NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|359829637|gb|AEV77615|]
View 

deoxynucleoside kinase [Staphylococcus aureus subsp. aureus M013]

Protein Classification

deoxynucleoside kinase( domain architecture ID 10787652)

deoxynucleoside kinase catalyzes the phosphorylation of deoxyribonucleosides to yield the corresponding monophosphates

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
7-212 5.60e-97

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


:

Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 280.90  E-value: 5.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   7 PQNAIITIAGTVGVGKSTLTQALADKLNFKTSFENVEHNPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQ 86
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVEDNPFLEDFYEDPKRWAFPLQLFFLLSRFKQLKDLRQFGGNVVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  87 DRSIYEDVdIFAKMHEEEGTMSKEDFKTYSDLFNAmvMTPYFPKPDVMIYLECNYDEVIDRIIERGREMEINTDPEYWKK 166
Cdd:COG1428   81 DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDN--LTEDLPKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLER 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 359829637 167 LFKRYDDWINSFNACPVVRININEYDIHKDPDSLNPMIDKIARIIK 212
Cdd:COG1428  158 LNEAYEEWFEHYDASPVLIIDTDELDFVNNPEDLELLLEQIEEKLK 203
 
Name Accession Description Interval E-value
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
7-212 5.60e-97

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 280.90  E-value: 5.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   7 PQNAIITIAGTVGVGKSTLTQALADKLNFKTSFENVEHNPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQ 86
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVEDNPFLEDFYEDPKRWAFPLQLFFLLSRFKQLKDLRQFGGNVVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  87 DRSIYEDVdIFAKMHEEEGTMSKEDFKTYSDLFNAmvMTPYFPKPDVMIYLECNYDEVIDRIIERGREMEINTDPEYWKK 166
Cdd:COG1428   81 DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDN--LTEDLPKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLER 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 359829637 167 LFKRYDDWINSFNACPVVRININEYDIHKDPDSLNPMIDKIARIIK 212
Cdd:COG1428  158 LNEAYEEWFEHYDASPVLIIDTDELDFVNNPEDLELLLEQIEEKLK 203
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 12-212 2.69e-69

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 210.64  E-value: 2.69e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   12 ITIAGTVGVGKSTLTQALADKLNFKTSFENVEH--NPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQDRS 89
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFKVFEEPVDRwtNPYLDKFYKDPSRWSFALQTYFLNSRFKQQLEAFFTGQVVILERS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   90 IYEDVDIFAKMHEEEGTMSKEDFKTYSDLFNAmvMTPYFPKPDVMIYLECNYDEVIDRIIERGREMEINTDPEYWKKLFK 169
Cdd:pfam01712  81 IYSDRYIFAKMLYDKGTMSDEEYKTYKDLYDN--MLLEFPKPDLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 359829637  170 RYDDWINSFNACPVVRININEYDIHKDPDSLNPMIDKIARIIK 212
Cdd:pfam01712 159 KYEAWLKKLNLSPVLVIDGDELDFVFFEEDREDVMNEVNEFVS 201
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 11-197 1.84e-59

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 185.12  E-value: 1.84e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLNFKTSFE----NVEHNPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEY---GGG 83
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVVPEpvepDVEGNPFLEKFYEDPKRWAFPFQLYFLLSRLKQYKDALEHlstGQG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  84 FVQDRSIYEDVDIFAKMHEEEGtMSKEDFKTYSDLFNAMVmtPYFPKPDVMIYLECNYDEVIDRIIERGREMEINTDPEY 163
Cdd:cd01673   81 VILERSIFSDRVFAEANLKEGG-IMKTEYDLYNELFDNLI--PELLPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDY 157

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 359829637 164 WKKLFKRYDDW--INSFNACPVVRININEYDIHKDP 197
Cdd:cd01673  158 LEDLHEAYEKWflPQMYEKAPVLIIDANEADIEYNK 193
 
Name Accession Description Interval E-value
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
7-212 5.60e-97

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 280.90  E-value: 5.60e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   7 PQNAIITIAGTVGVGKSTLTQALADKLNFKTSFENVEHNPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQ 86
Cdd:COG1428    1 MKPRYIAVEGNIGAGKTTLARLLAEHLGAELLLEPVEDNPFLEDFYEDPKRWAFPLQLFFLLSRFKQLKDLRQFGGNVVS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  87 DRSIYEDVdIFAKMHEEEGTMSKEDFKTYSDLFNAmvMTPYFPKPDVMIYLECNYDEVIDRIIERGREMEINTDPEYWKK 166
Cdd:COG1428   81 DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDN--LTEDLPKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLER 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 359829637 167 LFKRYDDWINSFNACPVVRININEYDIHKDPDSLNPMIDKIARIIK 212
Cdd:COG1428  158 LNEAYEEWFEHYDASPVLIIDTDELDFVNNPEDLELLLEQIEEKLK 203
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 12-212 2.69e-69

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 210.64  E-value: 2.69e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   12 ITIAGTVGVGKSTLTQALADKLNFKTSFENVEH--NPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEYGGGFVQDRS 89
Cdd:pfam01712   1 ISIEGNIGAGKSTLTKILSKRLGFKVFEEPVDRwtNPYLDKFYKDPSRWSFALQTYFLNSRFKQQLEAFFTGQVVILERS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   90 IYEDVDIFAKMHEEEGTMSKEDFKTYSDLFNAmvMTPYFPKPDVMIYLECNYDEVIDRIIERGREMEINTDPEYWKKLFK 169
Cdd:pfam01712  81 IYSDRYIFAKMLYDKGTMSDEEYKTYKDLYDN--MLLEFPKPDLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHE 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 359829637  170 RYDDWINSFNACPVVRININEYDIHKDPDSLNPMIDKIARIIK 212
Cdd:pfam01712 159 KYEAWLKKLNLSPVLVIDGDELDFVFFEEDREDVMNEVNEFVS 201
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 11-197 1.84e-59

