|
Name |
Accession |
Description |
Interval |
E-value |
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
55-641 |
1.03e-143 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 434.75 E-value: 1.03e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 55 EDILAGLDEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSL---GAV 131
Cdd:COG0210 1 SDLLAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALlgrLAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 132 GVQTRTFHSAALRQLRYFWPSAIGGSFPDIV--KHKAGLITEAAQRLRMSVDRALVRDIAAEIEWAKVSLFTPDTLtphl 209
Cdd:COG0210 81 GLWVGTFHSLALRILRRHAELLGLPPNFTILdgDDQLRLIKELLKELGLDEKRFPPRELLSLISRAKNEGLTPEEL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 210 hQRNLPSGITPQNMVRLFRAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLDAW 289
Cdd:COG0210 157 -AELLAADPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 290 LGERDDLCVVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLTRDYRSHSQVVELANRLLAARRPRPDSTefswapplk 369
Cdd:COG0210 236 AGDGRNLCVVGDDDQSIYGFRGADPENILRFEKDFPDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKN--------- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 370 LVSQRGPGVESQWFGYTDDEREAEGIAEQIQDLLEkDGVPASEIAVLFRTNGQSGLLEAALADRGIPYQLRGAEQFFDRP 449
Cdd:COG0210 307 LWTDNGEGEKVRLYVAPDEEEEARFVADEIRELHE-EGVPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 450 EVKQAMLALRASAKSTDGSE-----NVPR-------------YVRE----VLEPLGYTEKAPQSAGAVRQKWESLAAIVS 507
Cdd:COG0210 386 EIKDLLAYLRLLANPDDDVAllrilNVPRrgigaatlerlreAAREegisLLEALRDLGELAGLSGRAAKALRRFAELLE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 508 -----------------------MVDHLEA-------TRIEDIAQ-AEAAG--APVPHRLTVHDVVATLAhrLAT---QD 551
Cdd:COG0210 466 alraaaerlpleellealldesgYEEELREeageeaeRRLENLEElVDAAArfEERNPGASLEAFLEELA--LLSdldAA 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 552 APVMEGVTLASLHSAKGLEWDAVFLCGLNEGLMPITFA-QTSDEIDEERRLLYVGITRARKYLWFTWSDSRTTGGRGKRR 630
Cdd:COG0210 544 DEDEDAVTLMTLHAAKGLEFPVVFLVGLEEGLFPHQRSlDDEEELEEERRLFYVAITRARERLYLTYAASRRLWGETQDN 623
|
650
....*....|..
gi 503162784 631 RS-RFLDDIDPS 641
Cdd:COG0210 624 EPsRFLDELPEE 635
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
56-620 |
2.78e-64 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 225.52 E-value: 2.78e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 56 DILAGLDEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSLgaVGVQT 135
Cdd:PRK11773 5 YLLDSLNDKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQL--LGTSQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 136 R-----TFHSAALRQLRYFWPSA-IGGSFpDIvkhkagLITEAAQRLRMSVDRAL--------VRDIAAEIEWAKvslft 201
Cdd:PRK11773 83 GgmwvgTFHGLAHRLLRAHWQDAnLPQDF-QI------LDSDDQLRLLKRLIKALnldekqwpPRQAQWYINGQK----- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 202 PDTLTPHlhqrNLPSGITP--QNMVRLFRAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVS 279
Cdd:PRK11773 151 DEGLRPQ----HIQSYGDPveQTWLKIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 280 PLQQrlldAWL----GERDDLCVVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLTRDYRSHSQVVELANRLLAARRP 355
Cdd:PRK11773 227 AIQY----AWIrllaGDTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTANILKAANALIANNNG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 356 RPDS---TEFSWAPPLKLVSQrgpgvesqwFGYTDderEAEGIAEQIQDLLEkDGVPASEIAVLFRTNGQSGLLEAALAD 432
Cdd:PRK11773 303 RLGKelwTDGGDGEPISLYCA---------FNELD---EARFVVERIKTWQD-NGGALSDCAILYRSNAQSRVLEEALLQ 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 433 RGIPYQLRGAEQFFDRPEVKQAMLALRASAKSTDGSE-----NVP---------RYVREVLEPLGYT----------EK- 487
Cdd:PRK11773 370 AGIPYRIYGGMRFFERQEIKDALAYLRLIANRNDDAAfervvNTPtrgigdrtlDVVRQTARDRQLTlwqacrallqEKv 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 488 -APQSAGAVRQKWE---SLAAIVS------MVDH------LEA-----------TRIEDIAQ---AEAAGAPVPHRLTVH 537
Cdd:PRK11773 450 lAGRAASALQRFIElidALAQETAdmplheQTDRvikdsgLRAmyeqekgekgqARIENLEElvtATRQFSYPDEDEDLT 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 538 DVVATLAHrlA------TQDAPVMEGVTLASLHSAKGLEWDAVFLCGLNEGLMPitFAQTSDE---IDEERRLLYVGITR 608
Cdd:PRK11773 530 PLQAFLSH--AaleageGQADAHEDAVQLMTLHSAKGLEFPLVFIVGMEEGLFP--SQMSLEEggrLEEERRLAYVGITR 605
|
650
....*....|..
gi 503162784 609 ARKYLWFTWSDS 620
Cdd:PRK11773 606 AMQKLTLTYAES 617
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
62-336 |
2.74e-55 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 186.18 E-value: 2.74e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 62 DEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSL----GAVGVQTRT 137
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLRKLlgeqLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 138 FHSAALRQLRYFWpsaiggsfpdivkhkagliteaaqrlrmsvdralvrdiaaeiewakvslftpdtltphlhqrnlpsg 217
Cdd:cd17932 81 FHSFALRILRRYG------------------------------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 218 itpqnmvrlfrayedlkdernliDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLDAWLGERDDLC 297
Cdd:cd17932 94 -----------------------DFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLF 150
|
250 260 270
....*....|....*....|....*....|....*....
gi 503162784 298 VVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLTRDY 336
Cdd:cd17932 151 VVGDDDQSIYGFRGADPENILDFEKDFPDAKVIKLEENY 189
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
61-324 |
1.84e-53 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 184.37 E-value: 1.84e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 61 LDEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSL----GAVGVQTR 136
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERILKLlgkaELSELNIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 137 TFHSAALRQLRYFWPSA-IGGSFPDIVKH-KAGLITEAAQRLRMSVD--RALVRDIAAEIEWAKVSLFTPdtltphlHQR 212
Cdd:pfam00580 81 TFHSFCLRILRKYANRIgLLPNFSILDELdQLALLKELLEKDRLNLDpkLLRKLELKELISKAKNRLLSP-------EEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 213 NLPSGITPQNMVRLF-RAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLDAWLG 291
Cdd:pfam00580 154 QQGAADPRDKLAAEFyQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAG 233
|
250 260 270
....*....|....*....|....*....|...
