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Conserved domains on  [gi|446850745|ref|WP_000928001|]
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MULTISPECIES: SET domain-containing protein [Leptospira]

Protein Classification

SET domain-containing protein( domain architecture ID 11459262)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1-127 1.34e-33

SET domain-containing protein (function unknown) [General function prediction only];


:

Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 113.90  E-value: 1.34e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   1 MLLVPTYIADSPIGGFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLLpHSVQEMFRTYSYQTEGKWF----YCSDNSK 76
Cdd:COG2940    3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGE---VITWAEAERR-EPHKEPLHTYLFELDDDGVidgaLGGNPAR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446850745  77 FMNHSDDPNTKedftSDQTNPIGQDSATRLILKGEELTCNYKLFDDNWKMK 127
Cdd:COG2940   79 FINHSCDPNCE----ADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYP 125
 
Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1-127 1.34e-33

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 113.90  E-value: 1.34e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   1 MLLVPTYIADSPIGGFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLLpHSVQEMFRTYSYQTEGKWF----YCSDNSK 76
Cdd:COG2940    3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGE---VITWAEAERR-EPHKEPLHTYLFELDDDGVidgaLGGNPAR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446850745  77 FMNHSDDPNTKedftSDQTNPIGQDSATRLILKGEELTCNYKLFDDNWKMK 127
Cdd:COG2940   79 FINHSCDPNCE----ADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYP 125
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 15-118 1.96e-20

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 79.87  E-value: 1.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   15 GFGLFAGRDIQKGELIWKYHPKTVWVLTDSELNLLPHSVQE---MFRTYSYQTEGKWFYCSD--------NSKFMNHSDD 83
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKLelrLWGPYLFTLDEDSEYCIDaralyygnWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 446850745   84 PNTKEDFTSDQTNPIGQDSATRLILKGEELTCNYK 118
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 9-117 7.31e-16

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 66.89  E-value: 7.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   9 ADSPIGGFGLFAGRDIQKGELIWkyhpktvwvltdselnllphsvqemfrtysyqtegkwfycsdNSKFMNHSDDPNTKE 88
Cdd:cd08161    5 STIPGAGFGLFATRDIPKGEVIG------------------------------------------LARFINHSCEPNCEF 42

                         90       100
                 ....*....|....*....|....*....
gi 446850745  89 DFTSDQTNPIGQDSATRLILKGEELTCNY 117
Cdd:cd08161   43 EEVYVGGKPRVFIVALRDIKAGEELTVDY 71
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 4-123 7.08e-15

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 65.82  E-value: 7.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745     4 VPTYIADSPIGGFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLLPHSVQEMFRTYSYQTEGKWFYCSDN------SKF 77
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGE---IITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDArrkgnlARF 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 446850745    78 MNHSDDPNTKEDFTSDQTNPIGQDSATRLILKGEELTCNYKLFDDN 123
Cdd:smart00317  78 INHSCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
 
Name Accession Description Interval E-value
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
1-127 1.34e-33

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 113.90  E-value: 1.34e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   1 MLLVPTYIADSPIGGFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLLpHSVQEMFRTYSYQTEGKWF----YCSDNSK 76
Cdd:COG2940    3 MLHPRIEVRPSPIHGRGVFATRDIPKGTLIGEYPGE---VITWAEAERR-EPHKEPLHTYLFELDDDGVidgaLGGNPAR 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446850745  77 FMNHSDDPNTKedftSDQTNPIGQDSATRLILKGEELTCNYKLFDDNWKMK 127
Cdd:COG2940   79 FINHSCDPNCE----ADEEDGRIFIVALRDIAAGEELTYDYGLDYDEEEYP 125
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 15-118 1.96e-20

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 79.87  E-value: 1.96e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   15 GFGLFAGRDIQKGELIWKYHPKTVWVLTDSELNLLPHSVQE---MFRTYSYQTEGKWFYCSD--------NSKFMNHSDD 83
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKLelrLWGPYLFTLDEDSEYCIDaralyygnWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 446850745   84 PNTKEDFTSDQTNPIGQDSATRLILKGEELTCNYK 118
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 9-117 7.31e-16

