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Conserved domains on  [gi|9947051|gb|AAG04520|]
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probable major facilitator superfamily (MFS) transporter [Pseudomonas aeruginosa PAO1]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 32-392 1.79e-110

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17388:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 385  Bit Score: 329.98  E-value: 1.79e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVApLAVRDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17388  11 DAMGIGLIMPVLPTLLREFV-GDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNA 191
Cdd:cd17388  90 TLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNF 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  192 LLAGLFLEETLPPTRRRRLDPRRMNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLA 271
Cdd:cd17388 170 LLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLA 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  272 LYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGSLATPAMQGLLSARVPVDRQ 351
Cdd:cd17388 250 VFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQ 329

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 9947051  352 GELQGVLSSLMSLAAIVGPPLMSGLFHWGSGPLAPLP-LAGA 392
Cdd:cd17388 330 GELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAwIIGA 371
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 32-392 1.79e-110

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 329.98  E-value: 1.79e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVApLAVRDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17388  11 DAMGIGLIMPVLPTLLREFV-GDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNA 191
Cdd:cd17388  90 TLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNF 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  192 LLAGLFLEETLPPTRRRRLDPRRMNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLA 271
Cdd:cd17388 170 LLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLA 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  272 LYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGSLATPAMQGLLSARVPVDRQ 351
Cdd:cd17388 250 VFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQ 329

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 9947051  352 GELQGVLSSLMSLAAIVGPPLMSGLFHWGSGPLAPLP-LAGA 392
Cdd:cd17388 330 GELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAwIIGA 371
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
32-366 3.74e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 99.66  E-value: 3.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVAPlavrdAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:COG2814  22 SGLGIGIVLPALPLIAADLGA-----SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASV-ATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVH-GTTLPLLLAAGLCLL 189
Cdd:COG2814  97 SLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  190 NALLAGLFLEETLPPTRRrrldprrmNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYS 269
Cdd:COG2814 177 ALLLLLRLLPESRPAARA--------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  270 LALYGVLAVLAQTLGVNLcKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPV 348
Cdd:COG2814 249 LALFGLGGVLGALLAGRL-ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPP 327

                       330
                ....*....|....*...
gi 9947051  349 DRQGELQGVLSSLMSLAA 366
Cdd:COG2814 328 EARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
65-370 6.42e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.39  E-value: 6.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051     65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA-MACAADLGTH 143
Cdd:pfam07690  37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAaLALIADWFPP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    144 GQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDPRRMNALRSISG 223
Cdd:pfam07690 117 EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    224 LARQPGVgrLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCKRRLDDARLLRLGLA 303
Cdd:pfam07690 197 LLRDPVL--WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    304 LQGC--GLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGP 370
Cdd:pfam07690 275 LILAalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
65-172 1.80e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 75.76  E-value: 1.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051     65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA-MACAADLGTH 143
Cdd:TIGR00880   3 LLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPP 82

                          90       100
                  ....*....|....*....|....*....
gi 9947051    144 GQRTRHFGWLYAGLALGMILGPALGGLLA 172
Cdd:TIGR00880  83 EERGVALGLMSAGIALGPLLGPPLGGVLA 111
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
34-174 1.36e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 53.39  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    34 AGVGLIVPLLPTLIGSVAPLAVRDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSL 113
Cdd:PRK09874  28 AAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNI 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9947051   114 WMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:PRK09874 108 WQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADS 168
 
Name Accession Description Interval E-value
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 32-392 1.79e-110

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 329.98  E-value: 1.79e-110
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVApLAVRDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17388  11 DAMGIGLIMPVLPTLLREFV-GDSADAATHYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAP 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNA 191
Cdd:cd17388  90 TLWWLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISPRAPFLVAAGLNGLNF 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  192 LLAGLFLEETLPPTRRRRLDPRRMNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLA 271
Cdd:cd17388 170 LLGLFVLPESLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLA 249

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  272 LYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGSLATPAMQGLLSARVPVDRQ 351
Cdd:cd17388 250 VFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLALGGIAGPALQGLLSRQVPENEQ 329

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 9947051  352 GELQGVLSSLMSLAAIVGPPLMSGLFHWGSGPLAPLP-LAGA 392
Cdd:cd17388 330 GELQGVLTSLTSLTSIIGPLLFTGIFAASPATWPGLAwIIGA 371
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 32-377 1.40e-39

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 145.03  E-value: 1.40e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVAPLAvrDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17330   8 DALGFGIVFPVLPFYVREFNKLG--ASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAvhgttlplllaaglcllna 191
Cdd:cd17330  86 NLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLS------------------- 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  192 llaglfleeTLPPTRRRRLDPRRMNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLA 271
Cdd:cd17330 147 ---------TPYGYALPFLVAAALALLNLVLVLFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLA 217

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  272 LYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDR 350
Cdd:cd17330 218 LVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGtGIVFPALSALLSKSVPSKE 297

                       330       340
                ....*....|....*....|....*..
gi 9947051  351 QGELQGVLSSLMSLAAIVGPPLMSGLF 377
Cdd:cd17330 298 QGKAQGIIQSLQSLARIIGPLLAGPLY 324
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 32-385 1.38e-28

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 115.37  E-value: 1.38e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVAplavrDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17325   8 DMLGYGIIIPILPLYAESLG-----ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASVAT-AMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLA-VHGTTLPLLLAAGLCLL 189
Cdd:cd17325  83 SYWQLLLARFLQGLASAAVWPaAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLAdALGYRAPFLVCAALALL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  190 NALLAGLFLEETLPPTRRRRLDPRRMNalRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYS 269
Cdd:cd17325 163 ALVLALLLLPEPRPPPNKRAVSAARLR--SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLL 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  270 LALYGVLAVLAQTLGVNLCkRRLDDARLLRLGLALQGCGLLLFALVdSSFWLVCALLPF--ALGSLATPAMQGLLSARVP 347
Cdd:cd17325 241 FGAQGLASALSQPPAGKLS-DRIGRKPLILIGLLLSAVALLLLPLA-TSFWLLLLLLALlgLGLGLVFPATLALLADIVP 318

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 9947051  348 VDRQGELQGVLSSLMSLAAIVGPPLMSGLFHWGSGPLA 385
Cdd:cd17325 319 PEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
32-366 3.74e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 99.66  E-value: 3.74e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVAPlavrdAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:COG2814  22 SGLGIGIVLPALPLIAADLGA-----SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASV-ATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVH-GTTLPLLLAAGLCLL 189
Cdd:COG2814  97 SLWLLLAARFLQGLGAGALfPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  190 NALLAGLFLEETLPPTRRrrldprrmNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYS 269
Cdd:COG2814 177 ALLLLLRLLPESRPAARA--------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLL 248

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  270 LALYGVLAVLAQTLGVNLcKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPV 348
Cdd:COG2814 249 LALFGLGGVLGALLAGRL-ADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALVAELAPP 327

                       330
                ....*....|....*...
gi 9947051  349 DRQGELQGVLSSLMSLAA 366
Cdd:COG2814 328 EARGRASGLYNSAFFLGG 345
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 38-378 4.83e-23

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 99.60  E-value: 4.83e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   38 LIVPLLPTLIGSvapLAVrDAATWGAaLVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLF 117
Cdd:cd17331  18 LQQPVLPYLTKK---LGV-DSVVFGY-LQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLF 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  118 LGR----ALAGLTGASvatamACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALL 193
Cdd:cd17331  93 LSRlpsvFMHAMQAAQ-----MVVTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIV 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  194 AGLFLEETLPPTRRRRLDPRRMNA-----LRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGY 268
Cdd:cd17331 168 LVILLIPSNTKSKREKEAKESASPpsvfnLKEILRLLRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGY 247

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  269 SLALYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVP 347
Cdd:cd17331 248 LMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGgSVLYTVITSLLTKAVP 327

                       330       340       350
                ....*....|....*....|....*....|.
gi 9947051  348 VDRQGELQGVLSSLMSLAAIVGPPLMSGLFH 378
Cdd:cd17331 328 PEDTGTALGLSHALFSLVRTVSPTIGGALLQ 358
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 32-376 1.83e-21

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 94.60  E-value: 1.83e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   32 DAAGVGLIVPLLPTLIGSVAPlavrdAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17390   8 DLFGVSMILPLLSTHIRSLGA-----SPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFST 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  112 SLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNA 191
Cdd:cd17390  83 SLALLFLSRIPLGIFKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDGGFYYVALLCSAIFIL 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  192 llaglfleeTLPPTRRRRLDPRRMNALRSISGLarqpgvgrllavlalvflglqAVMVVWPFFVI---EKFHWSSAWIGY 268
Cdd:cd17390 163 ---------NAGLVWFLLSKLWDLLLVRFLMGF---------------------SVLLFRSNFSLyleERFDLSPKTIGY 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  269 SLALYGVLAVLAQTLGVNLCKR-RLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGS-LATPAMQGLLSARV 346
Cdd:cd17390 213 LISYSGVLGALSGFLVGRILKLyKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSaVLRTCSTSLLLSRG 292

                       330       340       350
                ....*....|....*....|....*....|
gi 9947051  347 PVDRQGELQGVLSSLMSLAAIVGpPLMSGL 376
Cdd:cd17390 293 KSKERGTLLGVGQSVTSLARILA-PLLSGL 321
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 69-394 2.10e-18

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 86.17  E-value: 2.10e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   69 FALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTR 148
Cdd:cd17389  73 FSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSK 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  149 HFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGL-------FLEETLPPtrrrrldprrmnALRSI 221
Cdd:cd17389 153 GMALIGVAFSLGFIIGPMIGAYFASFTRSLGEVFFSMPALFALVLALAdllfiffFLPETLPS------------NLRRL 220

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  222 sglarqpgvGRLLAVLALVFLGLQAVMvvwPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTlGVNLCKRRLDDARLLRLG 301
Cdd:cd17389 221 ---------GLVYFLYLFLFSGLEFTL---TFLTHQRFQYTSMQQGKMFFFIGIIMALVQG-GYVRRIKPGKEKKAVLQG 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  302 LALQGCGLLLFALVDSSFWLVCALLPFALGS-LATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPLMSGLFhWG 380
Cdd:cd17389 288 LILLIPAFLLIGWASSVTVLYAGLFLYSFAAaTVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVY-WL 366

                       330
                ....*....|....
gi 9947051  381 SGPLAPLPLAGAPF 394
Cdd:cd17389 367 AGSEACYTIGALLF 380
MFS_1 pfam07690
Major Facilitator Superfamily;
65-370 6.42e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 84.39  E-value: 6.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051     65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA-MACAADLGTH 143
Cdd:pfam07690  37 LLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAaLALIADWFPP 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    144 GQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDPRRMNALRSISG 223
Cdd:pfam07690 117 EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    224 LARQPGVgrLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCKRRLDDARLLRLGLA 303
Cdd:pfam07690 197 LLRDPVL--WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLL 274

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    304 LQGC--GLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGP 370
Cdd:pfam07690 275 LILAalGLLLLSLTLSSLWLLLALLLLGFGfGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 35-381 3.02e-17

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 82.62  E-value: 3.02e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   35 GVGLIVPLLPTLIGSVAplavrdAATWGAALVMT-FALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSL 113
Cdd:cd17474  14 GVSIVDPILPAIAEALG------ASPAQVGLLITaFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSF 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  114 WMLFLGRALAGLTGAS-VATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNAL 192
Cdd:cd17474  88 ALLLAGRALQGIGAAGlGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAISWRYPFFLLAALIPVAFL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  193 LAGLFLEETLPPTRRRRLdprrmNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLAL 272
Cdd:cd17474 168 AILFLLPEPKEKAKSSSA-----TKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAG 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  273 YGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGS-LATPAMQGLLSARVPVDRQ 351
Cdd:cd17474 243 WSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEER 322

                       330       340       350
                ....*....|....*....|....*....|
gi 9947051  352 GELQGVLSSLMSLAAIVGPPLMSGLFHWGS 381
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
2_A_01_02 TIGR00880
Multidrug resistance protein;
65-172 1.80e-16

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 75.76  E-value: 1.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051     65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA-MACAADLGTH 143
Cdd:TIGR00880   3 LLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAgAALIADIYPP 82

                          90       100
                  ....*....|....*....|....*....
gi 9947051    144 GQRTRHFGWLYAGLALGMILGPALGGLLA 172
Cdd:TIGR00880  83 EERGVALGLMSAGIALGPLLGPPLGGVLA 111
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 58-392 2.03e-16

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 80.35  E-value: 2.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   58 AATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATAM-AC 136
Cdd:cd17329  33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASeAM 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  137 AADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLEETlpptRRRRLDPRRMN 216
Cdd:cd17329 113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLPET----RPKRRAAEKTE 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  217 ALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLgVNLCKRRLDDAR 296
Cdd:cd17329 189 ILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFP-VARLVERFRLRK 267

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  297 LLRLGLALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGpPLMSG 375
Cdd:cd17329 268 ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGeMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIG-PLVGG 346

                       330
                ....*....|....*..
gi 9947051  376 LFHWGSGPLAPLPLAGA 392
Cdd:cd17329 347 LLLDLLGPGLPWLILAA 363
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 65-377 3.60e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 73.61  E-value: 3.60e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA-MACAADLGTH 143
Cdd:cd06174  36 LFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAvLALIADLFPE 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  144 GQRTRHFGWLYAGLALGMILGPALGGLLAVHGTT---LPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDPRRMNALRS 220
Cdd:cd06174 116 RERGRALGLLQAFGSVGGILGPLLGGILASSLGFgwrAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKL 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  221 ISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCKRRLDDARLLRL 300
Cdd:cd06174 196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI 275

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9947051  301 GLALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPLMSGLF 377
Cdd:cd06174 276 GLLLMALGLALLLLAPSLLLLLLLLLLLGFGlGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL 353
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 57-377 2.86e-13

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 70.77  E-value: 2.86e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   57 DAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLL------ALADSLWMLFLGRALAGLTGASV 130
Cdd:cd17386  27 YAANFYLYMNLMGSIPPLFSSLFLGSWSDRYGRKPPLLMSLVGLLLSSLILvlivyfTTVPSVWWFYLSAIPLALFGGFT 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  131 ATAMACAA---DLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNAllaglfleeTLPPTRR 207
Cdd:cd17386 107 AFLSASFAyisDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLFKALGYAWSFSISAALLLIA---------LLYILFF 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  208 RRLDPRRMNALrsisGLARQPGVGrllavlalvflglqaVMVVWPFFVIEKFHWSSAWIGYSLALyGVLAVLAQTLGVNL 287
Cdd:cd17386 178 LTLLILLLLAA----FLTIFVLSG---------------ESDVLYLFVLEKFAWNVKDFSYFSTL-GSLIYLTGMLGGVL 237

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  288 ---CKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGSLATPAMQGLLSARVPVDRQGELQGVLSSLMSL 364
Cdd:cd17386 238 llrCLLKMSDSTLAMLGLASHILSSLLFAFATNTWMMYLAAVVGMFNGIVGPMIRSILSKLVPKSEQGKIFSLLSVLESL 317

                       330
                ....*....|...
gi 9947051  365 AAIVGPPLMSGLF 377
Cdd:cd17386 318 SPLVASPIYNNIY 330
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 38-394 4.44e-13

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 70.27  E-value: 4.44e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   38 LIVPLLPTLIGSvapLAVRDAATwgAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLF 117
Cdd:cd17324  17 VIQGLLPDIARD---FGVSVAQA--GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  118 LGRALAGLTGASV-ATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGL 196
Cdd:cd17324  92 LARALAGLAHGGFwAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLW 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  197 FLEETLPPTRRRRLdprrmNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVL 276
Cdd:cd17324 172 RLLPSLPPKKPGSL-----GLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  277 AVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGSLATPAMQGLLSARVPVDRqGELQG 356
Cdd:cd17324 247 GVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASS 325

