATNS 97
Cdd:cd00068    8 VEQLRKELSRERLKVS-----------------------------------KAAAELLKYCEQNAENDPLLTGPPSPSNP 52


                 ....*
gi 940516954  98 FKEKK 102
Cdd:cd00068   53 WIEKK 57
G-gamma pfam00631
GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the ...
 69-102 2.78e-04

GGL domain; G-protein gamma like domains (GGL) are found in the gamma subunit of the heterotrimeric G protein complex and in regulators of G protein signaling (RGS) proteins. It is also found fused to an inactive Galpha in the Dictyostelium protein gbqA. G-gamma likely shares a common origin with the helical N-terminal unit of G-beta. All organizms that posses a G-beta possess a G-gamma.


Pssm-ID: 459879 [Multi-domain]  Cd Length: 69  Bit Score: 36.17  E-value: 2.78e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 940516954   69 KMAADLLKFCTEQAKNDPFLVGI---PAATNSFKEKK 102
Cdd:pfam00631  27 KACEELIDYCEQRSTKDPLLPGVwgpPAGENPWREDD 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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