NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|902763202|ref|NP_001298024|]
View 

leucine-rich repeat-containing protein 49 isoform 4 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 111-306 5.64e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 143.39  E-value: 5.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 111 LNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENV 190
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 191 NHLCDLRVLNLARN-------LLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAES 262
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 902763202 263 -TSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERR 306
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQ 211
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 111-306 5.64e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 143.39  E-value: 5.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 111 LNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENV 190
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 191 NHLCDLRVLNLARN-------LLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAES 262
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 902763202 263 -TSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERR 306
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-288 7.39e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.79  E-value: 7.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  88 RLTLERQKLTVCPI-IDGEEHLRLLNFQHNFITRIQN-ISNLQRLIFLDLYDNQIEEIS-GLSTLKSLRVLLLGKNRIKK 164
Cdd:COG4886  117 SLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 165 ISN-LENLKNLDVLDLHGNQITKI-ENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQR 242
Cdd:COG4886  197 LPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKT 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 902763202 243 LFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQESWYKHTVLQN 288
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR_9 pfam14580
Leucine-rich repeat;
177-308 2.84e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.78  E-value: 2.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  177 LDLHGNQITKIENVNHLCD-LRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQRLFLSFNNITSF 253
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLDqFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 902763202  254 ESVSCLAESTSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRVA 308
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-251 1.95e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 122 QNISNLQRLIFLDLYDNQIEeiSGLSTLK----SLRVLLLGKNRI-KKISNLENLKNLDVLDLHGNQITKI--ENVNHLC 194
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQ--GRINSRKwdmpSLQMLSLARNKFfGGLPDSFGSKRLENLDLSRNQFSGAvpRKLGSLS 499

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 902763202 195 DLRVLNLARNLLSHV--DNLNGLDSLTELNLRHNQIT--FVRDVDNLPCLQRLFLSFNNIT 251
Cdd:PLN00113 500 ELMQLKLSENKLSGEipDELSSCKKLVSLDLSHNQLSgqIPASFSEMPVLSQLDLSQNQLS 560
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 111-306 5.64e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 143.39  E-value: 5.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 111 LNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIENV 190
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 191 NHLCDLRVLNLARN-------LLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAES 262
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 902763202 263 -TSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERR 306
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQ 211
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-288 7.39e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 110.79  E-value: 7.39e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  88 RLTLERQKLTVCPI-IDGEEHLRLLNFQHNFITRIQN-ISNLQRLIFLDLYDNQIEEIS-GLSTLKSLRVLLLGKNRIKK 164
Cdd:COG4886  117 SLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 165 ISN-LENLKNLDVLDLHGNQITKI-ENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQR 242
Cdd:COG4886  197 LPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKT 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 902763202 243 LFLSFNNITSFESVSCLAESTSLSDITFDGNPIAQESWYKHTVLQN 288
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-275 5.34e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 99.24  E-value: 5.34e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  74 ILQRSSEEKTLYSDRLTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEI-SGLSTLKSL 152
Cdd:COG4886   59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 153 RVLLLGKNRIKKI-SNLENLKNLDVLDLHGNQITKI-ENVNHLCDLRVLNLARNLLSHV-DNLNGLDSLTELNLRHNQIT 229
Cdd:COG4886  139 KELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLT 218

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 902763202 230 FV-RDVDNLPCLQRLFLSFNNITSFESVSCLaesTSLSDITFDGNPI 275
Cdd:COG4886  219 DLpEPLANLTNLETLDLSNNQLTDLPELGNL---TNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-255 6.40e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 6.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 108 LRLLNFQHNFITRI-QNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITK 186
Cdd:COG4886  207 LEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 902763202 187 IeNVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFES 255
Cdd:COG4886  287 L-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
59-296 4.53e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 4.53e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  59 GDHISLVSSSMPAFPILQRSSEEKTLYSDRLTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDN 138
Cdd:COG4886    5 LLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 139 QIEEISGLSTLKSLRVLLLGKNriKKISNLENLKnldVLDLHGNQITKI-ENVNHLCDLRVLNLARNLLSHV-DNLNGLD 216
Cdd:COG4886   85 LLLGLTDLGDLTNLTELDLSGN--EELSNLTNLE---SLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 217 SLTELNLRHNQITFV-RDVDNLPCLQRLFLSFNNITSFESVscLAESTSLSDITFDGNPIAQESwykhTVLQNMMQLRQL 295
Cdd:COG4886  160 NLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTDLP----EPLANLTNLETL 233


                 .
gi 902763202 296 D 296
Cdd:COG4886  234 D 234
LRR_9 pfam14580
Leucine-rich repeat;
177-308 2.84e-10

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 59.78  E-value: 2.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  177 LDLHGNQITKIENVNHLCD-LRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQRLFLSFNNITSF 253
Cdd:pfam14580  24 LDLRGYKIPIIENLGATLDqFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 902763202  254 ESVSCLAESTSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRVA 308
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-288 2.00e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 2.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 107 HLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIK--KISNLENLKNLDVLDLHGNQI 184
Cdd:COG4886  229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 185 TKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQRLFLSFNNITSFESVSCLAESTS 264
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                        170       180
                 ....*....|....*....|....
gi 902763202 265 LSDITFDGNPIAQESWYKHTVLQN 288
Cdd:COG4886  389 LLLLLLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
110-297 1.28e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.64  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 110 LLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLKSLRVLLLGKNRIKKISNLENLKNLDVLDLHGNQITKIEN 189
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 190 VNHLCDLRVLNLARNllshvDNLNGLDSLTELNLRHNQITFV-RDVDNLPCLQRLFLSFNNITSFESVscLAESTSLSDI 268
Cdd:COG4886   92 LGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEP--LGNLTNLKSL 164

                        170       180
                 ....*....|....*....|....*....
gi 902763202 269 TFDGNPIAQESwykhTVLQNMMQLRQLDM 297
Cdd:COG4886  165 DLSNNQLTDLP----EELGNLTNLKELDL 189
LRR_8 pfam13855
Leucine rich repeat;
196-250 6.76e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.76e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 902763202  196 LRVLNLARNLLSHVD--NLNGLDSLTELNLRHNQITFVRDV--DNLPCLQRLFLSFNNI 250
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 150-192 1.02e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 45.70  E-value: 1.02e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 902763202  150 KSLRVLLLGKNRIKKISNLENLKNLDVLDLHGN-QITKIENVNH 192
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 128-170 7.85e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 43.39  E-value: 7.85e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 902763202  128 QRLIFLDLYDNQIEEISGLSTLKSLRVL-LLGKNRIKKISNLEN 170
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDLSDLAN 44
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 115-229 1.03e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 48.63  E-value: 1.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 115 HNFITRIQNISNLQRLiflDLYDNQIEE------ISGLSTLKSLRVLLLGKNRIKK------ISNLENLKNLDVLDLHGN 182
Cdd:COG5238  254 IALAEALKNNTTVETL---YLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYN 330

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 902763202 183 QITK------IENVNHLCDLRVLNLARNLLSH------VDNLNGLDSLTELNLRHNQIT 229
Cdd:COG5238  331 GIGAqgaialAKALQENTTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIG 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-254 1.36e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 48.01  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  88 RLTLERQKLTVCPIIDGEEHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEIS--GLSTLKSLRVLLLGKNRIKKI 165
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlkELELLLGLNSLLLLLLLLNLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 166 SNLENLKNLDVLDLHGNQITKIENVNHLCDLRVLNLARNLLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQRLFL 245
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391


                 ....*....
gi 902763202 246 SFNNITSFE 254
Cdd:COG4886  392 LLLTTTAGV 400
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 172-214 3.39e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.46  E-value: 3.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 902763202  172 KNLDVLDLHGNQITKIENVNHLCDLRVLNLARN-LLSHVDNLNG 214
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 106-187 4.58e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 4.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 106 EHLRLLNFQHNFITRIQNISNLQRLIFLDLYDNQIEEISGLSTLkslrvlllgknrikkisnLENLKNLDVLDLHGNQIT 185
Cdd:cd21340  120 NSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDL------------------LSSWPSLRELDLTGNPVC 181