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 66.89  E-value: 7.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   9 ADSPIGGFGLFAGRDIQKGELIWkyhpktvwvltdselnllphsvqemfrtysyqtegkwfycsdNSKFMNHSDDPNTKE 88
Cdd:cd08161    5 STIPGAGFGLFATRDIPKGEVIG------------------------------------------LARFINHSCEPNCEF 42

                         90       100
                 ....*....|....*....|....*....
gi 446850745  89 DFTSDQTNPIGQDSATRLILKGEELTCNY 117
Cdd:cd08161   43 EEVYVGGKPRVFIVALRDIKAGEELTVDY 71
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 4-123 7.08e-15

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 65.82  E-value: 7.08e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745     4 VPTYIADSPIGGFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLLPHSVQEMFRTYSYQTEGKWFYCSDN------SKF 77
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGE---IITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDArrkgnlARF 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 446850745    78 MNHSDDPNTKEDFTSDQTNPIGQDSATRLILKGEELTCNYKLFDDN 123
Cdd:smart00317  78 INHSCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYAN 123
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 5-117 6.18e-11

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 55.34  E-value: 6.18e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   5 PTYIADSPIGGFGLFAGRDIQKGELIWKYHpktVWVLTDSELNLLPHSVQEMfRTYSYqtegkwfycSDNSKFM------ 78
Cdd:cd10540    1 RLEVKPSTLKGRGVFATRPIKKGEVIEEAP---VIVLPKEEYQHLCKTVLDH-YVFSW---------GDGCLALalgygs 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446850745  79 --NHSDDPNT--KEDFTSDQTNPIgqdsATRLILKGEELTCNY 117
Cdd:cd10540   68 mfNHSYTPNAeyEIDFENQTIVFY----ALRDIEAGEELTINY 106
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 7-125 8.87e-11

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 55.90  E-value: 8.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   7 YIADSPIGGFGLFAGRDIQKGELIWKYhpktVWVLTDSELNllphSVQEmfRTYSYQTEGKWFYCSDN------------ 74
Cdd:cd19171   17 YLARSRIQGLGLYAARDIEKHTMVIEY----IGEIIRNEVA----NRRE--KIYESQNRGIYMFRIDNdwvidatmtggp 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446850745  75 SKFMNHSDDPN-TKEDFTSDQTNPIgQDSATRLILKGEELTCNYKL-FDDNWK 125
Cdd:cd19171   87 ARYINHSCNPNcVAEVVTFDKEKKI-IIISNRRIAKGEELTYDYKFdFEDDQH 138
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 14-117 4.83e-09

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 50.80  E-value: 4.83e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  14 GGFGLFAGRDIQKGELIWKYhpktVWVLTD---SELNLLPHsvqeMFRTYSYQTEGKWFYCSDNSK-----FMNHSDDPN 85
Cdd:cd10522   13 NGLGLFAAETIAKGEFVGEY----TGEVLDrweEDRDSVYH----YDPLYPFDLNGDILVIDAGKKgnltrFINHSDQPN 84

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446850745  86 TKEDFTSDQTNPIGQDSATRLILKGEELTCNY 117
Cdd:cd10522   85 LELIVRTLKGEQHIGFVAIRDIKPGEELFISY 116
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 11-118 6.03e-09

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 50.85  E-value: 6.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  11 SPIGGFGLFAGRDIQKGELIWKYHPKTVW-VLTDSelnllphsvQE-----------MFRTYSYQ-----TEGkwfycsD 73
Cdd:cd19170   21 SPIHGRGLFCKRNIDAGEMVIEYAGEVIRsVLTDK---------REkyyeskgigcyMFRIDDDEvvdatMHG------N 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 446850745  74 NSKFMNHSDDPNTkedfTSDQTNPIGQDS----ATRLILKGEELTCNYK 118
Cdd:cd19170   86 AARFINHSCEPNC----YSRVVNIDGKKHivifALRRILRGEELTYDYK 130
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 15-119 7.41e-09

