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Conserved domains on  [gi|157822677|ref|NP_001100747|]
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leucine-rich repeat LGI family member 3 precursor [Rattus norvegicus]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
112-172 9.19e-14

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 9.19e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157822677  112 SHLQYLFIENNDIWGLSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILSDLDLRGNAL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 268-308 3.93e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 52.09  E-value: 3.93e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  268 QLRDYDRIPAPSAVHCKPMVVDGQLYVVVAQLFGGSYIYHW 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 410-451 2.25e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 2.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  410 QFVAQGEVTqVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRW 451
Cdd:pfam03736   1 KFVPYQTIP-TRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 143-218 1.05e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.09  E-value: 1.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822677   143 LANNNLQTLPRDIFRPLDILSDLDLRGNALNCDCKVKWLVEWLAHTNTTVA---PIYCASPPRFQEHKVQDLPLREFDC 218
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 455-495 1.18e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  455 RFSEVQALPSRGSLALQPFLVGGHRYLALGSDFSFTQIYQW 495
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 314-359 2.02e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 2.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157822677  314 RFTKLQDIDPQRVRkpnDLEAFRIDGDWFFAVADSSkaGATSLYRW 359
Cdd:pfam03736   1 KFVPYQTIPTRGAR---DVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 222-262 3.26e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  222 DFVLYQTLSFP-AVSAEPFLYSSDLYLALAqPGASACTILKW 262
Cdd:pfam03736   1 KFVPYQTIPTRgARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 501-541 7.30e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.84  E-value: 7.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  501 KFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRH 541
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR_8 pfam13855
Leucine rich repeat;
68-124 5.36e-05

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677   68 SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDI 124
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 363-404 1.61e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  363 GFYSHQALHAWhRDTDLEFVDGEGKPRLIVSSSSQAPVIYQW 404
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
112-172 9.19e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 9.19e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157822677  112 SHLQYLFIENNDIWGLSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILSDLDLRGNAL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 2.67e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 2.67e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWGLSKfTFRGLKSLTHLSLANNNLQTLPrDIFRpLDILSDLDLRGNAL 172
Cdd:COG4886  190 SNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGN-LTNLEELDLSNNQL 262
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 268-308 3.93e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 52.09  E-value: 3.93e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  268 QLRDYDRIPAPSAVHCKPMVVDGQLYVVVAQLFGGSYIYHW 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 410-451 2.25e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 2.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  410 QFVAQGEVTqVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRW 451
Cdd:pfam03736   1 KFVPYQTIP-TRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 143-218 1.05e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.09  E-value: 1.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822677   143 LANNNLQTLPRDIFRPLDILSDLDLRGNALNCDCKVKWLVEWLAHTNTTVA---PIYCASPPRFQEHKVQDLPLREFDC 218
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 455-495 1.18e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  455 RFSEVQALPSRGSLALQPFLVGGHRYLALGSDFSFTQIYQW 495
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 314-359 2.02e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 2.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157822677  314 RFTKLQDIDPQRVRkpnDLEAFRIDGDWFFAVADSSkaGATSLYRW 359
Cdd:pfam03736   1 KFVPYQTIPTRGAR---DVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 222-262 3.26e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  222 DFVLYQTLSFP-AVSAEPFLYSSDLYLALAqPGASACTILKW 262
Cdd:pfam03736   1 KFVPYQTIPTRgARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 501-541 7.30e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.84  E-value: 7.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  501 KFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRH 541
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR_8 pfam13855
Leucine rich repeat;
68-124 5.36e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677   68 SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDI 124
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
170-218 5.37e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.88  E-value: 5.37e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 157822677   170 NALNCDCKVKWLVEWLA---HTNTTVAPiYCASPPRFQEhKVQDLPLREFDC 218
Cdd:smart00082   1 NPFICDCELRWLLRWLQaneHLQDPVDL-RCASPSSLRG-PLLELLHSEFKC 50
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 363-404 1.61e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  363 GFYSHQALHAWhRDTDLEFVDGEGKPRLIVSSSSQAPVIYQW 404
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
135-158 1.71e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 38.87  E-value: 1.71e-04
                           10        20
                   ....*....|....*....|....
gi 157822677   135 LKSLTHLSLANNNLQTLPRDIFRP 158
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-173 5.76e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157822677 108 FTGLSHLQYLFIENNDIWGLSKFTF-----RGL-KSLTHLSLANNNLQTLprDIFRPLDILSDLDLRGNALN 173
Cdd:cd21340   86 LENLTNLEELHIENQRLPPGEKLTFdprslAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
112-172 9.19e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 9.19e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 157822677  112 SHLQYLFIENNDIWGLSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLDILSDLDLRGNAL 172
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
96-148 6.78e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 6.78e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 157822677   96 NSNKFTLIGDNAFTGLSHLQYLFIENNDIWGLSKFTFRGLKSLTHLSLANNNL 148
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 2.67e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 2.67e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWGLSKfTFRGLKSLTHLSLANNNLQTLPrDIFRpLDILSDLDLRGNAL 172
Cdd:COG4886  190 SNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGN-LTNLEELDLSNNQL 262
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 268-308 3.93e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 52.09  E-value: 3.93e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  268 QLRDYDRIPAPSAVHCKPMVVDGQLYVVVAQLFGGSYIYHW 308
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 8.04e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 8.04e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677  96 NSNKFTLIgDNAFTGLSHLQYLFIENNDIWGLSKfTFRGLKSLTHLSLANNNLQTLPRDIFRpLDILSDLDLRGNAL 172
Cdd:COG4886  167 SNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLAN-LTNLETLDLSNNQL 240
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 410-451 2.25e-08