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 9947051  357 VLSSLMSLAAIVGPPLMSGLFHWGSGPLAPLPLAGAPF 394
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLL 363
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 38-392 8.89e-13

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 69.14  E-value: 8.89e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   38 LIVPLLPTLIGSVAPlavrdAATWGAALVMTF-ALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWML 116
Cdd:cd17473  17 AIAPALPAIAQHFVP-----NSELLVPLLLTLpALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  117 FLGRALAGLTGASVAT-AMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAG 195
Cdd:cd17473  92 LASRALLGIGVAGIMTlATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLVYLLALPVLILVLL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  196 LFLEETlpptrrrRLDPRRMNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGV 275
Cdd:cd17473 172 FLPEPA-------RKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASL 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  276 LAVLAQTLGVNLcKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDRQGEL 354
Cdd:cd17473 245 AGAIGALLFGRL-KRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGfGLLLPTLNSWAMSLVPPELRGRA 323

                       330       340       350
                ....*....|....*....|....*....|....*...
gi 9947051  355 QGVLSSLMSLAAIVGPPLMSGLFHWGSGPLAPLPLAGA 392
Cdd:cd17473 324 MGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGV 361
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 76-392 5.63e-11

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 63.73  E-value: 5.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   76 FSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGAS-VATAMACAADLGTHGQRTRHFGWLY 154
Cdd:cd17321  47 LLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAiMPASLALIAATFPGERRGRALGLWG 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  155 AGLALGMILGPALGGLLAVHgttlplllaaglcllnallaglfleetlpptrRRRLDPRRMNALRSISGLARQPGVGRLL 234
Cdd:cd17321 127 AVVGIGAALGPLLGGLLLEL--------------------------------FGWRWIFLINVPIGLVALLLARTFSGAV 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  235 AVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCkRRLDDARLLRLGLALQGCGLLLFAL 314
Cdd:cd17321 175 LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLA-DRFGPRLVLVAGLLLTAVGLLLLAL 253

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  315 VDSSFWLVCALLPFALGS----LATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPLMSGLFHWGSGPLAPLPLA 390
Cdd:cd17321 254 LGADSSVWLLLPGLVLLGlglgLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLGDSGV 333


                ..
gi 9947051  391 GA 392
Cdd:cd17321 334 AA 335
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 59-385 7.41e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 63.40  E-value: 7.41e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   59 ATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLG-----FALSYLLLALADSLWMLFLGRALAGLTGASVATA 133
Cdd:cd06173  33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLrallaAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  134 -MACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDP 212
Cdd:cd06173 113 rQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSL 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  213 RRMNALRSISGLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCKRRL 292
Cdd:cd06173 193 LLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  293 DDARLLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGSLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPL 372
Cdd:cd06173 273 RGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALL 352

                       330
                ....*....|...
gi 9947051  373 MSGLFHWGSGPLA 385
Cdd:cd06173 353 AGLLADALGLSAV 365
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 33-172 1.95e-10

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 61.90  E-value: 1.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   33 AAGVGLIVPLLPTLIGSVAPLAVRDAATW-GAALVMTFaLLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17391   9 GIGFSLIAPFLPLYIEQLGVTSGGLVELWsGLAFSSTF-LVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVT 87

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9947051  112 SLWMLFLGRALAGLTGASVATAMACAAdlgTHGQRtRHFGW----LYAGLALGMILGPALGGLLA 172
Cdd:cd17391  88 NVWQLLILRLLQGVFSGYVPNATALIA---SQTPK-EKSGWalgtLSTGVVAGTLIGPLLGGFLA 148
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 64-381 2.52e-10

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 61.46  E-value: 2.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   64 ALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA-MACAADLGT 142
Cdd:cd17489  35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAaATLVADIIP 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  143 HGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRldprrmNALRSIS 222
Cdd:cd17489 115 PSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEA------EAGTRAF 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  223 GLARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSsawIGYSLALYGVLAVLAQTLGVNLCKRRlDDARLLRLGL 302
Cdd:cd17489 189 RRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGISN---AGLFFTVYAIALLLSRPFSGKLSDRK-GPKTVIIPGL 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  303 ALQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPLMSGLFHWGS 381
Cdd:cd17489 265 LLLALGLLLLSFAGSPWMLLLAAVLYGLGfGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 69-175 3.93e-10

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 61.08  E-value: 3.93e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   69 FALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGlTGASVATAMACAADLGTHGQRTR 148
Cdd:cd17472  41 YGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLADLTREENRTK 119

                        90       100       110
                ....*....|....*....|....*....|.
gi 9947051  149 HFGWLYAGL----ALGMILGPALGGLLAVHG 175
Cdd:cd17472 120 AMALIGASIgiafAISMVLGPLLAAHLGVSG 150
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 60-172 1.12e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 59.94  E-value: 1.12e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   60 TWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVAT-AMACAA 138
Cdd:cd17328  34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPiAPTIIA 113

                        90       100       110
                ....*....|....*....|....*....|....
gi 9947051  139 DLGTHGQRTRHFGWLYAGLALGMILGPALGGLLA 172
Cdd:cd17328 114 DLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVA 147
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 69-392 1.46e-09