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 50.49  E-value: 7.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  15 GFGLFAGRDIQKGELIWKYHPKtvwVLTDSElnllphsVQEMFRTYSYQTEGKWFYC-------------SDNSKFMNHS 81
Cdd:cd19175   11 GWGLVADEDINAGEFIIEYVGE---VIDDKT-------CEERLWDMKHKGEKNFYMCeidkdmvidatfkGNLSRFINHS 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446850745  82 DDPNTK-EDFTSDQTNPIGQdSATRLILKGEELTCNYKL 119
Cdd:cd19175   81 CDPNCElQKWQVDGETRIGV-FAIRDIKKGEELTYDYQF 118
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 11-119 4.05e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 48.86  E-value: 4.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  11 SPIGGFGLFAGRDIQKGELIWKYHPKTVW-VLTDSELNLLPHSVQ--EMFRTYSYQTEGKWFYcSDNSKFMNHSDDPNTk 87
Cdd:cd19206   21 SPIHGRGLFCKRNIDAGEMVIEYSGNVIRsILTDKREKYYDSKGIgcYMFRIDDSEVVDATMH-GNAARFINHSCEPNC- 98

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446850745  88 edfTSDQTNPIGQDS----ATRLILKGEELTCNYKL 119
Cdd:cd19206   99 ---YSRVINIDGQKHivifAMRKIYRGEELTYDYKF 131
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 7-126 4.17e-08

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 48.85  E-value: 4.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   7 YIADSPIGGFGLFAGRDIQKGELIWKYhpktVWVLTDSELnllphsVQEMFRTYSYQTEGKWFYCSDN------------ 74
Cdd:cd19208   18 YLARSRIQGLGLYAARDIEKHTMVIEY----IGTIIRNEV------ANRKEKLYESQNRGVYMFRIDNdhvidatltggp 87

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446850745  75 SKFMNHSDDPN-TKEDFTSDQTNPIgQDSATRLILKGEELTCNYK--LFDDNWKM 126
Cdd:cd19208   88 ARYINHSCAPNcVAEVVTFEKGHKI-IISSSRRIQKGEELCYDYKfdFEDDQHKI 141
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 7-127 1.73e-07

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 47.21  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   7 YIADSPIGGFGLFAGRDIQKGELIWKYHPKTVW-VLTDselnllphsvqemFRTYSYQTEGK---WFYCSDN-------- 74
Cdd:cd10518   17 RVGKSGIHGWGLFAKRPIAAGEMVIEYVGEVIRpIVAD-------------KREKRYDEEGGggtYMFRIDEdlvidatk 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446850745  75 ----SKFMNHSDDPNTKedftSDQTNPIGQDS----ATRLILKGEELTCNYKL-FDDNWKMK 127
Cdd:cd10518   84 kgniARFINHSCDPNCY----AKIITVDGEKHivifAKRDIAPGEELTYDYKFpIEDEEKIP 141
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 8-117 8.86e-07

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 44.68  E-value: 8.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   8 IADSPIG-GFGLFAGRDIQKGELIWKYHPkTVWVLTDSeLNLLPHSVQE---MFRTYSyqtegkwfycsdnskFMNHSDD 83
Cdd:cd20071    2 VRESEGSkGRGLVATRDIEPGELILVEKP-LVSVPSNS-FSLTDGLNEIgvgLFPLAS---------------LLNHSCD 64

                         90       100       110
                 ....*....|....*....|....*....|....
gi 446850745  84 PNTkedFTSDQTNPIGQDSATRLILKGEELTCNY 117
Cdd:cd20071   65 PNA---VVVFDGNGTLRVRALRDIKAGEELTISY 95
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 15-119 1.08e-06

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 44.55  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  15 GFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNllphsvqEMFRTYsYQTEGKWFYC---SDN-----------SKFMNH 80
Cdd:cd10531   11 GWGVKAKEDIQKGEFIIEYVGE---VIDKKEFK-------ERLDEY-EELGKSNFYIlslSDDvvidatrkgnlSRFINH 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446850745  81 SDDPNTKedftSDQTNPIGQDS----ATRLILKGEELTCNYKL 119
Cdd:cd10531   80 SCEPNCE----TQKWIVNGEYRigifALRDIPAGEELTFDYNF 118
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 14-117 1.51e-06

