|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
15-398 |
3.17e-114 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 339.20 E-value: 3.17e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 15 TFLSLYIAQTIPMSFFSTILPVLMRQQDYSLETIGMLQFLKLPWVLKFLWSPAIDR-SCHTLNDYKRWIFSSELIYAVII 93
Cdd:cd17485 1 LLFGLYLAQGLPYGFQSQALPVLLRSAGVSLTAIGLLKLLYLPWVLKFLWAPLVDRyGLPRLGRRRSWLLPTQLGLALLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 94 LAISFLDLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHKLGWNQL 173
Cdd:cd17485 81 LALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLWLYDLIGWQSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 174 LPYLAIFVVVALIPLMLFKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVDYGYS 253
Cdd:cd17485 161 LLSLAALYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGTRWLLLFLLLYKLGEQGALAMLPPFLVDRGFS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 254 MKQIGVMSGVIGTSIGCVGSLTGGFIVRKIGCYIPRIVFAVFILATTVYFYLLVTHLAVNT-ATLHLGITLLWGSYGMAT 332
Cdd:cd17485 241 LSQIGLLSGVGGSLVSIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNwVLLLASLALLHLVGGMIT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1821117515 333 IVVYTTSMYCVREGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIAVTSLLYIL 398
Cdd:cd17485 321 TALFTLMMDCSQQAQAGTDYTLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| MFS_AmpG_like |
cd17486 |
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner ... |
17-398 |
1.02e-46 |
|
AmpG and similar transporters of the Major Facilitator Superfamily; AmpG acts as an inner membrane permease in the beta-lactamase induction system and in peptidoglycan recycling. It transports meuropeptide from the periplasm into the cytosol in gram-negative bacteria, which is essential for the induction of the ampC encoding beta-lactamase. The AmpG family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341039 [Multi-domain] Cd Length: 387 Bit Score: 164.69 E-value: 1.02e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 17 LSLYIAQTIPMSFFSTILPVLMRQQDYSLETIGMLQFLKLPWVLKFLWSPAIDR-SCHTLNDYKRWIFSSELIYAVIILA 95
Cdd:cd17486 2 LLLGFASGLPYLLTGTTLQAWLKEAGVDLDTIGLFSLVGLPYSLKFLWAPLVDRySTPFLGRRRGWILLTQILLMAALIA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 96 ISFLDLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHKLGWNQLLP 175
Cdd:cd17486 82 LAFLDPFTNLVLSALLFLLVAFFSATQDIAIDAYRIEALEDKEQGAGAGVRVNGYRIGMLVAGAGALYLADSLSWSAVYL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 176 YLAIFVVVALIPLMLFKKKQVEEPQERKK--YAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVDYGYS 253
Cdd:cd17486 162 IMAALMGPGILATLFAPEPPRTDPPANSLseTVVAFFAPFKDFFGQPGALLILAFILLYKLGDAMLGAMATPFLLDLGFT 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 254 MKQIGVMSGVIGTSIGCVGSLTGGFIVRKIGCYIPRIVFAVFILATTVYFYLLvTHLAVNTATLHLGITLLWGSYGMATI 333
Cdd:cd17486 242 KTEIGAVYKTVGLIATIVGGLLGGFLMSRLGLKRSLWLFGILQALSNLGFIYL-AHAGPNLTLLVAAVAVENFGGGLGTT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1821117515 334 VVYTTSMYCVREGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIAVTSLLYIL 398
Cdd:cd17486 321 AFVAYLMSLCNGEFTATQYALLSSLMALGRMVLGAPSGWLAEALGWTGFFLLTTLAAIPGLLLLL 385
|
|
| sider_RhtX_FptX |
TIGR02718 |
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from ... |
19-395 |
4.96e-44 |
|
siderophore transporter, RhtX/FptX family; RhtX from Sinorhizobium meliloti 2011 and FptX from Pseudomonas aeruginosa appear to be single polypeptide transporters, from the major facilitator family (see pfam07690) for import of siderophores as a means to import iron. This function was suggested by proximity to siderophore biosynthesis genes and then confirmed by study of knockout and heterologous expression phenotypes. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 131765 Cd Length: 390 Bit Score: 157.75 E-value: 4.96e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 19 LYIAQTIPMSFFSTILPVLMRQQDYSLETIGMLQFLKLPWVLKFLWSPAIDR-SCHTLNDYKRWIFSSELIYAVIILAIS 97
Cdd:TIGR02718 9 LYLSQGIPIGLAMDALPTLLREDGAPLTALAFLPLVGLPWVVKFLWAPLVDNwWSWRLGRRRSWVLPMQCLVSACLASLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 98 FL--DLETNIYTIIILIVfAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHKLGWNQLLP 175
Cdd:TIGR02718 89 LVgpDVAGAGWAVGLLAC-ASLASATQDIATDGMAAEHFNGRTLAKGNAVQIAGVMIGFFGGGAGTLVLFGKFGQRPAFL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 176 YLAIFVVVALIPLMLFKKKQVEEPQErkkyAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVDYGYSMK 255
Cdd:TIGR02718 168 LVACVPLASLVCVLWLKDRAVASPEA----PLARRASLFRFFRRPLAWSLLALALLSAMTAVSGFGLSKLYLVDAGWPLE 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 256 QIGVMSGVIGTSIGCVGSLTGGFIVRKIGcyipriVFAVFILATTVYFYLLVTHLAVNTATLHLGITLLWG-------SY 328
Cdd:TIGR02718 244 WIGRLGMAGGAVTVLLGCGGGAWLVRRAG------LWRTFILGVGLAGSLALLWFAQAAFWLAPGIAVAWScsafgslIT 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1821117515 329 GMATIVVYTTSMYCVREGYE-GTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIAVTSLL 395
Cdd:TIGR02718 318 GITSVAIYTAFMRFAGDGDQaGTDVTAVQSTRDLGELIASSIAGYLTDRFGYAGGFLSGTVLAVLAIL 385
|
|
| ampG |
PRK11902 |
muropeptide transporter; Reviewed |
17-399 |
8.81e-22 |
|
muropeptide transporter; Reviewed
Pssm-ID: 183369 [Multi-domain] Cd Length: 402 Bit Score: 96.46 E-value: 8.81e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 17 LSLYIAQTIPMSFFSTILPVLMRQQDYSLETIGMLQFLKLPWVLKFLWSPAIDRSCHTLNDYKR-WIFSSELIYAVIILA 95
Cdd:PRK11902 5 LLLGFASGLPLALTSGTLQAWMTVEGLDIQTIGFFSLVGQAYIFKFLWAPLMDRYTPPLLGRRRgWLLLTQVGLAASIAA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 96 ISFLDLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLY-HKLGWNQLL 174
Cdd:PRK11902 85 MAFCPPHAALWPLAGLAVLVAFLSASQDIVFDAYSTDVLHPEERGAGAAVKVLGYRLAMLVSGGLALWLAdRVLGWGNTY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 175 PYLAIFVVVALIPLMLfkkkqveEPQERKKYAPPHP------DDLLGFFKQKGIWKQILFLFLY-----YAGLIGTLAML 243
Cdd:PRK11902 165 LLMAGLMLAGALTTLW-------APEPEVPARPPRSlgeavvGPLRDFFSRRGAWALLLLIVLYklgdaFAGSLSTTFLI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 244 KPMlvdyGYSMKQIGVMSGVIGTSIGCVGSLTGGFIVRKIGCYIPRIVFAVFILATTV-YFYLLVTHLAVNTATLHLGIT 322
Cdd:PRK11902 238 RGA----GFSAGEVGIVNKTLGLAATIVGALAGGTLMVRLGLYRSLMLFGVLQAVSNLgYWVLAVTPKHLWTMALAIGIE 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821117515 323 LLWGSYGMATIVVYTTSMycVREGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIAVTSLLYILA 399
Cdd:PRK11902 314 NLCGGMGTAAFVALLMAL--CNRSFSATQYALLSALASVGRVYVGPTSGYLVEAYGWPGFYLMTVVIALPGLALLWL 388
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-401 |
1.81e-18 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 86.33 E-value: 1.81e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 16 FLSLYIAQTIPMSFFSTILPVLMRQQDYSLETIGMLQFLKL--PWVLKFLWSPAIDRSchtlnDYKRWIFSSELIYAVII 93
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSlgYALLQPLAGLLADRF-----GRRPVLLLGLLLFALGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 94 LAISFLdleTNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGG--GVLLLLYHKLGWN 171
Cdd:cd06174 76 LLFAFA---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPllGGILASSLGFGWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 172 QLLPYLAIFVVVALIPLMLFKKKQVEEPQERKKYAPPHP--DDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVD 249
Cdd:cd06174 153 AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSvlKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 250 YGYSMKQIGVMSGVIGTSIGCVGSLTGGFIVRKIGCYIPRIVFAVFILATTVYFYLLVTHLAVNTatlhLGITLLWGSYG 329
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLL----LLLLLLGFGLG 308
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1821117515 330 MATIVVYTTSMYCVREGYEGTDFTLQTVITHLSGMLMAAGAGKI-AGMYGYANLFLFescIAVTSLLYILATF 401
Cdd:cd06174 309 GLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLV---LAVLLLLAAILLL 378
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
16-365 |
3.42e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 76.30 E-value: 3.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 16 FLSLYIAQTIPMSFFSTILPVLMRQQ-DYSLETIGMLQ--FLKLPWVLKFLWSPAIDRSchtlnDYKRWIFSSELIYAVI 92
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLtlFSLGYALAQPLAGRLSDRF-----GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 93 ILAISFLdleTNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHKLGWNQ 172
Cdd:pfam07690 76 LLLLLFA---SSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 173 LLPYLAIFVVVALIPLMLFKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVDYGY 252
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 253 SMKQIGVMSGVIGTsIGCVGSLTGGFIVRKIGCYIPRIVFAVFILATTVYFYLLVThlaVNTATLHLGITLLWG-SYGMA 331
Cdd:pfam07690 233 SALLAGLLLGLGGL-LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSL---TLSSLWLLLALLLLGfGFGLV 308
|
330 340 350
....*....|....*....|....*....|....
