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Conserved domains on  [gi|21355095|ref|NP_649790|]
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copper transporter 1B [Drosophila melanogaster]

Protein Classification

copper transporter family protein( domain architecture ID 10514254)

copper transporter (Ctr) family protein is involved in high affinity copper uptake

Gene Ontology:  GO:0005375|GO:0016020|GO:0035434

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ctr pfam04145
Ctr copper transporter family; The redox active metal copper is an essential cofactor in ...
 19-160 5.55e-40

Ctr copper transporter family; The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.


:

Pssm-ID: 461194  Cd Length: 151  Bit Score: 132.43  E-value: 5.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355095    19 MVFHAGHCE-RILWRGWVASTVTEFVLSALAIFLVSFLYEALKFLRQQLARREARRASEQLAAEQRRKNEAPAAGGCCSE 97
Cdd:pfam04145   1 MLFNWSTIDtCLLFKSWHITSTGAFAGSCIGLFLLAVLYEFLRALRARLERRYDRWLARRARARSRSVSAASSSSSASSS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21355095    98 APLAEPREQ--------TYWQRLFASSHIVQSLLNLLQIVISYLLMLIFMTFNYWLCLAVILGLGLGYFFF 160
Cdd:pfam04145  81 SGDSSASESvpvllrsgFSPRPFRPSVDLIRALLHAVQVGLGYLLMLAVMTYNGYYFLAVVLGAFLGYFLF 151
 
Name Accession Description Interval E-value
Ctr pfam04145
Ctr copper transporter family; The redox active metal copper is an essential cofactor in ...
 19-160 5.55e-40

Ctr copper transporter family; The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.


Pssm-ID: 461194  Cd Length: 151  Bit Score: 132.43  E-value: 5.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355095    19 MVFHAGHCE-RILWRGWVASTVTEFVLSALAIFLVSFLYEALKFLRQQLARREARRASEQLAAEQRRKNEAPAAGGCCSE 97
Cdd:pfam04145   1 MLFNWSTIDtCLLFKSWHITSTGAFAGSCIGLFLLAVLYEFLRALRARLERRYDRWLARRARARSRSVSAASSSSSASSS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21355095    98 APLAEPREQ--------TYWQRLFASSHIVQSLLNLLQIVISYLLMLIFMTFNYWLCLAVILGLGLGYFFF 160
Cdd:pfam04145  81 SGDSSASESvpvllrsgFSPRPFRPSVDLIRALLHAVQVGLGYLLMLAVMTYNGYYFLAVVLGAFLGYFLF 151
 
Name Accession Description Interval E-value
Ctr pfam04145
Ctr copper transporter family; The redox active metal copper is an essential cofactor in ...
 19-160 5.55e-40

Ctr copper transporter family; The redox active metal copper is an essential cofactor in critical biological processes such as respiration, iron transport, oxidative stress protection, hormone production, and pigmentation. A widely conserved family of high-affinity copper transport proteins (Ctr proteins) mediates copper uptake at the plasma membrane. A series of clustered methionine residues in the hydrophilic extracellular domain, and an MXXXM motif in the second transmembrane domain, are important for copper uptake. These methionine probably coordinate copper during the process of metal transport.


Pssm-ID: 461194  Cd Length: 151  Bit Score: 132.43  E-value: 5.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21355095    19 MVFHAGHCE-RILWRGWVASTVTEFVLSALAIFLVSFLYEALKFLRQQLARREARRASEQLAAEQRRKNEAPAAGGCCSE 97
Cdd:pfam04145   1 MLFNWSTIDtCLLFKSWHITSTGAFAGSCIGLFLLAVLYEFLRALRARLERRYDRWLARRARARSRSVSAASSSSSASSS 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21355095    98 APLAEPREQ--------TYWQRLFASSHIVQSLLNLLQIVISYLLMLIFMTFNYWLCLAVILGLGLGYFFF 160
Cdd:pfam04145  81 SGDSSASESvpvllrsgFSPRPFRPSVDLIRALLHAVQVGLGYLLMLAVMTYNGYYFLAVVLGAFLGYFLF 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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