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 59.51  E-value: 1.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   69 FALLQLFFspvlGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGAS-VATAMACAADLGTHGQRT 147
Cdd:cd17320  47 FALGQLLY----GPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAgSVVARAIVRDLYSGAELA 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  148 RHFGWLYAGLALGMILGPALGGLLAVH-GTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDPRRmnaLRSISGLAR 226
Cdd:cd17320 123 KIFSLLMMILAIAPALAPLLGGLLLLFfGWRAIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSL---LRAYKRVLK 199

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  227 QPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQG 306
Cdd:cd17320 200 NRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLA 279

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  307 CGLLL----FALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDR------QGELQGVLSSLMSLAAIVGPPLMSG 375
Cdd:cd17320 280 AALVLllaaLLGGLSLWPLVAPLFLIFFGfGLIFPNATSLALEPFPHVAgtasalLGFLQFLIGALAGALVGLLPNGTAL 359

                       330
                ....*....|....*..
gi 9947051  376 LFHWGSGPLAPLPLAGA 392
Cdd:cd17320 360 PMGLLILVLGLLALLLL 376
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 65-280 2.57e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.82  E-value: 2.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGL-TGASVATAMACAADLGTH 143
Cdd:COG0477  54 IVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPA 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  144 GQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDPRRMNALRSISG 223
Cdd:COG0477 134 RERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALAL 213

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 9947051  224 LARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLA 280
Cdd:COG0477 214 ALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLL 270
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 76-174 2.92e-08

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 55.26  E-value: 2.92e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   76 FSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVAT-AMACAADLGTHGQRTRHFGWLY 154
Cdd:cd17502  46 FQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSlAFIIIADLVPPRERGKYQGYIG 125

                        90       100
                ....*....|....*....|
gi 9947051  155 AGLALGMILGPALGGLLAVH 174
Cdd:cd17502 126 AVFGIASVAGPLIGGAFTDH 145
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 37-176 5.07e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 54.50  E-value: 5.07e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   37 GLIVPLLPTLIGSVAPLAVRD------AATWGAALVM-TFALLQLFFSPvlgsLSDRFGRRPVLVLAMLGFALSYLLLAL 109
Cdd:cd17323   8 TFVVTFGSSIYSPALPQIAEDfhvseeVANLGVSLFVlGFGLGPLIWAP----LSELYGRRPVYLVSLFIFVIFQIGCAL 83

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9947051  110 ADSLWMLFLGRALAGLTGASV-ATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGT 176
Cdd:cd17323  84 APNIAMLIILRFLQGFFGSSPlAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG 151
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 58-171 5.44e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 54.47  E-value: 5.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   58 AATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATAM-AC 136
Cdd:cd17370 232 SAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIErAA 311

                        90       100       110
                ....*....|....*....|....*....|....*
gi 9947051  137 AADLGTHGQRTRHFGWLYAGLALGMILGPALGGLL 171
Cdd:cd17370 312 VADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYL 346
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
34-174 1.36e-07

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 53.39  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    34 AGVGLIVPLLPTLIGSVAPLAVRDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSL 113
Cdd:PRK09874  28 AAFSLVMPFLPLYVEQLGVTGHSALNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNI 107

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 9947051   114 WMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:PRK09874 108 WQFLILRALLGLLGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADS 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
63-174 1.64e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.95  E-value: 1.64e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   63 AALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGL-TGASVATAMACAADLG 141
Cdd:COG2271  48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWF 127

                        90       100       110
                ....*....|....*....|....*....|...
gi 9947051  142 THGQRTRHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:COG2271 128 PPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 69-172 2.16e-07

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 52.60  E-value: 2.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   69 FALLQLFFSPVLGSLSDRFG--RRPVLV---LAMLG-FALSYLLLALADSLWMLFLGRALAGLTGASVATAMACAADLGT 142
Cdd:cd17326  45 YSLGQLVFSPVFGYWSNKTSsvKEPLIVsilIAIVGnILYALAEYFPSNRKYVMLVARFLIGVGAGNVAVLRAYVAAAST 124

                        90       100       110
                ....*....|....*....|....*....|
gi 9947051  143 HGQRTRHFGWLYAGLALGMILGPALGGLLA 172
Cdd:cd17326 125 LKDRTRAMAVISAAQALGFIVGPALQAAFT 154
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
65-377 8.44e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.65  E-value: 8.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLT-GASVATAMACAADLGTH 143
Cdd:COG2223  45 LFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGgGGSFAVGIALVSKWFPP 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  144 GQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFleetLPPTRRRRLDPRRMNALRSISG 223
Cdd:COG2223 125 DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWL----FLRDPPAGAAAAAKASLRDQLE 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  224 LARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCKrRLDDARLLRLGLA 303
Cdd:COG2223 201 ALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD-RIGGRRVLLIVFA 279

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9947051  304 LQGCGLLLFALVDSSFWL--VCALLPFALGSLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPLMSGLF 377
Cdd:COG2223 280 LMALGLLLLALALGSLWLflVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALL 355
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
55-171 9.91e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 9.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   55 VRDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAML--GFALSYLLLALADSLWMLFLGRALAGLTGASVAT 132
Cdd:COG2211 259 LGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLlaALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILV 338