gi 503162784 292 ERDDLCVVGDASQTIYSFTGATSRHLLEFPRRY 324
Cdd:pfam00580 234 GHENLFLVGDPDQSIYGFRGADIENILKFEKDF 266
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
70-620 |
1.09e-20 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 97.11 E-value: 1.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 70 SELNGAMRVLAGAGTGKTRAITH---RIAYGIacGKYVPQRVMALTFTTRAAEEMRLRLRS-----LGAVGVQTR----- 136
Cdd:TIGR00609 6 IPLNGTFLIEASAGTGKTFTIAQlylRLLLEG--GPLTVEEILVVTFTNAATEELKTRIRGrihqaLRALKAALTsqelp 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 137 ------------------------TFHSAA-----------LRQ------------------------LRYFWPSAIGGS 157
Cdd:TIGR00609 84 eplkeaiqdekvkqaitrlrnalaTMDEAAiytihgfcqrmLEQhafesdeifdveliedeslllaeiTKDFWRRNFYNL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 158 FPDIVKH--------KAGLITEAAQRLRMSVD--RALVRDIAAEIEWAKVSLFTPDTLTP----HLHQRNLPSGITPQNM 223
Cdd:TIGR00609 164 PFDIAQIvlktkkspQAVLTQILADLLLQSYLafPSPPLDLEQLIKWHEQIYKDLDKLDHavfeEIDKLNAERNNLFCLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 224 VRLF-RAYEDL-------KDERNLIDFEDVL--LLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLD-AWL-G 291
Cdd:TIGR00609 244 DRVFlTLLKEVqeelkkeKKRRREIGFDDLLsrLETALKSAEGEKLAQAIREQYPIALIDEFQDTDPQQYRIFSkLFIaQ 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 292 ERDDLCVVGDASQTIYSFTGATSRHLLE----FPRRYrgahtvRLTRDYRSHSQVVELANRLLA-ARRP---RPDSTEFS 363
Cdd:TIGR00609 324 KETSLFLIGDPKQAIYSFRGADIFTYLQakskADARY------TLGTNWRSTPALVGSLNKLFSlISNPfleKPIFIPVL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 364 WAPPLKLVSQRGPGVESQWFGYTDDEREAEGI-----------AEQIQDLLEKDG--------------VPASEIAVLFR 418
Cdd:TIGR00609 398 AHQKNSKGSFVINGQEQPPIHFFTTEVESEGVddyrqtiaqkcAREIALWLASAAlglanfiatfggrpLRAGDIAVLVR 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 419 TNGQSGLLEAALADRGIPYQLRGAEQFFDRPEVKQAMLALrasakstdgsenvpryvrevLEPLGYtekaPQSAGAVRqk 498
Cdd:TIGR00609 478 GRKEANQIRKALKKAQIPSVYLSDKSSVFATEEAQELLAL--------------------LEALLE----PENEGTLR-- 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 499 weslAAIVSMVDHLEATRIEDIAQAEAAG-------------------APVPHR--------------------LTVHDV 539
Cdd:TIGR00609 532 ----AALASSIFGLSALELETLNQDEITWervvekfreyhdiwrkigvLAMFQRlmlekgigerllsqpggeriLTNLLH 607
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 540 VATLAHRLATQ------------------------------DAPVMEGVTlasLHSAKGLEWDAVFL------------- 576
Cdd:TIGR00609 608 LAELLQEAAHQernklsllrwledqisneeeeeeeiirlesDAELVKIVT---IHKSKGLEYPIVFLpfitdakksnfas 684
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 503162784 577 ---------CGLNEGLMPITFAQTSDEI-DEERRLLYVGITRARKYLWFTWSDS 620
Cdd:TIGR00609 685 lhdqhsheyQLYDFNQSEENQKLARVERlAEDLRLLYVALTRAKKQLFIGIAPL 738
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| UvrD |
COG0210 |
Superfamily I DNA or RNA helicase [Replication, recombination and repair]; |
55-641 |
1.03e-143 |
|
Superfamily I DNA or RNA helicase [Replication, recombination and repair];
Pssm-ID: 439980 [Multi-domain] Cd Length: 721 Bit Score: 434.75 E-value: 1.03e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 55 EDILAGLDEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSL---GAV 131
Cdd:COG0210 1 SDLLAGLNPEQRAAVEHPEGPLLVLAGAGSGKTRVLTHRIAYLIAEGGVDPEQILAVTFTNKAAREMRERIEALlgrLAR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 132 GVQTRTFHSAALRQLRYFWPSAIGGSFPDIV--KHKAGLITEAAQRLRMSVDRALVRDIAAEIEWAKVSLFTPDTLtphl 209
Cdd:COG0210 81 GLWVGTFHSLALRILRRHAELLGLPPNFTILdgDDQLRLIKELLKELGLDEKRFPPRELLSLISRAKNEGLTPEEL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 210 hQRNLPSGITPQNMVRLFRAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLDAW 289
Cdd:COG0210 157 -AELLAADPEWRAAAELYEAYQERLRANNALDFDDLLLLAVRLLEENPEVLEKYQNRFRYILVDEYQDTNPAQYELLRLL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 290 LGERDDLCVVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLTRDYRSHSQVVELANRLLAARRPRPDSTefswapplk 369
Cdd:COG0210 236 AGDGRNLCVVGDDDQSIYGFRGADPENILRFEKDFPDAKVIKLEQNYRSTQNILDAANAVIANNPGRLGKN--------- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 370 LVSQRGPGVESQWFGYTDDEREAEGIAEQIQDLLEkDGVPASEIAVLFRTNGQSGLLEAALADRGIPYQLRGAEQFFDRP 449
Cdd:COG0210 307 LWTDNGEGEKVRLYVAPDEEEEARFVADEIRELHE-EGVPLSDIAVLYRTNAQSRALEEALRRAGIPYRVVGGLRFYERA 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 450 EVKQAMLALRASAKSTDGSE-----NVPR-------------YVRE----VLEPLGYTEKAPQSAGAVRQKWESLAAIVS 507
Cdd:COG0210 386 EIKDLLAYLRLLANPDDDVAllrilNVPRrgigaatlerlreAAREegisLLEALRDLGELAGLSGRAAKALRRFAELLE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 508 -----------------------MVDHLEA-------TRIEDIAQ-AEAAG--APVPHRLTVHDVVATLAhrLAT---QD 551
Cdd:COG0210 466 alraaaerlpleellealldesgYEEELREeageeaeRRLENLEElVDAAArfEERNPGASLEAFLEELA--LLSdldAA 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 552 APVMEGVTLASLHSAKGLEWDAVFLCGLNEGLMPITFA-QTSDEIDEERRLLYVGITRARKYLWFTWSDSRTTGGRGKRR 630
Cdd:COG0210 544 DEDEDAVTLMTLHAAKGLEFPVVFLVGLEEGLFPHQRSlDDEEELEEERRLFYVAITRARERLYLTYAASRRLWGETQDN 623
|
650
....*....|..
