|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1251-1484 |
5.03e-40 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 150.87 E-value: 5.03e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1251 VALQQALIGAAAQAHCKILEDLLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALW 1330
Cdd:COG0666 13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1331 LAVKEGHWSVVEHLLQRGALLDEPLGQTRkTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKT 1410
Cdd:COG0666 93 AAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24663106 1411 LIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKL 1484
Cdd:COG0666 172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1363-1455 |
3.51e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 80.93 E-value: 3.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1363 LMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRhhEDHNGRTALDLAAYQGAASLVI 1442
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN--LKDNGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 24663106 1443 YILEQGGNLEHID 1455
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1152-1237 |
1.93e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 73.23 E-value: 1.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1152 LCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDitQRCALVHAARMGHLSVVK 1231
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVK 78
|
....*.
gi 24663106 1232 YLLACD 1237
Cdd:pfam12796 79 LLLEKG 84
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1126-1484 |
1.49e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 75.87 E-value: 1.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1126 LKVSRLVLLAGASPNHRtDYMGGAPILcIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGS 1205
Cdd:PHA02876 158 LLIAEMLLEGGADVNAK-DIYCITPIH-YAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1206 SLGQLDITqrcaLVHAARMGHLSVVkyLLACDWSPRPHSQDVTRSVALQQAligAAAQAHCKILEDLLdlnetEFDLDVN 1285
Cdd:PHA02876 236 NINKNDLS----LLKAIRNEDLETS--LLLYDAGFSVNSIDDCKNTPLHHA---SQAPSLSRLVPKLL-----ERGADVN 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1286 GmEPSSGELALTAAARHGC-IDVVGILLSRGAQIDARNRQGYSALWLAVK-EGHWSVVEHLLQRGALLDePLGQTRKTPL 1363
Cdd:PHA02876 302 A-KNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN-ARDYCDKTPI 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1364 MIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWA-CLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVI 1442
Cdd:PHA02876 380 HYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLDVI 459
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 24663106 1443 -YILEQGGNLEHIDVHGMRPLDRAIACRNIqaVQVFLRKGAKL 1484
Cdd:PHA02876 460 eMLLDNGADVNAINIQNQYPLLIALEYHGI--VNILLHYGAEL 500
|
|
| Spy |
COG3914 |
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ... |
1378-1617 |
3.38e-08 |
|
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443119 [Multi-domain] Cd Length: 658 Bit Score: 58.47 E-value: 3.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1378 LLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVH 1457
Cdd:COG3914 1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1458 GMRPLDRAIACRNIQAVQVFLRKGAKLGPTtwsmamgkpeiLVILLNKLledGNVLYRKNRFQEAAHRYQyalrkisgle 1537
Cdd:COG3914 81 LELAALLLQALGRYEEALALYRRALALNPD-----------NAEALFNL---GNLLLALGRLEEALAALR---------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1538 QLLERNAIFAQLrtnlLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQAAQ 1617
Cdd:COG3914 137 RALALNPDFAEA----YLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPD 212
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1130-1200 |
1.32e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 56.45 E-value: 1.32e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24663106 1130 RLVLLAGASPNHRtDYMGGAPiLCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPL 1200
Cdd:PTZ00322 99 RILLTGGADPNCR-DYDGRTP-LHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1293-1488 |
5.81e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 51.17 E-value: 5.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1293 ELALTAAARHGCIDVVGILL-SRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLqRGA--LLDEP------LGQTrktPL 1363
Cdd:cd22192 18 ESPLLLAAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLM-EAApeLVNEPmtsdlyQGET---AL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1364 MIAAEEGHLELVDLLLARGAQ-----------REAQD---HEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTAL 1429
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADvvspratgtffRPGPKnliYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24663106 1430 DLAAYQGAASLV------IYILEQGGN---LEHIDVH-GMRPLDRAIACRNIQAVQVFLRKGAK----LGPTT 1488
Cdd:cd22192 174 HILVLQPNKTFAcqmydlILSYDKEDDlqpLDLVPNNqGLTPFKLAAKEGNIVMFQHLVQKRRHiqwtYGPLT 246
|
|
| HCR |
pfam07111 |
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ... |
1518-1634 |
1.31e-04 |
|
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 46.67 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1518 RFQEAAHRYQYALRKISGLEQLLERNAIFAQLR--------------TNLLLNLSRCKRKLNELDASIDLATQAIAQkph 1583
Cdd:pfam07111 430 RIPSLSNRLSYAVRKVHTIKGLMARKVALAQLRqescpppppappvdADLSLELEQLREERNRLDAELQLSAHLIQQ--- 506
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 24663106 1584 syEGYYARAKARMELGALNEALVDANEAMQQAAQSGV-LCEVVEVLKRIQTE 1634
Cdd:pfam07111 507 --EVGRAREQGEAERQQLSEVAQQLEQELQRAQESLAsVGQQLEVARQGQQE 556
|
|
| PLN03088 |
PLN03088 |
SGT1, suppressor of G2 allele of SKP1; Provisional |
1568-1613 |
2.57e-04 |
|
SGT1, suppressor of G2 allele of SKP1; Provisional
Pssm-ID: 215568 [Multi-domain] Cd Length: 356 Bit Score: 45.16 E-value: 2.57e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 24663106 1568 DASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQ 1613
Cdd:PLN03088 19 ALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIE 64
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
1240-1452 |
5.62e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 44.69 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1240 PRPHSQDVTRSVAlQQALIGAAAQAHCKILEDLLDLNETEfdldvngmePSSGElALTAAARHGCIDVVGILLSRGAQID 1319
Cdd:TIGR00870 40 PKKLNINCPDRLG-RSALFVAAIENENLELTELLLNLSCR---------GAVGD-TLLHAISLEYVDAVEAILLHLLAAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1320 arnRQGYSaLWLAVKEghwsvvehllqrgALLDEPLGQTrktPLMIAAEEGHLELVDLLLARGAQREAQDHEGFtalswa 1399
Cdd:TIGR00870 109 ---RKSGP-LELANDQ-------------YTSEFTPGIT---ALHLAAHRQNYEIVKLLLERGASVPARACGDF------ 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 24663106 1400 CLRGHlaaaktliEHGCNRHhedhnGRTALDLAAYQGAASLVIYILEQGGNLE 1452
Cdd:TIGR00870 163 FVKSQ--------GVDSFYH-----GESPLNAAACLGSPSIVALLSEDPADIL 202
|
|
| 3a0801s09 |
TIGR00990 |
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ... |
1505-1607 |
1.06e-03 |
|
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273380 [Multi-domain] Cd Length: 615 Bit Score: 43.82 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1505 KLLEDGNVLYRKNRFQEAAHRYQYALrkisgleqLLERNAIFAQlrtnlllNLSRCKRKLNELDASIDLATQAIAQKPHS 1584
Cdd:TIGR00990 129 KLKEKGNKAYRNKDFNKAIKLYSKAI--------ECKPDPVYYS-------NRAACHNALGDWEKVVEDTTAALELDPDY 193
|
90 100
....*....|....*....|...
