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Conserved domains on  [gi|37958193|gb|AAP21506|]
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NodA, partial [Burkholderia sp. UCT 11]

Protein Classification

GNAT family protein( domain architecture ID 106742)

GNAT (Gcn5-related N-acetyltransferase) family protein similar to N-acetyltransferases that catalyze the transfer of an acetyl group from acetyl-CoA to a substrate

PubMed:  15581578

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NAT_SF super family cl17182
N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of ...
 1-123 1.01e-79

N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase which catalyze the transfer of an acetyl group to a substrate. The mechanism is an ordered Bi-Bi ternary complex kinetic mechanism for most GNATs: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and then CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/ph enylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


The actual alignment was detected with superfamily member TIGR04245:

Pssm-ID: 473072  Cd Length: 193  Bit Score: 232.67  E-value: 1.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37958193     1 RRFIKVGAVDLLVAELGLYAVRPDLEGLGIPHLMRVMYPVLQELDVPFGFGTVRHALRQHIARLLgRHGLATIVSGVRVR 80
Cdd:TIGR04245  70 RRFIKVGAVDLLVAELGLYGVRPDLEGLGIGHSIRAMYPVLQELGVPFAFGTVRHALRNHVERLC-RNGLATIVSGVRVR 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 37958193    81 STLRDVHLDTPPTRIEDVLIVVLPIGRSMSDWPTGTIIDRNGP 123
Cdd:TIGR04245 149 STLPDVHLDLPPTRIEDVLVVVFPIGRSMDEWPAGTLIERNGP 191
 
Name Accession Description Interval E-value
nodulat_NodA TIGR04245
N-acyltransferase NodA; Nodulation factors are lipo-chitooligosaccharides made by bacterial ...
 1-123 1.01e-79

N-acyltransferase NodA; Nodulation factors are lipo-chitooligosaccharides made by bacterial nitrogen-fixing bacteria as a signal to plant hosts. Nod factors differ slightly from system to system are serve as host range determinants. Because the N-acyl group varies from one NodA to another, the family treated as a subfamily, but all members of this family belong to NodABC systems.


Pssm-ID: 211968  Cd Length: 193  Bit Score: 232.67  E-value: 1.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37958193     1 RRFIKVGAVDLLVAELGLYAVRPDLEGLGIPHLMRVMYPVLQELDVPFGFGTVRHALRQHIARLLgRHGLATIVSGVRVR 80
Cdd:TIGR04245  70 RRFIKVGAVDLLVAELGLYGVRPDLEGLGIGHSIRAMYPVLQELGVPFAFGTVRHALRNHVERLC-RNGLATIVSGVRVR 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 37958193    81 STLRDVHLDTPPTRIEDVLIVVLPIGRSMSDWPTGTIIDRNGP 123
Cdd:TIGR04245 149 STLPDVHLDLPPTRIEDVLVVVFPIGRSMDEWPAGTLIERNGP 191
PRK00756 PRK00756
acyltransferase NodA; Provisional
 1-123 2.37e-79

acyltransferase NodA; Provisional


Pssm-ID: 179111  Cd Length: 196  Bit Score: 231.91  E-value: 2.37e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37958193    1 RRFIKVGAVDLLVAELGLYAVRPDLEGLGIPHLMRVMYPVLQELDVPFGFGTVRHALRQHIARLLgRHGLATIVSGVRVR 80
Cdd:PRK00756  73 RRFIKVGEVDLLVAELGLYGVRPDLEGLGIAHSIRAMYPVLQELGVPFAFGTVRHALRNHVERLC-RNGLATIVTGVRVR 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 37958193   81 STLRDVHLDTPPTRIEDVLIVVLPIGRSMSDWPTGTIIDRNGP 123
Cdd:PRK00756 152 STLPDVYLDLPPTRTEDVLVVVFPIGRPMSEWPSGTLIERNGP 194
NodA pfam02474
Nodulation protein A (NodA); Rhizobia nodulation (nod) genes control the biosynthesis of Nod ...
 1-123 4.81e-68

Nodulation protein A (NodA); Rhizobia nodulation (nod) genes control the biosynthesis of Nod factors required for infection and nodulation of their legume hosts. Nodulation protein A (NodA) is a N-acetyltransferase involved in production of Nod factors that stimulate mitosis in various plant protoplasts.