gi 503162784 631 RS-RFLDDIDPS 641
Cdd:COG0210 624 EPsRFLDELPEE 635
|
|
| uvrD |
PRK11773 |
DNA-dependent helicase II; Provisional |
56-620 |
2.78e-64 |
|
DNA-dependent helicase II; Provisional
Pssm-ID: 236976 [Multi-domain] Cd Length: 721 Bit Score: 225.52 E-value: 2.78e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 56 DILAGLDEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSLgaVGVQT 135
Cdd:PRK11773 5 YLLDSLNDKQREAVAAPLGNMLVLAGAGSGKTRVLVHRIAWLMQVENASPYSIMAVTFTNKAAAEMRHRIEQL--LGTSQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 136 R-----TFHSAALRQLRYFWPSA-IGGSFpDIvkhkagLITEAAQRLRMSVDRAL--------VRDIAAEIEWAKvslft 201
Cdd:PRK11773 83 GgmwvgTFHGLAHRLLRAHWQDAnLPQDF-QI------LDSDDQLRLLKRLIKALnldekqwpPRQAQWYINGQK----- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 202 PDTLTPHlhqrNLPSGITP--QNMVRLFRAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVS 279
Cdd:PRK11773 151 DEGLRPQ----HIQSYGDPveQTWLKIYQAYQEACDRAGLVDFAELLLRAHELWLNKPHILQHYQERFTHILVDEFQDTN 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 280 PLQQrlldAWL----GERDDLCVVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLTRDYRSHSQVVELANRLLAARRP 355
Cdd:PRK11773 227 AIQY----AWIrllaGDTGKVMIVGDDDQSIYGWRGAQVENIQRFLNDFPGAETIRLEQNYRSTANILKAANALIANNNG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 356 RPDS---TEFSWAPPLKLVSQrgpgvesqwFGYTDderEAEGIAEQIQDLLEkDGVPASEIAVLFRTNGQSGLLEAALAD 432
Cdd:PRK11773 303 RLGKelwTDGGDGEPISLYCA---------FNELD---EARFVVERIKTWQD-NGGALSDCAILYRSNAQSRVLEEALLQ 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 433 RGIPYQLRGAEQFFDRPEVKQAMLALRASAKSTDGSE-----NVP---------RYVREVLEPLGYT----------EK- 487
Cdd:PRK11773 370 AGIPYRIYGGMRFFERQEIKDALAYLRLIANRNDDAAfervvNTPtrgigdrtlDVVRQTARDRQLTlwqacrallqEKv 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 488 -APQSAGAVRQKWE---SLAAIVS------MVDH------LEA-----------TRIEDIAQ---AEAAGAPVPHRLTVH 537
Cdd:PRK11773 450 lAGRAASALQRFIElidALAQETAdmplheQTDRvikdsgLRAmyeqekgekgqARIENLEElvtATRQFSYPDEDEDLT 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 538 DVVATLAHrlA------TQDAPVMEGVTLASLHSAKGLEWDAVFLCGLNEGLMPitFAQTSDE---IDEERRLLYVGITR 608
Cdd:PRK11773 530 PLQAFLSH--AaleageGQADAHEDAVQLMTLHSAKGLEFPLVFIVGMEEGLFP--SQMSLEEggrLEEERRLAYVGITR 605
|
650
....*....|..
gi 503162784 609 ARKYLWFTWSDS 620
Cdd:PRK11773 606 AMQKLTLTYAES 617
|
|
| RecB |
COG1074 |
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, ... |
63-620 |
8.63e-63 |
|
3#-5# helicase subunit RecB of the DNA repair enzyme RecBCD (exonuclease V) [Replication, recombination and repair];
Pssm-ID: 440692 [Multi-domain] Cd Length: 866 Bit Score: 223.69 E-value: 8.63e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 63 EDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRS-LGAVGVQT------ 135
Cdd:COG1074 8 DAQRRALDPLGGSVLVEASAGSGKTYTLVARYLRLLLERGLDPEEILVVTFTRAAAAEMRERIRErLAEAADLEdpdlee 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 136 --------------------RTFHSAALRQLR-YFWPSAIGGSFPDIVKHKAGLITEAAQRL------------------ 176
Cdd:COG1074 88 lararrrlaralenldraaiSTIHSFCQRLLReFAFEAGLDPNFELLDDAEALLLEEAVDDLlreayapldalalarlld 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 177 ---------------------RMSVDRALVRDIAAEIEWAKVSLFTPDTLTPHLHQRNLPSGITPQNMVRLFRA----YE 231
Cdd:COG1074 168 afgrdddsleelllalyklrsRPDWLEELAELDEALEALREALLKAKEALAALREALAAAAAPLLAALLRLLAAvlarYE 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 232 DLKDERNLIDFEDVLLLTVGIIEDDDA--LAATIREQYRHFVVDEYQDVSPLQQRLLDAWLGERDD----LCVVGDASQT 305
Cdd:COG1074 248 RRKRERGLLDFDDLLHRALRLLRDEDApwVAERLRERYRHILVDEFQDTSPLQWEILRRLAGEALAdgrtLFLVGDPKQS 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 306 IYSFTGATSRHLLEFPRRYRGAH---TVRLTRDYRSHSQVVELANRLLAARRPRPDStEFSWAPPLKLVSQRGPGVESQW 382
Cdd:COG1074 328 IYRFRGADPELFLEARRALEGRVdgeRLTLTTNFRSTPEVVDAVNALFAQLMGAGFG-EIPYEPVEALRPGAYPAVELWP 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 383 FGYTD------DEREAEGIAEQIQDLLEKD--------GVPASEIAVLFRTNGQSGLLEAALADRGIPYQLRGAEQFFDR 448
Cdd:COG1074 407 LEPDDvseedaREREARAVAARIRRLLAEGttvegggrPVRPGDIAVLVRTRSEAAAIARALKAAGIPVAASDRLSLFES 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 449 PEVKQAMLALRASAKSTDgsenvPRYVREVL--EPLGYTE------KAPQSAGAVRQKWESLAAIVSMVDHLEATR---- 516
Cdd:COG1074 487 PEVRDLLALLRALLNPED-----DLALAAVLrsPLFGLSDedlaalAADRKGESLWEALRAYERLARALERLRALRelar 561
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 517 -------IEDIAQAEAAGAPV------PHRLTVHDVVATLAHRLATQDAPVMEG-------------------------- 557
Cdd:COG1074 562 rlglaelLERLLEETGLLERLlalpggERRLANLLHLDELLQLALEYEQTGGPGlagflrwlerliedggdeekrrlesd 641
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503162784 558 ---VTLASLHSAKGLEWDAVFLCGLNEglmpitfAQTSDEIDEERRLLYVGITRARKYLWFTWSDS 620
Cdd:COG1074 642 adaVRIMTIHKSKGLEFPVVFLPALRE-------RARAEELAEELRLLYVALTRARDRLVLSGAVK 700
|
|
| PRK10919 |
PRK10919 |
ATP-dependent DNA helicase Rep; Provisional |
61-616 |
2.42e-58 |
|
ATP-dependent DNA helicase Rep; Provisional
Pssm-ID: 182838 [Multi-domain] Cd Length: 672 Bit Score: 208.16 E-value: 2.42e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 61 LDEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGI-ACGkYVPQRVMALTFTTRAAEEMRLRL-RSLG---AVGVQT 135
Cdd:PRK10919 3 LNPGQQQAVEFVTGPCLVLAGAGSGKTRVITNKIAHLIrGCG-YQARHIAAVTFTNKAAREMKERVaQTLGrkeARGLMI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 136 RTFHSAALRQLRYFWpSAIG-----GSFPDivKHKAGLITEAAQRLrMSVDRALVRDIAAEIEWAKVSLFTPdtltphlh 210
Cdd:PRK10919 82 STFHTLGLDIIKREY-AALGmksnfSLFDD--TDQLALLKELTEGL-IEDDKVLLQQLISTISNWKNDLKTP-------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 211 QRNLPSGITPQN--MVRLFRAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLDA 288
Cdd:PRK10919 150 AQAAAGAKGERDriFAHCYGLYDAHLKACNVLDFDDLILLPTLLLQRNEEVRERWQNKIRYLLVDEYQDTNTSQYELVKL 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 289 WLGERDDLCVVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLTRDYRSHSQVVELANRLLAArrpRPDSTEfswappL 368
Cdd:PRK10919 230 LVGSRARFTVVGDDDQSIYSWRGARPQNLVLLSQDFPALQVIKLEQNYRSSGRILKAANILIAN---NPHVFE------K 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 369 KLVSQRGPGVESQWFGYTDDEREAEGIAEQI--QDLLEKdgVPASEIAVLFRTNGQSGLLEAALADRGIPYQLRGAEQFF 446
Cdd:PRK10919 301 RLFSELGYGDELKVLSANNEEHEAERVTGELiaHHFVNK--TQYKDYAILYRGNHQSRVFEKFLMQNRIPYKISGGTSFF 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 447 DRPEVKQAMLALRASAKSTDGSE-----NVPRyvREV----LEPLGytEKAPQS-------------------------- 491
Cdd:PRK10919 379 SRPEIKDLLAYLRVLTNPDDDSAflrivNTPK--REIgpatLQKLG--EWAMTRnkslftasfdmglsqtlsgrgyeslt 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 492 ------AGAVRQ-KWESLAAIVSMVDHL--EATRIEDIAQAEAA-------------------GAPVPHRLTVHDVVATL 543
Cdd:PRK10919 455 rfthwlAEIQRLaEREPVAAVRDLIHGIdyESWLYETSPSPKAAemrmknvnqlfswmtemleGSELDEPMTLTQVVTRF 534
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 503162784 544 AHRLATQDAPVMEG---VTLASLHSAKGLEWDAVFLCGLNEGLMPITFAQTSDEIDEERRLLYVGITRARKYLWFT 616
Cdd:PRK10919 535 TLRDMMERGESEEEldqVQLMTLHASKGLEFPYVYLVGMEEGLLPHQSSIDEDNIDEERRLAYVGITRAQKELTFT 610
|
|
| DEXQc_UvrD |
cd17932 |
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch ... |
62-336 |
2.74e-55 |
|
DEXQD-box helicase domain of UvrD; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. UvrD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350690 [Multi-domain] Cd Length: 189 Bit Score: 186.18 E-value: 2.74e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 62 DEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSL----GAVGVQTRT 137
Cdd:cd17932 1 NPEQREAVTHPDGPLLVLAGAGSGKTRVLTHRIAYLILEGGVPPERILAVTFTNKAAKEMRERLRKLlgeqLASGVWIGT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 138 FHSAALRQLRYFWpsaiggsfpdivkhkagliteaaqrlrmsvdralvrdiaaeiewakvslftpdtltphlhqrnlpsg 217
Cdd:cd17932 81 FHSFALRILRRYG------------------------------------------------------------------- 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 218 itpqnmvrlfrayedlkdernliDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLDAWLGERDDLC 297
Cdd:cd17932 94 -----------------------DFDDLLLYALELLEENPDVREKLQSRFRYILVDEYQDTNPLQYELLKLLAGDGKNLF 150
|
250 260 270
....*....|....*....|....*....|....*....
gi 503162784 298 VVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLTRDY 336
Cdd:cd17932 151 VVGDDDQSIYGFRGADPENILDFEKDFPDAKVIKLEENY 189
|
|
| UvrD-helicase |
pfam00580 |
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural ... |
61-324 |
1.84e-53 |
|
UvrD/REP helicase N-terminal domain; The Rep family helicases are composed of four structural domains. The Rep family function as dimers. REP helicases catalyze ATP dependent unwinding of double stranded DNA to single stranded DNA. Swiss:P23478, Swiss:P08394 have large insertions near to the carboxy-terminus relative to other members of the family.
Pssm-ID: 395462 [Multi-domain] Cd Length: 267 Bit Score: 184.37 E-value: 1.84e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 61 LDEDQRRVASELNGAMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRSL----GAVGVQTR 136
Cdd:pfam00580 1 LNPEQRKAVTHLGGPLLVLAGAGSGKTRVLTERIAYLILEGGIDPEEILAVTFTNKAAREMKERILKLlgkaELSELNIS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 137 TFHSAALRQLRYFWPSA-IGGSFPDIVKH-KAGLITEAAQRLRMSVD--RALVRDIAAEIEWAKVSLFTPdtltphlHQR 212
Cdd:pfam00580 81 TFHSFCLRILRKYANRIgLLPNFSILDELdQLALLKELLEKDRLNLDpkLLRKLELKELISKAKNRLLSP-------EEL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 213 NLPSGITPQNMVRLF-RAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLDAWLG 291
Cdd:pfam00580 154 QQGAADPRDKLAAEFyQEYQERLKENNALDFDDLLLLTLELLRSDPELLEAYRERFKYILVDEFQDTNPIQYRLLKLLAG 233
|
250 260 270
....*....|....*....|....*....|...
gi 503162784 292 ERDDLCVVGDASQTIYSFTGATSRHLLEFPRRY 324
Cdd:pfam00580 234 GHENLFLVGDPDQSIYGFRGADIENILKFEKDF 266
|
|
| UvrD_C |
pfam13361 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
330-618 |
3.95e-33 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 433145 [Multi-domain] Cd Length: 377 Bit Score: 130.99 E-value: 3.95e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 330 VRLTRDYRSHSQVVELANRLLAARRPRpdstefswAPPLKLVSQRGPGVESQWFGYT---DDEREAEGIAEQIQDLLEKD 406
Cdd:pfam13361 1 IHLEINYRSTKNLLKAANEFINNNFGR--------ATIYPKKILAETVEDGEKIKIIeaeTEEEEAEWIALEIKKLVARD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 407 GvPASEIAVLFRTNGQSGLLEAALADRGIPYQLRGAEQFFDRPEVKQAMLALRASAKSTDG------------------- 467
Cdd:pfam13361 73 E-KYNDIAVLTRSNSDADLIEEALKKLGIPYFVVGQTKFFRREEIKDILAYLRLIANKHDSislkrilngpkrgignatl 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 468 -----SENVPRYVREVLEPLGYTEKAPQSA-----------------------------------GAVRQKWES-LAAIV 506
Cdd:pfam13361 152 erireYKKRGLRLSDFINPDTLTYGDPFVIaleqdnivvfdvettgldttedeiiqiaaiklnkkGVVIESFERfLRLKK 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 507 SMVDHLEATRIEDI------AQAEAAGAPVPHRL-TVHDVVAT----------------LAHRLAT--------QDAPVM 555