gi 24663106 1585 YEGYYARAKARMELGALNEALVD 1607
Cdd:TIGR00990 194 SKALNRRANAYDGLGKYADALLD 216
|
|
| zf-RING_5 |
pfam14634 |
zinc-RING finger domain; |
97-134 |
4.14e-03 |
|
zinc-RING finger domain;
Pssm-ID: 434085 [Multi-domain] Cd Length: 43 Bit Score: 36.64 E-value: 4.14e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 24663106 97 CPSCRISFDKGKRRKLIdTCGH---ERCYSCMFRNDQCPMC 134
Cdd:pfam14634 2 CNKCFKELSKTRPFYLT-SCGHifcEECLTRLLQERQCPIC 41
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1360-1383 |
5.99e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.64 E-value: 5.99e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1251-1484 |
5.03e-40 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 150.87 E-value: 5.03e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1251 VALQQALIGAAAQAHCKILEDLLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALW 1330
Cdd:COG0666 13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1331 LAVKEGHWSVVEHLLQRGALLDEPLGQTRkTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKT 1410
Cdd:COG0666 93 AAARNGDLEIVKLLLEAGADVNARDKDGE-TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKL 171
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24663106 1411 LIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKL 1484
Cdd:COG0666 172 LLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADL 245
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1272-1553 |
2.94e-33 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 131.23 E-value: 2.94e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1272 LLDLNETEFDLDVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALL 1351
Cdd:COG0666 1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1352 DEPlGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDL 1431
Cdd:COG0666 81 NAK-DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1432 AAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGA------KLGPTTWSMA--MGKPEILVILL 1503
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAdvnakdNDGKTALDLAaeNGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 24663106 1504 NKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQLLERNAIFAQLRTNL 1553
Cdd:COG0666 240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1080-1396 |
4.35e-31 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 124.68 E-value: 4.35e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1080 MLKAHLYGGTSLTLLSPRDLQSYWLAGAADNISSSLGALRNVYSPNLKVSRLVLLAGASPNHRTDYMGGAPiLCIAAHEG 1159
Cdd:COG0666 20 LLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTL-LHAAARNG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1160 ILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACdws 1239
Cdd:COG0666 99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA--- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1240 prphsqdvtrsvalqqaliGAaaqahckiledlldlnetefdlDVNgMEPSSGELALTAAARHGCIDVVGILLSRGAQID 1319
Cdd:COG0666 176 -------------------GA----------------------DVN-ARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24663106 1320 ARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLgQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTAL 1396
Cdd:COG0666 214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD-KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1363-1455 |
3.51e-18 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 80.93 E-value: 3.51e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1363 LMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRhhEDHNGRTALDLAAYQGAASLVI 1442
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN--LKDNGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 24663106 1443 YILEQGGNLEHID 1455
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1152-1237 |
1.93e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 73.23 E-value: 1.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1152 LCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDitQRCALVHAARMGHLSVVK 1231
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVK 78
|
....*.
gi 24663106 1232 YLLACD 1237
Cdd:pfam12796 79 LLLEKG 84
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1296-1389 |
3.43e-15 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 72.46 E-value: 3.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1296 LTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGqtrKTPLMIAAEEGHLELV 1375
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAARSGHLEIV 77
|
90
....*....|....
gi 24663106 1376 DLLLARGAQREAQD 1389
Cdd:pfam12796 78 KLLLEKGADINVKD 91
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1126-1484 |
1.49e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 75.87 E-value: 1.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1126 LKVSRLVLLAGASPNHRtDYMGGAPILcIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGS 1205
Cdd:PHA02876 158 LLIAEMLLEGGADVNAK-DIYCITPIH-YAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1206 SLGQLDITqrcaLVHAARMGHLSVVkyLLACDWSPRPHSQDVTRSVALQQAligAAAQAHCKILEDLLdlnetEFDLDVN 1285
Cdd:PHA02876 236 NINKNDLS----LLKAIRNEDLETS--LLLYDAGFSVNSIDDCKNTPLHHA---SQAPSLSRLVPKLL-----ERGADVN 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1286 GmEPSSGELALTAAARHGC-IDVVGILLSRGAQIDARNRQGYSALWLAVK-EGHWSVVEHLLQRGALLDePLGQTRKTPL 1363
Cdd:PHA02876 302 A-KNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVN-ARDYCDKTPI 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1364 MIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWA-CLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVI 1442
Cdd:PHA02876 380 HYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNCKLDVI 459
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 24663106 1443 -YILEQGGNLEHIDVHGMRPLDRAIACRNIqaVQVFLRKGAKL 1484
Cdd:PHA02876 460 eMLLDNGADVNAINIQNQYPLLIALEYHGI--VNILLHYGAEL 500
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
1254-1482 |
7.26e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 72.72 E-value: 7.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1254 QQALIGAAAQAHCKILEDLLDLN-ETEFDLdVNGMEPssgelaLTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLA 1332
Cdd:PHA02875 3 QVALCDAILFGELDIARRLLDIGiNPNFEI-YDGISP------IKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1333 VKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLI 1412
Cdd:PHA02875 76 VEEGDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLI 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24663106 1413 EHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNlehIDVHGMRPlDRAIACRNIQ-----AVQVFLRKGA 1482
Cdd:PHA02875 156 DHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN---IDYFGKNG-CVAALCYAIEnnkidIVRLFIKRGA 226
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1118-1349 |
1.07e-11 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 69.28 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1118 LRNVYSPNLKVSRLVLLAGASPNHRTDYmGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPL--ILAAMRGHCD 1195
Cdd:PHA03095 55 LHYSSEKVKDIVRLLLEAGADVNAPERC-GFTPLHLYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPK 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1196 VVRPLVAAGSSLGQLDITQRCALvhAARMGH----LSVVKYLLACDWSPrpHSQDVTRSVALQQALIGAAAQAhcKILED 1271
Cdd:PHA03095 134 VIRLLLRKGADVNALDLYGMTPL--AVLLKSrnanVELLRLLIDAGADV--YAVDDRFRSLLHHHLQSFKPRA--RIVRE 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1272 LLDLNETEFDLDVNGMEPssgelaLTAAARHG-CID-VVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGA 1349
Cdd:PHA03095 208 LIRAGCDPAATDMLGNTP------LHSMATGSsCKRsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1185-1322 |
9.70e-11 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 59.74 E-value: 9.70e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1185 LILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACdwsprphsqdvtrsvalqqaligaaaqa 1264
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---------------------------- 52
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 24663106 1265 hckiledlldlnetefdldVNGMEPSSGELALTAAARHGCIDVVGILLSRGAQIDARN 1322
Cdd:pfam12796 53 -------------------ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1257-1457 |
1.81e-10 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 66.04 E-value: 1.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1257 LIGAAAQAHCKILEDLLdlnETEFDLDVNGmepSSGELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEG 1336
Cdd:PLN03192 529 LLTVASTGNAALLEELL---KAKLDPDIGD---SKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAK 602
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1337 HWSVVEHLLQRGALLDEplgqtrktplmiaaeeghlelvdlllargaqreaqdHEGFTALSWACLRGHLAAAKTLIEHGC 1416
Cdd:PLN03192 603 HHKIFRILYHFASISDP------------------------------------HAAGDLLCTAAKRNDLTAMKELLKQGL 646
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 24663106 1417 NRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVH 1457
Cdd:PLN03192 647 NVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1299-1482 |
4.66e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 60.45 E-value: 4.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1299 AARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGH-----WSVVEHLLQRGALLDEPlGQTRKTPLMIAAEE--GH 1371
Cdd:PHA03100 42 AKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAP-DNNGITPLLYAISKksNS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1372 LELVDLLLARGAQREAQDHEGFTALSWA--CLRGHLAAAKTLIEHG-----CNR-----------HHEDHNGRTALDLAA 1433
Cdd:PHA03100 121 YSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDKGvdinaKNRvnyllsygvpiNIKDVYGFTPLHYAV 200
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 24663106 1434 YQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGA 1482
Cdd:PHA03100 201 YNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1155-1364 |
6.69e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 60.36 E-value: 6.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1155 AAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLL 1234
Cdd:PHA02874 131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1235 AcdwsprpHSQDVTRS-----VALQQALIgaaaqaHCKILEDLLDLNETEFDLDVNGMEPssgelaLTAAARHGC-IDVV 1308
Cdd:PHA02874 211 D-------HGNHIMNKckngfTPLHNAII------HNRSAIELLINNASINDQDIDGSTP------LHHAINPPCdIDII 271
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 24663106 1309 GILLSRGAQIDARNRQGYSALWLAVKE-GHWSVVEHLLQRGALLDEpLGQTRKTPLM 1364
Cdd:PHA02874 272 DILLYHKADISIKDNKGENPIDTAFKYiNKDPVIKDIIANAVLIKE-ADKLKDSDFL 327
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1167-1371 |
1.52e-08 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 59.88 E-value: 1.52e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1167 LLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLLACDWSPRPHSqd 1246
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHA-- 621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1247 vtrsvalqqaligaaaqahckiledlldlnetefdldvngmepsSGELaLTAAARHGCIDVVGILLSRGAQIDARNRQGY 1326
Cdd:PLN03192 622 --------------------------------------------AGDL-LCTAAKRNDLTAMKELLKQGLNVDSEDHQGA 656
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 24663106 1327 SALWLAVKEGHWSVVEHLLQRGAL-----LDEPLGQTRKTPLMIAAEEGH 1371
Cdd:PLN03192 657 TALQVAMAEDHVDMVRLLIMNGADvdkanTDDDFSPTELRELLQKRELGH 706
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1283-1488 |
1.96e-08 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 58.88 E-value: 1.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1283 DVNGMEpSSGELALTAAARHGC-IDVVGILLSRGAQIDARNRQGYSAL--WLAVKEGHWSVVEHLLQRGALLDEpLGQTR 1359
Cdd:PHA03095 75 DVNAPE-RCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNA-LDLYG 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1360 KTPLMIAAEEGH--LELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAA--KTLIEHGCNRHHEDHNGRTALDLAAYQ 1435
Cdd:PHA03095 153 MTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRFRSLLHHHLQSFKPRARivRELIRAGCDPAATDMLGNTPLHSMATG 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 24663106 1436 G--AASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGAKLGPTT 1488
Cdd:PHA03095 233 SscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVS 287
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1361-1412 |
2.68e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 51.51 E-value: 2.68e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 24663106 1361 TPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLI 1412
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Spy |
COG3914 |
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ... |
1378-1617 |
3.38e-08 |
|
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443119 [Multi-domain] Cd Length: 658 Bit Score: 58.47 E-value: 3.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1378 LLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVH 1457
Cdd:COG3914 1 AAAAALLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1458 GMRPLDRAIACRNIQAVQVFLRKGAKLGPTtwsmamgkpeiLVILLNKLledGNVLYRKNRFQEAAHRYQyalrkisgle 1537
Cdd:COG3914 81 LELAALLLQALGRYEEALALYRRALALNPD-----------NAEALFNL---GNLLLALGRLEEALAALR---------- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1538 QLLERNAIFAQLrtnlLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQAAQ 1617
Cdd:COG3914 137 RALALNPDFAEA----YLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPD 212
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1306-1466 |
4.04e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 57.67 E-value: 4.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1306 DVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGAllDEPLGQTRKT-PLMIAAEEGHLELVDLLLARGAQ 1384
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGA--DVNIEDDNGCyPIHIAIKHNFFDIIKLLLEKGAY 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1385 REAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAAslVIYILEQGGNLEHIDVHGMRPLDR 1464
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASINDQDIDGSTPLHH 260
|
..
gi 24663106 1465 AI 1466
Cdd:PHA02874 261 AI 262
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1119-1480 |
6.39e-08 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 57.34 E-value: 6.39e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1119 RNVYSPNLKVSRLVLL--AGASPNHRTDYmgGAPILCIAAHEGILP---MVSLLLEFGADVGLTNSQGCTPLILAAMRGH 1193
Cdd:PHA03095 18 YLLNASNVTVEEVRRLlaAGADVNFRGEY--GKTPLHLYLHYSSEKvkdIVRLLLEAGADVNAPERCGFTPLHLYLYNAT 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1194 C-DVVRPLVAAGSslgqlDITQRCalvhaarmghlsvvkyllacdwsprphsqDVTRSvALQQALIGAAAqaHCKILEDL 1272
Cdd:PHA03095 96 TlDVIKLLIKAGA-----DVNAKD-----------------------------KVGRT-PLHVYLSGFNI--NPKVIRLL 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1273 LDLNETEFDLDVNGMEPssgeLALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALwlavkeghwsvvEHLLQrgalld 1352
Cdd:PHA03095 139 LRKGADVNALDLYGMTP----LAVLLKSRNANVELLRLLIDAGADVYAVDDRFRSLL------------HHHLQ------ 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1353 eplgQTRKTPlmiaaeeghlELVDLLLARGAQREAQDHEGFTALSWA-----CLRGHLAaakTLIEHGCNRHHEDHNGRT 1427
Cdd:PHA03095 197 ----SFKPRA----------RIVRELIRAGCDPAATDMLGNTPLHSMatgssCKRSLVL---PLLIAGISINARNRYGQT 259
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 24663106 1428 ALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRK 1480
Cdd:PHA03095 260 PLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAK 312
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1121-1211 |
9.88e-08 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 51.27 E-value: 9.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1121 VYSPNLKVSRLVLLAGASPNHRTDYmgGAPILCIAAHEGILPMVSLLLEFgADVGLTNsQGCTPLILAAMRGHCDVVRPL 1200
Cdd:pfam12796 5 AKNGNLELVKLLLENGADANLQDKN--GRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLL 80
|
90
....*....|.
gi 24663106 1201 VAAGSSLGQLD 1211
Cdd:pfam12796 81 LEKGADINVKD 91
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1130-1200 |
1.32e-07 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 56.45 E-value: 1.32e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24663106 1130 RLVLLAGASPNHRtDYMGGAPiLCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPL 1200
Cdd:PTZ00322 99 RILLTGGADPNCR-DYDGRTP-LHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| TPR |
COG0457 |
Tetratricopeptide (TPR) repeat [General function prediction only]; |
1510-1613 |
3.25e-07 |
|
Tetratricopeptide (TPR) repeat [General function prediction only];
Pssm-ID: 440225 [Multi-domain] Cd Length: 245 Bit Score: 53.47 E-value: 3.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1510 GNVLYRKNRFQEAAHRYQYALRkisgleqlLERNAIFAqlrtnlLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYY 1589
Cdd:COG0457 15 GLAYRRLGRYEEAIEDYEKALE--------LDPDDAEA------LYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80
|
90 100
....*....|....*....|....