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 9947051  133 AM------ACAADLGTHGQRTR--HFGWLYAGLALGMILGPALGGLL 171
Cdd:COG2211 339 LPwamladVVDYDEWKTGRRREglYFGIFTFAIKLGQALAGALAGLL 385
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
65-387 1.89e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.85  E-value: 1.89e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATAM-ACAADLGTH 143
Cdd:COG0738  48 LLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAAnPYVAALGPE 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  144 gQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLeETLPPTRRRRLDPRRMNALRSISG 223
Cdd:COG0738 128 -TAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLF-LRSKLPEIEEEEEEAAGSAASLKS 205

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  224 LARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLcKRRLDDARLLRLGLA 303
Cdd:COG0738 206 LLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFL-LKRFGPVRLLRLSAL 284

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  304 LQGCGLLLFALVDSSFWLVCALLPFALG-SLATPAMQGLLSARVPVDRQGELqGVLSSLMSLAAIVGPPLMSGLFHWGSG 382
Cdd:COG0738 285 LAAVGLLLALLAPGPWLALIGLALVGLGlSLMFPTIFSLALDGLGKRTAAAV-SAVLIMGIVGGAIGPPLIGFLADAFGL 363


                ....*
gi 9947051  383 PLAPL 387
Cdd:COG0738 364 RAAFL 368
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 45-174 2.07e-06

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 49.51  E-value: 2.07e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   45 TLIGSVAPLAVRDAATWGAAL--VMTFALLQLFF-SPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRA 121
Cdd:cd17365  16 AVMGFVAPALAQDWGLSPAQLgpVGSAALFGMAIgALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRF 95

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 9947051  122 LAGL-TGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:cd17365  96 LTGLgLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPA 149
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 71-377 2.23e-06

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 49.34  E-value: 2.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   71 LLQLFFSPVLGSLSDRFGRRPVLVLAMlgFALSYLLLALADSLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHF 150
Cdd:cd17387  47 ILSFLSAPLIGALSDVWGRKSFLLLTV--FFTCAPIPLMRISPWWYFAMISVSGIFSVTFSVIFAYVADITTEEERSTAY 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  151 GWLYAGLALGMILGPALGGLL-AVHGTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDPRRmNALRSISGLARQPG 229
Cdd:cd17387 125 GLVSATFAASLVTSPALGAYLsESYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWGAP-ISWEQADPFASLRK 203

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  230 VGRLLAVlalvflgLQAVMVVWPFFVIEKFHWSSAW------IGYS-------LALYGVLAVLAQTLGVNLCKRRLDDAR 296
Cdd:cd17387 204 VGKDKTV-------LLICITVFLSYLPEAGQYSSFFvylkqvMGFEyeevaafIAVVGILSITAQTLLLSILMRSIGAKN 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  297 LLRLGLALQGCGLLLFALVDSSFWLVCALLPFALGSLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPLMSGL 376
Cdd:cd17387 277 TILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMSSITFPAISALVSRYADPDQQGAVQGMITGIRGLCNGLGPALFGFV 356


                .
gi 9947051  377 F 377
Cdd:cd17387 357 F 357
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 66-171 2.69e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 49.28  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051     66 VMTFALLQLFF-SPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGL-TGASVATAMACAADLGTH 143
Cdd:TIGR00895  57 LFSAGLIGMAFgALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPK 136

                          90       100
                  ....*....|....*....|....*...
gi 9947051    144 GQRTRHFGWLYAGLALGMILGPALGGLL 171
Cdd:TIGR00895 137 RFRGTAVGLMFCGYPIGAAVGGFLAGWL 164
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 78-171 1.41e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 46.80  E-value: 1.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   78 PVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVA-TAMACAADLGTHGQRTRHFGWLYAG 156
Cdd:cd17503  49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIpLAQTILLRIYPPEKRGAAMGLVGLV 128

                        90
                ....*....|....*
gi 9947051  157 LALGMILGPALGGLL 171
Cdd:cd17503 129 ILLAPAIGPTLGGWL 143
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 70-171 2.96e-05

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 46.03  E-value: 2.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   70 ALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA-MACAADLGT-HGQRT 147
Cdd:cd17384  41 ALVQLITNPIVGPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGSACSSVAgMGMLASLYPdDKERG 120

                        90       100
                ....*....|....*....|....
gi 9947051  148 RHFGWLYAGLALGMILGPALGGLL 171
Cdd:cd17384 121 KAMGIALGGLALGVLVGPPFGGVM 144
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 42-171 3.16e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 45.76  E-value: 3.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   42 LLPTLIGSVAPLAVRDAAtWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRA 121
Cdd:cd17371  17 LLGLVLPALIAEFGLDEA-EAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRA 95

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 9947051  122 LAGL-TGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLL 171
Cdd:cd17371  96 LAGLgFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALL 146
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 71-169 5.80e-05

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 45.18  E-value: 5.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   71 LLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWM----LFLGRALAGLTG---ASVATAMACAADLGTH 143
Cdd:cd17449  76 LVGLFSVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLhvayFLIGRILSGLLGdfnGILAGCFAYVADVSDR 155

                        90       100
                ....*....|....*....|....*.
gi 9947051  144 GQRTRHFGWLYAGLALGMILGPALGG 169
Cdd:cd17449 156 RSRTFRVAVLEACLGLAGMLASIIGG 181
emrD PRK11652
multidrug transporter EmrD;
63-172 1.07e-04

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 44.13  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    63 AALVMTFALLQLFFSPvlgsLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLtGASVATAMA--CAADL 140
Cdd:PRK11652  50 AAYLLTYGLSQLFYGP----LSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGL-GTGVGGVMArtLPRDL 124

