|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-625 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 626.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRgFVR---DNLPIIPDTFTLVPrqvr 77
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLKPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDER-YKRwrlEDLPIIPEKWKLVV---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 78 tekgyKPDSGvvSQIKVIKRLF-DASEqIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLEDGS 156
Cdd:PRK07726 76 -----KKKTA--KQFNVVKKLLkQATE-IVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 157 KYDNLYLTAKARSESDWLVGINGTQALSIAAGHGTY----SVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIATDGCDG 232
Cdd:PRK07726 148 ETIPLYYSALARSRADWLVGINMTRAYTLLGRKAGYngvlSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 233 EIVKFSSSEKWKEKES---AMELYNKVK---EAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQK 306
Cdd:PRK07726 228 FTAKWQPSEPYQDEEGrllDRPLAEQVVariQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQS 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 307 LYEK-KLITYPRTGSRYIPEDVYAEIPKLLAFIGTQPEWKDKVRAKATPTRRS--VDDGKVTDHHALLVTGEKPLF--LS 381
Cdd:PRK07726 308 LYEThKLITYPRTDSRYLPEDMVATLPEVLNAISKVDPYLLLAPPVLDPSIRSraWNDKKVTAHHAIIPTEQPPNLskLS 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 382 KEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEKED----VILPDLHEGDYLTIKG 457
Cdd:PRK07726 388 EDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDeekeQPLPVLAKGDELKVEK 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 458 VSVTEGRTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDC-GIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLAL 536
Cdd:PRK07726 468 GEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQL 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 537 NSVVKTMrIADVAMTGEWERELARIERGEVSADAFHREIEAYTREITSELLSCDKLFGSRD-SGCACPKCGtGRMRFY-- 613
Cdd:PRK07726 548 IDALPEE-LTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYKFDNlTGPKCPDCG-KPMLKVkg 625
|
650
....*....|....
gi 498224087 614 --GKVVRCDNAECG 625
Cdd:PRK07726 626 knGKMLVCQDRECG 639
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-582 |
1.21e-176 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 514.64 E-value: 1.21e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGAtkreegyfeggGYAVTWAFGHLVQLAMPDGYgvrgfVRDNLPIIPDtftlvprqvrtek 80
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGK-----------DYVVTASVGHLRDLPKPELD-----VDVENDFEPK------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 81 gYKPDSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLEDgsKYDN 160
Cdd:COG0550 52 -YEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPRD--IDMN 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 161 LYLTAKARSESDWLVGINGTQALSIAAGHGTySVGRVQTPTLAMVCERYWENRRFTPEAFWQLHiATDGCDGEIVKFS-- 238
Cdd:COG0550 129 LVDAQQARRILDRLVGYNLSPLLWKKVKRGL-SAGRVQSPALRLIVEREREIEAFVPEEYWTIE-ATFKTGGGEFTAKlv 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 239 --SSEKWKEKESAMELYNKVKEAGcATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYP 316
Cdd:COG0550 207 kiDGKKILDEEEAEAILAALKGKT-FTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYM 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 317 RTGSRYIPEDVYAEIPKllaFIGTQpewKDKVRAKATPTRRSVDDGKVTDHHALLVTGEKPLF--LSKEDGILYHMIAGR 394
Cdd:COG0550 286 RTDSVRLSEDAVAAARE---YIEAL---YGKEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPesLSGDEFKLYDLIWKR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 395 MVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEK------EDVILPDLHEGDYLTIKGVSVTEGRTKPK 468
Cdd:COG0550 360 FLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeeEEKRLPPLKEGEKLKLKKIEPEQHFTKPP 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 469 PLHTEATLLSAMETAgkeieddalrqamkdcGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTM--RIA 546
Cdd:COG0550 440 PRYTEASLVKAMEEL----------------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHfpDLV 503
|
570 580 590
....*....|....*....|....*....|....*.
gi 498224087 547 DVAMTGEWERELARIERGEVSADAFHREIEAYTREI 582
Cdd:COG0550 504 DYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKEL 539
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-632 |
4.80e-161 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 479.34 E-value: 4.80e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGATKREEGYFEGG-GYAVTWAFGHLVQLAMPDGYGVR--GFVRDNLPIIPDTFTLVPRqvr 77
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKKKKGNGYLEIGvGGFVTWAVGHLVELAEPEEYDEKykNWRTYDLPLEPEDWQLVVS--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 78 tekgykPDSGvvSQIKVIKRLFDASE--QIIVATDAGREGELIFRYLYHYTGST--TPFVRLWISSLTDKAIREGLRKLE 153
Cdd:TIGR01056 78 ------DKTK--KQFNVIKRILKENKvdEVVIATDPDREGELIAREILDYLKVTdkVTIKRLWISSLVDSSIRKAFKNLR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 154 DGSKYDNLYLTAKARSESDWLVGINGTQALSI----AAGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQL--HIAT 227
Cdd:TIGR01056 150 PKSETEGLYKSGVARARADWLVGINLTRAFTKlgreAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVsaTINK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 228 DGcdgeiVKFSSSEKWKEKESAMELYNKVKE-------AGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQT 300
Cdd:TIGR01056 230 DE-----QEFTTEWQPYKDEEERELHEFLAEnvvtdltQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 301 LETAQKLYEK-KLITYPRTGSRYIPEDVYAEIPKLLAFIGTQPEWKDKVRAKATPTR-RSVDDGKVTDHHALLVTGEKPL 378
Cdd:TIGR01056 305 LDIAQKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLPIKKRDELTNnRLWNDKKIEDHHAIIPTGNDFN 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 379 F--LSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYG-----EEKEDVILPDLHEGD 451
Cdd:TIGR01056 385 LsdLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGkqeedEETEDTTLPAFQKGD 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 452 YLTIKGVSVTEGRTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDC-GIGTPATRASIIETLFKRGYMERCKKSLVPT 530
Cdd:TIGR01056 465 ELDVETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETkGLGTEATRADIIENLFKRGFIQKKKNKIYIT 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 531 EKGLALNSVVKTMrIADVAMTGEWERELARIERGEVSADAFHREIEAYTREITSELLSCDKLF-------GSRDSGCACP 603
Cdd:TIGR01056 545 KNGKLLCLLLPEL-LTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEKKNPETIqkvakepVSCGGIAKCP 623
|
650 660 670
....*....|....*....|....*....|...
gi 498224087 604 KCGTGRMRFYGKVVRCD----NAECGLPVFRLK 632
Cdd:TIGR01056 624 AKDNGRLIDCKKFPECTeygnGCEFTIPKKLRE 656
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
156-571 |
2.63e-157 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 460.17 E-value: 2.63e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 156 SKYDNLYLTAKARSESDWLVGINGTQALSIAA-GHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLH-IATDGCDGE 233
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEaTLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 234 IVKFSSSEKWKEKESAMELYNKVKeAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEK-KL 312
Cdd:pfam01131 81 ANAKWKRGRIFDKEEAEAILEKLK-KGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 313 ITYPRTGSRYIPEDvyAEIPKLLAFIGTQP-EWKDKVRAKATPTRR--SVDDGKVTDHHALLVTGEKPL--FLSKEDGIL 387
Cdd:pfam01131 160 ITYPRTDSTYLSDD--ATLKAILEYLTKNYgKYLPYAPRLLKKTKGklTVGNAKVTAHEAIRPTGDIPVlpELSDDERKL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 388 YHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYG--EEKEDVILPDLHEGDYLTIKGVSVTEGRT 465
Cdd:pfam01131 238 YELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPyeKKEDEEELPELKEGEELKVTQVEVEEKKT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 466 KPKPLHTEATLLSAMETagkeieddalrqamkdCGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTM-R 544
Cdd:pfam01131 318 KPPPRYTEASLIKAMEK----------------AGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEALEKFpD 381
|
410 420
....*....|....*....|....*..
gi 498224087 545 IADVAMTGEWERELARIERGEVSADAF 571
Cdd:pfam01131 382 LVDPELTAELEEKLDEIAEGKLDWKDV 408
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
160-582 |
6.07e-106 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 327.25 E-value: 6.07e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 160 NLYLTAKARSESDWLVGINGTQALSIA-AGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWqlhiatdgcdgeivkfs 238
Cdd:cd00186 2 NLVNAQLARRILDRLVGFNLSRLLTKKlRRKGVLSAGRVQSPTLGLIVEREREIKAFVPEDYW----------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 239 ssekwkekesamelynKVKEAgcaTVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYPRT 318
Cdd:cd00186 65 ----------------EIKEA---VVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRT 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 319 GSRYIPEDvyaEIPKLLAFIGTQ-PEWKDKVRAKATPTRRSVDDGKVTDHHALLVTGEKPL-----FLSKEDGILYHMIA 392
Cdd:cd00186 126 DSTRLSEE---AILEAREYIQAIyGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTpeleaNLSEDEFKLYELIW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 393 GRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEK--EDVILPDLHEGDYLTIKGVSVTEGRTKPKPL 470
Cdd:cd00186 203 RRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKddEEEEPPPLKEGDELKLEEVELEEKETQPPPR 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 471 HTEATLLSAMETAgkeieddalrqamkdcGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTM--RIADV 548
Cdd:cd00186 283 YTEASLIKLMEKR----------------GIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHfpELVDP 346
|
410 420 430
....*....|....*....|....*....|....
gi 498224087 549 AMTGEWERELARIERGEVSADAFHREIEAYTREI 582
Cdd:cd00186 347 EFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKI 380
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
268-536 |
3.83e-73 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 237.14 E-value: 3.83e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 268 ERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYPRTGSRYIPEDvyaEIPKLLAFIGTQ--PEWK 345
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEE---AVLEARNYIQKLygKEYL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 346 DKVRAKATPTRRSVDDGKVTDHHALLVTG-----EKPLFLSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFT 420
Cdd:smart00437 78 DLAVVLLKPRKPRKGKKAQGAHEAIRPTKpiftpELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 421 VKGSVVKQAGWRAVYGEEK--EDVILPDLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLSAMETAgkeieddalrqamkd 498
Cdd:smart00437 158 AKGKTLLFDGWLKVYPEEKkeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKR--------------- 222
|
250 260 270
....*....|....*....|....*....|....*...