gi 24663106 1590 ARAKARMELGALNEALVDANEAMQ 1613
Cdd:COG0457 81 NLGLALQALGRYEEALEDYDKALE 104
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1150-1198 |
1.26e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 46.88 E-value: 1.26e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 24663106 1150 PILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVR 1198
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
|
|
| TPR |
COG0457 |
Tetratricopeptide (TPR) repeat [General function prediction only]; |
1510-1613 |
1.85e-06 |
|
Tetratricopeptide (TPR) repeat [General function prediction only];
Pssm-ID: 440225 [Multi-domain] Cd Length: 245 Bit Score: 51.16 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1510 GNVLYRKNRFQEAahryqyalrkISGLEQLLERNAIFAQLrtnlLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYY 1589
Cdd:COG0457 49 GLAYLRLGRYEEA----------LADYEQALELDPDDAEA----LNNLGLALQALGRYEEALEDYDKALELDPDDAEALY 114
|
90 100
....*....|....*....|....
gi 24663106 1590 ARAKARMELGALNEALVDANEAMQ 1613
Cdd:COG0457 115 NLGLALLELGRYDEAIEAYERALE 138
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1336-1482 |
2.64e-06 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 52.56 E-value: 2.64e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1336 GHWSVVEHLLQRGalLDEPLGQTR-KTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLieH 1414
Cdd:PLN03192 536 GNAALLEELLKAK--LDPDIGDSKgRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL--Y 611
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24663106 1415 GCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQAVQVFLRKGA 1482
Cdd:PLN03192 612 HFASISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1295-1345 |
3.15e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.73 E-value: 3.15e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 24663106 1295 ALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLL 1345
Cdd:pfam13637 4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1394-1445 |
4.99e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.34 E-value: 4.99e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 24663106 1394 TALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYIL 1445
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1174-1432 |
5.18e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 51.12 E-value: 5.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1174 VGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLL--ACDWS--PRPHSQDVTR 1249
Cdd:PHA02874 28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdnGVDTSilPIPCIEKDMI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1250 SVALQQALIGAAAQAHCKIL-------EDLLDLNET-EFDLDVNgMEPSSGELALTAAARHGCIDVVGILLSRGAQIDAR 1321
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFlhyaikkGDLESIKMLfEYGADVN-IEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVK 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1322 NRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRkTPLMIAAEegHLELVDLLLARGAQREAQDHEGFTALSWA-- 1399
Cdd:PHA02874 187 DNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGF-TPLHNAII--HNRSAIELLINNASINDQDIDGSTPLHHAin 263
|
250 260 270
....*....|....*....|....*....|....*
gi 24663106 1400 --ClrgHLAAAKTLIEHGCNRHHEDHNGRTALDLA 1432
Cdd:PHA02874 264 ppC---DIDIIDILLYHKADISIKDNKGENPIDTA 295
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1293-1488 |
5.81e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 51.17 E-value: 5.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1293 ELALTAAARHGCIDVVGILL-SRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLqRGA--LLDEP------LGQTrktPL 1363
Cdd:cd22192 18 ESPLLLAAKENDVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLM-EAApeLVNEPmtsdlyQGET---AL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1364 MIAAEEGHLELVDLLLARGAQ-----------REAQD---HEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTAL 1429
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADvvspratgtffRPGPKnliYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24663106 1430 DLAAYQGAASLV------IYILEQGGN---LEHIDVH-GMRPLDRAIACRNIQAVQVFLRKGAK----LGPTT 1488
Cdd:cd22192 174 HILVLQPNKTFAcqmydlILSYDKEDDlqpLDLVPNNqGLTPFKLAAKEGNIVMFQHLVQKRRHiqwtYGPLT 246
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1125-1417 |
6.22e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 50.82 E-value: 6.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1125 NLKVSRLVLLAGASPN-HRTDYMGGAPILCIAAH--EGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRghcdvvrplv 1201
Cdd:PHA03100 47 NIDVVKILLDNGADINsSTKNNSTPLHYLSNIKYnlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISK---------- 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1202 aagsslgqlditqrcalvhaaRMGHLSVVKYLLAcdwsprpHSQDVTrsvalqqaligaaaqahckiledlldlnetefd 1281
Cdd:PHA03100 117 ---------------------KSNSYSIVEYLLD-------NGANVN--------------------------------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1282 lDVNgmepSSGELALTAAARHGCID--VVGILLSRGAQIDARNRqgysalwlavkeghwsvVEHLLQRGALLDEP--LGQ 1357
Cdd:PHA03100 136 -IKN----SDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR-----------------VNYLLSYGVPINIKdvYGF 193
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1358 TrktPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCN 1417
Cdd:PHA03100 194 T---PLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
|
|
| BepA |
COG4783 |
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ... |
1491-1618 |
1.68e-05 |
|
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443813 [Multi-domain] Cd Length: 139 Bit Score: 46.34 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1491 MAMGKPEILVILLNKLLED-----------GNVLYRKNRFQEAAHRYQYALRKisgleqllernaifAQLRTNLLLNLSR 1559
Cdd:COG4783 15 LLAGDYDEAEALLEKALELdpdnpeafallGEILLQLGDLDEAIVLLHEALEL--------------DPDEPEARLNLGL 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 24663106 1560 CKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQAAQS 1618
Cdd:COG4783 81 ALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1296-1484 |
1.68e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 49.19 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1296 LTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGAlldeplgQTRKTPLMIAAEEghleLV 1375
Cdd:PHA02874 39 LIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDNGV-------DTSILPIPCIEKD----MI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1376 DLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHID 1455
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187
|
170 180
....*....|....*....|....*....
gi 24663106 1456 VHGMRPLDRAIACRNIQAVQVFLRKGAKL 1484
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGNHI 216
|
|
| TPR |
COG0457 |
Tetratricopeptide (TPR) repeat [General function prediction only]; |
1495-1611 |
2.10e-05 |
|
Tetratricopeptide (TPR) repeat [General function prediction only];
Pssm-ID: 440225 [Multi-domain] Cd Length: 245 Bit Score: 48.08 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1495 KPEILVILLNKlledGNVLYRKNRFQEAAHRYQYALRkisgleqlLERNAIFAqlrtnlLLNLSRCKRKLNELDASIDLA 1574
Cdd:COG0457 72 DPDDAEALNNL----GLALQALGRYEEALEDYDKALE--------LDPDDAEA------LYNLGLALLELGRYDEAIEAY 133
|
90 100 110
....*....|....*....|....*....|....*..
gi 24663106 1575 TQAIAQKPHSYEGYYARAKARMELGALNEALVDANEA 1611
Cdd:COG0457 134 ERALELDPDDADALYNLGIALEKLGRYEEALELLEKL 170
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1183-1234 |
6.11e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 42.26 E-value: 6.11e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 24663106 1183 TPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVKYLL 1234
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1306-1379 |
1.01e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 47.20 E-value: 1.01e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24663106 1306 DVVG--ILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGA---LLDeplgQTRKTPLMIAAEEGHLELVDLLL 1379
Cdd:PTZ00322 94 DAVGarILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGAdptLLD----KDGKTPLELAEENGFREVVQLLS 168
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1346-1484 |
1.25e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 46.56 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1346 QRGALLDEPLGQtrktpLMIAAEEGHLELVDLLLARGAQREAQDHEGFTAL-SWACLRGHLAAAKTLIEHGCNRHHEDHN 1424
Cdd:PHA03095 42 FRGEYGKTPLHL-----YLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKV 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24663106 1425 GRTALD--LAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRAIACRNIQA--VQVFLRKGAKL 1484
Cdd:PHA03095 117 GRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVelLRLLIDAGADV 180
|
|
| HCR |
pfam07111 |
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ... |
1518-1634 |
1.31e-04 |
|
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.
Pssm-ID: 284517 [Multi-domain] Cd Length: 749 Bit Score: 46.67 E-value: 1.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1518 RFQEAAHRYQYALRKISGLEQLLERNAIFAQLR--------------TNLLLNLSRCKRKLNELDASIDLATQAIAQkph 1583
Cdd:pfam07111 430 RIPSLSNRLSYAVRKVHTIKGLMARKVALAQLRqescpppppappvdADLSLELEQLREERNRLDAELQLSAHLIQQ--- 506
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 24663106 1584 syEGYYARAKARMELGALNEALVDANEAMQQAAQSGV-LCEVVEVLKRIQTE 1634
Cdd:pfam07111 507 --EVGRAREQGEAERQQLSEVAQQLEQELQRAQESLAsVGQQLEVARQGQQE 556
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1140-1435 |
1.55e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 46.41 E-value: 1.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1140 NHRTDYMGGAP-ILCIAAHEGI----LPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVaagSSLGQLDITQ 1214
Cdd:PHA02878 24 DHTENYSTSASlIPFIPLHQAVearnLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMI---RSINKCSVFY 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1215 rcALVHAARMGH---LSVVKYLLACDWSPRPHSQDVTRSVALQQALIGAaaqahcKILEDLLdlnetEFDLDVNGMEPSS 1291
Cdd:PHA02878 101 --TLVAIKDAFNnrnVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEA------EITKLLL-----SYGADINMKDRHK 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1292 GELALTAAARHGCIDVVGILLSRGAQIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEpLGQTRKTPLMIAAeeGH 1371
Cdd:PHA02878 168 GNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA-RDKCGNTPLHISV--GY 244
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24663106 1372 L---ELVDLLLARGAQREAQDH-EGFTALswaclrgHLA-----AAKTLIEHGCNRHHEDHNGRTALDLAAYQ 1435
Cdd:PHA02878 245 CkdyDILKLLLEHGVDVNAKSYiLGLTAL-------HSSikserKLKLLLEYGADINSLNSYKLTPLSSAVKQ 310
|
|
| PLN03088 |
PLN03088 |
SGT1, suppressor of G2 allele of SKP1; Provisional |
1568-1613 |
2.57e-04 |
|
SGT1, suppressor of G2 allele of SKP1; Provisional
Pssm-ID: 215568 [Multi-domain] Cd Length: 356 Bit Score: 45.16 E-value: 2.57e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 24663106 1568 DASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQ 1613
Cdd:PLN03088 19 ALAVDLYTQAIDLDPNNAELYADRAQANIKLGNFTEAVADANKAIE 64
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1364-1441 |
3.00e-04 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 45.66 E-value: 3.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1364 MIAAEEGHLEL------VDLLLARGAQREAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLAAYQGA 1437
Cdd:PTZ00322 81 MLTVELCQLAAsgdavgARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGF 160
|
....
gi 24663106 1438 ASLV 1441
Cdd:PTZ00322 161 REVV 164
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1141-1207 |
3.42e-04 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 45.63 E-value: 3.42e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24663106 1141 HRTDYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSL 1207
Cdd:PLN03192 615 SISDPHAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADV 681
|
|
| NrfG |
COG4235 |
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ... |
1510-1605 |
4.47e-04 |
|
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443378 [Multi-domain] Cd Length: 131 Bit Score: 41.92 E-value: 4.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1510 GNVLYRKNRFQEAAHRYQYALRkisgleqLLERNAifaqlrtNLLLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYY 1589
Cdd:COG4235 24 GRAYLRLGRYDEALAAYEKALR-------LDPDNA-------DALLDLAEALLAAGDTEEAEELLERALALDPDNPEALY 89
|
90
....*....|....*.
gi 24663106 1590 ARAKARMELGALNEAL 1605
Cdd:COG4235 90 LLGLAAFQQGDYAEAI 105
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1378-1432 |
5.54e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 39.64 E-value: 5.54e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 24663106 1378 LLARGAQR-EAQDHEGFTALSWACLRGHLAAAKTLIEHGCNRHHEDHNGRTALDLA 1432
Cdd:pfam13857 1 LLEHGPIDlNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
1240-1452 |
5.62e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 44.69 E-value: 5.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1240 PRPHSQDVTRSVAlQQALIGAAAQAHCKILEDLLDLNETEfdldvngmePSSGElALTAAARHGCIDVVGILLSRGAQID 1319
Cdd:TIGR00870 40 PKKLNINCPDRLG-RSALFVAAIENENLELTELLLNLSCR---------GAVGD-TLLHAISLEYVDAVEAILLHLLAAF 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1320 arnRQGYSaLWLAVKEghwsvvehllqrgALLDEPLGQTrktPLMIAAEEGHLELVDLLLARGAQREAQDHEGFtalswa 1399
Cdd:TIGR00870 109 ---RKSGP-LELANDQ-------------YTSEFTPGIT---ALHLAAHRQNYEIVKLLLERGASVPARACGDF------ 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 24663106 1400 CLRGHlaaaktliEHGCNRHhedhnGRTALDLAAYQGAASLVIYILEQGGNLE 1452
Cdd:TIGR00870 163 FVKSQ--------GVDSFYH-----GESPLNAAACLGSPSIVALLSEDPADIL 202
|
|
| PilF |
COG3063 |
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures]; |
1512-1616 |
6.14e-04 |
|
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
Pssm-ID: 442297 [Multi-domain] Cd Length: 94 Bit Score: 40.54 E-value: 6.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1512 VLYRKNRFQEAAHRYQYALRkisgleqlLERNAIFAqlrtnlLLNLSRCKRKLNELDASIDLaTQAIAQKPHSYEGYYAR 1591
Cdd:COG3063 1 LYLKLGDLEEAEEYYEKALE--------LDPDNADA------LNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNL 65
|
90 100
....*....|....*....|....*
gi 24663106 1592 AKARMELGALNEALVDANEAMQQAA 1616
Cdd:COG3063 66 AELLLELGDYDEALAYLERALELDP 90
|
|
| 3a0801s09 |
TIGR00990 |
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ... |
1505-1607 |
1.06e-03 |
|
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273380 [Multi-domain] Cd Length: 615 Bit Score: 43.82 E-value: 1.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1505 KLLEDGNVLYRKNRFQEAAHRYQYALrkisgleqLLERNAIFAQlrtnlllNLSRCKRKLNELDASIDLATQAIAQKPHS 1584
Cdd:TIGR00990 129 KLKEKGNKAYRNKDFNKAIKLYSKAI--------ECKPDPVYYS-------NRAACHNALGDWEKVVEDTTAALELDPDY 193
|
90 100
....*....|....*....|...
gi 24663106 1585 YEGYYARAKARMELGALNEALVD 1607
Cdd:TIGR00990 194 SKALNRRANAYDGLGKYADALLD 216
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1292-1396 |
1.56e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 43.08 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1292 GELALTAAARHGCIDVVGILLsRGA------QIDARNRQGYSALWLAVKEGHWSVVEHLLQRGALLDEPlgqtRKT---- 1361
Cdd:cd22192 51 GETALHVAALYDNLEAAVVLM-EAApelvnePMTSDLYQGETALHIAVVNQNLNLVRELIARGADVVSP----RATgtff 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 24663106 1362 -------------PLMIAAEEGHLELVDLLLARGAQREAQDHEGFTAL 1396
Cdd:cd22192 126 rpgpknliyygehPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1344-1396 |
2.03e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.10 E-value: 2.03e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 24663106 1344 LLQRGALLDEPLGQTRKTPLMIAAEEGHLELVDLLLARGAQREAQDHEGFTAL 1396
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1133-1188 |
2.11e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.71 E-value: 2.11e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 24663106 1133 LLAGASPNHRTDYMGGAPILCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILA 1188
Cdd:pfam13857 1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| LapB |
COG2956 |
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ... |
1491-1618 |
2.49e-03 |
|
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442196 [Multi-domain] Cd Length: 275 Bit Score: 41.64 E-value: 2.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1491 MAMGKPEILVILLNKLLE----DGNVLYRKNRFQEAAHRYQYALRKisgLEQLLERNAIFAQLrtnlLLNLSRCKRKLNE 1566
Cdd:COG2956 87 LKAGLLDRAEELLEKLLEldpdDAEALRLLAEIYEQEGDWEKAIEV---LERLLKLGPENAHA----YCELAELYLEQGD 159
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 24663106 1567 LDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQAAQS 1618
Cdd:COG2956 160 YDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDY 211
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1325-1379 |
3.07e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.25 E-value: 3.07e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 24663106 1325 GYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRkTPLMIAAEEGHLELVDLLL 1379
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGE-TALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1152-1236 |
3.27e-03 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 42.19 E-value: 3.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1152 LCIAAHEGILPMVSLLLEFGADVGLTNSQGCTPLILAAMRGHCDVVRPLVAAGSSLGQLDITQRCALVHAARMGHLSVVK 1231
Cdd:PTZ00322 86 LCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ 165
|
....*
gi 24663106 1232 YLLAC 1236
Cdd:PTZ00322 166 LLSRH 170
|
|
| zf-RING_5 |
pfam14634 |
zinc-RING finger domain; |
97-134 |
4.14e-03 |
|
zinc-RING finger domain;
Pssm-ID: 434085 [Multi-domain] Cd Length: 43 Bit Score: 36.64 E-value: 4.14e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 24663106 97 CPSCRISFDKGKRRKLIdTCGH---ERCYSCMFRNDQCPMC 134
Cdd:pfam14634 2 CNKCFKELSKTRPFYLT-SCGHifcEECLTRLLQERQCPIC 41
|
|
| TadD |
COG5010 |
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ... |
1499-1618 |
4.17e-03 |
|
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];
Pssm-ID: 444034 [Multi-domain] Cd Length: 155 Bit Score: 39.56 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1499 LVILLNKLLEDGNVLYRKNRFQEAAHRYQYALRKISGLEQLLERNAIFAQLRTNLLLNLSRCKRKLNELDASIDLATQAI 1578
Cdd:COG5010 2 RALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQAL 81
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 24663106 1579 AQKPHSYEGYYARAKARMELGALNEALVDANEAMQQAAQS 1618
Cdd:COG5010 82 QLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDN 121
|
|
| zf-C3HC4 |
pfam00097 |
Zinc finger, C3HC4 type (RING finger); The C3HC4 type zinc-finger (RING finger) is a ... |
97-134 |
4.61e-03 |
|
Zinc finger, C3HC4 type (RING finger); The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid. Many proteins containing a RING finger play a key role in the ubiquitination pathway.
Pssm-ID: 395049 [Multi-domain] Cd Length: 40 Bit Score: 36.56 E-value: 4.61e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 24663106 97 CPSCrisFDKGKRRKLIDTCGHERCYSCMFR-----NDQCPMC 134
Cdd:pfam00097 1 CPIC---LEEPKDPVTLLPCGHLFCSKCIRSwlesgNVTCPLC 40
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1411-1465 |
5.13e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.94 E-value: 5.13e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 24663106 1411 LIEHGCNRH-HEDHNGRTALDLAAYQGAASLVIYILEQGGNLEHIDVHGMRPLDRA 1465
Cdd:pfam13857 1 LLEHGPIDLnRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| LapB |
COG2956 |
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ... |
1506-1632 |
5.47e-03 |
|
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 442196 [Multi-domain] Cd Length: 275 Bit Score: 40.48 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1506 LLEDGNVLYRKNRFQEAAHRYQYALRkisgleqlLERNAIFAQLrtnlllNLSRCKRKLNELDASIDLATQAIAQKPHSY 1585
Cdd:COG2956 147 YCELAELYLEQGDYDEAIEALEKALK--------LDPDCARALL------LLAELYLEQGDYEEAIAALERALEQDPDYL 212
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 24663106 1586 EGYYARAKARMELGALNEALVDANEAMQQAAQSGVLCEVVEVLKRIQ 1632
Cdd:COG2956 213 PALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKE 259
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1360-1383 |
5.99e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 35.64 E-value: 5.99e-03
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1361-1390 |
8.51e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 35.34 E-value: 8.51e-03
10 20 30
....*....|....*....|....*....|.
gi 24663106 1361 TPLMIAAEE-GHLELVDLLLARGAQREAQDH 1390
Cdd:pfam00023 4 TPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
|
|
| BepA |
COG4783 |
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ... |
1554-1615 |
8.74e-03 |
|
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 443813 [Multi-domain] Cd Length: 139 Bit Score: 38.25 E-value: 8.74e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24663106 1554 LLNLSRCKRKLNELDASIDLATQAIAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQA 1615
Cdd:COG4783 7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELD 68
|
|
| PHA02736 |
PHA02736 |
Viral ankyrin protein; Provisional |
1301-1385 |
9.28e-03 |
|
Viral ankyrin protein; Provisional
Pssm-ID: 165103 [Multi-domain] Cd Length: 154 Bit Score: 38.70 E-value: 9.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1301 RHG--CIDVVG------------ILLSRGAQIDARNRQ-GYSALWLAVKEGHWSVVEHLLQRGALLDEPLGQTRKTPLMI 1365
Cdd:PHA02736 53 RHGkqCVHIVSnpdkadpqeklkLLMEWGADINGKERVfGNTPLHIAVYTQNYELATWLCNQPGVNMEILNYAFKTPYYV 132
|
90 100
....*....|....*....|
gi 24663106 1366 AAEEGHLELVDLLLARGAQR 1385
Cdd:PHA02736 133 ACERHDAKMMNILRAKGAQC 152
|
|
| TadD |
COG5010 |
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ... |
1498-1615 |
9.29e-03 |
|
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];
Pssm-ID: 444034 [Multi-domain] Cd Length: 155 Bit Score: 38.79 E-value: 9.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24663106 1498 ILVILLNKLLEDGNVLYRKNRFQEAAHRYQYALrkisgleQLLERNAifaqlrtNLLLNLSRCKRKLNELDASIDLATQA 1577
Cdd:COG5010 49 KLAKAFAIESPSDNLYNKLGDFEESLALLEQAL-------QLDPNNP-------ELYYNLALLYSRSGDKDEAKEYYEKA 114
|
90 100 110
....*....|....*....|....*....|....*...
gi 24663106 1578 IAQKPHSYEGYYARAKARMELGALNEALVDANEAMQQA 1615
Cdd:COG5010 115 LALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTS 152
|
|
| |