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 45.44  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  14 GGFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLLPHSVQEMFRTYSYQTEGKWF-------------YCSDNSKFMNH 80
Cdd:cd10538   99 KGWGVRSLEFIPKGSFVCEYVGE---VITTSEADRRGKIYDKSGGSYLFDLDEFSDsdgdgeelcvdatFCGNVSRFINH 175

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 446850745  81 SDDPNTKedftsdqTNPIGQDS-----------ATRLILKGEELTCNY 117
Cdd:cd10538  176 SCDPNLF-------PFNVVIDHddlryprialfATRDILPGEELTFDY 216
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 6-117 2.75e-06

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 43.39  E-value: 2.75e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   6 TYIADSPIGGFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLLPHSVQEMFRTYSYQTEGKW----FYCSDNSKFMNHS 81
Cdd:cd10519    3 LLLGKSDVAGWGLFLKEPIKKDEFIGEYTGE---LISQDEADRRGKIYDKYNSSYLFNLNDQFvvdaTRKGNKIRFANHS 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446850745  82 DDPNTK-EDFTSDQTNPIGQdSATRLILKGEELTCNY 117
Cdd:cd10519   80 SNPNCYaKVMMVNGDHRIGI-FAKRDIEAGEELFFDY 115
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 15-123 1.74e-05

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 41.50  E-value: 1.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  15 GFGLFAGRDIQKGELIWKYHpKTVWVLTDSELNLLPHSVQEMFRTYSyqtegkwfyCSDNS--------KFMNHSDDPNT 86
Cdd:cd10524   19 GAKIIATKPIKKGEKIHELC-GCIAELSEEEEALLRPGGNDFSVMYS---------SRKKCsqlwlgpaAFINHDCRPNC 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446850745  87 KedFTsdqtnPIGQDS----ATRLILKGEELTCNY--KLFDDN 123
Cdd:cd10524   89 K--FV-----PTGKSTacvkVLRDIEPGEEITVYYgdNYFGEN 124
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 7-123 1.79e-05

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 41.99  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   7 YIADSPIGGFGLFAGRDIQKGELIWKYhpktVWVLTDSELnllphsVQEMFRTYSYQTEGKWFYCSDN------------ 74
Cdd:cd19209   19 YLARSRIQGLGLYAAKDLEKHTMVIEY----IGTIIRNEV------ANRREKIYEEQNRGIYMFRINNehvidatltggp 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446850745  75 SKFMNHSDDPN-TKEDFTSDQTNPIGQDSATRlILKGEELTCNYKL-FDDN 123
Cdd:cd19209   89 ARYINHSCAPNcVAEVVTFDKEDKIIIISSRR-IPKGEELTYDYQFdFEDD 138
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 15-118 2.47e-05

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 41.03  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  15 GFGLFAGRDIQKGELIWKYHPKtvwVLTDSELNLlphsvqemfRTYSYQTEG-KWFY--------CSD------NSKFMN 79
Cdd:cd19172   13 GWGLRAAEDLPKGTFVIEYVGE---VLDEKEFKR---------RMKEYAREGnRHYYfmalksdeIIDatkkgnLSRFIN 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446850745  80 HSDDPNTK-EDFTSDQTNPIGQdSATRLILKGEELTCNYK 118
Cdd:cd19172   81 HSCEPNCEtQKWTVNGELRVGF-FAKRDIPAGEELTFDYQ 119
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 4-119 2.59e-05

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 41.15  E-value: 2.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   4 VPTYIADSPIGGFGLFAGRDIQKGELIWKYhpktVWVLTDSE--LNLLPHSVQEMFRTYSYQTEGKWFYC-----SDNSK 76
Cdd:cd19173    2 PPTEPFKTGDRGWGLRTKRDIKKGDFVIEY----VGELIDEEecRRRLKKAHENNITNFYMLTLDKDRIIdagpkGNLSR 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446850745  77 FMNHSDDPNTK-EDFTSDQTNPIGQdSATRLILKGEELTCNYKL 119
Cdd:cd19173   78 FMNHSCQPNCEtQKWTVNGDTRVGL-FAVRDIPAGEELTFNYNL 120
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 11-119 1.90e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 38.85  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  11 SPIGGFGLFAGRDIQKGELIWKYHPKTVW-VLTDSELNLLPHSVQ--EMFRTYSYQTEGKWFYcSDNSKFMNHSDDPNTK 87
Cdd:cd19207   21 SAIHGRGLFCKRNIDAGEMVIEYSGIVIRsVLTDKREKFYDSKGIgcYMFRIDDFDVVDATMH-GNAARFINHSCEPNCY 99