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 185.12  E-value: 1.84e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLNFKTSFE----NVEHNPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEY---GGG 83
Cdd:cd01673    1 VIVVEGNIGAGKSTLAKELAEHLGYEVVPEpvepDVEGNPFLEKFYEDPKRWAFPFQLYFLLSRLKQYKDALEHlstGQG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  84 FVQDRSIYEDVDIFAKMHEEEGtMSKEDFKTYSDLFNAMVmtPYFPKPDVMIYLECNYDEVIDRIIERGREMEINTDPEY 163
Cdd:cd01673   81 VILERSIFSDRVFAEANLKEGG-IMKTEYDLYNELFDNLI--PELLPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDY 157

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 359829637 164 WKKLFKRYDDW--INSFNACPVVRININEYDIHKDP 197
Cdd:cd01673  158 LEDLHEAYEKWflPQMYEKAPVLIIDANEADIEYNK 193
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 11-173 3.06e-14

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 68.92  E-value: 3.06e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLNFKTSFENVEH------------------NPYLDKFY---SDFERWSFHLQIYFLAE 69
Cdd:cd02030    1 VITVDGNIASGKGKLAKELAEKLGMKYFPEAGIHyldsttgdgkpldpafngNCSLEKFYddpKSNDGNSYRLQSWMYSS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637  70 RFKEQKRMFEY----GGGFVQDRSIYEDVdIFAKMHEEEGTMSKEDFKTYSDLFNAMVmtPYFPKPDVMIYLECNYDEVI 145
Cdd:cd02030   81 RLLQYSDALEHllstGQGVVLERSPFSDF-VFLEAMYKQGYIRKQCVDHYNEVKGNTI--PELLPPHLVIYLDVPVPEVQ 157

                        170       180
                 ....*....|....*....|....*...
gi 359829637 146 DRIIERGREMEINTDPEYWKKLFKRYDD 173
Cdd:cd02030  158 KRIKKRGDPHEMKVTSAYLQDIENAYKK 185
AAA_18 pfam13238
AAA domain;
12-165 1.97e-06

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 45.50  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   12 ITIAGTVGVGKSTLTQALADKLNFKTSFENVEHNPYLDKFYSDFERWSFHLQIYFLAERFKEQKRMFEYGGGfvqdrsiy 91
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEG-------- 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 359829637   92 eDVDIFakmheeEGTMskedfktySDLFnamvmtPYFPKPDVMIYLECNYDEVIDRIIERGRE---MEINTDPEYWK 165
Cdd:pfam13238  73 -GNLII------DGHL--------AELE------PERAKDLVGIVLRASPEELLERLEKRGYEeakIKENEEAEILG 128
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 11-36 1.47e-04

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 40.55  E-value: 1.47e-04
                         10        20
                 ....*....|....*....|....*.
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLNFK 36
Cdd:cd02020    1 IIAIDGPAGSGKSTVAKLLAKKLGLP 26
Cmk COG0283
Cytidylate kinase [Nucleotide transport and metabolism];
11-49 2.04e-04

Cytidylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 440052 [Multi-domain]  Cd Length: 220  Bit Score: 40.78  E-value: 2.04e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLNFKtsfenvehnpYLD 49
Cdd:COG0283    2 VIAIDGPAGSGKSTVAKALAKRLGYH----------YLD 30
Pgk2 COG2074
2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and ...
 11-36 1.07e-03

2-phosphoglycerate kinase/Mevalonate-3-phosphate 5-kinase [Carbohydrate transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 441677  Cd Length: 207  Bit Score: 38.78  E-value: 1.07e-03
                         10        20
                 ....*....|....*....|....*.
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLNFK 36
Cdd:COG2074    8 IILIGGASGVGKSTIAAELARRLGIP 33
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
11-36 1.63e-03

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 37.87  E-value: 1.63e-03
                         10        20
                 ....*....|....*....|....*.
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLNFK 36
Cdd:COG1936    2 RIAITGTPGTGKTTVAKLLAERLGLE 27
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 4-76 3.83e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 37.46  E-value: 3.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 359829637   4 YGIPQNA-IITIAGTVGVGKSTLTQALADKLNfktsfENVE----HNPYL----------DKF---YSDFERWSFHLQIY 65
Cdd:COG3267   37 YALAQGGgFVVLTGEVGTGKTTLLRRLLERLP-----DDVKvayiPNPQLspaellraiaDELglePKGASKADLLRQLQ 111

                         90
                 ....*....|..
gi 359829637  66 -FLAERFKEQKR 76
Cdd:COG3267  112 eFLLELAAAGRR 123
CoaA COG1072
Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the ...
 11-34 8.06e-03

Panthothenate kinase [Coenzyme transport and metabolism]; Panthothenate kinase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 440690  Cd Length: 309  Bit Score: 36.42  E-value: 8.06e-03
                         10        20
                 ....*....|....*....|....
gi 359829637  11 IITIAGTVGVGKSTLTQALADKLN 34
Cdd:COG1072   88 IIGIAGSVAVGKSTTARLLQALLS 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH