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Conserved domains on  [gi|75047962|sp|Q8WND5|]
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RecName: Full=Elongator complex protein 1; Short=ELP1; AltName: Full=IkappaB kinase complex-associated protein; Short=IKK complex-associated protein

Protein Classification

elongator complex 1 family protein( domain architecture ID 12057718)

elongator complex 1 family protein is a component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-955 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


:

Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1228.73  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962      1 MRNLKLLQTLEFKDIQAPGKpqcfSLRTEPGTVLIGSEHGLIEVDPVTREVKNEIPLVAEGF-----------LPEDKSG 69
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDP----DLTLLASAFDTTSDSITFVLGPTESEGAIEVQQFMKDGqvsvlasfpapLPVGPDD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962     70 CIVGIQDLLDQESVCIATASGDVILC----NLSTHQLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPIME 145
Cdd:pfam04762   77 KILSFQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPISE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    146 QQIHQDDFGESKFITVGWGKKETQFHGSEGRQAAFQiqTHESALP---------WDDHRPRVTWRGDGQFFAVSVVCPET 216
Cdd:pfam04762  157 TSLDPDDLKISKHVSVGWGKKETQFHGKGAKAAERP--LRDPTMPekvdeklssLDDHRVTISWRGDGEYFAVSSIEPET 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    217 G-ARKVRVWNREFALQSTSEPVPGLGPALAWKPSGSLIASTQNKPNQQDVVFFEKNGLLHGQFTLPFLKDEVKVNDLLWN 295
Cdd:pfam04762  235 GsRRAIRVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWN 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    296 ADSSVLAVWLEDLqreedsvlktyVQLWTVGNYHWYLNECLPFSTYGKSKIVSLMWDPVIPYRLHVLCQGWHYLCYDWRW 375
Cdd:pfam04762  315 SDSEVLAVVLEDR-----------VQLWTTGNYHWYLKQELYYPQSASLAGVFLKWHPEKPLTLMVGTSGGQILVYDFAW 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    376 TTDRSSGDNESDLANVAVIDGNRILVTVFQQTVVPPPMCTYRLLLPHPVNQVTFCALPKKsndLAVLDASNQISVYKCGD 455
Cdd:pfam04762  384 KTARGPTSSPNDNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNDVAFSKSNSK---LAALTSDGDISISVLSL 460

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    456 SPSMdptvklgavggngfkvSLRTPHLEKRYKIQFESNEDQETNPLKLSLLSWIEEDIFLAICHSqcspqqSVIHRLTVV 535
Cdd:pfam04762  461 APMK----------------AGAHPKLVSEFSKNEIANSDFETALDSLRQLAFINDSTLLVLSDS------DNLSEILLV 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    536 PCevDEEQGQLSVSSSISVDGIIISMCCNSKTKsVALQLADGQILKYiwespSLAVEPWKNPGGfpiQFPYPCIQTELAM 615
Cdd:pfam04762  519 DI--DDISNPLLVSSSTSLEKIVLAKSSNDYSH-VVVETSDGKVHEG-----SLSAEGELLEIT---KFPQLCRDFRVVR 587

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    616 IGGEE---CVLGLTDRCRFFINDTEVASNITSFAVYDEFLLLTTHSHTCQCYCLKDaSIKTLQAGLSSSHVSNGEILRKV 692
Cdd:pfam04762  588 VHNEGmkgVAFGLTSNGKLYANGRLLASNVTSFAVTDSHLLFTTAQHLLKFVHLNS-SVKDLEVVEDDREESHDERIRQI 666

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    693 ERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKIMFKEAFECMRKLRINLNLIHDHNPEVFLQNVETFI 772
Cdd:pfam04762  667 ERGSRLVTVVPSKASVVLQMPRGNLETIYPRILVLAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFV 746

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    773 RQIDCVNHINLFFTELKEEDVTKTMYPPPV---------PSSVQQSRDPGGTKLDLICDALRVAMENINPHKYCLPILTS 843
Cdd:pfam04762  747 DQINKVDYLDLFLSCLKEEDVTKTMYKDTLslppptsmpPYNKKKSFDPKDSKVNKVCDAILKALEPEYSDKYLLTILTA 826

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    844 HVKKTTPELEIVLQKVHELQGNapsdpDAVSAEEALKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFLN 923
Cdd:pfam04762  827 YACKNPPNLEAALQLIASLREE-----DEEQAEEALKHLCFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQ 901

                          970       980       990
                   ....*....|....*....|....*....|..
gi 75047962    924 TLKKMETNYQRFTIDKYLKRYEKAIGHLSKCG 955
Cdd:pfam04762  902 ELQKMEELRRKFLIDDYLKRYEKALGHLVEAG 933
 
Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-955 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1228.73  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962      1 MRNLKLLQTLEFKDIQAPGKpqcfSLRTEPGTVLIGSEHGLIEVDPVTREVKNEIPLVAEGF-----------LPEDKSG 69
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDP----DLTLLASAFDTTSDSITFVLGPTESEGAIEVQQFMKDGqvsvlasfpapLPVGPDD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962     70 CIVGIQDLLDQESVCIATASGDVILC----NLSTHQLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPIME 145
Cdd:pfam04762   77 KILSFQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPISE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    146 QQIHQDDFGESKFITVGWGKKETQFHGSEGRQAAFQiqTHESALP---------WDDHRPRVTWRGDGQFFAVSVVCPET 216
Cdd:pfam04762  157 TSLDPDDLKISKHVSVGWGKKETQFHGKGAKAAERP--LRDPTMPekvdeklssLDDHRVTISWRGDGEYFAVSSIEPET 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    217 G-ARKVRVWNREFALQSTSEPVPGLGPALAWKPSGSLIASTQNKPNQQDVVFFEKNGLLHGQFTLPFLKDEVKVNDLLWN 295
Cdd:pfam04762  235 GsRRAIRVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWN 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    296 ADSSVLAVWLEDLqreedsvlktyVQLWTVGNYHWYLNECLPFSTYGKSKIVSLMWDPVIPYRLHVLCQGWHYLCYDWRW 375
Cdd:pfam04762  315 SDSEVLAVVLEDR-----------VQLWTTGNYHWYLKQELYYPQSASLAGVFLKWHPEKPLTLMVGTSGGQILVYDFAW 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    376 TTDRSSGDNESDLANVAVIDGNRILVTVFQQTVVPPPMCTYRLLLPHPVNQVTFCALPKKsndLAVLDASNQISVYKCGD 455
Cdd:pfam04762  384 KTARGPTSSPNDNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNDVAFSKSNSK---LAALTSDGDISISVLSL 460

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    456 SPSMdptvklgavggngfkvSLRTPHLEKRYKIQFESNEDQETNPLKLSLLSWIEEDIFLAICHSqcspqqSVIHRLTVV 535
Cdd:pfam04762  461 APMK----------------AGAHPKLVSEFSKNEIANSDFETALDSLRQLAFINDSTLLVLSDS------DNLSEILLV 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    536 PCevDEEQGQLSVSSSISVDGIIISMCCNSKTKsVALQLADGQILKYiwespSLAVEPWKNPGGfpiQFPYPCIQTELAM 615
Cdd:pfam04762  519 DI--DDISNPLLVSSSTSLEKIVLAKSSNDYSH-VVVETSDGKVHEG-----SLSAEGELLEIT---KFPQLCRDFRVVR 587

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    616 IGGEE---CVLGLTDRCRFFINDTEVASNITSFAVYDEFLLLTTHSHTCQCYCLKDaSIKTLQAGLSSSHVSNGEILRKV 692
Cdd:pfam04762  588 VHNEGmkgVAFGLTSNGKLYANGRLLASNVTSFAVTDSHLLFTTAQHLLKFVHLNS-SVKDLEVVEDDREESHDERIRQI 666

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    693 ERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKIMFKEAFECMRKLRINLNLIHDHNPEVFLQNVETFI 772
Cdd:pfam04762  667 ERGSRLVTVVPSKASVVLQMPRGNLETIYPRILVLAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFV 746

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    773 RQIDCVNHINLFFTELKEEDVTKTMYPPPV---------PSSVQQSRDPGGTKLDLICDALRVAMENINPHKYCLPILTS 843
Cdd:pfam04762  747 DQINKVDYLDLFLSCLKEEDVTKTMYKDTLslppptsmpPYNKKKSFDPKDSKVNKVCDAILKALEPEYSDKYLLTILTA 826

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    844 HVKKTTPELEIVLQKVHELQGNapsdpDAVSAEEALKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFLN 923
Cdd:pfam04762  827 YACKNPPNLEAALQLIASLREE-----DEEQAEEALKHLCFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQ 901

                          970       980       990
                   ....*....|....*....|....*....|..
gi 75047962    924 TLKKMETNYQRFTIDKYLKRYEKAIGHLSKCG 955
Cdd:pfam04762  902 ELQKMEELRRKFLIDDYLKRYEKALGHLVEAG 933
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
71-1277 4.48e-157

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 505.69  E-value: 4.48e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962   71 IVGIQDLLDQESVCIATASGDVI-LCNLSTHQ---LECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPIMEQ 146
Cdd:COG5290   70 LLSFKHFHVLTFEYFLIDEGDIIhLVNDPTPAeleMEIVGKVSNGIVAASWSADEKTWCVVTSTREILLFDKYFDPISEY 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  147 QIHQDDFGE-SKFITVGWGKKETQFHGSEGRQaafqiQTHESALPW----------DDHRPRVTWRGDGQFFAVSVVcPE 215
Cdd:COG5290  150 HLKKSDLVEfGKHIRVGWGKKETQFRGKGARA-----QLRDPTMPYmvdygdlfavDTNKKIIFWRGDTEYNLVGRS-EE 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  216 TGARKVRVWNREFALQSTSEPVPGLGPALAWKPSGSLIASTQNKP--NQQDVVFFEKNGLLHGQFTLPFLKDEvKVNDLL 293
Cdd:COG5290  224 RPRRAFRVYSREGQLDSASEPVTGMEHQLSWKPQGSKYATIGTDGcsTSESVIFFERNGLRHGEFDLRVGCDE-KAFLEN 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  294 WNADSSVLAVWLEDLqreedsvlktyVQLWTVGNYHWYLNECLPFSTYGKSKivslmWDPVIPYRLHVLCQGW-HYLCYD 372
Cdd:COG5290  303 WNLLSTVLAVAEGNL-----------LKLWTTKNYHWYLKVERQIPGISYVK-----WHPEEKNTLLFRDGERiLRVFFS 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  373 WRWTTDRSSGDNesDLANVAVIDGNRILVTVFQQTVVPPPMCTYRLLLPHPVnQVTFCALpkksndlavldasnqisvyk 452
Cdd:COG5290  367 EKKTHHGSEYPF--DNGTSYVIDGSYMLYTPLSLKNLPPPMFSVRVGFDTNV-VDVFPSF-------------------- 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  453 cgdspsmdpTVKLGAVGGNGFKVSLRTPHLEKRYKIQF--ESNEDQETNPLKLSLLSwiEEDIFLAICHSQCSpqqsvih 530
Cdd:COG5290  424 ---------AEKKGAALLRDRLIMFRWDSEEFINKRTEflESEFDSIVLFDGFLVLK--SGHVFLLKDTNNES------- 485

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  531 RLTVVPCEVDEEQGQLSVSSSISVDGIIISMCCNSKTksvaLQLADGQILKYIWESPSLAVepwknpggfpIQFPYPCIQ 610
Cdd:COG5290  486 DTYITRNGDVDERKKRGTVETRRTSTLVHQLCQTLLR----YGTCVGVVKHYNFEEKLYEL----------LKFPNGVID 551