                 ..
gi 902763202 186 KI 187
Cdd:cd21340  182 KK 183
LRR_8 pfam13855
Leucine rich repeat;
151-206 4.93e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 4.93e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  151 SLRVLLLGKNRIKKI--SNLENLKNLDVLDLHGNQITKIENV--NHLCDLRVLNLARNLL 206
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 168-251 6.48e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 6.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 168 LENLKNLDVLDLHGNQITKI------ENVNHLCDLRVLNLARNLLSHVD-------NLNGLDSLTELNLRHNQIT----- 229
Cdd:cd00116  189 LKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNNLTDAGaaalasaLLSPNISLLTLSLSCNDITddgak 268

                         90       100
                 ....*....|....*....|...
gi 902763202 230 -FVRDVDNLPCLQRLFLSFNNIT 251
Cdd:cd00116  269 dLAEVLAEKESLLELDLRGNKFG 291
LRR_8 pfam13855
Leucine rich repeat;
217-275 5.76e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 5.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 902763202  217 SLTELNLRHNQITFVRDV--DNLPCLQRLFLSFNNITSFESVScLAESTSLSDITFDGNPI 275
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 128-262 6.00e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.85  E-value: 6.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 128 QRLIFLDLYDNQIEEiSGLSTLK-------SLRVLLLGKNRIKK------ISNLENLKNLDVLDLHGNQITkienvnhlc 194
Cdd:COG5238  180 NSVETVYLGCNQIGD-EGIEELAealtqntTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIG--------- 249

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 902763202 195 DLRVLNLARNLLSHvdnlnglDSLTELNLRHNQIT------FVRDVDNLPCLQRLFLSFNNITsFESVSCLAES 262
Cdd:COG5238  250 DEGVIALAEALKNN-------TTVETLYLSGNQIGaegaiaLAKALQGNTTLTSLDLSVNRIG-DEGAIALAEG 315
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 217-257 6.49e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 6.49e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 902763202  217 SLTELNLRHNQITFVRDVDNLPCLQRLFLSFNN-ITSFESVS 257
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDLA 43
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 107-147 1.65e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 902763202  107 HLRLLNFQHNFITRIQNISNLQRLIFLDLYDN-QIEEISGLS 147
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 122-251 1.95e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 122 QNISNLQRLIFLDLYDNQIEeiSGLSTLK----SLRVLLLGKNRI-KKISNLENLKNLDVLDLHGNQITKI--ENVNHLC 194
Cdd:PLN00113 422 SEFTKLPLVYFLDISNNNLQ--GRINSRKwdmpSLQMLSLARNKFfGGLPDSFGSKRLENLDLSRNQFSGAvpRKLGSLS 499

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 902763202 195 DLRVLNLARNLLSHV--DNLNGLDSLTELNLRHNQIT--FVRDVDNLPCLQRLFLSFNNIT 251
Cdd:PLN00113 500 ELMQLKLSENKLSGEipDELSSCKKLVSLDLSHNQLSgqIPASFSEMPVLSQLDLSQNQLS 560
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 196-238 2.84e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 902763202  196 LRVLNLARNLLSHVDNLNGLDSLTELNLRHNqiTFVRDVDNLP 238
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLA 43
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 108-226 3.58e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.60  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202 108 LRLLNFQHN-FITRIQNISNLQRLIFLDLYDNQIEEI--SGLSTLKSLRVLLLGKNRIKKI--SNLENLKNLDVLDLHGN 182
Cdd:PLN00113 454 LQMLSLARNkFFGGLPDSFGSKRLENLDLSRNQFSGAvpRKLGSLSELMQLKLSENKLSGEipDELSSCKKLVSLDLSHN 533

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 902763202 183 QIT-KI-ENVNHLCDLRVLNLARNLLSH--VDNLNGLDSLTELNLRHN 226
Cdd:PLN00113 534 QLSgQIpASFSEMPVLSQLDLSQNQLSGeiPKNLGNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
107-162 4.25e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763202  107 HLRLLNFQHNFITRI--QNISNLQRLIFLDLYDNQIEEISG--LSTLKSLRVLLLGKNRI 162
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH