|
Name |
Accession |
Description |
Interval |
E-value |
| MATE_like_4 |
cd13144 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
8-439 |
1.56e-158 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240549 [Multi-domain] Cd Length: 434 Bit Score: 455.15 E-value: 1.56e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 8 MGTHKMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDL 87
Cdd:cd13144 1 MGSGPVLRLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 88 ETANKTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPM 167
Cdd:cd13144 81 KEANKAANNGLLLALLSYLLFLLLGLFGVKPFFRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 168 FLQIIGAVTNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGI 247
Cdd:cd13144 161 IAQLIGAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMFLAFFFLLRKNKDVQPDLRLFRPSLRIIKEIYAVGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 248 PSFFIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICV 327
Cdd:cd13144 241 PSIIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAV 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 328 AINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMA 407
Cdd:cd13144 321 VIMLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLA 400
|
410 420 430
....*....|....*....|....*....|..
gi 492558571 408 YILGRIYGLTGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13144 401 WLLAKMFGLNGVWWSFPIAEIVSFLLSLLFLK 432
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
8-437 |
1.20e-103 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 314.77 E-value: 1.20e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 8 MGTHKMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDL 87
Cdd:COG0534 1 LTEGPILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 88 ETANKTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPM 167
Cdd:COG0534 81 EEARRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 168 FLQIIGAVTNIILDPILIYGyfgiPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGI 247
Cdd:COG0534 161 IIMLIGNVLNIVLDPLLIFG----GGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 248 PSFFIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICV 327
Cdd:COG0534 237 PAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLAL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 328 AINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMA 407
Cdd:COG0534 317 GIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLA 396
|
410 420 430
....*....|....*....|....*....|.
gi 492558571 408 YILGR-IYGLTGVWLAFPTVEVITCMISIYM 437
Cdd:COG0534 397 YLLAFlGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MATE_MepA_like |
cd13143 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-439 |
8.45e-98 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.
Pssm-ID: 240548 [Multi-domain] Cd Length: 426 Bit Score: 299.81 E-value: 8.45e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 12 KMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKL-GTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETA 90
Cdd:cd13143 1 PIGKLFLKFALPAIIGMLVNGLYNIVDGIFVGHGvGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 91 NKTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQ 170
Cdd:cd13143 81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLGASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAMLGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 171 IIGAVTNIILDPILIyGYFGipaMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSF 250
Cdd:cd13143 161 LIGAVLNIILDPLFI-FVLG---LGIAGAALATVIAQLISLLLLLLYFFRGKSLLKLSLLRFKLSLKIIKEILALGFPSF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 251 fIMSIGSFLVMGI--NFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVA 328
Cdd:cd13143 237 -LMQLSSSVVTIVlnLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALIVALI 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 329 INFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAY 408
Cdd:cd13143 316 YGLVLFLILLLFPEQIVSLFTDDPELIALAARILRIFLLAFPLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFLIPLLL 395
|
410 420 430
....*....|....*....|....*....|.
gi 492558571 409 ILGRIYGLTGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13143 396 ILPRLFGLDGIWLAFPLAEILTLLLALILLK 426
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
13-444 |
1.43e-79 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 253.15 E-value: 1.43e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 13 MLPLLLSMSIPPTISMLINSLYNIVDSIFVAK-LGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETAN 91
Cdd:cd13138 1 ILKTLLLFALPLLLSNLLQQLYNLVDLLIVGQfLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 92 KTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQI 171
Cdd:cd13138 81 KAVGTLLVLFLILGIVLTILGLLFAPPILRLMNTPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFVI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 172 IGAVTNIILDPILIYGyfgiPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFF 251
Cdd:cd13138 161 IACVLNIILDLLFIAV----FHMGVAGAALATVIAQAISVLLALYYLRKKKLPFKLSLKDFRFDKEILKEILKIGLPSAL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 252 IMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINF 331
Cdd:cd13138 237 QQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISLIIGL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 332 LGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILG 411
Cdd:cd13138 317 IIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLAYLLS 396
|
410 420 430
....*....|....*....|....*....|....*
gi 492558571 412 RIY--GLTGVWLAFPTVEVITCMISIYMYRNFVRK 444
Cdd:cd13138 397 RLTglGLFGIWLAMPISNILSAIICIIYYRKGRWK 431
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
17-439 |
1.60e-78 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 250.51 E-value: 1.60e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13137 3 IWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRALGQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVT 176
Cdd:cd13137 83 SLLLALLLSLPLALLGLLFAEPLLRLLGADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMIIVNVL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 177 NIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSIG 256
Cdd:cd13137 163 NIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLPIKISFKGFRLDRKIIKKLLRIGLPAGLEQLLR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 257 SFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVL 336
Cdd:cd13137 243 SLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLFMGLLGLL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 337 FWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILGRI--Y 414
Cdd:cd13137 323 LFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYLLGFVlgL 402
|
410 420
....*....|....*....|....*
gi 492558571 415 GLTGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13137 403 GLTGIWLAMFVDTIVRAILLLYRFR 427
|
|
| MATE_MJ0709_like |
cd13147 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ... |
17-444 |
3.66e-78 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240552 [Multi-domain] Cd Length: 441 Bit Score: 249.77 E-value: 3.66e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13147 11 IIKLSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVH 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFtKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVT 176
Cdd:cd13147 91 SILLGLIISIILTIVLLPFLEPILVLM-GAGEVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSIL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 177 NIILDPILIYgYFGipaMGVKGAAIATIIGQMTALLCSIYVLFFMKQE-IKIERKDFVWNNKIIREIYSVGIPSFFIMSI 255
Cdd:cd13147 170 NIILDPIFIY-TLG---LGIAGAAWATVISMLISSLVLLYWFFVKKDTyVSLSLKNFKFDKKIVKDILKVGIPASLEQLI 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 256 GSFLVMGINFILSGIS-TLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGS 334
Cdd:cd13147 246 MSVLMIILNLILVIVAgTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIELIIA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 335 VLFWLFPQEILHFFNATDEMMSIG---VRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILG 411
Cdd:cd13147 326 ILIFIFAPQIAYLFTYSEESAHLApeiVAFLRIMCLFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFAYLFA 405
|
410 420 430
....*....|....*....|....*....|....*
gi 492558571 412 RI--YGLTGVWLAFPTVEVITCMISIYMYRNFVRK 444
Cdd:cd13147 406 IVlgLGLFGVWWGIVLGNAIGSIVGYLWARLYIKR 440
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
21-439 |
2.31e-70 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 228.75 E-value: 2.31e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 21 SIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAASGLTL 100
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 101 SVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVTNIIL 180
Cdd:cd12082 81 AILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 181 DPILIYGYFGiPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSIGSFLV 260
Cdd:cd12082 161 DPLLIFGLGP-PELGIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 261 MGINFILSGI-STLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVLFWL 339
Cdd:cd12082 240 LIIVAIVAAFgGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLGLLILL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 340 FPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILGRI-YGLTG 418
Cdd:cd12082 320 FPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLAYLgLGLYG 399
|
410 420
....*....|....*....|.
gi 492558571 419 VWLAFPTVEVITCMISIYMYR 439
Cdd:cd12082 400 IWLALVISLILAALVLLLFFR 420
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-439 |
5.30e-69 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 225.92 E-value: 5.30e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 13 MLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANK 92
Cdd:cd13142 9 ILRTLLKLAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYDKANK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 93 TAASGLTLSVIHYLILVLLGVIFIKPFFLLF-TKESNILKMGIDYTYIVtFLSIGTIAQIAI-EKILQATGNTLAPMFLQ 170
Cdd:cd13142 89 VAGQTFSFVIILSLILAVLGYILSRPLLLLLiGAPEEVYPLALAYLRII-FLGLPFMFIFFVfNSLLRGIGDTKTPMKIM 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 171 IIGAVTNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSF 250
Cdd:cd13142 168 FGSVLLNVILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGRVGLKISLRDLKPDWEWLKKIFRIGLPSS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 251 FIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAIN 330
Cdd:cd13142 248 IEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAALLIFLIL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 331 FLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYIL 410
Cdd:cd13142 328 VIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIRIPLAYLL 407
|
410 420 430
....*....|....*....|....*....|.
gi 492558571 411 GRIYGL--TGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13142 408 AYVLGLgvTGIWIAMAISNIVAALIALAWFK 438
|
|
| MATE_like_5 |
cd13145 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
16-444 |
3.51e-65 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240550 [Multi-domain] Cd Length: 440 Bit Score: 215.92 E-value: 3.51e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 16 LLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAA 95
Cdd:cd13145 10 LIRKLAIPASVGFFFNTMFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 96 SGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAV 175
Cdd:cd13145 90 QGLSFGIILAILLTVIGLFAAPPLFRLLGAEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKSYRNFLIIGFF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 176 TNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPS---FFI 252
Cdd:cd13145 170 LNIILDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRLRDFIPRLDVYKEILKQGFPAslnMMT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 253 MSIGSFLvmgINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFL 332
Cdd:cd13145 250 IGLGIFV---ITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKYDRVRETYKKALKYGFVIMVV 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 333 GSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILGR 412
Cdd:cd13145 327 ATVFLLFFAEPLMSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLYRQLVGPALVFWLLVN 406
|
410 420 430
....*....|....*....|....*....|....
gi 492558571 413 I--YGLTGVWLAFPTVEVITCMISIYMYRNFVRK 444
Cdd:cd13145 407 VlgLGVTGIWWGIFTIVWSAAIIALLYTRRVLKK 440
|
|
| MATE_like_2 |
cd13149 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-436 |
2.82e-62 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240554 [Multi-domain] Cd Length: 434 Bit Score: 208.31 E-value: 2.82e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 12 KMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETAN 91
Cdd:cd13149 6 SIPRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 92 KTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQI 171
Cdd:cd13149 86 RLATDSLILSLLLSVIVSLLGLFTIPPLFSLLGASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVML 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 172 IGAVTNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFF 251
Cdd:cd13149 166 GAALVNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFLHYHHRLIDFSEPSLKALFRSWKDILSIGIPAAL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 252 IMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINF 331
Cdd:cd13149 246 SNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLIYGA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 332 LGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILG 411
Cdd:cd13149 326 ILGIVLALFAGWLASLFSAEPEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNLIRVFLLYIPLAYVGS 405
|
410 420
....*....|....*....|....*
gi 492558571 412 RIYGLTGVWLAFPTVEVITCMISIY 436
Cdd:cd13149 406 HLLGFAGVFIGALAGNLIAGILAYF 430
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-444 |
1.29e-55 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 190.43 E-value: 1.29e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13140 7 LLRLALPIMGTSFIQMAYNLTDMFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARN 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFT-KESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAV 175
Cdd:cd13140 87 ALQLNLLLGILYGLLLLLFAKPLIGFFNlGDAEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 176 TNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSI 255
Cdd:cd13140 167 LNIILDPLLIFGFGPFPALGVAGAALATVLAQAIVFLLFLYALKKKKGLFLKIRILKRPDRKYIKEILKLGLPVALQSIL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 256 GSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSV 335
Cdd:cd13140 247 FALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 336 LFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIP----SLTITMLRqlillLPMAYILG 411
Cdd:cd13140 327 LLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPpaiiSIVFNGLR-----IPLALLLS 401
|
410 420 430
....*....|....*....|....*....|....
gi 492558571 412 RI-YGLTGVWLAFPTVEVITCMISIYMYRNFVRK 444
Cdd:cd13140 402 PTgLGLNGIWWAISISSILKGIILTIWFLLYKKK 435
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-439 |
1.49e-55 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 190.41 E-value: 1.49e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13134 5 LFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIAGV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVT 176
Cdd:cd13134 85 ALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLIMNIL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 177 NIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSIG 256
Cdd:cd13134 165 NIVGNYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRLKDLRPFPKKLLKKILKIGLPSAGEELSY 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 257 SFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVL 336
Cdd:cd13134 245 NLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLVSLAVALL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 337 FWLFPQEILHFFNATDEMMSIGvRTIRIISTSYSFG-SICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILGRI-- 413
Cdd:cd13134 325 LALFREPILGLFTDDPEIIALG-KTLLLISILLEPGrAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYLLGIVlg 403
|
410 420
....*....|....*....|....*.
gi 492558571 414 YGLTGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13134 404 LGLLGVWIAFAADEWVRGIIMLWRWR 429
|
|
| vmrA |
PRK09575 |
MATE family efflux transporter; |
21-447 |
1.74e-52 |
|
MATE family efflux transporter;
Pssm-ID: 236576 [Multi-domain] Cd Length: 453 Bit Score: 182.89 E-value: 1.74e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 21 SIPPTISMLINSLYNIVDSIFVAK-LGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAASGLT 99
Cdd:PRK09575 18 TIPSIAAMLVNGLYQIVDGIFIGHyVGAEGLAGINMAWPVIGIILGIGLMVGMGTGSLLSIKRGEGDLEKAKRILTTGLL 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 100 LSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVTNII 179
Cdd:PRK09575 98 LLLLLGPIVSVILFLFADDFLRAQGAEGRTLELALQYIQVLIWGCLFTLGAIALPFLLRNDESPNLATGLMVIGALINIV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 180 LDPILIyGYFGipaMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSIGSFL 259
Cdd:PRK09575 178 LDYLFI-GWLD---WGLTGAAIATALAQLVVTVLGLGYFFSSRANIRLTLKELRFNWSLAPKIVLLGSSSFFMYLYGSFV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 260 VMGIN--FILSGiSTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVLF 337
Cdd:PRK09575 254 VALHNrlFMEYG-SALTVGAYAIVGYLMVLYYLVAEGIAEGMQPPVSYYFGARQYDNIKKLLKLAMKVTVLAGIAWVLLL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 338 WLFPQEILHFFNATD-EMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLIlLLPMAYILGRIYGL 416
Cdd:PRK09575 333 NLFPETMIALFNSGDsELIAETIVGIRLHLFAMFLDGFLVLASAYFMAVNQGGKALFISIGNMLI-QLPFLFILPKWLGV 411
|
410 420 430
....*....|....*....|....*....|.