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  611 TELAMIGGEECVLGLTDRCRFFINDTEVASNITSFAVYDEFLLLTTHSHTCQcYCLKDASIKTLQAglssshVSNG---- 686
Cdd:COG5290  552 FSVDPVHSTLVAIGITDIGQLFALQVLLKKSVFSHNGTKLFVLFTTTENILS-FVHLESTFKPLIT------VEEGtvrf 624

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  687 --EILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKIMFKEAFECMRKLRINLNLIHDHNPEVF 764
Cdd:COG5290  625 fdERKRSVERGSHKVELLPSKDFVVLQVTRGNLETIYPRIMVLAFVRKLIAAKKYKDAFDVCRTHRVPLGILLDYDPELF 704

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  765 LQNVETFIRQIDCVNHINLFFTELKEEDVTKTMYPPPVPSS-VQQSRDPGGTKLDLICDALR-VAMENINPHKYCLPILT 842
Cdd:COG5290  705 IENLEVFVTECRRVDYLSLFSEALQRDDVTKTDYSFISKSEqARRFRKVFDLKVNLECKDTReHLESLIYNDESIQTIIT 784

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  843 SHVKKTTPELEIVLQKVHELQGNAPSDPDAVsaeealKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFL 922
Cdd:COG5290  785 AYLIGNPGNGKAALMRISPLSRCSESLDEDV------KNLCFLRDVNFFNEFALSLYDKSLALLIAQLSQKDPREYLPFL 858

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  923 NTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCgPEYFSECLNLIKDKNLYNEALKLYPPTSQEYKDISIAYGEHLMEEHQ 1002
Cdd:COG5290  859 VERQDLEALRRKFSIDNYLSIYESALGHLNED-LNVIREVMKYICRHDLYDFLLLLYRYDGELQKFKINIFAGNLVDNLY 937

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962 1003 YEPAGLVFARCGAHEKALSAFLTCGSWQQTLCMAAQ-----LNMTEEQLAglgrtlAGKLAEQRKHSDAAIVLEQYTQDY 1077
Cdd:COG5290  938 HISAAKAYEVEGKYIEAHGAYDSALMWRECGSISTQekgyeFNLCAELLP------SDLLVEFRKAGDAEKILLTYLENL 1011

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962 1078 EEAVLLLLEGAAWEEALRLVYKYNRLDIIETNIKPSILEAYKNYMAFLESQSATFSRHKERLLEVRELKERAQQVDLDDE 1157
Cdd:COG5290 1012 YEAVAMDCKGSEYREAFCEAMVSRLVESEKHYEAGQLGEEFGGKPELAADEYVQIKSQGDRLRVLRDKKCEMPEAREILR 1091

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962 1158 MPHGQEADL---FSETSSIVSGSEMSSKYSHSnSRISARSSKNRRKAERKKHSLKEGSPLEDLALLEALNEVVQSLDKLK 1234
Cdd:COG5290 1092 EELLTLDDVseaFVKYSTRLSALTEYTKDECM-SKTSRSTTKNMRRGERKRARGKKGTRYEEEYLVSSIRRLILRLVGWR 1170

                       1210      1220      1230      1240
                 ....*....|....*....|....*....|....*....|...
gi 75047962 1235 DEVYRILKVLFLFEFDEQGRELQKTFQDTLQLVERSLPEIWTL 1277
Cdd:COG5290 1171 PETERLVEILKRFNMEEQARAHQTNFDEVGRAIKTEVDSIFSV 1213
 
Name Accession Description Interval E-value
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 1-955 0e+00