Pssm-ID: 426792  Cd Length: 195  Bit Score: 203.09  E-value: 4.81e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37958193     1 RRFIKVGAVDLLVAELGLYAVRPDLEGLGIPHLMRVMYPVLQELDVPFGFGTVRHALRQHIARlLGRHGLATIVSGVRVR 80
Cdd:pfam02474  72 RRFIKVGGVDLLVAELGLYAVRPDLEGLGIGHSILVMTPVLKELGVPFGFGTVRHALRKHVER-LCRNGLATIVSGVRVR 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 37958193    81 STLRDVHLDTPPTRIEDVLIVVLPIGRSMSDWPTGTIIDRNGP 123
Cdd:pfam02474 151 STLPDVYPDLPPTRIEDLLVVVLPVGRPLDEWPAGTVIDRNGP 193
 
Name Accession Description Interval E-value
nodulat_NodA TIGR04245
N-acyltransferase NodA; Nodulation factors are lipo-chitooligosaccharides made by bacterial ...
 1-123 1.01e-79

N-acyltransferase NodA; Nodulation factors are lipo-chitooligosaccharides made by bacterial nitrogen-fixing bacteria as a signal to plant hosts. Nod factors differ slightly from system to system are serve as host range determinants. Because the N-acyl group varies from one NodA to another, the family treated as a subfamily, but all members of this family belong to NodABC systems.


Pssm-ID: 211968  Cd Length: 193  Bit Score: 232.67  E-value: 1.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37958193     1 RRFIKVGAVDLLVAELGLYAVRPDLEGLGIPHLMRVMYPVLQELDVPFGFGTVRHALRQHIARLLgRHGLATIVSGVRVR 80
Cdd:TIGR04245  70 RRFIKVGAVDLLVAELGLYGVRPDLEGLGIGHSIRAMYPVLQELGVPFAFGTVRHALRNHVERLC-RNGLATIVSGVRVR 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 37958193    81 STLRDVHLDTPPTRIEDVLIVVLPIGRSMSDWPTGTIIDRNGP 123
Cdd:TIGR04245 149 STLPDVHLDLPPTRIEDVLVVVFPIGRSMDEWPAGTLIERNGP 191
PRK00756 PRK00756
acyltransferase NodA; Provisional
 1-123 2.37e-79

acyltransferase NodA; Provisional


Pssm-ID: 179111  Cd Length: 196  Bit Score: 231.91  E-value: 2.37e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37958193    1 RRFIKVGAVDLLVAELGLYAVRPDLEGLGIPHLMRVMYPVLQELDVPFGFGTVRHALRQHIARLLgRHGLATIVSGVRVR 80
Cdd:PRK00756  73 RRFIKVGEVDLLVAELGLYGVRPDLEGLGIAHSIRAMYPVLQELGVPFAFGTVRHALRNHVERLC-RNGLATIVTGVRVR 151

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 37958193   81 STLRDVHLDTPPTRIEDVLIVVLPIGRSMSDWPTGTIIDRNGP 123
Cdd:PRK00756 152 STLPDVYLDLPPTRTEDVLVVVFPIGRPMSEWPSGTLIERNGP 194
NodA pfam02474
Nodulation protein A (NodA); Rhizobia nodulation (nod) genes control the biosynthesis of Nod ...
 1-123 4.81e-68

Nodulation protein A (NodA); Rhizobia nodulation (nod) genes control the biosynthesis of Nod factors required for infection and nodulation of their legume hosts. Nodulation protein A (NodA) is a N-acetyltransferase involved in production of Nod factors that stimulate mitosis in various plant protoplasts.


Pssm-ID: 426792  Cd Length: 195  Bit Score: 203.09  E-value: 4.81e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37958193     1 RRFIKVGAVDLLVAELGLYAVRPDLEGLGIPHLMRVMYPVLQELDVPFGFGTVRHALRQHIARlLGRHGLATIVSGVRVR 80
Cdd:pfam02474  72 RRFIKVGGVDLLVAELGLYAVRPDLEGLGIGHSILVMTPVLKELGVPFGFGTVRHALRKHVER-LCRNGLATIVSGVRVR 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 37958193    81 STLRDVHLDTPPTRIEDVLIVVLPIGRSMSDWPTGTIIDRNGP 123
Cdd:pfam02474 151 STLPDVYPDLPPTRIEDLLVVVLPVGRPLDEWPAGTVIDRNGP 193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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