Cdd:pfam13361 232 PVGDSLQVHGFSDEflqengETPAEALRDFLEKLeNLRELYSIlreyddieetpepedaLRNFLEIatlsnselEGSDIK 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 503162784 556 EGVTLASLHSAKGLEWDAVFLCGLNEGLMPITFAQ-TSDEIDEERRLLYVGITRARKYLWFTWS 618
Cdd:pfam13361 312 ERIPIMTIHQAKGLEFDTVFLAGLEEGIFPSYRSIkDEGNLEEERRLFYVAITRAKKRLYISYS 375
|
|
| AddB |
COG3857 |
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair]; |
78-618 |
9.85e-25 |
|
ATP-dependent helicase/DNAse subunit B [Replication, recombination and repair];
Pssm-ID: 443066 [Multi-domain] Cd Length: 1019 Bit Score: 109.84 E-value: 9.85e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 78 VLAGAGTGKTRAITHRIAYGIACGKY----VPQRvmaltFTTRAAEEMRLRLRSLGAVGVQTRTFHSAALRQLRYFWP-- 151
Cdd:COG3857 3 ILGRAGSGKTTYLLEEIKEELKEGKPiillVPEQ-----MTFQAERALLKRLGLGGSIRAQVLSFSRLAWRVLQETGGat 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 152 ----SAIGGSFpdIVKHkagLITEAAQRL----RMSVDRALVRDIAAEI-EWaKVSLFTPDTLTP--HLHQRNLpsgitp 220
Cdd:COG3857 78 rpllSDAGKRM--LLRK---ILEEHKDELkvfaRAADKPGFIEQLAELItEL-KRYGITPEDLEEaaELLKEKL------ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 221 QNMVRLFRAYEDLKDERnLIDFEDVLLLTVGIIEDDDALaatireQYRHFVVDEYQDVSPLQQRLLDAWLGERDDLCV-- 298
Cdd:COG3857 146 RDLALIYEAYEEKLAGR-YIDSEDLLRLLAEKLEKSEFL------EGAEIYIDGFTDFTPQELELLEALLKKAKEVTItl 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 299 -VGDASQTIYSFTGATSRHLLEFprryrgAHTVRLTRDYRSHSQVVELANRLLaaRRPRPDSTEfswapplklvsqrgpG 377
Cdd:COG3857 219 tLDPDELDLFSATGETYERLLEL------AKENGVEVEFKKSPELAHLERNLF--AYPPEEEPE---------------G 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 378 VesQWFGYTDDEREAEGIAEQIQDLLEKDGVPASEIAVLFR-TNGQSGLLEAALADRGIPYQLRGAEQFFDRPEVKQAML 456
Cdd:COG3857 276 I--EIIEAANRRAEVEAVAREIRRLVREEGYRYRDIAVVVRdLEAYAPLIERVFAEYGIPYFIDEKRPLSHHPLVELILS 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 457 ALRASAK-----------STDGSENVPR--------YVRE------------------------------------VLEP 481
Cdd:COG3857 354 LLELVRSnfryedvfrllKTGLLRPLSReeidrlenYVLAygirgrrwleryleeeeeltdeeeedlerlnelrdrLLEP 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 482 LGYTEKAPQSAGAVRqkwESLAAIVSMVDHLE-ATRIEDIAQAEAAGAPV------------------------PHRLTV 536
Cdd:COG3857 434 LLPLRERLKKAKTVR---EWAEALYEFLEELGvPEKLEEWREAEEAGDLEeareheqawnalielldelvevlgDEKLSL 510
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 537 HDVVATLAHRLATQD----APVMEGVTLASLHSAKGLEWDAVFLCGLNEGLMP---------------------ITFAQT 591
Cdd:COG3857 511 EEFLRILESGLEELTfgliPPSLDQVQVGGLDRARGLDFKAVFVLGLNEGVFParpredgllsdeererlnelgLELPPT 590
|
650 660
....*....|....*....|....*...
gi 503162784 592 SDE-IDEERRLLYVGITRARKYLWFTWS 618
Cdd:COG3857 591 SRErLLEERFLFYRALTRASERLYLSYP 618
|
|
| SF1_C_UvrD |
cd18807 |
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase ... |
338-617 |
1.15e-22 |
|
C-terminal helicase domain of UvrD family helicases; UvrD is a highly conserved helicase involved in mismatch repair, nucleotide excision repair, and recombinational repair. It plays a critical role in maintaining genomic stability and facilitating DNA lesion repair in many prokaryotic species including Helicobacter pylori and Escherichia coli. This family also includes ATP-dependent helicase/nuclease AddA and helicase/nuclease RecBCD subunit RecB, among others. UvrD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350194 [Multi-domain] Cd Length: 150 Bit Score: 94.61 E-value: 1.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 338 SHSQVVELANRLLAARRPRPDStefswapPLKLVSQRGPGVEsqWFGYTDDEREAEGIAEQIQDLLEKDGVPASEIAVLF 417
Cdd:cd18807 1 STKNILDAANSLIKQNKNRPKK-------PLKAGNKSGGPVE--LLLAKDEADEAKAIADEIKRLIESGPVQYSDIAILV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 418 RTNGQSglleaaladrgipyqlrgaeqffdrpevkqamlalrasakstdgsenvpRYVREVLEplgytekapqsagavrq 497
Cdd:cd18807 72 RTNRQA-------------------------------------------------RVIEEALR----------------- 85
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 498 kweslaaivsmvdhleatriediaqaeaagapvphrltvhdvvatlahrlatqdapvmegVTLASLHSAKGLEWDAVFLC 577
Cdd:cd18807 86 ------------------------------------------------------------VTLMTIHASKGLEFPVVFIV 105
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 503162784 578 GLNEGLMPITFAQTSDEID-----EERRLLYVGITRARKYLWFTW 617
Cdd:cd18807 106 GLGEGFIPSDASYHAAKEDeerleEERRLLYVALTRAKKELYLVG 150
|
|
| helD |
PRK11054 |
DNA helicase IV; Provisional |
61-348 |
6.88e-22 |
|
DNA helicase IV; Provisional
Pssm-ID: 182930 [Multi-domain] Cd Length: 684 Bit Score: 100.41 E-value: 6.88e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 61 LDEDQRRvaSELNG--AMRVLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMRLRLRS-LGAVGVQTRT 137
Cdd:PRK11054 197 LNPSQAR--AVVNGedSLLVLAGAGSGKTSVLVARAGWLLARGQAQPEQILLLAFGRQAAEEMDERIRErLGTEDITART 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 138 FHSAAL---RQLRYFWPsAIGGSFPDIVKHKAGLITEAAQRLRM-------------------------SVDRALVRDIA 189
Cdd:PRK11054 275 FHALALhiiQQGSKKVP-VISKLENDSKARHALLIAEWRKQCSEkkaqakgwrqwlteelqwdvpegnfWDDEKLQRRLA 353
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 190 AEIE-WAKVSL-----------FTPDTLTPHLHQR-NLpsgitpqnMVRLFRAYED-LKDErNLIDFEDVLLLTVGIIED 255
Cdd:PRK11054 354 SRLErWVSLMRmhggsqaemiaQAPEEVRDLFQKRlKL--------MAPLLKAWKKaLKAE-NAVDFSGLIHQAVNYLEK 424
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 256 ddalaATIREQYRHFVVDEYQDVSPLQQRLLDAWL--GERDDLCVVGDASQTIYSFTGATSRHLLEFPRRYRGAHTVRLT 333
Cdd:PRK11054 425 -----GRFISPWKHILVDEFQDISPQRAALLAALRkqNSQTTLFAVGDDWQAIYRFSGADLSLTTAFHERFGEGDRCHLD 499
|
330
....*....|....*
gi 503162784 334 RDYRSHSQVVELANR 348
Cdd:PRK11054 500 TTYRFNSRIGEVANR 514
|
|
| recB |
TIGR00609 |
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with ... |
70-620 |
1.09e-20 |
|
exodeoxyribonuclease V, beta subunit; The RecBCD holoenzyme is a multifunctional nuclease with potent ATP-dependent exodeoxyribonuclease activity. Ejection of RecD, as occurs at chi recombinational hotspots, cripples exonuclease activity in favor of recombinagenic helicase activity. All proteins in this family for which functions are known are DNA-DNA helicases that are used as part of an exonuclease-helicase complex (made up of RecBCD homologs) that function to generate substrates for the initiation of recombination and recombinational repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273172 [Multi-domain] Cd Length: 1087 Bit Score: 97.11 E-value: 1.09e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 70 SELNGAMRVLAGAGTGKTRAITH---RIAYGIacGKYVPQRVMALTFTTRAAEEMRLRLRS-----LGAVGVQTR----- 136
Cdd:TIGR00609 6 IPLNGTFLIEASAGTGKTFTIAQlylRLLLEG--GPLTVEEILVVTFTNAATEELKTRIRGrihqaLRALKAALTsqelp 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 137 ------------------------TFHSAA-----------LRQ------------------------LRYFWPSAIGGS 157
Cdd:TIGR00609 84 eplkeaiqdekvkqaitrlrnalaTMDEAAiytihgfcqrmLEQhafesdeifdveliedeslllaeiTKDFWRRNFYNL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 158 FPDIVKH--------KAGLITEAAQRLRMSVD--RALVRDIAAEIEWAKVSLFTPDTLTP----HLHQRNLPSGITPQNM 223
Cdd:TIGR00609 164 PFDIAQIvlktkkspQAVLTQILADLLLQSYLafPSPPLDLEQLIKWHEQIYKDLDKLDHavfeEIDKLNAERNNLFCLK 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 224 VRLF-RAYEDL-------KDERNLIDFEDVL--LLTVGIIEDDDALAATIREQYRHFVVDEYQDVSPLQQRLLD-AWL-G 291
Cdd:TIGR00609 244 DRVFlTLLKEVqeelkkeKKRRREIGFDDLLsrLETALKSAEGEKLAQAIREQYPIALIDEFQDTDPQQYRIFSkLFIaQ 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 292 ERDDLCVVGDASQTIYSFTGATSRHLLE----FPRRYrgahtvRLTRDYRSHSQVVELANRLLA-ARRP---RPDSTEFS 363
Cdd:TIGR00609 324 KETSLFLIGDPKQAIYSFRGADIFTYLQakskADARY------TLGTNWRSTPALVGSLNKLFSlISNPfleKPIFIPVL 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 364 WAPPLKLVSQRGPGVESQWFGYTDDEREAEGI-----------AEQIQDLLEKDG--------------VPASEIAVLFR 418
Cdd:TIGR00609 398 AHQKNSKGSFVINGQEQPPIHFFTTEVESEGVddyrqtiaqkcAREIALWLASAAlglanfiatfggrpLRAGDIAVLVR 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 419 TNGQSGLLEAALADRGIPYQLRGAEQFFDRPEVKQAMLALrasakstdgsenvpryvrevLEPLGYtekaPQSAGAVRqk 498
Cdd:TIGR00609 478 GRKEANQIRKALKKAQIPSVYLSDKSSVFATEEAQELLAL--------------------LEALLE----PENEGTLR-- 531
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 499 weslAAIVSMVDHLEATRIEDIAQAEAAG-------------------APVPHR--------------------LTVHDV 539
Cdd:TIGR00609 532 ----AALASSIFGLSALELETLNQDEITWervvekfreyhdiwrkigvLAMFQRlmlekgigerllsqpggeriLTNLLH 607
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 540 VATLAHRLATQ------------------------------DAPVMEGVTlasLHSAKGLEWDAVFL------------- 576
Cdd:TIGR00609 608 LAELLQEAAHQernklsllrwledqisneeeeeeeiirlesDAELVKIVT---IHKSKGLEYPIVFLpfitdakksnfas 684
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....
gi 503162784 577 ---------CGLNEGLMPITFAQTSDEI-DEERRLLYVGITRARKYLWFTWSDS 620
Cdd:TIGR00609 685 lhdqhsheyQLYDFNQSEENQKLARVERlAEDLRLLYVALTRAKKQLFIGIAPL 738
|
|
| COG3972 |
COG3972 |
Superfamily I DNA and RNA helicases [Replication, recombination and repair]; |
54-610 |
6.82e-19 |
|
Superfamily I DNA and RNA helicases [Replication, recombination and repair];
Pssm-ID: 443172 [Multi-domain] Cd Length: 565 Bit Score: 90.66 E-value: 6.82e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 54 PEDILAGLDEDQRRVASELNGAMRVLAG-AGTGKTRAITHRIAYGIAcgKYVPQRVMALTFTtraaeemrlrlRSLgavg 132
Cdd:COG3972 153 FLPLIAVLDLQQERIARSIPDGPQRIRGvAGSGKTVLLAAKAAYLAL--KHPGWRILVTCFN-----------RSL---- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 133 vqtrtfhsaalrqlryfwpsaiggsfpdivkhkagliteaAQRLRMSVDRALvRDIAAEIEWAKVSLFtpdtltpHLHQ- 211
Cdd:COG3972 216 ----------------------------------------ADHLRDLIPRFL-RRFSNGEPEDNVKLI-------VFHAw 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 212 --RNLPS-GITPQNMVRLFRAYEDLkdernlidFEDVLlltvgiiedDDALAATIREQYRHFVVDEYQDVSPLQQRLLDA 288
Cdd:COG3972 248 ggKLLKQyGIPPLTFSQPNEAFDEA--------CKALL---------EAIQGEIIPPIYDAILIDEAQDFEPEFLRLLYQ 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 289 WL-GERDDLCVVGDASQTIYSFTgATSRHLLEFPRRyrgaHTVRLTRDYRSHSQVVELANRL----------LAARRPRP 357
Cdd:COG3972 311 LLkPPKKRLIWAYDEAQNIYGRK-IPSAGGIPAGIG----RDTILKKNYRNTRPILTFAHAFgmgllrppglLQGDAEDY 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 358 DSTEFSWAPPLKLVSQ----RGPGVEsqWFGYTDDEREAEGIAEQIQDLLEKDGVPASEIAVLFRTNGQSGLLEAALADr 433
Cdd:COG3972 386 EVERPGDKVTLIRPPEpagrKGPLPE--FKKYDDRAEELEAIAEEIKKNLRDEGLRPSDIAVIYLGNNEAKELGDRLAA- 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 434 gipyqlrgaeqffdrpevkqamlalrasakstdgsenvpryvrevleplgytekapqsagavrqkweslaaivsmvdHLE 513
Cdd:COG3972 463 -----------------------------------------------------------------------------ALE 465
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 514 ATRIE-DIAQAEAagapVPHRLTVHDvvatlahrlatqdapvmeGVTLASLHSAKGLEWDAVFLCGLNEglmpitFAQTS 592
Cdd:COG3972 466 RQGIDsYIAGARS----DPNFFWKDG------------------GVTISTIHRAKGLEAPVVIIVGLDQ------LAKGE 517
|
570
....*....|....*...
gi 503162784 593 DEIDEeRRLLYVGITRAR 610
Cdd:COG3972 518 SLERL-RNLLYVAMTRAR 534
|
|
| HelD |
COG3973 |
DNA helicase IV [Replication, recombination and repair]; |
56-444 |
4.42e-18 |
|
DNA helicase IV [Replication, recombination and repair];
Pssm-ID: 443173 [Multi-domain] Cd Length: 699 Bit Score: 88.38 E-value: 4.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 56 DILAGLDEDQRR-VASELNGAMRVLAGAGTGKTRAITHRIAYgiacgkyvpqrvmaLTFTTR---AAEEM------RLRL 125
Cdd:COG3973 187 DIVATIQAEQDRiIRADLRGVLVVQGGAGSGKTAVALHRAAY--------------LLYTHRerlERGGVlivgpnRLFL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 126 R-------SLGAVGVQTRTFHSAALRQLR-------YFWPSAIGGS--FPDIVKH-----------------------KA 166
Cdd:COG3973 253 DyisqvlpSLGEEGVVQTTFGDLVPELLGveataeeDPEVARLKGSlrMAEVLDRavrdlerevpfedirveggevilSA 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 167 GLITEA----------AQRLRMSVDR----------------------ALVRDIAAEIEWAKV--SLFTPDTLTPHLHQ- 211
Cdd:COG3973 333 EEIAEAfyrarrslphNKRRERLRERlldalkdqlaaelgklwdeerdELRRELRRSKPVRAAlnRLWPFLDPAELYRDl 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 212 -------RNLPSGITPQNMVRLFRAYEDLKDERnlIDFEDVLLLtvgiieddDALAATI-----REQYRHFVVDEYQDVS 279
Cdd:COG3973 413 fsdpellARAAGWLSPEERALLLRPTRELKKGR--WTVADVALL--------DELAELLggpdrTWTYGHVVVDEAQDLS 482
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 280 PLQQRLLdAWLGERDDLCVVGDASQTIYSFTGATS-RHLLE--FPRRyrgAHTVRLTRDYRSHSQVVELANRLLAARRPR 356
Cdd:COG3973 483 PMQWRVL-KRRFPSASFTIVGDLAQAIHPYRGAESwEEVLEplGGDR---ARLVELTKSYRSTAEIMEFANRVLRAAGPD 558
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 357 pdstefswAPPLKLVsqRGPGVESQWFGYTDDEREAEGIAEQIQDLLEKDGvpASeIAVLFRTNGQSGLLEAALADrGIP 436
Cdd:COG3973 559 --------LPPPESV--RRHGEPPRVVRVPSEAELAAAVVEAVRELLAEGE--GT-IAVICKTAREAEALYAALKA-GLP 624
|
....*...
gi 503162784 437 YQLRGAEQ 444
Cdd:COG3973 625 VTLIDDES 632
|
|
| addA_alphas |
TIGR02784 |
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, ... |
225-613 |
7.98e-15 |
|
double-strand break repair helicase AddA, alphaproteobacterial type; AddAB, also called RexAB, substitutes for RecBCD in several bacterial lineages. These DNA recombination proteins act before synapse and are particularly important for DNA repair of double-stranded breaks by homologous recombination. The term AddAB is used broadly, with AddA homologous between the alphaproteobacteria (as modeled here) and the Firmicutes, while the partner AddB proteins show no strong homology across the two groups of species. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 274298 [Multi-domain] Cd Length: 1135 Bit Score: 78.19 E-value: 7.98e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 225 RLFRAYEDLKDERNLIDFEDVLLLTVGIIEDDDALAATireQYR------HFVVDEYQDVSPLQ----QRLLD---AWLG 291
Cdd:TIGR02784 346 RLLQRYARLKKARGLLDFNDLIERTVALLARPGAGAWV---HYKldrgidHILVDEAQDTSPEQwdiiQALAEeffSGEG 422
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 292 ERDD----LCVVGDASQTIYSFTGATSRHLLE----FPRRYRGA----HTVRLTRDYRSHSQVVELANRLLAARRPRPDS 359
Cdd:TIGR02784 423 ARSGvertIFAVGDEKQSIYSFQGADPERFAEerreFSRKVRAVgrkfEDLSLNYSFRSTPDVLAAVDLVFADPENARGL 502
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 360 TEFSWAPPLKLVSQRGPGV--------------ESQWFGYTDDERE-------AEGIAEQIQDLLEKdGVP--------- 409
Cdd:TIGR02784 503 SADSDAPVHEAFRDDLPGRvdlwdliskeegeePEDWTDPVDELGErapevrlAERIAAEIRAWLDR-GTPipgrgravr 581
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 410 ASEIAVLFRTngQSGLLEA---ALADRGIPyqLRGAE--QFFDRPEVKQAMLALRASAKSTDGSEnvpryVREVLE-PL- 482
Cdd:TIGR02784 582 PGDILVLVRK--RDAFFSAlirALKRRGIP--VAGADrlKLTSHIAVKDLMALGRFVLQPEDDLS-----LAALLKsPLf 652
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 483 GYTEK------APQSAG----AVRQKWESLAAIVSMVDHLEatriediaqAEAAGAPvPHR-----LTVHDVVATLAHRL 547
Cdd:TIGR02784 653 GLDEDdlfrlaAGRSGGslwaALRRREAEFAATLAVLRDWL---------SLADFLT-PFEfyarlLGRDGGRRKLLARL 722
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 548 ATQ------------------DAPVMEG--VTLASL--------------------HSAKGLEWDAVFLC---------- 577
Cdd:TIGR02784 723 GAEaedildeflsqalayertGLPGLQAflSWLEADdpeikremdqardevrvmtvHGAKGLEAPVVFLVdtgskpfasq 802
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 578 --------GLNEGLMP----------------ITFAQTSDEiDEERRLLYVGITRARKYL 613
Cdd:TIGR02784 803 raplllatGGSGGKAPlwrpasafdpslsaaaRERLKERAE-DEYRRLLYVAMTRAEDRL 861
|
|
| AAA_19 |
pfam13245 |
AAA domain; |
65-309 |
2.38e-12 |
|
AAA domain;
Pssm-ID: 433059 [Multi-domain] Cd Length: 136 Bit Score: 64.55 E-value: 2.38e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 65 QRR-VASELN-GAMRVLAGAGTGKTRAITHRIAYGIACGKyVPQRVMALTFTTRAAEEMRLRLrslgavGVQTRTFHSaa 142
Cdd:pfam13245 1 QREaVRTALPsKVVLLTGGPGTGKTTTIRHIVALLVALGG-VSFPILLAAPTGRAAKRLSERT------GLPASTIHR-- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 143 lrqlryfwpsaiggsfpdivkhkagliteaaqrlrmsvdralvrdiaaeiewakvslftpdtltphlhqrnlpsgitpqn 222
Cdd:pfam13245 --------------------------------------------------------------------------------
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 223 mvrlfrayedlkdernLIDFEDvlLLTVGIIEDDDalaatIREQYRHFVVDEYQDVS-PLQQRLLDAWLgERDDLCVVGD 301
Cdd:pfam13245 72 ----------------LLGFDD--LEAGGFLRDEE-----EPLDGDLLIVDEFSMVDlPLAYRLLKALP-DGAQLLLVGD 127
|
....*...
gi 503162784 302 ASQTIYSF 309
Cdd:pfam13245 128 PDQLPSVG 135
|
|
| PRK13909 |
PRK13909 |
RecB-like helicase; |
229-577 |
7.02e-12 |
|
RecB-like helicase;
Pssm-ID: 237554 [Multi-domain] Cd Length: 910 Bit Score: 68.84 E-value: 7.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 229 AYEDLKDERNLIDFEDVLLLT---VGIIEDD-DALAATIREQYRHFVVDEYQDVSPLQQRLLD-------AWLGERDDLC 297
Cdd:PRK13909 287 AKNELNKKKNALDFDDISKKVyelLGEEEIDkDFLYFRLDSKISHILIDEFQDTSVLQYKILLplideikSGEGQKKFRS 366
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 298 V--VGDASQTIYSFTGAtSRHLLEFPRRYRGAHTVRLTRDYRSHSQVVELANRLLAARRPRpdsteFSWAPPLKLVSQrg 375
Cdd:PRK13909 367 FfyVGDVKQSIYRFRGG-KKELFDKVSKDFKQKVDNLDTNYRSAPLIVDFVNEVFKKKYKN-----YKTQYAEQHKSG-- 438
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 376 pgvesqwfGY-----TDDEREA--EGIAEQIQDLLEKdGVPASEIAVLFRTNGQSGLLEAALADR-GIPYQLRGAEQFFD 447
Cdd:PRK13909 439 --------GYvevveVADESEEllEQLLQEIQFLLEK-GIDPDDIAILCWTNDDALEIKEFLQEQfGIKAVTESSAKLIN 509
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 448 RPEVKqamlALRASAKSTDGSENVprYVREVLEPLGYTEKAPQSAGAVRQkweSLAAIVSMV-DHLEatrIEDiaqaEAA 526
Cdd:PRK13909 510 QPEVK----ALIEALKYCLFGEEI--YKHNVLKLLGKEPDKIPSFLPKEE---SVAEFVKKLiEELK---LYD----ENL 573
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 503162784 527 GAPVPHRLTVHDVVaTLAHRLATQDAPVM----EGVTLASLHSAKGLEWDAVFLC 577
Cdd:PRK13909 574 LKFLELASGYEDIE-EFLFKLEPCDKEIAseesKGVQIMTVHKSKGLEFEHVIVC 627
|
|
| UvrD_C_2 |
pfam13538 |
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety ... |
558-614 |
1.13e-09 |
|
UvrD-like helicase C-terminal domain; This domain is found at the C-terminus of a wide variety of helicase enzymes. This domain has a AAA-like structural fold.
Pssm-ID: 463913 [Multi-domain] Cd Length: 52 Bit Score: 54.12 E-value: 1.13e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 503162784 558 VTLASLHSAKGLEWDAVFLcglnegLMPITFAqtSDEIDEERRLLYVGITRARKYLW 614
Cdd:pfam13538 2 AYALTVHKAQGSEFPAVFL------VDPDLTA--HYHSMLRRRLLYTAVTRARKKLV 50
|
|
| recB |
PRK10876 |
exonuclease V subunit beta; Provisional |
257-457 |
2.00e-09 |
|
exonuclease V subunit beta; Provisional
Pssm-ID: 236784 [Multi-domain] Cd Length: 1181 Bit Score: 60.75 E-value: 2.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 257 DALAATIREQYRHFVVDEYQDVSPLQQRLLDAWLGERDD--LCVVGDASQTIYSFTGATsrhLLEFPR-RYRGAHTVRLT 333
Cdd:PRK10876 368 EALAAAIRTRYPVAMIDEFQDTDPQQYRIFRRIYRHQPEtaLLLIGDPKQAIYAFRGAD---IFTYMKaRSEVSAHYTLD 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 334 RDYRSHSQVVELANRLLaARRPRP-----------------DSTEFSWA----PPLKLVSQRGPGVesqwfGYTDDERE- 391
Cdd:PRK10876 445 TNWRSAPGMVNSVNKLF-SQTDDPflfreipfipvkaagknQALRFVVKgetqPAMKFWLMEGEGV-----GVGDYQQTm 518
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 392 AEGIAEQIQD----------LLEKDG----VPASEIAVLFRTNGQSGLLEAALADRGIP--YqLRGAEQFFDRPEVK--- 452
Cdd:PRK10876 519 AQQCAAQIRDwlqagqrgeaLLMNGDdsrpVRASDITVLVRSRQEAALIRDALTLLAIPsvY-LSNRDSVFETLEAQeml 597
|
....*...
gi 503162784 453 ---QAMLA 457
Cdd:PRK10876 598 wllQAVLA 605
|
|
| DExxQc_SF1-N |
cd17914 |
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members ... |
78-122 |
8.54e-07 |
|
DEXQ-box helicase domain of superfamily 1 helicase; The superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Like SF2, they do not form toroidal, predominantly hexameric structures like SF3-6. Their helicase core is surrounded by C and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains or domains engaged in protein-protein interactions. SF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438706 [Multi-domain] Cd Length: 121 Bit Score: 48.25 E-value: 8.54e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 503162784 78 VLAGAGTGKTRAITHRIAYGIACGKYVPQRVMALTFTTRAAEEMR 122
Cdd:cd17914 4 IQGPPGTGKTRVLVKIVAALMQNKNGEPGRILLVTPTNKAAAQLD 48
|
|
| SF1_C |
cd18786 |
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family ... |
558-616 |
2.31e-06 |
|
C-terminal helicase domain of superfamily 1 DEAD/H-box helicases; Superfamily (SF)1 family members include UvrD/Rep, Pif1-like, and Upf-1-like proteins. Similar to SF2 helicases, they do not form toroidal, predominantly hexameric structures like SF3-6. SF1 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350173 [Multi-domain] Cd Length: 89 Bit Score: 45.89 E-value: 2.31e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 503162784 558 VTLASLHSAKGLEWDAVFLCGLNEGlmpitfaqtsdeiDEERRLLYVGITRARKYLWFT 616
Cdd:cd18786 43 VGAITIDSSQGLTFDVVTLYLPTAN-------------SLTPRRLYVALTRARKRLVIY 88
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| SF1_C_RecD |
cd18809 |
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11. ... |
564-615 |
5.88e-04 |
|
C-terminal helicase domain of RecD family helicases; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD family helicases are DEAD-like helicases belonging to superfamily (SF)1, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF2 helicases, SF1 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350196 [Multi-domain] Cd Length: 80 Bit Score: 39.08 E-value: 5.88e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 503162784 564 HSAKGLEWDAVFLCGLNEGLMpitfaqtsdeidEERRLLYVGITRARKYLWF 615
Cdd:cd18809 39 HKSQGSEFDRVIVVLPTSHPM------------LSRGLLYTALTRARKLLTL 78
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| DEAD-like_helicase_N |
cd17912 |
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ... |
78-121 |
9.25e-04 |
|
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.
Pssm-ID: 350670 [Multi-domain] Cd Length: 81 Bit Score: 38.65 E-value: 9.25e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 503162784 78 VLAGAGTGKTRAITHRIAYGIACGKyvpqRVMALTFTTRAAEEM 121
Cdd:cd17912 4 HLGPTGSGKTLVAIQKIASAMSSGK----SVLVVTPTKLLAHEI 43
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| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
55-189 |
7.94e-03 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 37.87 E-value: 7.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 503162784 55 EDILAGLDEDQrrvaselngAMRVLAGAGTGKTRAIT---HRIAYG-----IACGKyvPQRVMALTFTTRAAEEMRLRLR 126
Cdd:cd17974 8 DDLLAAVKEHQ---------VLIIVGETGSGKTTQIPqylHEAGYTkgggkIGCTQ--PRRVAAMSVAARVAEEMGVKLG 76
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 503162784 127 SlgAVGVQTRTFHSAALRQ-LRYFWPSAIGGSF---PDIVKHKAGLITEAAQR-LRMSVDRALVRDIA 189
Cdd:cd17974 77 N--EVGYSIRFEDCTSEKTvLKYMTDGMLLREFltePDLASYSVMIIDEAHERtLHTDILFGLVKDIA 142
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