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446850745  88 EDFTSDQTNPIGQDSATRLILKGEELTCNYKL 119
Cdd:cd19207  100 SRVIHVEGQKHIVIFALRKIYRGEELTYDYKF 131
SET_SETD7 cd10530
SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2. ...
 7-117 8.63e-04

SET domain found in SET domain-containing protein 7 (SETD7) and similar proteins; SETD7 (EC 2.1.1.43; also termed histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, lysine N-methyltransferase 7 (KMT7) or SET7/9) is a histone-lysine N-methyltransferase that specifically monomethylates 'Lys-4' of histone H3. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. Set7/9 also methylates non-histone proteins, including estrogen receptor alpha (ERa), suggesting it has a role in diverse biological processes. ERa methylation by Set7/9 stabilizes ERa and activates its transcriptional activities, which are involved in the carcinogenesis of breast cancer. In a high-throughput screen, treatment of human breast cancer cells (MCF7 cells) with cyproheptadine, a Set7/9 inhibitor, decreased the expression and transcriptional activity of ERa, thereby inhibiting estrogen-dependent cell growth.


Pssm-ID: 380928  Cd Length: 130  Bit Score: 36.89  E-value: 8.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745   7 YIADSPI--GGFGLFAGRDIQKGELIWKYHPKTV---------WVLTDSELNLLPHSVQEMFRTYSYQTegkwFYCSDNS 75
Cdd:cd10530   10 YVAESLIpsAGEGLFAKVAVGPNTVMSFYNGVRIthqevdsrdWSLNGNTISLDEETVIDVPEPYNSVS----KYCASLG 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446850745  76 KFMNHSDDPNTKED-FTSDQTNPIGQDSATRLILKGEELTCNY 117
Cdd:cd10530   86 HKANHSFTPNCIYDpFVHPRFGPIKCIRTLRAVEAGEELTVAY 128
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 15-117 8.88e-04

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 36.89  E-value: 8.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  15 GFGLFAGRDIQKGELIWKYhpkTVWVLTDSELNllphsvQEMFRTYSYQTEgkwFYC--------------SDNSKFMNH 80
Cdd:cd19174   11 GWGVRTKEPIKAGQFIIEY---VGEVVSEQEFR------RRMIEQYHNHSH---HYClnldsgmvidgyrmGNEARFVNH 78

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446850745  81 SDDPNTK-EDFTSDQTNPIGQdSATRLILKGEELTCNY 117
Cdd:cd19174   79 SCDPNCEmQKWSVNGVYRIGL-FALKDIPAGEELTYDY 115
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 15-117 3.93e-03

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 34.86  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446850745  15 GFGLFAGRDIQKGELIWKYhpkTVWVLTDSELNLLPHSVQEMFRTYSYQTEGKW----FYCSDNSKFMNHSDDpntkedf 90
Cdd:cd19168   13 GLGLFAAEDIKEGEFVIEY---TGELISHDEGVRREHRRGDVSYLYLFEEQEGIwvdaAIYGNLSRYINHATD------- 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446850745  91 TSDQTNPIGQD-----------SATRLILKGEELTCNY 117
Cdd:cd19168   83 KVKTGNCMPKImyvnhewrikfTAIKDIKIGEELFFNY 120
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 8-30 5.33e-03

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 35.12  E-value: 5.33e-03
                         10        20
                 ....*....|....*....|...
gi 446850745   8 IADSPIGGFGLFAGRDIQKGELI 30
Cdd:cd10527    4 LAESPDGGRGLFATRDIAAGEVL 26
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 77-117 5.69e-03

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 34.97  E-value: 5.69e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 446850745  77 FMNHSDDPNTKEDFTSDQTNPIgqdsATRLILKGEELTCNY 117
Cdd:cd10536  153 LLNHSCDPNTIRSFYGNTIVVR----ATRPIKKGEEITICY 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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