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Conserved domains on  [gi|194389854|dbj|BAG60443|]
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unnamed protein product [Homo sapiens]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-276 8.66e-107

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 307.51  E-value: 8.66e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   93 NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGD 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRSRTVSRSLGLPEIIPKEKPPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  173 VGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTV 252
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|....
gi 194389854  253 DISLILSEAIRRIHNGESMAYLFR 276
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 2.59e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 83.62  E-value: 2.59e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 194389854    1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKM-RKRGSIVCKLLASMLAKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-276 8.66e-107

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 307.51  E-value: 8.66e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   93 NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGD 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRSRTVSRSLGLPEIIPKEKPPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  173 VGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTV 252
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|....
gi 194389854  253 DISLILSEAIRRIHNGESMAYLFR 276
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-276 1.17e-74

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 230.33  E-value: 1.17e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQ-SKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:COG0462   68 MELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYA 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEipNYRNAVIVakSPDA--AKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPpmvKNATVHpglelp 157
Cdd:COG0462  148 APLLADYIKSK--DLEDLVVV--SPDVggVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVM------ 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 158 lmmakekppiTVVGDVGGRI----------AiivddiiddvESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESS 227
Cdd:COG0462  204 ----------NIIGDVEGKTciivddmidtG----------GTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSP 263

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 194389854 228 VDEVVVTNTVPHEVQKlQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:COG0462  264 IDELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-276 2.62e-69

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 216.52  E-value: 2.62e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK01259  65 MELLIMIDALKRASAGRITAVIPYFGYARQDrKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEipNYRNAVIVakSPD--AAKRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVknATVhpglelp 157
Cdd:PRK01259 145 SPILLEDIKQK--NLENLVVV--SPDvgGVVRARALAKRLDADLAII------------DKRRPRANV--SEV------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 158 lmmakekppITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTV 237
Cdd:PRK01259 200 ---------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSI 270

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 194389854 238 PHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:PRK01259 271 PLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-276 2.98e-69

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 216.38  E-value: 2.98e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854    1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRG-SIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:TIGR01251  66 MELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   80 SPFLLQYIQEEIPNyrNAVIVakSPD--AAKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPPmvKNATVHPglelp 157
Cdd:TIGR01251 146 SPVLAEYLKKKILD--NPVVV--SPDagGVERAKKVADALGCPLAIIDKR-----------RISAT--NEVEVMN----- 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  158 lmmakekppitVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTV 237
Cdd:TIGR01251 204 -----------LVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTI 272

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 194389854  238 PHEVqklQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:TIGR01251 273 PHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 2.59e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 83.62  E-value: 2.59e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 194389854    1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKM-RKRGSIVCKLLASMLAKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-276 8.66e-107

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 307.51  E-value: 8.66e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   93 NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGD 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRSRTVSRSLGLPEIIPKEKPPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  173 VGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTV 252
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|....
gi 194389854  253 DISLILSEAIRRIHNGESMAYLFR 276
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-276 1.17e-74

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 230.33  E-value: 1.17e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQ-SKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:COG0462   68 MELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYA 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEipNYRNAVIVakSPDA--AKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPpmvKNATVHpglelp 157
Cdd:COG0462  148 APLLADYIKSK--DLEDLVVV--SPDVggVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVM------ 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 158 lmmakekppiTVVGDVGGRI----------AiivddiiddvESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESS 227
Cdd:COG0462  204 ----------NIIGDVEGKTciivddmidtG----------GTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSP 263

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 194389854 228 VDEVVVTNTVPHEVQKlQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:COG0462  264 IDELVVTDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-276 2.62e-69

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 216.52  E-value: 2.62e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK01259  65 MELLIMIDALKRASAGRITAVIPYFGYARQDrKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEipNYRNAVIVakSPD--AAKRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVknATVhpglelp 157
Cdd:PRK01259 145 SPILLEDIKQK--NLENLVVV--SPDvgGVVRARALAKRLDADLAII------------DKRRPRANV--SEV------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 158 lmmakekppITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTV 237
Cdd:PRK01259 200 ---------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSI 270

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 194389854 238 PHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:PRK01259 271 PLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-276 2.98e-69

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 216.38  E-value: 2.98e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854    1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRG-SIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:TIGR01251  66 MELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   80 SPFLLQYIQEEIPNyrNAVIVakSPD--AAKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPPmvKNATVHPglelp 157
Cdd:TIGR01251 146 SPVLAEYLKKKILD--NPVVV--SPDagGVERAKKVADALGCPLAIIDKR-----------RISAT--NEVEVMN----- 203

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  158 lmmakekppitVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTV 237
Cdd:TIGR01251 204 -----------LVGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTI 272

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 194389854  238 PHEVqklQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:TIGR01251 273 PHEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
1-275 1.06e-50

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 168.59  E-value: 1.06e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKM-RKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK03092  54 MEQLIMIDALKRASAKRITVVLPFYPYARQDKKhRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEIPNyRNAVIVakSPDAA--KRAQSYAERL-RLGLAVIHgeaqcteldmddGRHSPPMVKNATVHpglel 156
Cdd:PRK03092 134 MPLLADYVRDKYDL-DNVTVV--SPDAGrvRVAEQWADRLgGAPLAFIH------------KTRDPTVPNQVVAN----- 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 157 plmmakekppiTVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNT 236
Cdd:PRK03092 194 -----------RVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVVTDT 262

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 194389854 237 VPHEVQKlQCPKIKTVDISLILSEAIRRIHNGESMAYLF 275
Cdd:PRK03092 263 LPIPEEK-RFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
1-275 1.63e-48

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 163.56  E-value: 1.63e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQSK-MRK-RGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLR 78
Cdd:PRK04923  71 MELLVLIDALKRASAASVTAVIPYFGYSRQDRrMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVY 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  79 ASPFLLQYIQEEIpNYRNAVIVakSPDAAK--RAQSYAERL-RLGLAVIhgeaqcteldmdDGRHspPMVKNATVhpgle 155
Cdd:PRK04923 151 ASPLLLADIWRAY-GTDNLIVV--SPDVGGvvRARAVAKRLdDADLAII------------DKRR--PRANVATV----- 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 156 lplmmakekppITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTN 235
Cdd:PRK04923 209 -----------MNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTD 277

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 194389854 236 TVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLF 275
Cdd:PRK04923 278 TIPLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 1-276 7.26e-48

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 161.40  E-value: 7.26e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PLN02369  56 MELLIMIDACRRASAKRITAVIPYFGYARADrKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEIPNYRNAVIVakSPDAAK--RAQSYAERLR-LGLAVIhgeaqcteldmDDGRHSPPMVKnatvhpglel 156
Cdd:PLN02369 136 QPVILDYLASKTISSPDLVVV--SPDVGGvaRARAFAKKLSdAPLAIV-----------DKRRQGHNVAE---------- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 157 plmmakekpPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNT 236
Cdd:PLN02369 193 ---------VMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIVTNT 263

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 194389854 237 VPHEVQKlQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:PLN02369 264 IPVSEKN-YFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
1-275 8.86e-45

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 153.79  E-value: 8.86e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK02269  70 MEILIMVDALKRASAESINVVMPYYGYARQDrKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMG 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEIPNYRNAVIVakSPDAA--KRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVKNATVhpglelp 157
Cdd:PRK02269 150 APLIADYFDRRGLVGDDVVVV--SPDHGgvTRARKLAQFLKTPIAII------------DKRRSVDKMNTSEV------- 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 158 lmmakekppITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTV 237
Cdd:PRK02269 209 ---------MNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTI 279

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 194389854 238 PHEVQKLqCPKIKTVDISLILSEAIRRIHNGESMAYLF 275
Cdd:PRK02269 280 YLPEERL-IDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 1-276 3.31e-42

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 147.58  E-value: 3.31e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK02812  86 MELLIMVDACRRASARQITAVIPYYGYARADrKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYG 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEipNYRNAVIVakSPD--AAKRAQSYAERLRLG-LAVIhgeaqcteldmdDGRHSPPMVKNAtvhpglel 156
Cdd:PRK02812 166 SPVLLDYLASK--NLEDIVVV--SPDvgGVARARAFAKKLNDApLAII------------DKRRQAHNVAEV-------- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 157 plmmakekppITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNT 236
Cdd:PRK02812 222 ----------LNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNT 291

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 194389854 237 VPHEvQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:PRK02812 292 IPVP-EERRFPQLKVLSVANMLGEAIWRIHEESSVSSMFR 330
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-276 1.59e-41

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 145.65  E-value: 1.59e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKMRK-RGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK02458  74 WELLIMIDACKRASANTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIhgeaqctELDMDDGrhsppmvknatvhpglelplm 159
Cdd:PRK02458 154 VPLFAKHYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAII-------DYAQDDS--------------------- 205

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 160 makEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVph 239
Cdd:PRK02458 206 ---EREEGYIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSV-- 280

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 194389854 240 eVQKLQCPK-IKTVDISLILSEAIRRIHNGESMAYLFR 276
Cdd:PRK02458 281 -ATKERVPKnVTYLSASELIADAIIRIHERKPLSPLFA 317
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 1-275 6.49e-38

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 136.20  E-value: 6.49e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK00553  74 MELLIAIDALKRGSAKSITAILPYYGYARQDrKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEIpNYRNAVIVakSPD--AAKRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVKNAtvhpglelp 157
Cdd:PRK00553 154 YHVFLSRVLELL-GKKDLVVV--SPDygGVKRARLIAESLELPLAII------------DKRRPKHNVAES--------- 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 158 lmmakekppITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEES----SVDEVVV 233
Cdd:PRK00553 210 ---------INVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLIDKLFV 280

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 194389854 234 TNTVPHEVQKlQCPKIKTVDISLILSEAIRRIHNGESMAYLF 275
Cdd:PRK00553 281 SNSIPQTKFE-KKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 1-275 3.70e-37

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 136.54  E-value: 3.70e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFS--FPVDNL 77
Cdd:PTZ00145 184 IELLLMISTCRRASAKKITAVIPYYGYARQDrKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  78 RASPFLLQYIQEEiPNYRnAVIVakSPDAAK--RAQSYAERLrlglaVIHGEAQCTeLDMddgrhsppMVKNATvhpgle 155
Cdd:PTZ00145 264 EAQLIGLDYFTKK-DLYK-PVIV--SPDAGGvyRARKFQDGL-----NHRGISDCG-IAM--------LIKQRT------ 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 156 lplmMAKEKPPITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTN 235
Cdd:PTZ00145 320 ----KPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTD 395

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 194389854 236 TVPHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLF 275
Cdd:PTZ00145 396 TVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 1-244 5.67e-28

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 108.85  E-value: 5.67e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRG-SIVCKLLASMLAKAGlTHIITMDLHQKEIQGFFSFPVDNLRA 79
Cdd:PRK00934  63 VELLLLIDALRDEGAKSITLVIPYLGYARQDKRFKPGePISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  80 SPFLLQYIQEEIpnyRNAVIVAksPD--AAKRAQSYAERLrlGLAVIHGEAQcteldmddgRHSPPMVKNATVHpglelp 157
Cdd:PRK00934 142 APLIAEYIGDKL---DDPLVLA--PDkgALELAKEAAEIL--GCEYDYLEKT---------RISPTEVEIAPKN------ 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 158 lMMAKEKPpITVVGDV---GGRIAIivddiiddvesfvaAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVT 234
Cdd:PRK00934 200 -LDVKGKD-VLIVDDIistGGTMAT--------------AIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVT 263

                        250
                 ....*....|
gi 194389854 235 NTVPHEVQKL 244
Cdd:PRK00934 264 DTLESEVSKI 273
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 15-277 3.30e-22

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 94.63  E-value: 3.30e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  15 ARNIIGVIPYFPYSKQSKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGffSFPV---DNLRASPFLLQYIQEEI 91
Cdd:PRK06827 122 ARRITVIMPFLYESRQHKRKGRESLDCALALQELEELGVDNIITFDAHDPRIEN--AIPLmgfENLYPSYQIIKALLKNE 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  92 PNYR----NAVIVakSPD--AAKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPPMVKNatvhpglelplmmakeKP 165
Cdd:PRK06827 200 KDLEidkdHLMVI--SPDtgAMDRAKYYASVLGVDLGLFYKR-----------RDYSRVVNG----------------RN 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 166 PITVV----GDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGiLSAEAPRLI----EESSVDEVVVTNTV 237
Cdd:PRK06827 251 PIVAHeflgRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFG-FFTNGLEKFdkayEEGYFDRIIGTNLV 329

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 194389854 238 PHEVQKLQCPKIKTVDISLILSEAIRRIHNGESMAYLFRN 277
Cdd:PRK06827 330 YHPEELLSKPWYIEVDMSKLIARIIDALNHDVSLSKLLDP 369
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 2.59e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 83.62  E-value: 2.59e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 194389854    1 MELLIMAYALKTACARNIIGVIPYFPYSKQSKM-RKRGSIVCKLLASMLAKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
2-264 9.80e-08

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 52.25  E-value: 9.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854   2 ELLIMAYALKTACARNIIGVIPYFPYSKQSKMRKRGSIVC-KLLASMLAkAGLTHIITMD--LHQ-KEIQGFFSFPVDNL 77
Cdd:PRK07199  67 PLLFAAEAARELGARRVGLVAPYLAYMRQDIAFHPGEAISqRHFARLLS-GSFDRLVTVDphLHRyPSLSEVYPIPAVVL 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854  78 RASPFLLQYIQEEIPnyrNAVIVAksPDAAKR--AQSYAERLRLGLAVihgeaqCTELdmddgRHSPPMVK----NATVH 151
Cdd:PRK07199 146 SAAPAIAAWIRAHVP---RPLLIG--PDEESEqwVAAVAERAGAPHAV------LRKT-----RHGDRDVEislpDAAPW 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194389854 152 PGlelplmmakeKPPItVVGDV--GGRiaiivddiiddveSFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVD 229
Cdd:PRK07199 210 AG----------RTPV-LVDDIvsTGR-------------TLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIA 265

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 194389854 230 EVVVTNTVPHEVQklqcpkikTVDISLILSEAIRR 264
Cdd:PRK07199 266 RVVSTDTVPHPSN--------AISLAPLLAEALRR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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