                         90       100       110
                 ....*....|....*....|....*....|...
gi 9947051   141 GThGQRTRHF-GWLYAGLALGMILGPALGGLLA 172
Cdd:PRK11652 125 YE-GTQLRHAnSLLNMGILVSPLLAPLIGGLLT 156
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 38-174 1.40e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 43.72  E-value: 1.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   38 LIVPLLPTLIGSVAplavrDAATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLF 117
Cdd:cd17504  14 MLSPALPTIQREFG-----TSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLI 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 9947051  118 LGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:cd17504  89 AGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQH 145
MFS_1 pfam07690
Major Facilitator Superfamily;
243-381 3.26e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 42.41  E-value: 3.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    243 GLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALVDSSFWLV 322
Cdd:pfam07690  11 GRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV 90

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 9947051    323 CALLPFALGSLATPAMQGLLSARVPVDRQGELQGVLSSLMSLAAIVGPPLMSGLFHWGS 381
Cdd:pfam07690  91 LRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG 149
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
63-172 3.67e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 3.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   63 AALVMTFALLQLFFSPVLGSLSDRFGRR--PVLVLAMLGFALSYLLLALADSLWMLFLGRALAGL-TGASVATAMACAAD 139
Cdd:COG2271 219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFgLGGAFGLLWALAAE 298

                        90       100       110
                ....*....|....*....|....*....|...
gi 9947051  140 LGTHGQRTRHFGWLYAGLALGMILGPALGGLLA 172
Cdd:COG2271 299 LFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 69-174 4.70e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 41.99  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051     69 FALLQLFFSPvlgsLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTG-ASVATAMACAADLGTHGQRT 147
Cdd:TIGR00710  53 FAAGQLLWGP----LSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGAsAGSVISQALVRDIYPGEELS 128

                          90       100
                  ....*....|....*....|....*..
gi 9947051    148 RHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:TIGR00710 129 RIYSILMPVLALAPAVAPLLGGYILVW 155
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 33-175 6.10e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.78  E-value: 6.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   33 AAGVGLIVPLLPTLigsvapLAVRDAATWGAALVMT-FALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALAD 111
Cdd:cd17477   9 GLGSGLLLPLLSLR------LEREGVSTALIGLVASaYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 9947051  112 SLWMLFLGRALAGLTGASVATAMACA-ADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHG 175
Cdd:cd17477  83 SPWVWFLLRFVMGIGLAGLFVVSESWlNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAG 147
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 65-172 7.56e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.36  E-value: 7.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   65 LVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLG--------FALSYLLLALADSLWMLFLGRALAGLTGASVATAMAc 136
Cdd:cd17369 269 AVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLaalfafpfFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLA- 347

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 9947051  137 aadlGTHGQRTRhfgwlYAGLALGMILGPALGGLLA 172
Cdd:cd17369 348 ----ELFPTRVR-----YTGASLGYQLGAILGGGFA 374
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 38-172 9.58e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 41.46  E-value: 9.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   38 LIVPLLPTLIGS-VAPLAVRDAATWgaaLVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWML 116
Cdd:cd06179  12 FGVTLPAAVLPFiVADLGPSSNSTW---ISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNML 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 9947051  117 FLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLA 172
Cdd:cd06179  89 IGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALV 144
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 61-133 1.33e-03

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 40.64  E-value: 1.33e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 9947051   61 WGAALVMTFALL-QLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA 133
Cdd:cd17317  25 WLVALVQTIFFLgVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTV 98
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 39-171 1.40e-03

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 40.76  E-value: 1.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   39 IVPLLPTLIGSVAPLAVrdaatwgaaLVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFL 118
Cdd:cd17383  18 IVPIIPDYLNEDIAIGV---------LFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFF 88

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 9947051  119 GRALAGLTGASVATA-MACAADLGT-HGQRTRHFGWLYAGLALGMILGPALGGLL 171
Cdd:cd17383  89 ARSLQGVGSAFADTAgLAMIADRFTeEAERSKALGIALAFISFGCLVAPPFGGIL 143
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
59-163 1.47e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 1.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   59 ATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLT-GASVATAMACA 137
Cdd:COG2814 242 ASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGfGLLFPLLQALV 321

                        90       100
                ....*....|....*....|....*.
gi 9947051  138 ADLGTHGQRTRHFGWLYAGLALGMIL 163
Cdd:COG2814 322 AELAPPEARGRASGLYNSAFFLGGPL 347
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 65-387 1.49e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 40.38  E-value: 1.49e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   65 LVMTFALLQLFFSPVLgslSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGL-TGASVATAMACAADLGTH 143
Cdd:cd17333  39 SQNAGYLIGSLLAGFL---MKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLgAGILDTGANTFVGALFEE 115

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  144 GQRTRhFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGLCLLNALLAGLFLEETLPPTRRRRLDPRRMNALRSISG 223
Cdd:cd17333 116 SSATR-LNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASR 194

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  224 LARQPGVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWIGYSLALYGVLAVLAQTLGvNLCKRRLDDARLLRLGLA 303
Cdd:cd17333 195 LLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG-GPISRRIKPHTLLVLSGS 273

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  304 LQGCGLLLFALVDSSFWLV--CALLPFALGSLaTPAMQGLLSARVPVdRQGELQGVLSSLMSLAAIVGPPLMSGLFHWGS 381
Cdd:cd17333 274 GALLGLLILLLAPTLVVGLvaTALLGLFMAAL-FPTILSLGISNLPY-AKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVG 351


                ....*.
gi 9947051  382 GPLAPL 387
Cdd:cd17333 352 IQTAML 357
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
43-176 2.24e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.86  E-value: 2.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   43 LPTLIGSVAPLAVRDAATwgaaLVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLL-LALADSLWMLFLGRA 121
Cdd:COG2223 228 LPPYLVDQFGLSAATAGL----LAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLlALALGSLWLFLVLFL 303

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 9947051  122 LAGL-TGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGP-ALGGLLAVHGT 176
Cdd:COG2223 304 LLGLaLGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPlLFGALLDATGS 360
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
33-392 2.27e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.86  E-value: 2.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   33 AAGVGLIVPLLPTLIGSVAPL--AVRDA----ATWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLL 106
Cdd:COG2807  20 LLAIVLVALNLRPAITSVGPLlpEIRADlglsATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLL 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  107 LALADSLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHGTTLPLLLAAGL 186
Cdd:COG2807 100 RSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWAL 179

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  187 CLLNALLAglfleeTLPPTRRRRLDPRRMNALRSISGLARQPgVGRLLAVLALVFLGLQAVMVVWPFFVIEKFHWSSAWI 266
Cdd:COG2807 180 LALLALLL------WLPLLRRRPAAAAAAPAAASLRSLWRSP-LAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATA 252

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051  267 GYSLALYGVLAVLAQTLGVNLCKRRLDDARLLRLGLALQGCGLLLFALV-DSSFWLVCALLPFALGSLATPAMqGLLSAR 345
Cdd:COG2807 253 GLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLApGSLPWLWAVLLGLGQGGLFPLAL-TLIGLR 331

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 9947051  346 VPVDRQ-GELQGVLSSLMSLAAIVGPPLMSGLFHWGSGPLAPLPLAGA 392
Cdd:COG2807 332 ARTPAEaAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAA 379
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 33-175 2.50e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.89  E-value: 2.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   33 AAGVGLIVPLLPTLIGSVAPLAVrdaaTWGAALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLG---FALSYLLLAL 109
Cdd:cd17316 190 SFGYYGLTTFLPTYLQTVLGLSP----ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILsgiLALPLFYLLS 265

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9947051  110 ADSLWMLFLGRALAGLTGASVATAMACAADLGTHGQRTRHFGWLYAGLALGMILGPALGGLLAVHG 175
Cdd:cd17316 266 GSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
63-131 2.55e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 39.90  E-value: 2.55e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9947051    63 AALVMTFALLQLFFSPvlgsLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVA 131
Cdd:PRK11102  33 SAYILGFAIGQLFYGP----MADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAAS 97
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 81-175 5.36e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 38.79  E-value: 5.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051    81 GSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGL-TGASVATAMACAADLGTHGQRTRHFGWLYAGLAL 159
Cdd:PRK11551  71 GRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVgLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPF 150

                         90
                 ....*....|....*.
gi 9947051   160 GMILGPALGGLLAVHG 175
Cdd:PRK11551 151 GGALASVIGVLAAGDA 166
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 77-133 5.52e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 38.84  E-value: 5.52e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 9947051     77 SPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATA 133
Cdd:TIGR00898 144 SFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQ 200
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 68-174 6.58e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.36  E-value: 6.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   68 TFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLAL-ADSLWMLFLGRALAGLTGASVATAMACAADLGTHGQR 146
Cdd:cd17490  39 AYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIMIlFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEA 118

                        90       100
                ....*....|....*....|....*...
gi 9947051  147 TRHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:cd17490 119 AKAMGLINLVNNLGQLIAFLIGGLIAEH 146
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 63-174 6.75e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.31  E-value: 6.75e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   63 AALVMTFALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATAMACAADLGT 142
Cdd:cd17478  34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113

                        90       100       110
                ....*....|....*....|....*....|..
gi 9947051  143 HGQRTRHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:cd17478 114 GGRRGLAMSIFSVGGNLGFALGPLIAAALVAL 145
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 69-175 8.92e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 37.91  E-value: 8.92e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   69 FALLQLFFSPVLGSLSDR-FGRRPVLVLAMLGFALSYLLLALADSLWMLFL-GRALAGLTGASVATAMACA---ADLGTH 143
Cdd:cd17471  41 SALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVLLLvGVVLLSLGAAAFPQLFALAreyADRSSG 120

                        90       100       110
                ....*....|....*....|....*....|..
gi 9947051  144 GQRTRHFGWLYAGLALGMILGPALGGLLAVHG 175
Cdd:cd17471 121 RDATLFNSVLRAAFSLAWVIGPPLAFLLLDVL 152
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 69-174 9.47e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 37.94  E-value: 9.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9947051   69 FALLQLFFSPVLGSLSDRFGRRPVLVLAMLGFALSYLLLALADSLWMLFLGRALAGLTGASVATAMACA-ADLGTHGQRT 147
Cdd:cd17319  47 FFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAlAEWFPARERG 126

                        90       100
                ....*....|....*....|....*..
gi 9947051  148 RHFGWLYAGLALGMILGPALGGLLAVH 174
Cdd:cd17319 127 RATGLFNSGAPLGAAIGPPLSGWLLLL 153
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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