gi 498224087 499 cGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLAL 536
Cdd:smart00437 223 -GIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
624-682 |
3.64e-19 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 81.37 E-value: 3.64e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 498224087 624 CGLPVFRLKAGRTLSDDEIKDLLTEGHTKLLKGFKSKQGKSFDAVVAFDGEYNMTFVFP 682
Cdd:pfam13342 2 CGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKSKKGKKFDAYLVLDDDEKVEFDFE 60
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK07726 |
PRK07726 |
DNA topoisomerase 3; |
1-625 |
0e+00 |
|
DNA topoisomerase 3;
Pssm-ID: 236078 [Multi-domain] Cd Length: 658 Bit Score: 626.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRgFVR---DNLPIIPDTFTLVPrqvr 77
Cdd:PRK07726 1 MRLFIAEKPSVGRDIADVLKPHKKGDGYIEGNGYIVTWAIGHLLELAEPEAYDER-YKRwrlEDLPIIPEKWKLVV---- 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 78 tekgyKPDSGvvSQIKVIKRLF-DASEqIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLEDGS 156
Cdd:PRK07726 76 -----KKKTA--KQFNVVKKLLkQATE-IVIATDADREGELIAREILDYCGVRKPIKRLWISSLTDKAIKRAFANLKPGK 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 157 KYDNLYLTAKARSESDWLVGINGTQALSIAAGHGTY----SVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIATDGCDG 232
Cdd:PRK07726 148 ETIPLYYSALARSRADWLVGINMTRAYTLLGRKAGYngvlSVGRVQTPTLALVVRRDEEIENFVPKPYWEVEAHLTPGER 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 233 EIVKFSSSEKWKEKES---AMELYNKVK---EAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQK 306
Cdd:PRK07726 228 FTAKWQPSEPYQDEEGrllDRPLAEQVVariQGQPAKVTEVETKRKKEYAPLLYDLSELQIDANKRFGLSAKETLDIAQS 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 307 LYEK-KLITYPRTGSRYIPEDVYAEIPKLLAFIGTQPEWKDKVRAKATPTRRS--VDDGKVTDHHALLVTGEKPLF--LS 381
Cdd:PRK07726 308 LYEThKLITYPRTDSRYLPEDMVATLPEVLNAISKVDPYLLLAPPVLDPSIRSraWNDKKVTAHHAIIPTEQPPNLskLS 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 382 KEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEKED----VILPDLHEGDYLTIKG 457
Cdd:PRK07726 388 EDERKVYDLIARRYLAQFLPPAEYDKTTIELEIAGGTFIAKGKQVVEAGWKALLGKKEEDeekeQPLPVLAKGDELKVEK 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 458 VSVTEGRTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDC-GIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLAL 536
Cdd:PRK07726 468 GEVKEGQTQPPKRFTEGTLLSAMENIARFVQDKELKKTLKETdGLGTEATRAGIIEKLFKRGYLEKKGKYIHATDKGKQL 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 537 NSVVKTMrIADVAMTGEWERELARIERGEVSADAFHREIEAYTREITSELLSCDKLFGSRD-SGCACPKCGtGRMRFY-- 613
Cdd:PRK07726 548 IDALPEE-LTSPDMTAKWEQALDQISEGQLSYQDFMQPLKQWLKQLVEQAKQSSEKYKFDNlTGPKCPDCG-KPMLKVkg 625
|
650
....*....|....
gi 498224087 614 --GKVVRCDNAECG 625
Cdd:PRK07726 626 knGKMLVCQDRECG 639
|
|
| TopA |
COG0550 |
DNA topoisomerase IA [Replication, recombination and repair]; |
1-582 |
1.21e-176 |
|
DNA topoisomerase IA [Replication, recombination and repair];
Pssm-ID: 440316 [Multi-domain] Cd Length: 541 Bit Score: 514.64 E-value: 1.21e-176
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGAtkreegyfeggGYAVTWAFGHLVQLAMPDGYgvrgfVRDNLPIIPDtftlvprqvrtek 80
Cdd:COG0550 1 KKLVIVESPAKAKTIAKYLGK-----------DYVVTASVGHLRDLPKPELD-----VDVENDFEPK------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 81 gYKPDSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLEDgsKYDN 160
Cdd:COG0550 52 -YEVIPGKKKQVKELKKLAKKADEVILATDPDREGEAIAWHLLELLGDKKPVKRVVFNEITKKAIKEAFKNPRD--IDMN 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 161 LYLTAKARSESDWLVGINGTQALSIAAGHGTySVGRVQTPTLAMVCERYWENRRFTPEAFWQLHiATDGCDGEIVKFS-- 238
Cdd:COG0550 129 LVDAQQARRILDRLVGYNLSPLLWKKVKRGL-SAGRVQSPALRLIVEREREIEAFVPEEYWTIE-ATFKTGGGEFTAKlv 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 239 --SSEKWKEKESAMELYNKVKEAGcATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYP 316
Cdd:COG0550 207 kiDGKKILDEEEAEAILAALKGKT-FTVTSVEKKPKKRNPPPPFTTSTLQQEASRKLGFSAKKTMSIAQRLYEVGLITYM 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 317 RTGSRYIPEDVYAEIPKllaFIGTQpewKDKVRAKATPTRRSVDDGKVTDHHALLVTGEKPLF--LSKEDGILYHMIAGR 394
Cdd:COG0550 286 RTDSVRLSEDAVAAARE---YIEAL---YGKEYLPEKPRVYKTSKNAQEAHEAIRPTGVTRTPesLSGDEFKLYDLIWKR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 395 MVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEK------EDVILPDLHEGDYLTIKGVSVTEGRTKPK 468
Cdd:COG0550 360 FLASQMPPAEYETTTVTIEVGGEEFRASGKVIKFPGFLKVYGEGKddeeeeEEKRLPPLKEGEKLKLKKIEPEQHFTKPP 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 469 PLHTEATLLSAMETAgkeieddalrqamkdcGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTM--RIA 546
Cdd:COG0550 440 PRYTEASLVKAMEEL----------------GIGRPSTYASIIETLQDRGYVEREGKRLVPTELGFIVIDLLEEHfpDLV 503
|
570 580 590
....*....|....*....|....*....|....*.
gi 498224087 547 DVAMTGEWERELARIERGEVSADAFHREIEAYTREI 582
Cdd:COG0550 504 DYEFTAKMEEKLDEIAEGKLDWKDVLEEFYKPFKEL 539
|
|
| PRK08173 |
PRK08173 |
DNA topoisomerase III; Validated |
4-687 |
2.06e-171 |
|
DNA topoisomerase III; Validated
Pssm-ID: 236172 [Multi-domain] Cd Length: 862 Bit Score: 512.68 E-value: 2.06e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 4 IIAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVR----GFvrDNLPIIPDTFTLVPRQvRTE 79
Cdd:PRK08173 6 IIAEKPSVANDIARALGGFTKHDEYFESDEYVLSSAVGHLLEIAAPEEYEVKrgkwSF--AHLPVIPPHFDLNPIA-KTE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 80 kgykpdsgvvSQIKVIKRLF---DASEqIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLEDGS 156
Cdd:PRK08173 83 ----------SRLKVLTKLIkrkDVTR-LINACDAGREGELIFRLIAQHAKAKKPVKRLWLQSMTPQAIRDGFANLRSDE 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 157 KYDNLYLTAKARSESDWLVGINGTQAL----SIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLHiATDGCDG 232
Cdd:PRK08173 152 DMQPLADAARCRSEADWLVGINGTRAMtafnSKGGGFFLTTVGRVQTPTLSIVVEREEKIRRFVPRDYWEVR-AEFVAAA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 233 EIVK---FSSSEKWKEKES---AMELYNKVKE----AGC----ATVTKaERKEKTEDTPLLYDLTTLQKEANTKHGFTAE 298
Cdd:PRK08173 231 GFYEgrwFDPKFKKDEFDPekrASRLWSEAAAeaivAACrgkpGTVTE-ESKPSTQLSPLLFDLTSLQREANGRFGFSAK 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 299 QTLETAQKLYEK-KLITYPRTGSRYIPED----------VYAEIPKLLAFIGTQPEwKDKVRakatPTRRSVDDGKVTDH 367
Cdd:PRK08173 310 NTLGLAQALYEKhKVLTYPRTDSRALPEDylgtvkqtleMLKESNNYLPHAKQILD-KGWVK----PNKRIFDNSKISDH 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 368 HALLVTGEKPLFLSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEE--KEDVILP 445
Cdd:PRK08173 385 FAIIPTLQAPKSLSEPEQKLYDLVVKRFLAVFFPAAEFLVTTRITEVAGHHFKTEGKVLVNPGWLAVYGKEaqGADANLV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 446 DLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDCGIGTPATRASIIETLFKRGYMERCKK 525
Cdd:PRK08173 465 PVQKGEKVKTDKIEAVALTTKPPARYNEATLLSAMEGAGKLVEDDELREAMAEKGLGTPATRAAIIEGLLGEKYLVREGR 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 526 SLVPTEKGLALNSVVKTMRIADVA---MTGEWERELARIERGEVSADAFHREIEAYTREIT-------SELLSCDklFGS 595
Cdd:PRK08173 545 ELIPTAKAFQLMTLLRGLGVEELTspeLTGEWEYKLSQIERGKLSRDAFMQEIAQMTQQIVkrakeydSDTIPGD--YAT 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 596 RDSgcACPKCGTGRMRFYGKVVrCdnAECGLPVFRLKAGRTLSDDEIKDLLTEGHTKLLKGFKSKQGKSFDAVV---AFD 672
Cdd:PRK08173 623 LQT--PCPNCGGVVKENYRRFA-C--TKCDFSISKIPGGRQFEIAEVEELLRKKEIGPLSGFRSKMGRPFSAILklsDET 697
|
730
....*....|....*
gi 498224087 673 GEYNMTFVFPEAKKG 687
Cdd:PRK08173 698 KNYKLEFDFGQDQGG 712
|
|
| topB |
TIGR01056 |
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase ... |
1-632 |
4.80e-161 |
|
DNA topoisomerase III, bacteria and conjugative plasmid; This model describes topoisomerase III from bacteria and its equivalents encoded on plasmids. The gene is designated topB if found in the bacterial chromosome, traE on conjugative plasmid RP4, etc. These enzymes are involved in the control of DNA topology. DNA topoisomerase III belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273419 [Multi-domain] Cd Length: 660 Bit Score: 479.34 E-value: 4.80e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGATKREEGYFEGG-GYAVTWAFGHLVQLAMPDGYGVR--GFVRDNLPIIPDTFTLVPRqvr 77
Cdd:TIGR01056 1 MTLVLCEKPSQARDLATVLAKKKKGNGYLEIGvGGFVTWAVGHLVELAEPEEYDEKykNWRTYDLPLEPEDWQLVVS--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 78 tekgykPDSGvvSQIKVIKRLFDASE--QIIVATDAGREGELIFRYLYHYTGST--TPFVRLWISSLTDKAIREGLRKLE 153
Cdd:TIGR01056 78 ------DKTK--KQFNVIKRILKENKvdEVVIATDPDREGELIAREILDYLKVTdkVTIKRLWISSLVDSSIRKAFKNLR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 154 DGSKYDNLYLTAKARSESDWLVGINGTQALSI----AAGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQL--HIAT 227
Cdd:TIGR01056 150 PKSETEGLYKSGVARARADWLVGINLTRAFTKlgreAGNDGVLSVGRVQTPTLAMVVKRENEIKNFVGKPFYEVsaTINK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 228 DGcdgeiVKFSSSEKWKEKESAMELYNKVKE-------AGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQT 300
Cdd:TIGR01056 230 DE-----QEFTTEWQPYKDEEERELHEFLAEnvvtdltQKPALVTDIEKERKKTSAPLFYDLSALQEDANKRFGISAKRT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 301 LETAQKLYEK-KLITYPRTGSRYIPEDVYAEIPKLLAFIGTQPEWKDKVRAKATPTR-RSVDDGKVTDHHALLVTGEKPL 378
Cdd:TIGR01056 305 LDIAQKLYEThKLITYPRTDSRYLPEDEKEMLLEVLDALKVITPALLPIKKRDELTNnRLWNDKKIEDHHAIIPTGNDFN 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 379 F--LSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYG-----EEKEDVILPDLHEGD 451
Cdd:TIGR01056 385 LsdLSEEERNVYKLIAQNYLMQFMPKEEYETTTIEIAIGKLMFEAKGKILQDNGWKALLGkqeedEETEDTTLPAFQKGD 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 452 YLTIKGVSVTEGRTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDC-GIGTPATRASIIETLFKRGYMERCKKSLVPT 530
Cdd:TIGR01056 465 ELDVETLELLEKQTKPPARYTEGTLLSAMTNPAAFVQDKGLKKTLKETkGLGTEATRADIIENLFKRGFIQKKKNKIYIT 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 531 EKGLALNSVVKTMrIADVAMTGEWERELARIERGEVSADAFHREIEAYTREITSELLSCDKLF-------GSRDSGCACP 603
Cdd:TIGR01056 545 KNGKLLCLLLPEL-LTKPDLTAQWEQYLNGISAGEKDDDDFINTINEMIKQTINEEKKNPETIqkvakepVSCGGIAKCP 623
|
650 660 670
....*....|....*....|....*....|...
gi 498224087 604 KCGTGRMRFYGKVVRCD----NAECGLPVFRLK 632
Cdd:TIGR01056 624 AKDNGRLIDCKKFPECTeygnGCEFTIPKKLRE 656
|
|
| Topoisom_bac |
pfam01131 |
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes ... |
156-571 |
2.63e-157 |
|
DNA topoisomerase; This subfamily of topoisomerase is divided on the basis that these enzymes preferentially relax negatively supercoiled DNA, from a 5' phospho- tyrosine linkage in the enzyme-DNA covalent intermediate and has high affinity for single stranded DNA.
Pssm-ID: 426069 [Multi-domain] Cd Length: 410 Bit Score: 460.17 E-value: 2.63e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 156 SKYDNLYLTAKARSESDWLVGINGTQALSIAA-GHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLH-IATDGCDGE 233
Cdd:pfam01131 1 EIDENLVDAQLARRELDWLIGFNLSRLLTLKLkGNKLLSAGRVQTPTLALIVEREREIENFVPEPYWTIEaTLKDGGGVF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 234 IVKFSSSEKWKEKESAMELYNKVKeAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEK-KL 312
Cdd:pfam01131 81 ANAKWKRGRIFDKEEAEAILEKLK-KGTAVVTSVESKEKKKPPPLPFNTTTLQKEASRKLGFSAKKTMSIAQKLYEKhGL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 313 ITYPRTGSRYIPEDvyAEIPKLLAFIGTQP-EWKDKVRAKATPTRR--SVDDGKVTDHHALLVTGEKPL--FLSKEDGIL 387
Cdd:pfam01131 160 ITYPRTDSTYLSDD--ATLKAILEYLTKNYgKYLPYAPRLLKKTKGklTVGNAKVTAHEAIRPTGDIPVlpELSDDERKL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 388 YHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYG--EEKEDVILPDLHEGDYLTIKGVSVTEGRT 465
Cdd:pfam01131 238 YELIVRRFLASQMPPAVYETTTVVLEVGGEEFRASGKVILEDGWLKVYPyeKKEDEEELPELKEGEELKVTQVEVEEKKT 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 466 KPKPLHTEATLLSAMETagkeieddalrqamkdCGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTM-R 544
Cdd:pfam01131 318 KPPPRYTEASLIKAMEK----------------AGIGTPATRATIIETLLERGYVERKKKSLVPTELGKALVEALEKFpD 381
|
410 420
....*....|....*....|....*..
gi 498224087 545 IADVAMTGEWERELARIERGEVSADAF 571
Cdd:pfam01131 382 LVDPELTAELEEKLDEIAEGKLDWKDV 408
|
|
| PRK14724 |
PRK14724 |
DNA topoisomerase III; Provisional |
1-688 |
8.42e-139 |
|
DNA topoisomerase III; Provisional
Pssm-ID: 237803 [Multi-domain] Cd Length: 987 Bit Score: 431.69 E-value: 8.42e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKT-IIAEKPSVAREIAR----IVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGV-RG-FVRDNLPIIPDTFTLVP 73
Cdd:PRK14724 1 TKTlVIAEKPSVAQDIVRaltpVAGKFEKHDEHFESDSYVVTSAVGHLVEIQAPEEFDVkRGkWSFANLPVIPPYFDLKP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 74 RQvrtekgyKPDSGVVSQIKVIKRLfDASEqIIVATDAGREGELIFRYLYHYTGSTT-----PFVRLWISSLTDKAIREG 148
Cdd:PRK14724 81 VD-------KTKTRLNAVVKLAKRK-DVTE-LVNACDAGREGELIFRLIEQYAGGAKgglgkPVKRLWLQSMTPQAIRDG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 149 LRKLEDGSKYDNLYLTAKARSESDWLVGINGTQAL----SIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLH 224
Cdd:PRK14724 152 FDNLRSDAQMQGLASAARSRSEADWLVGINGTRAMtafnSRDGGFFLTTVGRVQTPTLSLVVEREEKIRKFVSRDYWEIH 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 225 IATDGCDGEIVKFSSSEKWKEKES--------------AMELYNKVKeAGCATVTKaERKEKTEDTPLLYDLTTLQKEAN 290
Cdd:PRK14724 232 AGFHAEAGEYLGKWFDPQWKKASDdpearadrvwsereARAIADAVR-GKAATVTE-ESKPTTQASPLLFDLTSLQREAN 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 291 TKHGFTAEQTLETAQKLYEK-KLITYPRTGSRYIPED---VYAEIPKLLAFIGTQ---PEWKDKVRAK-ATPTRRSVDDG 362
Cdd:PRK14724 310 GKFGFSAKTTLALAQSLYERhKALTYPRTDSRALPEDylpVAKQTFEMLATSGMRhlaPFAQQALDGNyVRPSKRIFDNS 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 363 KVTDHHALLVTGEKPLFLSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEKEDV 442
Cdd:PRK14724 390 KVSDHFAIIPTTQAPSGLSEAEQKLYDLVVRRFMAVFFPSAEYQVTTRISQVVGHSFKTEGKVLVKPGWLAIYGKEAANE 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 443 IlPDLHEGDyltiKG---VSVTEG-------------RTKPKPLHTEATLLSAMETAGKEIEDDALRQAMKDCGIGTPAT 506
Cdd:PRK14724 470 V-EDAKDGD----KGqplVPVKPGemvrtefaeakglKTKPPARYSEATLLGAMESAGKQIDDDELREAMQEKGLGTPAT 544
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 507 RASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTMRIADVA---MTGEWERELARIERGEVSADAFHREIEAYTREIT 583
Cdd:PRK14724 545 RAAIIEGLLTEKYMLREGRELIPTAKAFQLMTLLRGLGVEELSraeLTGEWEYKLAQMEKGQLSREAFMQQIAAMTEKLV 624
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 584 SELLSCDklfgsRDS--------GCACPKCGtGRMRFYGKVVRCDNAE-----CGLPVFRLKAGRTLSDDEIKDLLTEGH 650
Cdd:PRK14724 625 KKAKEYD-----RDTipgdyatlSTPCPNCG-GVVKENYRRYACTGANgagegCGFSFTKSPAGRTFETAEAEQLLRDRR 698
|
730 740 750 760
....*....|....*....|....*....|....*....|...
gi 498224087 651 TKLLKGFKSKQGKSFDA--VVAFDGE---YNMTFVFPEAKKGK 688
Cdd:PRK14724 699 IGPLEGFRSKAGWPFTAevVIKRDEEaknYKLEFDFGDDKNAE 741
|
|
| TOP1Ac |
cd00186 |
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA ... |
160-582 |
6.07e-106 |
|
DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA and then rejoin the broken phosphodiester backbone. Proposed catalytic mechanism of single stranded DNA cleavage is by phosphoryl transfer through a tyrosine nucleophile using acid/base catalysis. Tyr is activated by a nearby group (not yet identified) acting as a general base for nucleophilic attack on the 5' phosphate of the scissile bond. Arg and Lys stabilize the pentavalent transition state. Glu then acts as a proton donor for the leaving 3'-oxygen, upon cleavage of the scissile strand.
Pssm-ID: 238110 [Multi-domain] Cd Length: 381 Bit Score: 327.25 E-value: 6.07e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 160 NLYLTAKARSESDWLVGINGTQALSIA-AGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWqlhiatdgcdgeivkfs 238
Cdd:cd00186 2 NLVNAQLARRILDRLVGFNLSRLLTKKlRRKGVLSAGRVQSPTLGLIVEREREIKAFVPEDYW----------------- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 239 ssekwkekesamelynKVKEAgcaTVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYPRT 318
Cdd:cd00186 65 ----------------EIKEA---VVVSVEKKEKKKNPPPPFTTSTLQQEASSKLGFSAKKTMQIAQKLYEAGLITYPRT 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 319 GSRYIPEDvyaEIPKLLAFIGTQ-PEWKDKVRAKATPTRRSVDDGKVTDHHALLVTGEKPL-----FLSKEDGILYHMIA 392
Cdd:cd00186 126 DSTRLSEE---AILEAREYIQAIyGKEYLYPAPLLGRRNPKRGKKEQGAHEAIRPTKVAPTpeleaNLSEDEFKLYELIW 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 393 GRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEK--EDVILPDLHEGDYLTIKGVSVTEGRTKPKPL 470
Cdd:cd00186 203 RRFLASQMADAKYEETTVTLEIGGEKFKASGKVLLEDGWLEVYPEEKddEEEEPPPLKEGDELKLEEVELEEKETQPPPR 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 471 HTEATLLSAMETAgkeieddalrqamkdcGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTM--RIADV 548
Cdd:cd00186 283 YTEASLIKLMEKR----------------GIGRPSTYASIIETLLDRGYVEKEKKKLIPTELGFAVIELLEKHfpELVDP 346
|
410 420 430
....*....|....*....|....*....|....
gi 498224087 549 AMTGEWERELARIERGEVSADAFHREIEAYTREI 582
Cdd:cd00186 347 EFTAKLEEKLDEIAEGKKDYQEVLEEFYEEFKKI 380
|
|
| PRK07219 |
PRK07219 |
DNA topoisomerase I; Validated |
1-621 |
1.58e-90 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235971 [Multi-domain] Cd Length: 822 Bit Score: 299.99 E-value: 1.58e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGA----TKREEG---Y-FEGGG--YAVTWAFGHLVQLAMPDGYGvrgFVRD-NLPIIPDTf 69
Cdd:PRK07219 1 TELIIAEKNNAARRIADILSGgkakKKRVNGvpyYeFERKGekWIVIGLSGHIVTVDFPEEYG---DWRDvDPAELIDA- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 70 tlVPRQVRTEKGYkpdsgvvsqIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTT--PFVRLWISSLTDKAIRE 147
Cdd:PRK07219 77 --DPVKKITKQNY---------INALKKLAKDADEIIIATDYDREGELIGKEAYHILREVCqvPVKRARFSSLTKKEIRK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 148 GLRKLEDgskYD-NLYLTAKARSESDWLVGINGTQALSIAAG----HGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQ 222
Cdd:PRK07219 146 AFENPDE---IDfNLADAGEARQIIDLYWGAALTRFLSLSVRqlgrWDFLSVGRVQTPTLAFIVDREREIRAFDPEDYWK 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 223 LHIATDG----CDGEIVKFSSSEKWKEKESAMELYNKVKEAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAE 298
Cdd:PRK07219 223 IEALLDKeaqyFYRDLIGGHEAEKFWDEEEAEEIYEKLKGAKEATVSSVKKRERTISPPAPFNTTEFLREASKIFGISPK 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 299 QTLETAQKLYEKKLITYPRTGSRYIPEDVyaEIPKLLAFIGTQPEWKDKVRAKATPTRRSVDDGK--VTDHHALLVTGEK 376
Cdd:PRK07219 303 RAMEIAEKLYTAGYISYPRTDNTVYPDDL--DPKELLKKLSKKKEYGPYAESILEQENIKPTEGKkeTTDHPPIHPVDVP 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 377 PLF-LSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYG-EEKEDVILPDLHEGDYLT 454
Cdd:PRK07219 381 KREeLSDDEWKVYELIVRRFLATLADPAEWEYLKVELDVNGEIFKASGSRLVEEGWHEVYPyEKFDEKELPDLEEGEKLK 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 455 IKGVSVTEGRTKPKPLHTEATLLSAMEtagkeieddalrqamkDCGIGTPATRASIIETLFKRGYMERcKKSLVPTEKGL 534
Cdd:PRK07219 461 VNKIEIEAKETQPPKRYTQSSLIKEME----------------KRGLGTKATRHDIIEKLYKRGYVIE-GDPPRPTDLGI 523
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 535 ALNSVVKTM--RIADVAMTGEWERELARIERGEVSADAFHREIEAYTREITSELLSCDKLFGSR-----DSGCA------ 601
Cdd:PRK07219 524 AVIEALEKYapEIVSEEMTAQLEADMQAIEDGKKKKEDVTEESREMLKEILSELKEKRKEIGDHlagslKAENRslktig 603
|
650 660
....*....|....*....|....*
gi 498224087 602 -CPKCG----TGRMRFYGKVVRCDN 621
Cdd:PRK07219 604 kCPECGgdliIIRTDKGSRFVGCSG 628
|
|
| PRK05776 |
PRK05776 |
DNA topoisomerase I; Provisional |
4-606 |
2.59e-80 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 235602 [Multi-domain] Cd Length: 670 Bit Score: 268.78 E-value: 2.59e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 4 IIAEKPSVAREIARIVGAT---KREEG--YFE----GGGYAVTWAFGHLVQLAmPDGYGvrgfvrdnLPIIpdTFTLVPR 74
Cdd:PRK05776 5 VIAEKPKAARKIAEALSEKpirCRIYGvpYWIvkrdGKKIVVAPAAGHLFGLH-TKSKG--------FPVF--DYEWKPL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 75 -QVRTEKGYKPDsgvvsQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLE 153
Cdd:PRK05776 74 yEIDKGSKYTKK-----YYELLSSLSKYADEFINACDYDIEGSVIGYLIIKYLGDPKKAKRMKFSALTKSDIRRAFRNLE 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 154 --DgskYDNLYlTAKARSESDWLVGINGTQALSIAAGHGT-----YSVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIA 226
Cdd:PRK05776 149 tlD---YEMIN-AGIARHELDWLWGINVSRALMSSVRDASgkrviLSAGRVQSPTLKYVVEREIERNLFVPLPYFSVSII 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 227 TDGCDGEI-VKFSSSEKWKEKEsAMELYNKVKEAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQ 305
Cdd:PRK05776 225 IEKNGYEFtLKYENKKFETKEE-AKEILEEIKKTGYLKVTKVEVKIEILEPPPPFNLGDLQVEAARIYGFSPYKTQSIAE 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 306 KLYEKKLITYPRTGSRYIPEDV-YAEIpklLAFIGTQPEWKDKVRA--KATPTRRSVDDGKVTD--HHALLVTGEKPLFL 380
Cdd:PRK05776 304 DLYLDGLISYPRTNSQKLPPTLnIRNI---LKGLSRSPQYRPLVNLllKETKGVLKPVQGPKDDpaHPAIYPTGEPPKNL 380
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 381 SKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGV--EFTVKGSVVKQAGWRAVYGEEK-EDVILPDLHEGDYLTIKG 457
Cdd:PRK05776 381 SKDEFKLYDLIVRRFLASFAAPAVLSNTIVTLRVPGFplVFSASGQRIEERGWLKYYPFHKfDEEELPLLKKGERVKIVD 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 458 VSVTEGRTKPKPLHTEATLLSAMEtagkeieddalrqamkDCGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALN 537
Cdd:PRK05776 461 VKVRKSYTKPPSRYSKASLLKWME----------------SVGIGTEATRARIIETLFKRGYLTSNGKYIEVTPLGFGVA 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 538 SVVKTM--RIADVAMTGEWERELARIERGEVSADAFHRE--------IEAYTR---EITSELLscdKLFGSRDSGCACPK 604
Cdd:PRK05776 525 EVLEKYfpDIVSVELTRDFEEKLEMIRTGKATREEVIEEaketlnklLEEFKKnkdEIGEELA---KALGLIKPVGKCKI 601
|
..
gi 498224087 605 CG 606
Cdd:PRK05776 602 CG 603
|
|
| topA_arch |
TIGR01057 |
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These ... |
5-606 |
6.93e-79 |
|
DNA topoisomerase I, archaeal; This model describes topoisomerase I from archaea. These enzymes are involved in the control of DNA topology. DNA topoisomerase I belongs to the type I topoisomerases, which are ATP-independent. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273420 [Multi-domain] Cd Length: 618 Bit Score: 264.00 E-value: 6.93e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 5 IAEKPSVAREIARIVG---ATKREEG---YFE----GGGYAVTWAFGHLvqlampdgYGVRGFVRDNLPIIpdTFTLVPR 74
Cdd:TIGR01057 1 IAEKPKVAAKIAGALSdgrVLKKSEYgvpYWEvrrdGKKIIVASAVGHL--------FGLHPKSRGGYPVF--DIEWVPI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 75 QVRTE-KGYkpdsgVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLE 153
Cdd:TIGR01057 71 FEFDKgKGY-----VSKYIKALSKLAKGADEYINACDYDIEGEVIGFKALKYFCGVERAKRMKFSTLTKQDIRRAYANPE 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 154 --DGSKYDnlylTAKARSESDWLVGINGTQAL--SIAAGHG---TYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIA 226
Cdd:TIGR01057 146 eiDYGMVD----AGMARHILDWYWGINLSRALmeAIRAAAGrwvILSAGRVQGPTLAFLVEREREINLFVPKPYWVIKAT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 227 TDgcDGEIVKFSSSEKWK--EKESAMELYNKVKEAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETA 304
Cdd:TIGR01057 222 LE--KGGGVFDARPEKWKiwSEEEAKSIKEELKKSPWAAVEEVRSERSILKPPPPFDLGTLQREAYRIFGFSPKKTQSIA 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 305 QKLYEKKLITYPRTGSRYIPEDV-YAEIPKLLAFIGTQPEWKDkvRAKATPTRRSVDdGKVTD--HHALLVTGEKPLF-L 380
Cdd:TIGR01057 300 QELYEEALISYPRTSSQKLPPSInYRAILDNLAKGPLYREAAE--RLLETGVLKPVE-GKKEDpaHPAIHPTGEIPSQeL 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 381 SKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEK-EDVILPDLHEGDYLTIKGVS 459
Cdd:TIGR01057 377 SKDEKKVYDLIVRRFLAAFSEEAIREKSKVLLRIGQEKFRLSGLRVVKLGWLEYYHYSKfEEKELPPLDRGDKIKVVRVD 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 460 VTEGRTKPKPLHTEATLLSAMEtagkeieddalrqamkDCGIGTPATRASIIETLFKRGYMERCKKSLVpTEKGLALNSV 539
Cdd:TIGR01057 457 VRVKETQPPARYDKASLIREME----------------SRGLGTKATRARIIETLYKRGYIEGKKSIKV-TPLGEAVIET 519
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498224087 540 VKTM--RIADVAMTGEWERELARIERGEVSADAFHREIEAYTREITSELLSCD--------KLFGSRDSGCACPKCG 606
Cdd:TIGR01057 520 LQRYcpEIISEELTRRFESKLEDIMSGRITKDEVIDEAKKRLRKILEEFKKRLddigielgKSLGSVEVVGKCPKCG 596
|
|
| TOP1Ac |
smart00437 |
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, ... |
268-536 |
3.83e-73 |
|
Bacterial DNA topoisomerase I DNA-binding domain; Bacterial DNA topoisomerase I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase alpha subunit
Pssm-ID: 214663 [Multi-domain] Cd Length: 259 Bit Score: 237.14 E-value: 3.83e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 268 ERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYPRTGSRYIPEDvyaEIPKLLAFIGTQ--PEWK 345
Cdd:smart00437 1 EEKEKKKNPPPPFTTSTLQQEASRKLGFSAKKTMQIAQKLYEKGLITYPRTDSTRLSEE---AVLEARNYIQKLygKEYL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 346 DKVRAKATPTRRSVDDGKVTDHHALLVTG-----EKPLFLSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFT 420
Cdd:smart00437 78 DLAVVLLKPRKPRKGKKAQGAHEAIRPTKpiftpELEKELSEDEFKLYELIWRRFLASQMPDAKYEETKVTIKIGGEKFK 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 421 VKGSVVKQAGWRAVYGEEK--EDVILPDLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLSAMETAgkeieddalrqamkd 498
Cdd:smart00437 158 AKGKTLLFDGWLKVYPEEKkeEEIELPTLKKGDELKVEEVEVEEKETKPPARYTEASLIKLMEKR--------------- 222
|
250 260 270
....*....|....*....|....*....|....*...
gi 498224087 499 cGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLAL 536
Cdd:smart00437 223 -GIGRPSTYASIIETLLDRGYVTKKKKKLIPTELGIAV 259
|
|
| PRK06599 |
PRK06599 |
DNA topoisomerase I; Validated |
1-624 |
3.28e-58 |
|
DNA topoisomerase I; Validated
Pssm-ID: 235840 [Multi-domain] Cd Length: 675 Bit Score: 208.94 E-value: 3.28e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGatkreegyfegGGYAVTWAFGHlvqlampdgygvrgfVRDnlpiipdtftLVPRQ--VRT 78
Cdd:PRK06599 3 KKLVIVESPAKAKTIKKYLG-----------KDYKVLASFGH---------------VRD----------LPKKKggVDP 46
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 79 EKGYKPDSGVVSQ----IKVIKRLFDASEQIIVATDAGREGELI----FRYLYHYTGSTTPFVRLWISSLTDKAIREGL- 149
Cdd:PRK06599 47 DNDFAPKYEIIEGkekvVDALKKAAKKADAVYLATDPDREGEAIawhiAEVLKEAKLKDKNVKRVVFNEITKKAVQEAIe 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 150 --RKLEDgskydNLYLTAKARSESDWLVGINgtqaLS------IAAGhgtYSVGRVQTPTLAMVCERYWENRRFTPEAFW 221
Cdd:PRK06599 127 npRDIDM-----DLVDAQQARRALDYLVGFK----LSpllwkkVRRG---LSAGRVQSVALRLICEREDEIEAFIPQEYW 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 222 QLHIATDGCDGE-----IVKFSSS--EKW--KEKESAMELYNKVKEAGcATVTKAERKEKTEDTPLLYDLTTLQKEANTK 292
Cdd:PRK06599 195 TIEADLATSNGEpftakLVEVNGKklEKFsiTNEEQAKALVKALEGQA-YTVDKIEKKERKRNPPPPFITSTLQQEASRK 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 293 HGFTAEQTLETAQKLYE--------KKLITYPRTGSRYIPEDVYAEIPKllaFIGTQ--PEWK-DKVRAKATPTrrsvdd 361
Cdd:PRK06599 274 LGFSAKKTMRIAQKLYEgidlgegtVGLITYMRTDSVRLSNEALDEARK---YITKKygKEYLpAKPRVYKKKS------ 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 362 GKVTDHH------ALLVTGE--KPlFLSKEDGILYHMI-----AGRMVEAFSEkcvkDVTI-ITTECAGVEFTVKGSVVK 427
Cdd:PRK06599 345 KNAQEAHeairptSINRTPEslKP-YLTPDQFKLYELIwkrtvASQMAPAILD----QTSVdIASENGKYVFRATGSVIL 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 428 QAGWRAVYGEEKED------VILPDLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLSAMEtagkEIeddalrqamkdcGI 501
Cdd:PRK06599 420 FPGFLKVYGESKDDeeeddeKLLPPLKEGEKLKLDELLPEQHFTEPPPRYSEASLVKKLE----EY------------GI 483
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 502 GTPATRASIIETLFKRGYMERCKKSLVPTEKGLalnsVVKTM------RIADVAMTGEWERELARIERGEVS-------- 567
Cdd:PRK06599 484 GRPSTYASIISTLQDREYVELEKKRFIPTDLGR----IVNDFlvehfpKYVDYDFTAGLEDELDEIAEGKKDwkpvlref 559
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 498224087 568 ADAFHREIEAYTREITSELLscdklfGSRDSGCACPKCGTGRM--RF--YGKVVRCDN-AEC 624
Cdd:PRK06599 560 WEPFISNLEKVEEDVRTEKV------TQEETDETCPKCGGGPLvlKLgkNGKFLGCSGyPEC 615
|
|
| PRK07220 |
PRK07220 |
DNA topoisomerase I; Validated |
1-624 |
7.26e-57 |
|
DNA topoisomerase I; Validated
Pssm-ID: 180892 [Multi-domain] Cd Length: 740 Bit Score: 206.15 E-value: 7.26e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGATKREEGYFEG-GGYAVTWAF---------GHLVQLAMPDGYG------VRGFVRDNLPI 64
Cdd:PRK07220 1 MHLIITEKNIAARRIAQILAPKKPKKTRVSGvDVYRYEDNGddtvvvglsGHIVNIDFPKEYNnwqkvdARDLIDAEIIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 65 IPdtftlvprqvrTEKGykpdsgVVSqikVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTP---FVRLWISSLT 141
Cdd:PRK07220 81 TP-----------TQKK------IVT---ALKKLGKEADRVTIATDYDREGELIGVEALNIIKKVNPdikFDRVRYSAIT 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 142 DKAIregLRKLEDGSKYD-NLYLTAKARSESDWLVGINGTQALSIAA---GHGTYSVGRVQTPTLAMVCERYWENRRFTP 217
Cdd:PRK07220 141 KKEI---ERAFSNPVEVDfNLADAGHSRQVIDLVWGAALTRYISLAAgrlGKMFLSVGRVQSPTLALIVDREKEREAFVP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 218 EAFWQLHIATDGCDGEIVKFSSSEKWKEKESAMELYNKVKEAgcATVTKAERKEKTEDTPLLYDLTTLQKEANTKhGFTA 297
Cdd:PRK07220 218 TPYWEIYATLENNGETFVAQHSTRRFWEKEEADRVFEKLGKT--AEVTEVEKGTKTDKPPTPFNTTEFISAANSI-GFSA 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 298 EQTLETAQKLYEKKLITYPRTGSRYIPEDVyaEIPKLLAFIGTQP--EWKDKVRAKA--TPTRrsvddGK--VTDHHALL 371
Cdd:PRK07220 295 ANAMRIAESLYTNGYISYPRTDNTVYPESL--DLREQIEIFAEGPfgEYAQKLLEKGelVPTR-----GKkeTTDHPPIY 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 372 VTG-EKPLFLSKEDGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYG-EEKEDVILPDLHE 449
Cdd:PRK07220 368 PASlAKKSELKEDEWKVYELVVRRFFATFAGPAEWETMKLRFDIGGEEFRANGSRLTEPGWRWYYPyNAPEDRLLPELSE 447
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 450 GDYLTIKGVSVTEGRTKPKPLHTEATLLSAMEtagkeieddalrqamkDCGIGTPATRASIIETLFKRGYMErcKKSLVP 529
Cdd:PRK07220 448 GEELKVKKKEMLDKETQPPGRYGQGRLIKLME----------------DLGLGTKATRHEIISKLYSRAYIH--GNPIQP 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 530 TEKGLAlnsVVKTMR-----IADVAMTGEWERELARIERGEVSADAFHREIEAYTREITSEL--------------LSCD 590
Cdd:PRK07220 510 TNTAFA---VVDALEkyaptITKPDMTSRLEEDMDKIAEGKIKEDAVLEESREMLEQVFDELdknrekireslregLRED 586
|
650 660 670 680
....*....|....*....|....*....|....*....|...
gi 498224087 591 KLFGSrdsgcaCPKCGTGRM--------RFYGkvvrCDN-AEC 624
Cdd:PRK07220 587 KIIGK------CPLCGSDLMvrrskrgsRFIG----CEGyPEC 619
|
|
| PRK08780 |
PRK08780 |
DNA topoisomerase I; Provisional |
4-565 |
1.74e-46 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 181555 [Multi-domain] Cd Length: 780 Bit Score: 176.88 E-value: 1.74e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 4 IIAEKPSVAREIARIVGAtkreegyfeggGYAVTWAFGHlvqlampdgygvrgfVRDnlpiipdtftLVPRQ--VRTEKG 81
Cdd:PRK08780 6 VIVESPAKAKTINKYLGK-----------DFTVLASYGH---------------VRD----------LVPKEgaVDPENG 49
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 82 YKPDSGVVS----QIKVIKRLFDASEQIIVATDAGREGELIFRYLYHY-----TGSTTPFVRLWISSLTDKAIREGLRKL 152
Cdd:PRK08780 50 FAMRYDLIDknekHVEAIAKAAKSADDLYLATDPDREGEAISWHLAEIlkergLLKDKPMQRVVFTEITPRAIKEAMAKP 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 153 EDGSKydNLYLTAKARSESDWLVGINGTQAL--SIAAGhgtYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIAtdgC 230
Cdd:PRK08780 130 RDIAS--DLVDAQQARRALDYLVGFNLSPLLwrKIQRG---LSAGRVQSPALRMIVEREEEIEAFIAREYWSIEAD---C 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 231 DGEIVKFSS------SEKWKE-----KESAMELYNKVKEA--GCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTA 297
Cdd:PRK08780 202 AHPSQPFNAklikldGQKFEQftitdGDTAEAARLRIQQAaqGTLHVTDVESKERKRNPAPPFTTSTLQQEASRKLGFTT 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 298 EQTLETAQKLYEK---------KLITYPRTGSRYIPEDVYAEIPKLLAFIGTQPEWKDKVRAKATPTRRSVDdgkvtDHH 368
Cdd:PRK08780 282 RRTMQVAQKLYEGvdlgdegsvGLITYMRTDSVNLSQDALAEIRDVIARDYGTASLPDQPNTYKTKSKNAQE-----AHE 356
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 369 ALLVTG------EKPLFLSKEDGILYHMI-----AGRMVEAFSEKCVKDVTiittecAGVE--FTVKGSVVKQAGWRAVY 435
Cdd:PRK08780 357 AVRPTSalrtpaQVARFLSDDQRRLYELIwkravACQMIPATLNTVSVDLA------AGSEhvFRATGSTVVVPGFLAVY 430
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 436 GEEKEDV---------ILPDLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLSAMEtagkeieddalrqamkDCGIGTPAT 506
Cdd:PRK08780 431 EEGKDDKsaededegrKLPPMKEGDNVPLERIRAEQHFTEPPPRYTEASLVKALE----------------EYGIGRPST 494
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 498224087 507 RASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTM--RIADVAMTGEWERELARIERGE 565
Cdd:PRK08780 495 YASIISTLQFRKYVEMEGRRFRPTDVGRAVNKFLTGHftRYVDYDFTARLEDDLDAVSRGE 555
|
|
| TOPRIM_TopoIA_TopoIII |
cd03362 |
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type ... |
1-152 |
3.08e-46 |
|
TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173782 [Multi-domain] Cd Length: 151 Bit Score: 161.25 E-value: 3.08e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGATKR-------EEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRGFV-RDNLPIIPDTFTlv 72
Cdd:cd03362 1 MVLIIAEKPSVAKAIAKILGGGSKkkgkgryYEFYGEGGGYVVTWASGHLLELDFPEEYDPWDKVwPLEDPLFPAPFK-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 73 prqvrtekgYKPDSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTT--PFVRLWISSLTDKAIREGLR 150
Cdd:cd03362 79 ---------LKVDKGKKKQFKVLKKLAKRADEIVIATDADREGELIGREILEYAKCVKrkPVKRAWFSSLTPKAIRRAFK 149
|
..
gi 498224087 151 KL 152
Cdd:cd03362 150 NL 151
|
|
| PRK07561 |
PRK07561 |
DNA topoisomerase I subunit omega; Validated |
1-691 |
1.81e-45 |
|
DNA topoisomerase I subunit omega; Validated
Pssm-ID: 236048 [Multi-domain] Cd Length: 859 Bit Score: 174.21 E-value: 1.81e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARivgatkreegyFEGGGYAVTWAFGHlvqlampdgygvrgfVRDnLPI----IPDTFT--LVPR 74
Cdd:PRK07561 2 KSLVIVESPAKAKTINK-----------YLGSDYVVKASVGH---------------IRD-LPTsassVPAKEKgaLWAR 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 75 Q-VRTEKGYKP----DSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGST-TPFVRLWISSLTDKAIREG 148
Cdd:PRK07561 55 MgVDPDHDFEAlyevLPGKEKVVSELKKAAKDADELYLATDPDREGEAIAWHLLEVLGGDdVPVKRVVFNEITKNAIQEA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 149 LRKLEDgskYD----NLYLtakARSESDWLVGINgtqaLS------IAAGhgtYSVGRVQTPTLAMVCERYWENRRFTPE 218
Cdd:PRK07561 135 FENPRE---LDinlvNAQQ---ARRFLDRLVGYM----VSpllwkkIARG---LSAGRVQSVAVRLIVEREREIEAFVPE 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 219 AFWQLHIATDGCDGEIV----------KFSSSEKWKEKEsAMELYNKVKEAGCaTVTKAERKEKTEDTPLLYDLTTLQKE 288
Cdd:PRK07561 202 EYWDIHADLTTPRGDAFearlthldgkKFAPVDLLNEAQ-AEAAVAALEGARY-SVASVEDKPTTRKPSAPFTTSTLQQE 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 289 ANTKHGFTAEQTLETAQKLYEKKLITYPRT---------------------GSRYIPED--VYAEIPKllafiGTQpEWK 345
Cdd:PRK07561 280 ASRKLGFSVKKTMRIAQRLYEAGYITYMRTdstnlsqeainaargyigdnyGKKYLPEKprQYSSKAK-----NAQ-EAH 353
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 346 DKVRakatPTRRSVDDGKVTDhhallvtgekplfLSKEDGILYHMI-----AGRMVEAfsekcVKDVTIITTECAGVEFT 420
Cdd:PRK07561 354 EAIR----PSDVFRTPDQLKG-------------LEGDAQRLYELIwkrfvASQMAPA-----RYDSTTVTIAAGDAELR 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 421 VKGSVVKQAGWRAVYGE------EKEDVILPDLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLSAMEtagKEieddalrq 494
Cdd:PRK07561 412 ATGRVLRFDGFLKVYVEgrddalDDEDRRLPALKVGDALTLEKLDPTQHFTKPPARYSEASLVKELE---KL-------- 480
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 495 amkdcGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLAlnsVVKTM-----RIADVAMTGEWERELARIERGEVSA- 568
Cdd:PRK07561 481 -----GIGRPSTYASIISTIQDRGYVRLENRRFYPEKMGRI---VTDRLeeffpRLVDYDFTARMEEELDDIANGEADWk 552
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 569 ---DAFHREIEAYTREITSELLS--CDKLFGSRDSGcACPKCGTG---RMRFYGKVVRCDN----AECGLPvfrlkagRT 636
Cdd:PRK07561 553 pvlDDFYKDFSQQLEKAEELREEggMRPNQMVITDR-DCPTCGRGmgiRTGKTGVFLGCSGyalkERCKTT-------RN 624
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 498224087 637 LS-DDEIKDLL--TEGHTKLLkGFKSKQGKsfdAVVAFDGEYNMTFVFPEAKKGKKFS 691
Cdd:PRK07561 625 LTpEEETLNVLegEDAETRAL-GADPECGT---AMVLRSGRFGPYVQEGEGDKPRRLS 678
|
|
| PRK14973 |
PRK14973 |
DNA topoisomerase I; Provisional |
1-606 |
3.71e-44 |
|
DNA topoisomerase I; Provisional
Pssm-ID: 184936 [Multi-domain] Cd Length: 936 Bit Score: 170.80 E-value: 3.71e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGATKREEGYFEGGgyAVTWAF---------GHLVQLAMPDGY-GVRGFVRDNLPIIPDTFT 70
Cdd:PRK14973 1 MHLIIAEKNIAANRIAQILAGKTKVQVKKDGG--VSTYSFddtvvvglrGHVVEVDFEPGYtNWRSEEHTPRSLIDADTI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 71 LVPrqvrTEKGYkpdsgvvsqIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRL---WISSLTDKAIRe 147
Cdd:PRK14973 79 KKP----TEKKI---------VGLIQKLAKKADRVTIATDFDTEGELIGKEAYELVRAVNPKVPIdraRFSAITKEEIV- 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 148 glRKLEDGSKYD-NLYLTAKARSESDWLVGINGTQALSIAA---GHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQL 223
Cdd:PRK14973 145 --TAFAEPTDLDfALAAAGEARQIIDLIWGASLTRFISLAAhrgGDNILSVGRVQSPTLAMIVDREKEIEAFVPEKYWML 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 224 HIATDGcDGEIVKFSSSE-KWKEKESAMELYNKVKEAgcATVTKAERKEKTEDTPLLYDLTTLQKEAnTKHGFTAEQTLE 302
Cdd:PRK14973 223 SLATEK-DGEGIEARHTHgRFTDSAAAEAAYDATKEP--LVVTEVKEGHKVDRAPTPFDTTTFIVAA-SRLGFSAANAMR 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 303 TAQKLYEKKLITYPRTGSRYIPEDVyaEIPKLLAFIGTQPEWKD----KVRAKATPTRrsvddGK--VTDHHALLVTGek 376
Cdd:PRK14973 299 IAEDLYMNGYISYPRTDNTIYPKSL--DLNGVLATLAKGAFSKDvawvKDNRRPVPTR-----GKksSTDHPPIHPTG-- 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 377 plfLSKEDGI------LYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYG-EEKEDVILPDLHE 449
Cdd:PRK14973 370 ---VATREELgddrwkLYELVVRRFLATLSPDAEWATMKVNFDAGGEPYTATGGRLLEAGWRTVYPySEAKENILPAFAL 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 450 GDYLTIKGVSVTEGRTKPKPLHTEATLLsametagkeieddalrQAMKDCGIGTPATRASIIETLFKRGYMErcKKSLVP 529
Cdd:PRK14973 447 GEKLPILAVNLEEKETQPPARYSQSRLI----------------QRMEELGLGTKSTRHEVIGKLVSRKYIE--GNPLRP 508
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 530 TEKGLALNSVVKTM--RIADVAMTGEWERELARIERGEVSADA--------FHR---EIEAYTREITSELLscDKLFGSR 596
Cdd:PRK14973 509 TLVGRAVTESLEEHagTITEPDMTQTLEEHMQQIKERKRTRDDvvtesrkmLHRafdELEANEAVIGRDIM--ERTAEEL 586
|
650
....*....|
gi 498224087 597 DSGcACPKCG 606
Cdd:PRK14973 587 TIG-PCPVCG 595
|
|
| TOPRIM_TopoIA |
cd01028 |
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
1-152 |
1.39e-40 |
|
TOPRIM_TopoIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IA family of DNA topoisomerases (TopoIA). This subgroup contains proteins similar to the Type I DNA topoisomerases: E. coli topisomerases I and III, eukaryotic topoisomerase III and, ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA. These enzymes cleave one strand of the DNA duplex, covalently link to the 5' phosphoryl end of the DNA break and allow the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173778 [Multi-domain] Cd Length: 142 Bit Score: 145.06 E-value: 1.39e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGA-TKREEGYFEGGGYAVTWAFGHLVQLAMPDGYgVRGFVRDNLPIIPDTFtlvprqvrte 79
Cdd:cd01028 1 KVLIIAEKPSKAKTIAKILGKgSKKKGFYGEGGGYVVTASVGHLLELPFPEEY-VDWDKDWPLELFPFEP---------- 69
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498224087 80 kGYKPDSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFV-RLWISSLTDKAIREGLRKL 152
Cdd:cd01028 70 -KYVVIPDKKKQLKALKKLAKKADEIVLATDPDREGELIAWEILEVLKCDNKPVkRAWFSEITPKAIREAFKNL 142
|
|
| PRK06319 |
PRK06319 |
DNA topoisomerase I/SWI domain fusion protein; Validated |
79-561 |
2.32e-36 |
|
DNA topoisomerase I/SWI domain fusion protein; Validated
Pssm-ID: 235778 [Multi-domain] Cd Length: 860 Bit Score: 146.51 E-value: 2.32e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 79 EKGYKPDSGVVSQ----IKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLED 154
Cdd:PRK06319 47 ENDFEPDYQILPDkeevINKICKLAKKCDVVYLSPDPDREGEAIAWHIANQLPKNTKIQRISFNAITKGAVTEALKHPRE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 155 gskYDNLYLTAK-ARSESDWLVGINGTQALS--IAAGHGTySVGRVQTPTLAMVCERYWENRRFTPEAFWQLHI------ 225
Cdd:PRK06319 127 ---IDMALVNAQqARRLLDRIVGYKISPILSrkLQRRSGV-SAGRVQSVALKLVVDREKAIEAFVPVEYWNIRVhlkdpk 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 226 ----------ATDG--CDGEIVKFSSSEKW---KEKESAMElYNKVKEAGCATVTKAERKEKTEDTPLLYDLTTLQKEAN 290
Cdd:PRK06319 203 tqktfwahlySVDGkkWEKEIPEGKTEDEVlliNSKEKADH-IVELLESATYTVTRVESKEKRRNAYPPFITSTLQQEAS 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 291 TKHGFTAEQTLETAQKLYE---------KKLITYPRTGSRYIPEDVYAEIPKllaFIGTQ------PEwkdkvRAKATPT 355
Cdd:PRK06319 282 RHFRFSSSRTMNIAQTLYEgvdldsegaTGLITYMRTDSVRTDPEALKQVRK---YIEGTfgkeflPS-----SPNVYTT 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 356 RRSVDDGkvtdHHA-----LLVTGEK-PLFLSKEDGILYHMIAGRMVEAFSEKCVKD---VTIITTEcaGVEFTVKGSVV 426
Cdd:PRK06319 354 KKMAQDA----HEAirptdITLTPEKlRSKLTEDQYKLYSLIWKRFVASQMIPAIYDtlaIRITTNK--GIDLRATGSLL 427
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 427 KQAGWRAVYGE-------EKEDVILPDLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLsametagKEIEDDalrqamkdc 499
Cdd:PRK06319 428 KFKGFLAVYEEkrddegdEEENIHLPKLHEQDVLTKEELSAEQAFTKPLPRFTEASLV-------KELEKS--------- 491
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 498224087 500 GIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKT--MRIADVAMTGEWERELARI 561
Cdd:PRK06319 492 GIGRPSTYATIMNKIQSREYTLKENQRLRPTELGKIISQFLETnfPRIMDIGFTALMEDELELI 555
|
|
| PTZ00407 |
PTZ00407 |
DNA topoisomerase IA; Provisional |
104-563 |
9.71e-31 |
|
DNA topoisomerase IA; Provisional
Pssm-ID: 173597 [Multi-domain] Cd Length: 805 Bit Score: 128.90 E-value: 9.71e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 104 QIIVATDAGREGELIFRYLYH-----YTGSTTPFVRLWISSLTDKAIREGLR-KLEDGSKYDnLYLTAKARSESDWLVGI 177
Cdd:PTZ00407 127 EIILATDPDREGELIAVHALQtikrlYPKLKVPFSRAYMHSITEDGIRKAMReRHVEACDYD-LANAAETRHAMDRIFGF 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 178 NGTQALSiAAGHGTYSVGRVQTPTLAMVCER------YWENRR--FTPEAFWQLHIATDGCDGEIVKFSSSEK-----WK 244
Cdd:PTZ00407 206 LGSSVVR-AANSQMRSIGRVQTPALILINERedkikaFLESNKstFEVQAMCQFPSPHGTTFSQVVTITPDRKggashWA 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 245 EKESAMELYNKVKEAGCATVT---KAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYPRTGSR 321
Cdd:PTZ00407 285 TEAEARRCLEQWKLNNCTGFSvplEPKPQPSVVPPPQPFTMATAIAKANRQLKYSSEMVSGCLQDLFQLGHITYPRTDST 364
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 322 YIPE----DVYAEIPK------LLAFIGTQPEWKDKVRAKATPTRRSVDDGK--------VTDHHALL------VTGEKp 377
Cdd:PTZ00407 365 RIDEsalpDIYAAVKKefgkefLYRLEDRTVSAQEGKGSKKTGKKRSTKQKKgadtpvgnVEDAHEAIrptnidTTGES- 443
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 378 LFLSKEDGILYHMI-----AGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVY-----------GEEKED 441
Cdd:PTZ00407 444 LSLSPPTRAVYDLVrrntlAVFMIPMKTEKIVATVKFTSGSGEKLEFELQGKRVVEPGWTRAFhkgdkgttgpaEETDED 523
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 442 V--------ILPDLHEGDYLTIKGV------------------SVTEGRTKPKPLHTEATLLsametagkeieddalrQA 495
Cdd:PTZ00407 524 ItaveegapVVPSLSQEEFKAIMNLrsqlgsgvqkgffelrspQVRENRPVPPLPHSEGTLI----------------EE 587
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 498224087 496 MKDCGIGTPATRASIIETLFKRGYME-----RCKKSlvPTEKGLALNSVVKTMRIADVAMTGEWERELARIER 563
Cdd:PTZ00407 588 LKNNGVGRPSTYPMIVKTLLARGYIAvnpkgRCETT--PVGRMLVETAKSTFPSIVDIGFTAAFEKKLDRIAK 658
|
|
| TOP1Bc |
smart00436 |
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA ... |
134-222 |
7.77e-27 |
|
Bacterial DNA topoisomeraes I ATP-binding domain; Extension of TOPRIM in Bacterial DNA topoisomeraes I and III, Eukaryotic DNA topoisomeraes III, reverse gyrase beta subunit
Pssm-ID: 214662 [Multi-domain] Cd Length: 89 Bit Score: 104.20 E-value: 7.77e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 134 RLWISSLTDKAIREGLRKLEDgsKYDNLYLTAKARSESDWLVGINGTQALSIAAGHGTYSVGRVQTPTLAMVCERYWENR 213
Cdd:smart00436 3 RIEFSEITKKAIREALKNPRE--IDENLVNAQLARRILDRLIGFNLSRLLTKKLRNGVLSAGRVQTPTLGLIVEREREIK 80
|
....*....
gi 498224087 214 RFTPEAFWQ 222
Cdd:smart00436 81 NFVPKPYWE 89
|
|
| Toprim_Crpt |
pfam13342 |
C-terminal repeat of topoisomerase; |
624-682 |
3.64e-19 |
|
C-terminal repeat of topoisomerase;
Pssm-ID: 463851 [Multi-domain] Cd Length: 60 Bit Score: 81.37 E-value: 3.64e-19
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 498224087 624 CGLPVFRLKAGRTLSDDEIKDLLTEGHTKLLKGFKSKQGKSFDAVVAFDGEYNMTFVFP 682
Cdd:pfam13342 2 CGFSIGKTIAGKKLSEEQVKELLTKGKTGLIKGFKSKKGKKFDAYLVLDDDEKVEFDFE 60
|
|
| YrdD |
COG0551 |
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination ... |
5-625 |
1.51e-09 |
|
DNA topoisomerase I, ssDNA-binding Zn-finger and Zn-ribbon domains [Replication, recombination and repair];
Pssm-ID: 440317 [Multi-domain] Cd Length: 695 Bit Score: 61.42 E-value: 1.51e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 5 IAEKPSVAREIARIVGATKREEGYFEGGGYAVTWAFGHLVQLAMPDGYGVRGFVRDNLPIIPDTFTLVPRQVRTEKGYKP 84
Cdd:COG0551 1 AEKEIAAALAAAKEAVKLVKKKKKKKKEGKKKGLAGALGLKKKLVDLLLKEKLKKLVENEKLIAELDIKDLKKLKKDKKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 85 DSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGLRKLEDGSKYDNLYLT 164
Cdd:COG0551 81 KAKALAAALAAADDDAIEAAAAADEEEALKAAEALEAIRKAVVEEVKSRARKRAARAPADVAAAAAAAALARLLLLAAAS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 165 AKARSESDWLVGINGTQALSIAAGHGTYSVGRVQTPTLAMVCERYWENRRFTPEAFWQLHIATDgcDGEIVKFSSSEKWK 244
Cdd:COG0551 161 RALRLLLLLAAGRLRLLSAVAAGLLELEELLKEFEEEEEEEAAEEEEEEEEAKKKKEEDKKKKK--KKKKKDKEEETKAI 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 245 EKESAMELYNKVKEAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEKKLITYPRTGSRYIP 324
Cdd:COG0551 239 KKKKKAAEAVLAAKKAAKEAKAKKELPTTTTDALPEALATTSLTAAAAASALAAALLEEEGELLYTGGYIRYTRTPKSSE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 325 EDVYAEIPKLLAFIGTQPEWKDKVRAKATPTRRSVDDGKVTDHHALLVTGEKPLFLSKEDG---ILYHMIAGRMVEAFSE 401
Cdd:COG0551 319 ADALAALEALKKIAEEPPDERAKKKKKKAKKKKASEAKETTDHPPIPPTTAAALLELLEDRkllLELLVRRRFAAAADLA 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 402 KCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEKEDVILPDLHEGDYLTIKGVSVTEGRTKPKPLHTEATLLSAME 481
Cdd:COG0551 399 KVEELTKVEEADEEELVEAEGGLLEVLGEEEEDDEDEEEELLLPPLEEGEPLLLEELLLEKQTTTPPPRYTTELLLKKLE 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 482 TAGkeieddalrqamkdcgIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLALNSVVKTMRIADVAMTGEWERELARI 561
Cdd:COG0551 479 EEG----------------GGGRGTTATIIILILKRRYVVLEEKKTTPTELLVEVVLLLLLPFPKLEDTTETAEEEEALL 542
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 498224087 562 ERGEVSADAFHREIEAYTREITSELLSCDKLFGSRDS------GCACPKCG------TGRmrfYGKVVRCDN-AECG 625
Cdd:COG0551 543 DKEEGKEDKVVEIREEEYPFFKKLLEIAEEEGEEELSeedevlGEKCPKCGkplvikKGR---YGKFLGCSNyPECK 616
|
|
| TOPRIM_TopoIA_TopoI |
cd03363 |
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA ... |
1-149 |
3.11e-07 |
|
TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TOPRIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173783 [Multi-domain] Cd Length: 123 Bit Score: 49.48 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 1 MKTIIAEKPSVAREIARIVGAtkreegyfeggGYAVTWAFGHLVQLAmPDGYGVRGfvrDNLPIIPDtftlvprqvrtek 80
Cdd:cd03363 1 KKLVIVESPAKAKTIKKYLGK-----------EYEVLASVGHIRDLP-KKGLGVDG---EDDGFEPK------------- 52
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498224087 81 gYKPDSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVRLWISSLTDKAIREGL 149
Cdd:cd03363 53 -YVVIPGKKKVVKELKKLAKKADEIYLATDPDREGEAIAWHLAEVLKLKKNVKRVVFNEITKEAIKEAL 120
|
|
| CREPT |
pfam16566 |
Cell-cycle alteration and expression-elevated protein in tumour; CREPT (Cell-cycle alteration ... |
233-314 |
1.13e-05 |
|
Cell-cycle alteration and expression-elevated protein in tumour; CREPT (Cell-cycle alteration and expression-elevated protein in tumour) is a family of eukaryotic transcriptional regulators that ptromote the binding of RNA-polymerase to the CYCLIN D1, CCDN1, promoter and other genes involved in the cell-cycle. It promotes the formation of a chromatin loop in the CYCLIN D1 gene, and is preferentially expressed in a range of different human tumours.
Pssm-ID: 465181 [Multi-domain] Cd Length: 147 Bit Score: 45.69 E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 233 EIVKFSSSEKWKEKESAMELYNKVKEAgCATVT------KAERKEKTEDTPLLYDLTTLQKEANTKhgftAEQTLETaqk 306
Cdd:pfam16566 30 EVSDVSLLSKIQDKESAERLLKQVNEA-CELLAeyngrlAAELEDRKKVAQMLRDFLQLQKELLAQ----AEERLEE--- 101
|
....*...
gi 498224087 307 lYEKKLIT 314
Cdd:pfam16566 102 -YKEKLEK 108
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
4-140 |
2.54e-05 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 43.50 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 4 IIAEKPSVAREIARivgatkreegYFEGGGYAVTWAFGHLVQLampdgygvrgfvrdnlpiipdtftlvprqvrtekgyk 83
Cdd:pfam01751 3 IIVEGPSDAIALEK----------ALGGGFQAVVAVLGHLLSL------------------------------------- 35
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 498224087 84 PDSGVVSQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFV-RLWISSL 140
Cdd:pfam01751 36 EKGPKKKALKALKELALKAKEVILATDPDREGEAIALKLLELKELLENAGgRVEFSEL 93
|
|
| TOPRIM_TopoIA_RevGyr |
cd03361 |
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA ... |
4-150 |
4.05e-05 |
|
TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving one strand of the DNA duplex, covalently linking to the 5' phosphoryl end of the DNA break and, allowing the other strand of the duplex to pass through the gap. Reverse gyrase is also able to insert positive supercoils in the presence of ATP and negative supercoils in the presence of AMPPNP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). For topoisomerases the conserved glutamate is believed to act as a general base in strand joining and, as a general acid in strand cleavage. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173781 [Multi-domain] Cd Length: 170 Bit Score: 44.61 E-value: 4.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 4 IIAEKPSVAREIARIVG--ATKREEG--YFE---GGGY-AVTWAFGHLVQLAMPDGYgvRGFVRDNLPIIPdTFTLVPR- 74
Cdd:cd03361 4 MIVESPNKARTIANFFGrpSVRRLGGlvVYEvstGDGVlMITASGGHVYDLVTKEGG--HGVVEDDGRYVP-VYDSIKRc 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 75 -----QVRTEKGYKPDSGVV------SQIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFV-RLWISSLTD 142
Cdd:cd03361 81 rdcgyQFTEDSDKCPRCGSEniddklETLEALRELALEVDEVLIATDPDTEGEKIAWDVYLALRPYNKNIkRAEFHEVTR 160
|
....*...
gi 498224087 143 KAIREGLR 150
Cdd:cd03361 161 RAILEALR 168
|
|
| COG1754 |
COG1754 |
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown]; |
231-536 |
8.98e-05 |
|
Uncharacterized C-terminal domain of topoisomerase IA [Function unknown];
Pssm-ID: 441360 [Multi-domain] Cd Length: 892 Bit Score: 45.96 E-value: 8.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 231 DGEIVKFSSSEKWKEKESAMELYNKVKEAGCATVTKAERKEKTEDTPLLYDLTTLQKEANTKHGFTAEQTLETAQKLYEK 310
Cdd:COG1754 225 KGGGKLAAGGAAAAAAAAAAAAAAAAALAEAAAAAAVREPPTPTTTTTAQAATTTTTRAAAARTTRSAQQAARRTRLGGE 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 311 KLITYPRTGSR-------YIPEDVYAEIPKLLAFIGTQPEWKDKVRAKATPTRRSVDDGKVTDHHALLVTGEKPLFLSKE 383
Cdd:COG1754 305 GTYTTTTTTTTttsaaaaAAAAAAAALAAAAAAAYAPPPPYYYKKKAAAAAAAAAAAAAAAARRPPAARAALLSDDRLLL 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 498224087 384 DGILYHMIAGRMVEAFSEKCVKDVTIITTECAGVEFTVKGSVVKQAGWRAVYGEEKEDV------ILPDLHEGDYLTIKG 457
Cdd:COG1754 385 ELLLLRRTAAAAAAAAAATATTTAAAAAAGAGAVGTAAAGAVFFFGGFLLFAEEEDDDEedddddDLPALEEGLPLLKEG 464
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 498224087 458 VSVTEGRTKPKPLHTEATLLSAMETAgkeieddalrqamkdcGIGTPATRASIIETLFKRGYMERCKKSLVPTEKGLAL 536
Cdd:COG1754 465 VLADQHFTQPPPRYTEAPLVKRMEEL----------------GIGRPSTYASILSTLADRIYVRLDKRRLIPEDKGRLV 527
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
91-134 |
1.02e-03 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 38.56 E-value: 1.02e-03
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 498224087 91 QIKVIKRLFDASEQIIVATDAGREGELIFRYLYHYTGSTTPFVR 134
Cdd:cd00188 36 TRELLKRLLGEAKEVIIATDADREGEAIALRLLELLKSLGKKVR 79
|
|
| TOPRIM |
smart00493 |
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins; |
90-125 |
6.72e-03 |
|
topoisomerases, DnaG-type primases, OLD family nucleases and RecR proteins;
Pssm-ID: 214695 [Multi-domain] Cd Length: 75 Bit Score: 36.08 E-value: 6.72e-03
10 20 30
....*....|....*....|....*....|....*.
gi 498224087 90 SQIKVIKRLFDASEqIIVATDAGREGELIFRYLYHY 125
Cdd:smart00493 36 EQIKLLKKLAKKAE-VILATDPDREGEAIAWELAEL 70
|
|
| |