gi 492558571 417 TGVWLAFPTVEVITCMISIYMYRNFVRKDPV 447
Cdd:PRK09575 412 DGVWLAMPLSNIALSLVVAPMLWRDVKKLKK 442
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-440 |
4.52e-52 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 181.66 E-value: 4.52e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13139 16 IFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAAVQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVtFLSIGTIA-QIAIEKILQATGNTLAPMFLQIIGAV 175
Cdd:cd13139 96 AILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIM-FGGNGFIMlLFLINGIFRGAGDAAIAMRSLWLANG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 176 TNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSF--FIM 253
Cdd:cd13139 175 LNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKGKGRIQIRRRHLKLDWAIIKKIIKIAVGGIlqFLI 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 254 SIGSFLVMGInfILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLG 333
Cdd:cd13139 255 ASSSWIFLVR--IIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKYNMVFLGIV 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 334 SVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKgipSLTITMLRQL---ILLLPMAYIL 410
Cdd:cd13139 333 SLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGD---TKTPTLINLVgfwLFQIPLAYLL 409
|
410 420 430
....*....|....*....|....*....|..
gi 492558571 411 GRI--YGLTGVWLAFPTVEVITCMISIYMYRN 440
Cdd:cd13139 410 ARHlnLGPKGVFIAIPIAETVLAIAAIILFRR 441
|
|
| MATE_like_6 |
cd13146 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
13-437 |
6.86e-52 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240551 [Multi-domain] Cd Length: 433 Bit Score: 180.68 E-value: 6.86e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 13 MLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEA---LTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLET 89
Cdd:cd13146 6 ISPLLIRLALPILIGQLFQLLYNITDTIWISMIDPSDpalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKE 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 90 ANKTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFL 169
Cdd:cd13146 86 LDQAADSGLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLMGVLQGEGRTKYMMMA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 170 QIIGAVTNIILDPILIYGYfgipAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPS 249
Cdd:cd13146 166 MLIGTVVNIVLDPILIFVF----DMGVKGAALATVLAQAISLLYLLYVFLIGKSNVTIHIKLSNISSSVIVEILRVGLPQ 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 250 FFIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAI 329
Cdd:cd13146 242 MLLQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 330 NFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYI 409
Cdd:cd13146 322 VLVLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYL 401
|
410 420 430
....*....|....*....|....*....|
gi 492558571 410 LGRIY--GLTGVWLAFPTVEVITCMISIYM 437
Cdd:cd13146 402 LAYVFgkGITGVYFGIVSANFFTALLAMFW 431
|
|
| MATE_like_7 |
cd13133 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-439 |
6.37e-50 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240538 [Multi-domain] Cd Length: 438 Bit Score: 175.41 E-value: 6.37e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13133 7 ILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRVLWQ 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVT 176
Cdd:cd13133 87 GLYFSLLLAPLLALLSALAAPLLFLLLGHSPEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANLVMVVV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 177 NIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIE-RKDFVWNNKIIREIYSVGIPS--FFIM 253
Cdd:cd13133 167 NIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRRRFGlRRAWRFDRELLRRILRLGLPSglQFFL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 254 SIGSFLVMGINFILSGISTLAVSlfGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLG 333
Cdd:cd13133 247 DVGAFTVFFLLIGRLGTTELAAT--NIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALAYMLLL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 334 SVLFWLFPQEILHFFNATDEM---MSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYIL 410
Cdd:cd13133 325 GILFLLFPELLLSIFTPGADFaliAELAVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLYLLPPAYLL 404
|
410 420 430
....*....|....*....|....*....|
gi 492558571 411 GRI-YGLTGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13133 405 VVLgAGLAGAWTVETVYVIVLALIFLLRFR 434
|
|
| MATE_like_13 |
cd13141 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-444 |
3.51e-45 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240546 [Multi-domain] Cd Length: 443 Bit Score: 162.87 E-value: 3.51e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13141 13 IISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVFNQ 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTY-IVTFLSIgTIAQIAIEKILQATGNTLAPMFLQIIGAV 175
Cdd:cd13141 93 SLLLAAVLGLVVLVLGYLFGRLYLETLAADAATVEAATTYLYwFIPSLAL-QFILTVLGAALRGTGIVKPFMVIQILAVL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 176 TNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPS---FFI 252
Cdd:cd13141 172 LNIILAPILITGWGTGRALGVAGAGLASSISVAIAVVLLLYYFLRLEKYLRLDLALWRPDLPTWKRLLKIGLPSggeFLL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 253 MsigsFLVMGINF-ILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINF 331
Cdd:cd13141 252 T----FVYMAVIYwALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTALML 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 332 LGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLPMAYILG 411
Cdd:cd13141 328 VLTLLCQLVPELLVTPFSDDAAVIAVAATFLRYVSWNFVAAGLVFTCSGMFQALGNTWPSLLSSASRLLTFALPVIWLSA 407
|
410 420 430
....*....|....*....|....*....|....
gi 492558571 412 RIY-GLTGVWLAFPTVEVITCMISIYMYRNFVRK 444
Cdd:cd13141 408 QPDfRIEQIWYLSVATTILQAALSLLLLRRELKK 441
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
23-366 |
8.57e-41 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 148.55 E-value: 8.57e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 23 PPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAASGLTLSV 102
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 103 IHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVTNIILDP 182
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIILNY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 183 ILIYGYFGipAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSIGSFLVMG 262
Cdd:TIGR00797 161 ILIFGKFG--FLGIVGAALATVISYWLMFLLLLYYIKKAKKIGLKWEGLLKPDWEVLKRLLKLGLPIAFRVILESLSFAL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 263 INFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVLFWLFPQ 342
Cdd:TIGR00797 239 LALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIILILFRE 318
|
330 340
....*....|....*....|....
gi 492558571 343 EILHFFNATDEMMSIGVRTIRIIS 366
Cdd:TIGR00797 319 FIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_DinF_like |
cd13136 |
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ... |
17-423 |
6.74e-35 |
|
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240541 [Multi-domain] Cd Length: 424 Bit Score: 134.61 E-value: 6.74e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEA-LTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAA 95
Cdd:cd13136 5 ILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIALLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 96 SGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAV 175
Cdd:cd13136 85 RALLLALAIGLLLILLQSPLLALALLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLILQIVGNV 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 176 TNIILDPILIYGYfgipAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPsFFIMSI 255
Cdd:cd13136 165 VNIVLDPLFVFGL----GWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRLFKLNRD-IFIRTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 256 gsFLVMGINFILS-----GISTLAVslFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAIN 330
Cdd:cd13136 240 --ALLAAFLFFTAlaarlGDVILAA--NQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLQWGLGLG 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 331 FLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGiPSLTITMLRQLILLLPMAYIL 410
Cdd:cd13136 316 VLLALLFFLGGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDT-RYLRNSMLVSLAVFLPLLFLL 394
|
410
....*....|...
gi 492558571 411 GRIYGLTGVWLAF 423
Cdd:cd13136 395 VPLWGNHGLWLAL 407
|
|
| MATE_like_9 |
cd13135 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
17-439 |
6.77e-33 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240540 [Multi-domain] Cd Length: 429 Bit Score: 128.95 E-value: 6.77e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13135 3 INHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYAIS 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVT 176
Cdd:cd13135 83 SIVYNSIIGVILFLLWLFGARIIFVLFGVDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETKPIMYGGIIKNLL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 177 NIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLcsIYVLFFMKQEIKIERKDFVWNNKIIREIY----SVGIPSFFI 252
Cdd:cd13135 163 NVILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLI--ILVYLCRKIKKLTFKLSNTKVLKANIRPYkftiKLGLPLGGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 253 MSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFL 332
Cdd:cd13135 241 EFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLGLGLLIYIA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 333 GSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRQLILLLpMAYILGR 412
Cdd:cd13135 321 AAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKWMLYTQIIGTIIVVS-VALLLIF 399
|
410 420
....*....|....*....|....*....
gi 492558571 413 IY--GLTGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13135 400 VFklGLAGVYITLFIDEIIRAIINFLKYR 428
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
17-423 |
7.57e-33 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 128.77 E-value: 7.57e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:cd13131 5 LLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRAVRQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 97 GLTLSVIhYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVT 176
Cdd:cd13131 85 GLWLALL-LSLPLMLLLWLAPPILPLMGQEPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTRPAMVITLLALVL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 177 NIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMK--QEIKIERKDFVWNNKIIREIYSVGIPS----F 250
Cdd:cd13131 164 NIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYIRRHKrfRRYRLFARFWRPDWARLKELLRLGLPIgltiF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 251 FIMSIGSFlvmgINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAIN 330
Cdd:cd13131 244 FEVSLFAA----VALLMGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDPADARRAGLVGLGLGVGFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 331 FLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIistsysfgSICFIFSCFLQAIG----KGIPSLTITMLRQLI----L 402
Cdd:cd13131 320 ALTALLLLLFPEQIAGLYTNDPAVIALAASLLVF--------AALFQLFDGIQVVAagalRGYKDTRVPFLLALIsywgI 391
|
410 420
....*....|....*....|...
gi 492558571 403 LLPMAYILGRIYGL--TGVWLAF 423
Cdd:cd13131 392 GLPLGYLLAFTTGLgaFGVWIGL 414
|
|
| MATE_like_3 |
cd13148 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
14-422 |
5.49e-32 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240553 [Multi-domain] Cd Length: 441 Bit Score: 126.62 E-value: 5.49e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 14 LPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGS-GVGVNSYIARKLGEKDLETANK 92
Cdd:cd13148 11 LPTLLRLALPNILALLVQTLVGLAETYFVGQLGTDALAGVALVFPLLMLTQMMSNGAmGGGVSSAIARALGAGDRERAEA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 93 TAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQII 172
Cdd:cd13148 91 LVWHALVIALAGGLVFSLLFLLFGPALYRLLGGRGEALDAALAYSNVLFSGAILIWLVNLLAAALRGTGNMRVPALVTLV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 173 GAVTNIILDPILIYGYFGIPAMGVKGAAIATIIgqmTALLCSIYVLFFM---KQEIKIERKDFVWNNKIIREIYSVGIPS 249
Cdd:cd13148 171 GAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVL---YYALAALVLLRYLasgRSRLRLRLRALRLERRLFRDILRVGLLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 250 ffimSIGSFLVMGINFILSGI----STLAVSLFGIYFKLQtFIYMP-TSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSII 324
Cdd:cd13148 248 ----ALSPLQTNLTVLLLTGLvgrfGTAALAGYGIGSRLE-FLLIPlVFGLGAAMTAMVGMNIGAGQIARARRIAWTGAL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 325 ICVAINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRqLILLL 404
Cdd:cd13148 323 MAAVLAGAIGLVLALFPELWLGLFTHDPAVLAAGASYLRIVGPFYGFFGLGLALYFASQGAGRMLWPVLAGTLR-LLIAA 401
|
410 420
....*....|....*....|
gi 492558571 405 PMAYILGRI--YGLTGVWLA 422
Cdd:cd13148 402 GGGWIAVALfgAGLAGLFAA 421
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
23-183 |
1.22e-21 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 91.09 E-value: 1.22e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 23 PPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAASGLTLSV 102
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 103 IHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVTNIILDP 182
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISLLLNIPLNY 160
|
.
gi 492558571 183 I 183
Cdd:pfam01554 161 L 161
|
|
| MatE |
pfam01554 |
MatE; The MatE domain |
248-409 |
2.97e-17 |
|
MatE; The MatE domain
Pssm-ID: 334587 [Multi-domain] Cd Length: 161 Bit Score: 78.76 E-value: 2.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 248 PSFFIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICV 327
Cdd:pfam01554 1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 328 AINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLRqLILLLPMA 407
Cdd:pfam01554 81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIIS-LLLNIPLN 159
|
..
gi 492558571 408 YI 409
Cdd:pfam01554 160 YL 161
|
|
| MATE_yoeA_like |
cd13138 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-223 |
1.73e-14 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240543 [Multi-domain] Cd Length: 431 Bit Score: 75.19 E-value: 1.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 12 KMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETAN 91
Cdd:cd13138 222 EILKEILKIGLPSALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAK 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 92 KTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQI 171
Cdd:cd13138 302 KGLRTGIIISLIIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISI 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 492558571 172 IGAVTNIIldpILIYGYFGIPAMGVKGAAIATIIGQ-MTALLCSIYVLFFMKQ 223
Cdd:cd13138 382 LRLWLVRI---PLAYLLSRLTGLGLFGIWLAMPISNiLSAIICIIYYRKGRWK 431
|
|
| MATE_NorM_like |
cd13137 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ... |
12-212 |
2.45e-13 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240542 [Multi-domain] Cd Length: 432 Bit Score: 71.39 E-value: 2.45e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 12 KMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETAN 91
Cdd:cd13137 223 KIIKKLLRIGLPAGLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEAR 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 92 KTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQI 171
Cdd:cd13137 303 RYGKRALRLGVLFMGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINL 382
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 492558571 172 IGAVTNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALL 212
Cdd:cd13137 383 ISMWLVRLPLAYLLGFVLGLGLTGIWLAMFVDTIVRAILLL 423
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
17-387 |
9.96e-13 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 69.52 E-value: 9.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNL-ILAIAVGSGVGVNSYIARKLGEKDLETANKTAA 95
Cdd:cd13132 5 LLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVtGFSILLGLASALDTLCGQAFGAKNYKLVGVYLQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 96 SGLtlsVIHYLILVLLGVIFI--KPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIG 173
Cdd:cd13132 85 RAL---VILLLCCVPISLLWLntEPILLLLGQDPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIVLPLVYISLVA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 174 AVTNIILDPILIYGyfgiPAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIK----IERKDFVWNNKIIReiysVGIPS 249
Cdd:cd13132 162 LLLNILLNYLLVFV----LGLGFIGAALATSISYWLIVVLLLLYIFFSKGHKAtwggFSREAFRGWGPFLK----LAIPS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 250 FFIMSIG--SFLVMGinfILSGI--STLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIII 325
Cdd:cd13132 234 ALMLCLEwwAFEILV---LLAGLlpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAIVALIL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 492558571 326 CVAINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGK 387
Cdd:cd13132 311 SLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGR 372
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-172 |
1.71e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 69.07 E-value: 1.71e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 12 KMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETAN 91
Cdd:cd13134 225 KLLKKILKIGLPSAGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAY 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 92 KTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQI 171
Cdd:cd13134 305 KRVLKSLKIGLLVSLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGI 384
|
.