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.16  E-value: 2.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  410 QFVAQGEVTqVPDAQAVKHFRAGRDSYLCLSRYIGDSKILRW 451
Cdd:pfam03736   1 KFVPYQTIP-TRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 143-218 1.05e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.09  E-value: 1.05e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 157822677   143 LANNNLQTLPRDIFRPLDILSDLDLRGNALNCDCKVKWLVEWLAHTNTTVA---PIYCASPPRFQEHKVQDLPLREFDC 218
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRqpeAALCAGPGALAGQPLLGIPLLDSGC 80
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 455-495 1.18e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.85  E-value: 1.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  455 RFSEVQALPSRGSLALQPFLVGGHRYLALGSDFSFTQIYQW 495
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-247 1.34e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822677  96 NSNKFTLIGDnAFTGLSHLQYLFIENNDIWGLSKFTfrGLKSLTHLSLANNNLQTLPrdIFRPLDILSDLDLRGNALNcD 175
Cdd:COG4886  213 SGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLT-D 286

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157822677 176 CKVKWLVEWLAHTNTTVAPIYCASPPRFQEHKVQDLPLREFDCITTDFVLYQTLSFPAVSAEPFLYSSDLYL 247
Cdd:COG4886  287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 314-359 2.02e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 47.46  E-value: 2.02e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 157822677  314 RFTKLQDIDPQRVRkpnDLEAFRIDGDWFFAVADSSkaGATSLYRW 359
Cdd:pfam03736   1 KFVPYQTIPTRGAR---DVEPFSIGGDLFLAVANFS--GDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 222-262 3.26e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 44.00  E-value: 3.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  222 DFVLYQTLSFP-AVSAEPFLYSSDLYLALAqPGASACTILKW 262
Cdd:pfam03736   1 KFVPYQTIPTRgARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 501-541 7.30e-06

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 42.84  E-value: 7.30e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 157822677  501 KFVRFQELAVQAPRAFCYMPAGDAQLLLAPSFKGQTLVYRH 541
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR_8 pfam13855
Leucine rich repeat;
68-124 5.36e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677   68 SLTLVNAAFSEIQDGAFSHLPLLQFLLLNSNKFTLIGDNAFTGLSHLQYLFIENNDI 124
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
170-218 5.37e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.88  E-value: 5.37e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 157822677   170 NALNCDCKVKWLVEWLA---HTNTTVAPiYCASPPRFQEhKVQDLPLREFDC 218
Cdd:smart00082   1 NPFICDCELRWLLRWLQaneHLQDPVDL-RCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
137-173 1.43e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.43e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 157822677  137 SLTHLSLANNNLQTLPRDIFRPLDILSDLDLRGNALN 173
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT 38
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 363-404 1.61e-04

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 38.99  E-value: 1.61e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 157822677  363 GFYSHQALHAWhRDTDLEFVDGEGKPRLIVSSSSQAPVIYQW 404
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR smart00370
Leucine-rich repeats, outliers;
135-158 1.71e-04

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 38.87  E-value: 1.71e-04
                           10        20
                   ....*....|....*....|....
gi 157822677   135 LKSLTHLSLANNNLQTLPRDIFRP 158
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
135-158 1.71e-04

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 38.87  E-value: 1.71e-04
                           10        20
                   ....*....|....*....|....
gi 157822677   135 LKSLTHLSLANNNLQTLPRDIFRP 158
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
96-172 3.37e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 3.37e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677  96 NSNKFTLIGDNAFTGLSHLQYLFIENNDiwglskfTFRGLKSLTHLSLANNNLQTLPRDIFRpLDILSDLDLRGNAL 172
Cdd:COG4886   80 LLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQL 148
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 113-150 1.57e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 1.57e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 157822677  113 HLQYLFIENNDIWGLSkfTFRGLKSLTHLSLANNNLQT 150
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 108-173 5.76e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 5.76e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157822677 108 FTGLSHLQYLFIENNDIWGLSKFTF-----RGL-KSLTHLSLANNNLQTLprDIFRPLDILSDLDLRGNALN 173
Cdd:cd21340   86 LENLTNLEELHIENQRLPPGEKLTFdprslAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 232-363 6.16e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 38.72  E-value: 6.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157822677 232 PAVSAEPFLYSSDLYlalaqpgasACTILKWDYVERQLRDYDRIP-APSAVHCKPmvvDGQLYVvvAQLFGGsyIYHWDP 310
Cdd:COG3386   13 PVWDPDGRLYWVDIP---------GGRIHRYDPDGGAVEVFAEPSgRPNGLAFDP---DGRLLV--ADHGRG--LVRFDP 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 157822677 311 NTTRFTKLQDIDPQRVRKPNDLeafRIDGD---WFfavADSSK-AGATSLYRWHQNG 363
Cdd:COG3386   77 ADGEVTVLADEYGKPLNRPNDG---VVDPDgrlYF---TDMGEyLPTGALYRVDPDG 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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