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 1228.73  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962      1 MRNLKLLQTLEFKDIQAPGKpqcfSLRTEPGTVLIGSEHGLIEVDPVTREVKNEIPLVAEGF-----------LPEDKSG 69
Cdd:pfam04762    1 MRNLKVLSHGAFKPVSGTDP----DLTLLASAFDTTSDSITFVLGPTESEGAIEVQQFMKDGqvsvlasfpapLPVGPDD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962     70 CIVGIQDLLDQESVCIATASGDVILC----NLSTHQLECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPIME 145
Cdd:pfam04762   77 KILSFQHLADSESLCFASASGDIILVtydpDPETTVVEIVGSIDSGITAAAWSPDEELLALVTGEGTVLLMTRDFEPISE 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    146 QQIHQDDFGESKFITVGWGKKETQFHGSEGRQAAFQiqTHESALP---------WDDHRPRVTWRGDGQFFAVSVVCPET 216
Cdd:pfam04762  157 TSLDPDDLKISKHVSVGWGKKETQFHGKGAKAAERP--LRDPTMPekvdeklssLDDHRVTISWRGDGEYFAVSSIEPET 234

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    217 G-ARKVRVWNREFALQSTSEPVPGLGPALAWKPSGSLIASTQNKPNQQDVVFFEKNGLLHGQFTLPFLKDEVKVNDLLWN 295
Cdd:pfam04762  235 GsRRAIRVWSREGALDSVSEPVDGLEGSLSWRPSGSLIASIQRKDDRLDVVFFERNGLRHGEFTLRLNPAEEKVQSLAWN 314

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    296 ADSSVLAVWLEDLqreedsvlktyVQLWTVGNYHWYLNECLPFSTYGKSKIVSLMWDPVIPYRLHVLCQGWHYLCYDWRW 375
Cdd:pfam04762  315 SDSEVLAVVLEDR-----------VQLWTTGNYHWYLKQELYYPQSASLAGVFLKWHPEKPLTLMVGTSGGQILVYDFAW 383

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    376 TTDRSSGDNESDLANVAVIDGNRILVTVFQQTVVPPPMCTYRLLLPHPVNQVTFCALPKKsndLAVLDASNQISVYKCGD 455
Cdd:pfam04762  384 KTARGPTSSPNDNGTVAVIDGSTLLLTPFSLANVPPPMSARELELPANVNDVAFSKSNSK---LAALTSDGDISISVLSL 460

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    456 SPSMdptvklgavggngfkvSLRTPHLEKRYKIQFESNEDQETNPLKLSLLSWIEEDIFLAICHSqcspqqSVIHRLTVV 535
Cdd:pfam04762  461 APMK----------------AGAHPKLVSEFSKNEIANSDFETALDSLRQLAFINDSTLLVLSDS------DNLSEILLV 518

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    536 PCevDEEQGQLSVSSSISVDGIIISMCCNSKTKsVALQLADGQILKYiwespSLAVEPWKNPGGfpiQFPYPCIQTELAM 615
Cdd:pfam04762  519 DI--DDISNPLLVSSSTSLEKIVLAKSSNDYSH-VVVETSDGKVHEG-----SLSAEGELLEIT---KFPQLCRDFRVVR 587

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    616 IGGEE---CVLGLTDRCRFFINDTEVASNITSFAVYDEFLLLTTHSHTCQCYCLKDaSIKTLQAGLSSSHVSNGEILRKV 692
Cdd:pfam04762  588 VHNEGmkgVAFGLTSNGKLYANGRLLASNVTSFAVTDSHLLFTTAQHLLKFVHLNS-SVKDLEVVEDDREESHDERIRQI 666

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    693 ERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKIMFKEAFECMRKLRINLNLIHDHNPEVFLQNVETFI 772
Cdd:pfam04762  667 ERGSRLVTVVPSKASVVLQMPRGNLETIYPRILVLAGIRKAIDAKRYKDAFLTCRTHRIDLNILHDYDPELFLQNVELFV 746

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    773 RQIDCVNHINLFFTELKEEDVTKTMYPPPV---------PSSVQQSRDPGGTKLDLICDALRVAMENINPHKYCLPILTS 843
Cdd:pfam04762  747 DQINKVDYLDLFLSCLKEEDVTKTMYKDTLslppptsmpPYNKKKSFDPKDSKVNKVCDAILKALEPEYSDKYLLTILTA 826

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962    844 HVKKTTPELEIVLQKVHELQGNapsdpDAVSAEEALKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFLN 923
Cdd:pfam04762  827 YACKNPPNLEAALQLIASLREE-----DEEQAEEALKHLCFLVDVNKLYDVALGLYDLKLALLVAQKSQKDPKEYLPFLQ 901

                          970       980       990
                   ....*....|....*....|....*....|..
gi 75047962    924 TLKKMETNYQRFTIDKYLKRYEKAIGHLSKCG 955
Cdd:pfam04762  902 ELQKMEELRRKFLIDDYLKRYEKALGHLVEAG 933
COG5290 COG5290
IkappaB kinase complex, IKAP component [Transcription];
71-1277 4.48e-157

IkappaB kinase complex, IKAP component [Transcription];


Pssm-ID: 227610 [Multi-domain]  Cd Length: 1243  Bit Score: 505.69  E-value: 4.48e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962   71 IVGIQDLLDQESVCIATASGDVI-LCNLSTHQ---LECVGSVASGISVMSWSPDQELVLLATGQQTLIMMTKDFEPIMEQ 146
Cdd:COG5290   70 LLSFKHFHVLTFEYFLIDEGDIIhLVNDPTPAeleMEIVGKVSNGIVAASWSADEKTWCVVTSTREILLFDKYFDPISEY 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  147 QIHQDDFGE-SKFITVGWGKKETQFHGSEGRQaafqiQTHESALPW----------DDHRPRVTWRGDGQFFAVSVVcPE 215
Cdd:COG5290  150 HLKKSDLVEfGKHIRVGWGKKETQFRGKGARA-----QLRDPTMPYmvdygdlfavDTNKKIIFWRGDTEYNLVGRS-EE 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  216 TGARKVRVWNREFALQSTSEPVPGLGPALAWKPSGSLIASTQNKP--NQQDVVFFEKNGLLHGQFTLPFLKDEvKVNDLL 293
Cdd:COG5290  224 RPRRAFRVYSREGQLDSASEPVTGMEHQLSWKPQGSKYATIGTDGcsTSESVIFFERNGLRHGEFDLRVGCDE-KAFLEN 302

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  294 WNADSSVLAVWLEDLqreedsvlktyVQLWTVGNYHWYLNECLPFSTYGKSKivslmWDPVIPYRLHVLCQGW-HYLCYD 372
Cdd:COG5290  303 WNLLSTVLAVAEGNL-----------LKLWTTKNYHWYLKVERQIPGISYVK-----WHPEEKNTLLFRDGERiLRVFFS 366

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  373 WRWTTDRSSGDNesDLANVAVIDGNRILVTVFQQTVVPPPMCTYRLLLPHPVnQVTFCALpkksndlavldasnqisvyk 452
Cdd:COG5290  367 EKKTHHGSEYPF--DNGTSYVIDGSYMLYTPLSLKNLPPPMFSVRVGFDTNV-VDVFPSF-------------------- 423

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  453 cgdspsmdpTVKLGAVGGNGFKVSLRTPHLEKRYKIQF--ESNEDQETNPLKLSLLSwiEEDIFLAICHSQCSpqqsvih 530
Cdd:COG5290  424 ---------AEKKGAALLRDRLIMFRWDSEEFINKRTEflESEFDSIVLFDGFLVLK--SGHVFLLKDTNNES------- 485

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  531 RLTVVPCEVDEEQGQLSVSSSISVDGIIISMCCNSKTksvaLQLADGQILKYIWESPSLAVepwknpggfpIQFPYPCIQ 610
Cdd:COG5290  486 DTYITRNGDVDERKKRGTVETRRTSTLVHQLCQTLLR----YGTCVGVVKHYNFEEKLYEL----------LKFPNGVID 551

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  611 TELAMIGGEECVLGLTDRCRFFINDTEVASNITSFAVYDEFLLLTTHSHTCQcYCLKDASIKTLQAglssshVSNG---- 686
Cdd:COG5290  552 FSVDPVHSTLVAIGITDIGQLFALQVLLKKSVFSHNGTKLFVLFTTTENILS-FVHLESTFKPLIT------VEEGtvrf 624

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  687 --EILRKVERGSRIVTVVPQDTKLILQMPRGNLEVVHHRALVLAQIRKWLDKIMFKEAFECMRKLRINLNLIHDHNPEVF 764
Cdd:COG5290  625 fdERKRSVERGSHKVELLPSKDFVVLQVTRGNLETIYPRIMVLAFVRKLIAAKKYKDAFDVCRTHRVPLGILLDYDPELF 704

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  765 LQNVETFIRQIDCVNHINLFFTELKEEDVTKTMYPPPVPSS-VQQSRDPGGTKLDLICDALR-VAMENINPHKYCLPILT 842
Cdd:COG5290  705 IENLEVFVTECRRVDYLSLFSEALQRDDVTKTDYSFISKSEqARRFRKVFDLKVNLECKDTReHLESLIYNDESIQTIIT 784

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  843 SHVKKTTPELEIVLQKVHELQGNAPSDPDAVsaeealKYLLLLVDVNELYDHSLGTYDFDLVLMVAEKSQKDPKEYLPFL 922
Cdd:COG5290  785 AYLIGNPGNGKAALMRISPLSRCSESLDEDV------KNLCFLRDVNFFNEFALSLYDKSLALLIAQLSQKDPREYLPFL 858

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962  923 NTLKKMETNYQRFTIDKYLKRYEKAIGHLSKCgPEYFSECLNLIKDKNLYNEALKLYPPTSQEYKDISIAYGEHLMEEHQ 1002
Cdd:COG5290  859 VERQDLEALRRKFSIDNYLSIYESALGHLNED-LNVIREVMKYICRHDLYDFLLLLYRYDGELQKFKINIFAGNLVDNLY 937

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962 1003 YEPAGLVFARCGAHEKALSAFLTCGSWQQTLCMAAQ-----LNMTEEQLAglgrtlAGKLAEQRKHSDAAIVLEQYTQDY 1077
Cdd:COG5290  938 HISAAKAYEVEGKYIEAHGAYDSALMWRECGSISTQekgyeFNLCAELLP------SDLLVEFRKAGDAEKILLTYLENL 1011

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962 1078 EEAVLLLLEGAAWEEALRLVYKYNRLDIIETNIKPSILEAYKNYMAFLESQSATFSRHKERLLEVRELKERAQQVDLDDE 1157
Cdd:COG5290 1012 YEAVAMDCKGSEYREAFCEAMVSRLVESEKHYEAGQLGEEFGGKPELAADEYVQIKSQGDRLRVLRDKKCEMPEAREILR 1091

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75047962 1158 MPHGQEADL---FSETSSIVSGSEMSSKYSHSnSRISARSSKNRRKAERKKHSLKEGSPLEDLALLEALNEVVQSLDKLK 1234
Cdd:COG5290 1092 EELLTLDDVseaFVKYSTRLSALTEYTKDECM-SKTSRSTTKNMRRGERKRARGKKGTRYEEEYLVSSIRRLILRLVGWR 1170

                       1210      1220      1230      1240
                 ....*....|....*....|....*....|....*....|...
gi 75047962 1235 DEVYRILKVLFLFEFDEQGRELQKTFQDTLQLVERSLPEIWTL 1277
Cdd:COG5290 1171 PETERLVEILKRFNMEEQARAHQTNFDEVGRAIKTEVDSIFSV 1213
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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