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Conserved domains on  [gi|4416084|gb|AAD20223|]
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IgE autoantigen, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SART-1 super family cl25746
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 1-94 1.35e-23

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


The actual alignment was detected with superfamily member pfam03343:

Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 92.79  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4416084      1 AAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKYSRREEYR----- 54
Cdd:pfam03343 429 GATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEYARRENRQreqqe 508

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4416084     55 -GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHR 94
Cdd:pfam03343 509 aRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQ 548
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 1-94 1.35e-23

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 92.79  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4416084      1 AAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKYSRREEYR----- 54
Cdd:pfam03343 429 GATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEYARRENRQreqqe 508

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4416084     55 -GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHR 94
Cdd:pfam03343 509 aRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQ 548
 
Name Accession Description Interval E-value
SART-1 pfam03343
SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has ...
 1-94 1.35e-23

SART-1 family; SART-1 is a protein involved in cell cycle arrest and pre-mRNA splicing. It has been shown to be a component of U4/U6 x U5 tri-snRNP complex in human, Schizosaccharomyces pombe and Saccharomyces cerevisiae. SART-1 is a known tumour antigen in a range of cancers recognized by T cells.


Pssm-ID: 460888 [Multi-domain]  Cd Length: 569  Bit Score: 92.79  E-value: 1.35e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4416084      1 AAALLLCQNKGLLETTV-------------------QKVARVKAPNKSLPSAVYCIEDKMA--IDDKYSRREEYR----- 54
Cdd:pfam03343 429 GATLALLRQKGLLEESTaeelererrqkflaeklrlERELEEQARLQRERDRASGRLDKMSarEREEYARRENRQreqqe 508

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 4416084     55 -GFTQDFKEKDgYKPDVKIEYVDETGRKLTPKEAFRQLSHR 94
Cdd:pfam03343 509 aRPLAEFFEKD-YKPDVKLKYVDEFGRELNQKEAFKHLSHQ 548
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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