gi 492558571 172 I 172
Cdd:cd13134 385 I 385
|
|
| PRK00187 |
PRK00187 |
NorM family multidrug efflux MATE transporter; |
14-348 |
2.49e-12 |
|
NorM family multidrug efflux MATE transporter;
Pssm-ID: 166843 [Multi-domain] Cd Length: 464 Bit Score: 68.62 E-value: 2.49e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 14 LPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKT 93
Cdd:PRK00187 9 LKAILRLAGPLIASQLAHMLMVFTDTLMMGRLGPEALAGGGLGAASYSFVSIFCVGVIAAVGTLVAIRHGAGDIEGATRL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 94 AASGLTLSVIHYLILVLLgVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIG 173
Cdd:PRK00187 89 AQAGLWLAWLLALVAALL-LWNLKPLLLLFGQAPQNVDAAMQFLHLLPFALPGYLSFMALRGFTSALGRAGPVMVISLAG 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 174 AVTNIILDPILIYGYFGIPAMGVKGAAIAT-IIGQMTALLCSIYVLFFMKQEIKIERKDFV-WNNKIIREIYSVGIP--S 249
Cdd:PRK00187 168 AVANLLLNYALIEGWFGLPKLGLMGIGLVTaLVSNGMALALALYIRRHPAYAAYPLRKGLSrPSRAALRELWRLGLPigG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 250 FFIMSIGSF----LVMGInfilSGISTLAVSLFGIYFKLQTFIyMPTSGVTQGAMPImGYSYGAKNSKRLSDVLNYSIII 325
Cdd:PRK00187 248 TYAVEVGLFtfaaLCMGA----LGSTQLAAHQIALQIVSVAFM-VPVGLSYAVTMRV-GQHYGAGRLLEARRAGRVGIGF 321
|
330 340
....*....|....*....|...
gi 492558571 326 CVAINFLGSVLFWLFPQEILHFF 348
Cdd:PRK00187 322 GAVVMLLFAGLFWLLPEAIIGLF 344
|
|
| MATE_like_8 |
cd13134 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
240-397 |
2.74e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240539 [Multi-domain] Cd Length: 438 Bit Score: 68.30 E-value: 2.74e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 240 REIYSVGIPSFFIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVL 319
Cdd:cd13134 3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIA 82
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492558571 320 NYSIIICVAINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITML 397
Cdd:cd13134 83 GVALLFNLLLGLVFSLLLLFFGAELLRLMGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLI 160
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
26-439 |
3.66e-12 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 67.57 E-value: 3.66e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 26 ISMLINSLYNIVDSIFVAK-LGTEALTAVSLAFPIQNLILAIAVGsgvGVNSYIARKLGEKDLETANKTAASGLTLSVIh 104
Cdd:cd13128 10 VGNIISKLLGFLVRVYLARyLGPEGFGILSLALAFVGLFSIFADL---GLPTALVREIARYRKEKIREIISTSLVLKLI- 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 105 yLILVLLGVIFIKPFFLLFTKESNILkmgidYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVTNIILDPIL 184
Cdd:cd13128 86 -LGILALLLLFLFAFLIAFYDPELVL-----LLYILALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILALIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 185 IYGYFGIPamgvkGAAIATIIGqmtALLCSIYVLFFMKQEIKIeRKDFVWNNKIIREIYSVGIPsFFIMSIGSFLVMGIN 264
Cdd:cd13128 160 VLLGGGLI-----GFALAYLIA---SVLSAILLLYIYRKKILL-PKFFSFDLKLAKELLRFSIP-LALSGIFSLIYTRID 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 265 FILSGI--STLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYgAKNSKRLSDVLNYSIIICVAINFLGSVLFWLFPQ 342
Cdd:cd13128 230 TIMLGYflGDAAVGIYNAAYRIAELLLFIPSAISTALFPRISELY-KNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAE 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 343 EILHFFNATDEMMSIGVrtIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLrQLILLLPMAYILGRIYGLTGVWLA 422
Cdd:cd13128 309 PIITLLFGEEYLPAALV--LQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLI-GALLNVILNLLLIPKYGIIGAAIA 385
|
410
....*....|....*..
gi 492558571 423 FPTVEVITCMISIYMYR 439
Cdd:cd13128 386 TLISEFIIFILLLYLLK 402
|
|
| MATE_like_12 |
cd13142 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-222 |
4.98e-12 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240547 [Multi-domain] Cd Length: 444 Bit Score: 67.60 E-value: 4.98e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 12 KMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETAN 91
Cdd:cd13142 234 EWLKKIFRIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAE 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 92 KTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFlSIGTIA-QIAIEKILQATGNTLAPMFLQ 170
Cdd:cd13142 314 EIVKKAALLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAP-SFPFFGlFQVINGAFRGSGHTLTAMIIS 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 492558571 171 IIG-AVTNIILDPILIYGYFgipaMGVKGAAIATIIGQMTALLcsIYVLFFMK 222
Cdd:cd13142 393 ILRlWVIRIPLAYLLAYVLG----LGVTGIWIAMAISNIVAAL--IALAWFKR 439
|
|
| PRK10189 |
PRK10189 |
EmmdR/YeeO family multidrug/toxin efflux MATE transporter; |
33-308 |
1.42e-11 |
|
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
Pssm-ID: 182293 [Multi-domain] Cd Length: 478 Bit Score: 66.30 E-value: 1.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 33 LYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAASGLTLSVIHYLILVLLG 112
Cdd:PRK10189 47 LMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVLLAVLI 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 113 VIFIKPFFLLFTKESNILKMGIDYTYI-VTFLSIGTIAQIAI-EKILQATGNTLAPMFLQIIGAVTNIILDPILIYGYFG 190
Cdd:PRK10189 127 HFFGEQIIDLVAGDATPEVKALALTYLeLTVWSYPAAAITLIgSGALRGAGNTKIPLLINGGMNILNIIISSILIYGLFS 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 191 IPAMGVKGAAIATIIGQMTALLCSIYVLFF-MKQEIKIERKDFV--WNNKIIREIYSVGIPSffimSIGSFLVMGINFI- 266
Cdd:PRK10189 207 WQGLGFVGAGLGLTISRYIGAVAIIWVLMIgFNPALRISLKSYFkpLNFAIIWEVMGIGIPA----SIESVLFNGGKLLt 282
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 492558571 267 ---LSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYG 308
Cdd:PRK10189 283 qmfVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGTRLG 327
|
|
| PRK01766 |
PRK01766 |
multidrug efflux protein; Reviewed |
16-423 |
7.97e-11 |
|
multidrug efflux protein; Reviewed
Pssm-ID: 234981 [Multi-domain] Cd Length: 456 Bit Score: 63.68 E-value: 7.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 16 LLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIqnLILAIAVGSGV--GVNSYIARKLGEKDLETANKT 93
Cdd:PRK01766 13 QLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSI--WLPVILFGHGLllALTPIVAQLNGAGRRERIAHQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 94 AASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIG 173
Cdd:PRK01766 91 VRQGLWLALFLSVLIMLVLYNAVPPILNMMNLEPEVADIAVGYLHALLWGIPAYLLYQVLRSFIDGLGKTKPTMVIGFLG 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 174 AVTNIILDPILIYGYFGIPAMGVKGAAIATIIGQMTALLCSIYVLFFMK--QEIKIERKDFVWNNKIIREIYSVGIPS-- 249
Cdd:PRK01766 171 LLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARrfRDFRLFKGLYKPDWAVIKRLLKLGLPIgl 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 250 --FFIMSIGSFlvmgINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICV 327
Cdd:PRK01766 251 aiFFEVSLFAV----VTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDARQYAYIGLAVGL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 328 AINFLGSVLFWLFPQEILHFFNATDEMmsigvrtIRIISTSYSFgSICFIFSCFLQAIGKGI----PSLTITMLRQLI-- 401
Cdd:PRK01766 327 GMALLTAIFLVLFREQIALLYTDDPEV-------VALASHLLLF-AALFQFSDAIQVIGSGAlrgyKDTRVIFFITFIay 398
|
410 420
....*....|....*....|....*.
gi 492558571 402 --LLLPMAYILGRI--YGLTGVWLAF 423
Cdd:PRK01766 399 wvLGLPLGYILALTdpMGPFGFWIGL 424
|
|
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
25-435 |
1.31e-09 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 59.58 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 25 TISMLINSLYNIVDSIFVAK-LGTEALTAVSLAFPIQNLILAIAvgsGVGVNSYIARKLGEKDLETANKTAASGLTLSVI 103
Cdd:COG2244 12 LLGQLLGALLGFLLLPLLARlLGPEEYGLFALALSIVALLSVLA---DLGLSTALVRFIAEYREEELRRLLSTALLLRLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 104 HYLILVLLGVIFIKPFFLLFTKESNILkmgidYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQIIGAVTNIILDPI 183
Cdd:COG2244 89 LSLLLALLLLLLAPFIAALLGEPELAL-----LLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLLLALL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 184 LIYGYFGIPAMgvkgaaiatiigqmtallcsiyvlffmkqeikierkdfvwnnkiireIYSVGIPSFFIMSIGSFLVMGI 263
Cdd:COG2244 164 LALLGLGLWGL-----------------------------------------------VLKYSLPLLLSGLLGLLLTNLD 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 264 NFILSGISTL-AVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVLFWLFPQ 342
Cdd:COG2244 197 RLLLGALLGPaAVGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELRRLYRKALRLLLLLGLPLALGLALLAP 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 343 EILHFFnaTDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLrQLILLLPMAYILGRIYGLTGVWLA 422
Cdd:COG2244 277 PLLSLL--FGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLI-GAVLNLVLNLLLIPRYGLVGAAIA 353
|
410
....*....|...
gi 492558571 423 FPTVEVITCMISI 435
Cdd:COG2244 354 TLLSYLVLLLLLL 366
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
38-439 |
1.63e-09 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 59.39 E-value: 1.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 38 DSIFVAKLGTEALT-AVSLAFPIQNLILAIaVGSGVGVNSYI---ARKLGEKDLETANKTAASGLTLSVIHYLILVLLGV 113
Cdd:cd13123 15 DVLIAAAFGAGPLAdAFFVAFRIPNLLRRL-FAEGALSAAFVpvfSEYLEKEGEEEARRFASRVLTLLLLVLLLLTLLGI 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 114 IFIKPFFLLFTK--ESNILKMGIDYTYI----VTFLSIGTIAQiaieKILQATGNTLAPMFlqiIGAVTNIILdpIL-IY 186
Cdd:cd13123 94 LFAPLLVKLLAPgfSGDKFELAVALTRImfpyLLFISLSALLG----GILNAHGRFFAPAL---APVLLNLVI--IAgLL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 187 GYFGIPAMGVKGAAIATIIGqmtALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSIGSFLVMGINFI 266
Cdd:cd13123 165 LLAPLFDLGIYALAWGVLLG---GVLQLLVQLPALRRLGFRFRPRLDFRDPGVRRVLKLMLPALLGVSVSQINLLVDTIL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 267 LSGISTLAVSLFGIYFKLQTFIY-MPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVLFWLFPQEIL 345
Cdd:cd13123 242 ASFLPEGSISALYYADRLYQLPLgIFGVAIATALLPRLSRLAAAGDLDEFRRTLSRGLRLVLFLLLPAAVGLIVLAEPIV 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 346 HF------FNATDEMMSIGVRTIriistsYSFGSICFIFSCFLQ----AIGKGIPSLTITMLrQLILLLPMAYILGRIYG 415
Cdd:cd13123 322 RLlfergaFTAEDTLMTASALAA------YALGLPAFALVKLLSrafyALKDTKTPVKIAVI-AVAVNILLNLLLIKPLG 394
|
410 420
....*....|....*....|....
gi 492558571 416 LTGVWLAFPTVEVITCMISIYMYR 439
Cdd:cd13123 395 HVGLALATSLSAWVNALLLLVLLR 418
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
248-438 |
2.73e-09 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 58.41 E-value: 2.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 248 PSFFIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICV 327
Cdd:TIGR00797 1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 328 AINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQAIGKGIPSLTITMLrQLILLLPMA 407
Cdd:TIGR00797 81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLI-GNVINIILN 159
|
170 180 190
....*....|....*....|....*....|....*
gi 492558571 408 YILgrIYGLTGVW----LAFPTVEVITCMISIYMY 438
Cdd:TIGR00797 160 YIL--IFGKFGFLgivgAALATVISYWLMFLLLLY 192
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
26-415 |
1.04e-08 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 57.09 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 26 ISMLINSLYNIVdsiFVAKLGTEALTAVSLAFPIQNLILAIAV-GSGVGVNSYIARKLGEKDLETANKTAASGLTLSVIH 104
Cdd:cd13124 9 ISKILGAIYRIP---LQNIIGDEGMGLYQMAYPIYGIFLTLATaGIPVAISKLVAEYNALGDYKGARRIFRVSLILLLIL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 105 YLILVLLGVIFIKPF--FLLFTKESNILKMGIDYTY-IVTFLSI--------GTIAQIAIEKILQatgntlapmflQIIG 173
Cdd:cd13124 86 GLVFFLLLFFGAPFLaqLLLGDPRLAPVIRALAPAIlIVPLLSVlrgyfqglQNMTPTAVSQVIE-----------QIVR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 174 AVTNIILDPILIYGYFGIpAMGVKGAAIATIIGQMTALLCSIYVLFFMKQEIKIERKDFVWNN----KIIREIYSVGIP- 248
Cdd:cd13124 155 VIVILVLAYLLLPVGGGL-YYAAAGATFGAVIGALAGLLVLLYYYRKKRRELKRLLRKSPRSKistkEILKELLSYAIPi 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 249 ------SFFIMSIGSFLVMGInFILSGISTL-AVSLFGIY-FKLQTFIYMPTSGVTQGAM---PIMGYSYGAKNSKRLSD 317
Cdd:cd13124 234 tlssliLPLLQLIDSFTVPRR-LQAAGLSESeATALYGILtGRAQPLVQLPTVIATALSTslvPAISEAYAKGDKKELRR 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 318 VLNYSIIICVAINFLGSVLFWLFPQEILHFFNATDEmmsiGVRTIRIISTSYSFGSICFIFSCFLQAIGK-GIP--SLTI 394
Cdd:cd13124 313 RINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSE----GGLILQILAPSILFLSLQQVTAAILQGLGKvKIPviNLLI 388
|
410 420
....*....|....*....|.
gi 492558571 395 TMLRQLILLLPMAYILGrIYG 415
Cdd:cd13124 389 GLLVKIVLNYVLIPIFG-IYG 408
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
2-218 |
1.04e-08 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 57.09 E-value: 1.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 2 SKQENKMGTHKMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKL----GTEALTAVSL-------AFPIQNLILAIAVGS 70
Cdd:cd13124 211 KSPRSKISTKEILKELLSYAIPITLSSLILPLLQLIDSFTVPRRlqaaGLSESEATALygiltgrAQPLVQLPTVIATAL 290
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 71 GVGVNSYIARKLGEKDLETANKTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQ 150
Cdd:cd13124 291 STSLVPAISEAYAKGDKKELRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGDSEGGLILQILAPSILFLSLQQVTA 370
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 492558571 151 IaiekILQATGNTLAPMFLQIIGAVTNIILDpiliygYFGIPAMGVKGAAIATIIGQMTALLCSIYVL 218
Cdd:cd13124 371 A----ILQGLGKVKIPVINLLIGLLVKIVLN------YVLIPIFGIYGAAIATVIGFLVAALLNLRAL 428
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
2-280 |
2.01e-08 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 56.32 E-value: 2.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 2 SKQENKMGTHKMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKL----GTEALTAVSL-------AFPIQNLILAIAVGS 70
Cdd:COG5841 220 SKTKSKESSKDILKELLRIAIPITLSSLVLPLFQLIDSFTVPRRlqaaGLSASEATSLygilsgmAQPLVNLPTVLATAL 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 71 GVGVNSYIARKLGEKDLETANKTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQ 150
Cdd:COG5841 300 ATSLVPAISEAFAKKDRKLVRRRINQALRLTLLIGLPAAVGLAVLAEPINTLLFGNPEGGGILAILAPSAIFLSLQQVTT 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 151 IaiekILQATGNTLAPMFLQIIGAVTNIILDPILIygyfgiPAMGVKGAAIATIIGqmtALLCSIYVLFFMKQEIKIerk 230
Cdd:COG5841 380 G----ILQGLGKQKIPVINLLIGLLVKIILNYLLV------PLFGIYGAALATVIG---YLVAAILNLAALKKYTGF--- 443
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 492558571 231 DFVWNNKIIREIYSVGIpsFFIMSIGSFLVMGINFILSGISTLAVSLFGI 280
Cdd:COG5841 444 KLDLRRRLLKPLLASLI--MGIVVLLLYRLLSLFLPESRLGALLATLIAV 491
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
38-439 |
2.97e-08 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 55.93 E-value: 2.97e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 38 DSIFVAKLGTEALT-AVSLAFPIQNLILAIaVGSGVGVNSYI---ARKLGEKDLETANKTAASGLTLSVIHYLILVLLGV 113
Cdd:COG0728 22 DILIAAAFGAGAVAdAFFVAFRIPNLLRRL-FAEGALSAAFVpvlAEALEKEGEEEARRFASRVLTLLLLVLLVLTLLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 114 IFIKPFFLLFTK--ESNILKMGIDYTYI----VTFLSIGTIAQiaieKILQATGNTLAPMFLQIIGAVTNIILdpILIYG 187
Cdd:COG0728 101 LFAPLLVKLLAPgfDPEKFALAVALTRImfpyILFIGLSALLG----GVLNARGRFAAPALAPVLLNLVIIAG--LLLLA 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 188 YFGIPamGVKGAAIATIIGqmtALLCSIYVLFFMKQEIKIERKDFVWNNKIIREIYSVGIPSFFIMSIGSFLVMGINFIL 267
Cdd:COG0728 175 PLFGP--GIYALAWGVLLG---GVLQLLIQLPALRRLGLRLRPRFDLRDPGVRRVLKLMLPALLGVSVSQINLLVDTILA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 268 SGISTLAVSLFGIYFKLQTFIY-MPTSGVTQGAMPIMGYSYGAKNSKRLSDVLNYSIIICVAINFLGSVLFWLFPQEILH 346
Cdd:COG0728 250 SFLPEGSVSALYYADRLYQLPLgLFGVAIGTALLPRLSRAAAAGDLEEFRRTLSRGLRLVLLLTLPAAVGLIVLAEPIVR 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 347 FFNATDEMMSIGVRTIRIISTSYSFGSICFIFSCFLQ----AIGKGIPSLTITMLrQLILLLPMAYILGRIYGLTGVWLA 422
Cdd:COG0728 330 LLFERGAFTAEDTALTALALAAYALGLPAFALVKVLArafyARQDTRTPVRIAVI-AVVVNIVLNLLLVPPLGHAGLALA 408
|
410
....*....|....*..
gi 492558571 423 FPTVEVITCMISIYMYR 439
Cdd:COG0728 409 TSLSALVNALLLLVLLR 425
|
|
| MATE_like_1 |
cd13140 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
12-193 |
4.63e-08 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240545 [Multi-domain] Cd Length: 435 Bit Score: 54.84 E-value: 4.63e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 12 KMLPLLLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETAN 91
Cdd:cd13140 228 KYIKEILKLGLPVALQSILFALISMILARIIASFGPVAIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIR 307
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 92 KTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFLQI 171
Cdd:cd13140 308 KGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPETIAIGVDYLRILGFSQLFMCLEITTTGAFNGLGRTKPPAIISI 387
|
170 180
....*....|....*....|..
gi 492558571 172 IGAVTNIILDPILIYGYFGIPA 193
Cdd:cd13140 388 VFNGLRIPLALLLSPTGLGLNG 409
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
17-218 |
1.68e-07 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 53.23 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIaVGSGVGVNSY--IARKLGEKDLETANKTA 94
Cdd:COG0728 224 VLKLMLPALLGVSVSQINLLVDTILASFLPEGSVSALYYADRLYQLPLGL-FGVAIGTALLprLSRAAAAGDLEEFRRTL 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 95 ASGLTLSVihyLILVLLGVIFI---KPFFLL------FTKESNILkmgidYTYIVTFLSIGTIAQIAIeKILQ----ATG 161
Cdd:COG0728 303 SRGLRLVL---LLTLPAAVGLIvlaEPIVRLlfergaFTAEDTAL-----TALALAAYALGLPAFALV-KVLArafyARQ 373
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 492558571 162 NTLAPMFLQIIGAVTNIILDPILiygyfgIPAMGVKGAAIATIIGQMTALLCSIYVL 218
Cdd:COG0728 374 DTRTPVRIAVIAVVVNIVLNLLL------VPPLGHAGLALATSLSALVNALLLLVLL 424
|
|
| MATE_MurJ_like |
cd13123 |
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
17-218 |
1.61e-06 |
|
MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli MurJ (MviN) has been identified as essential for murein biosynthesis. It has been suggested that MurJ functions as the peptidoglycan lipid II flippase which is involved in translocation of lipid-anchored peptidoglycan precursors across the cytoplasmic membrane, though results obtained in Bacillus subtilis seem to indicate that its MurJ homologs are not essential for growth. Some MviN family members (e.g. in Mycobacterium tuberculosis) possess an extended C-terminal region that contains an intracellular pseudo-kinase domain and an extracellular domain resembling carbohydrate-binding proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240528 [Multi-domain] Cd Length: 420 Bit Score: 50.14 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIaVGSGVGVNSY--IARKLGEKDLETANKTA 94
Cdd:cd13123 217 VLKLMLPALLGVSVSQINLLVDTILASFLPEGSISALYYADRLYQLPLGI-FGVAIATALLprLSRLAAAGDLDEFRRTL 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 95 ASGLTLSVIHYLILVLLGVIFIKPFFLL------FTKESNILKmgidyTYIVTFLSIGTIAQIAIeKILQ----ATGNTL 164
Cdd:cd13123 296 SRGLRLVLFLLLPAAVGLIVLAEPIVRLlfergaFTAEDTLMT-----ASALAAYALGLPAFALV-KLLSrafyALKDTK 369
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 492558571 165 APMFLQIIGAVTNIILDPILiygyfgIPAMGVKGAAIATIIGQMTALLCSIYVL 218
Cdd:cd13123 370 TPVKIAVIAVAVNILLNLLL------IKPLGHVGLALATSLSAWVNALLLLVLL 417
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
11-218 |
4.64e-06 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 48.69 E-value: 4.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 11 HKMLPLLLSMSIPPTISMLINSLYNIVDSIFV-AKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIArKLGEKDLET 89
Cdd:cd13128 202 LKLAKELLRFSIPLALSGIFSLIYTRIDTIMLgYFLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRIS-ELYKNDKDE 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 90 ANKTAASGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNIlkMGIDYTYIVTFLSIGTIAQIAIEKILQATGNTLAPMFL 169
Cdd:cd13128 281 LKKLLKKSFKYLFLISLPIAIGLFLFAEPIITLLFGEEYL--PAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKI 358
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 492558571 170 QIIGAVTNIILDPILIygyfgiPAMGVKGAAIATIIGQMTALLCSIYVL 218
Cdd:cd13128 359 LLIGALLNVILNLLLI------PKYGIIGAAIATLISEFIIFILLLYLL 401
|
|
| MATE_like_14 |
cd13139 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ... |
238-382 |
8.02e-06 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240544 [Multi-domain] Cd Length: 448 Bit Score: 47.99 E-value: 8.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 238 IIREIYSVGIPSFFIMSIGSFLVMGINFILSGISTLAVSLFGIYFKLQTFIYMPTSGVTQGAMPIMGYSYGAKNSKRLSD 317
Cdd:cd13139 12 LNRAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGF 91
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 492558571 318 VLNYSIIICVAINFLGSVLFWLFPQEILHFFNATDEMMSIGVRTIRIIstsysFGSICFIFSCFL 382
Cdd:cd13139 92 AAVQAILLGVALSLILSILGYFFAEDILSLMGASPAVIAEGYGYTRIM-----FGGNGFIMLLFL 151
|
|
| matE |
TIGR00797 |
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ... |
17-141 |
2.80e-04 |
|
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]
Pssm-ID: 273273 [Multi-domain] Cd Length: 342 Bit Score: 43.00 E-value: 2.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKLGTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAAS 96
Cdd:TIGR00797 218 LLKLGLPIAFRVILESLSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARV 297
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 492558571 97 GLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVT 141
Cdd:TIGR00797 298 ALKLSLLLGLVLAIILILFREFIARLFTNDPEVLELAAIYLIFVA 342
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
25-267 |
1.18e-03 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 40.99 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 25 TISMLINSLYNIVDSIFVAK-----LGTEALTAVSLafpIQNLILAIAVGSGVGVNSYIARKLGE--KDLETANKTAASG 97
Cdd:cd13125 3 SSLSGISTLIKILAGLIINKvvavyLGPSGVALLGQ---LQNFVTILQTIAGGGINNGVVKYTAEykDDEEKLARVWSTA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 98 LTLSVIHYLILVLLGVIFIKPFfllftkeSNILKMGIDYTYIVTFLSI---GTIAQIAIEKILQATGNTLAPMFLQIIGA 174
Cdd:cd13125 80 FRITLILSILGGLLLLLFSKPL-------SSLLFGDIDYSWVFILLGLalpLFALNNLLLAILNGLKEIKRYALINIISS 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 175 VTNIILDPILIYGYfgipamGVKGAAIATIIGQmtALLCSIYVLFFMKQEI-KIERKDFVWNNKIIREIYsvgipSFFIM 253
Cdd:cd13125 153 LIGLLVSVLLVYFY------GLKGALLALVLNQ--SLIFLVTLIYSRKQPWfKLKYLWGRLDKDIIKKLL-----KFSLM 219
|
250
....*....|....
gi 492558571 254 SIGSFLVMGINFIL 267
Cdd:cd13125 220 ALVSALSLPLSQII 233
|
|
| MATE_eukaryotic |
cd13132 |
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ... |
17-221 |
1.33e-03 |
|
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.
Pssm-ID: 240537 [Multi-domain] Cd Length: 436 Bit Score: 41.02 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 17 LLSMSIPPTISMLINSLYNIVDSIFVAKL-GTEALTAVSLAFPIQNLILAIAVGSGVGVNSYIARKLGEKDLETANKTAA 95
Cdd:cd13132 226 FLKLAIPSALMLCLEWWAFEILVLLAGLLpGTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRAKLAAI 305
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 492558571 96 SGLTLSVIHYLILVLLGVIFIKPFFLLFTKESNILKMGIDYTYIVTFLSIGTIAQIAIEKILQATGntlapmfLQIIGAV 175
Cdd:cd13132 306 VALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCG-------RQKLGAY 378
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170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 492558571 176 TNIIldpiliyGY--FGIPA---------MGVKGAAIATIIGQMTALLCSIYVLFFM 221
Cdd:cd13132 379 VNLV-------AYylIGLPVglllafvlgLGLKGLWIGLIAGLILQAVILLLIILRT 428
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