gi 1821117515 332 TIVVYTTSMYCVREGYEGTDFTLQTVITHLSGML 365
Cdd:pfam07690 309 FPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
79-406 |
6.70e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 72.61 E-value: 6.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 79 KRWIFSSELIYAVIILAISFLdleTNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGG 158
Cdd:COG2223 70 RRVLLIGLLLLGIGLLLLALA---VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAA 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 159 GVLLLLYHKLGWNQLLPYLAIFVVVALIPLMLFKKkqvEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIG 238
Cdd:COG2223 147 FLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR---DPPAGAAAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIG 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 239 TLAMLKPMLVD-YGYSMKQIGVMSGVIGTsIGCVGSLTGGFIVRKIGcyIPRIVFAVFILATTVYFYLLVTHLAVNTATl 317
Cdd:COG2223 224 FSSWLPPYLVDqFGLSAATAGLLAALFAL-LGALGRPLGGWLSDRIG--GRRVLLIVFALMALGLLLLALALGSLWLFL- 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 318 hLGITLLWGSYGMATIVVYTTSMYCVREGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYG-YANLFLFESCIAVTSLLY 396
Cdd:COG2223 300 -VLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVL 378
|
330
....*....|
gi 1821117515 397 ILATFKKEKK 406
Cdd:COG2223 379 TLLLYRRPRR 388
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
87-379 |
6.32e-12 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 66.85 E-value: 6.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 87 LIYAVIILAISF--------LDLETNIYTIIILIVFAFTASATQDIATDAL-AVLSFSKKDKSLVNSMQSVGSFAGAMIG 157
Cdd:COG2211 84 ILIGAIPLALSFvllftapdLSPTGKLIYALVTYLLLGLAYTLVNIPYSALgAELTPDYEERTRLSSWRFAFAGLGGLLA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 158 GGVLLLLYHKLGWNQLLPYLAIFVVVALI--PLMLFKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAG 235
Cdd:COG2211 164 SVLPPPLVAAFGGDAALGYRLTALIFAVLglLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLA 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 236 LIGTLAMLKPMLVDY-GYSMKQIGVMSGVIGTSiGCVGSLTGGFIVRKIGcyiPRIVFAVFILATTVYFYLLVTHLAVNT 314
Cdd:COG2211 244 LALVAALLLYYFKYVlGLSAALVGLLLALYFLA-ALLGAPLWPRLAKRFG---KKKAFIIGLLLAALGLLLLFFLGPGNL 319
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1821117515 315 ATLHLGITLLWGSYGMATIVVYTTSMYCVREGY-------EGTDFTLQTVITHLSGMLMAAGAGKIAGMYGY 379
Cdd:COG2211 320 WLLLVLAALAGIGLGAILVLPWAMLADVVDYDEwktgrrrEGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
79-406 |
3.99e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.12 E-value: 3.99e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 79 KRWIFSSELIYAVIILAISFLdleTNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGG 158
Cdd:COG2271 75 RRVLAIGLLLWGLATLLFGFA---TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAP 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 159 GVLLLLYHKLGWNqllpylAIFVVVALIPLmlfkkkqveepqerkkyapphpddLLGFFKqkgIWKQILFLFLYYAGLIG 238
Cdd:COG2271 152 PLLGWLLAAFGWR------AAFLILGLPGL------------------------LLALLR---FWLLALAYFLVYFALYG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 239 TLAMLKPMLVD-YGYSMKQIGVMSGVIGTsIGCVGSLTGGFIVRKIGcYIPRIVFAVFILATTVYFYLLVthLAVNTATL 317
Cdd:COG2271 199 FLTWLPTYLVEvRGLSLAQAGLLLSLPFL-AGIVGSLLGGWLSDRLG-RRRKLVLAIGLLLAALALLLLA--LLPSPALA 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 318 HLGITLLWGSYGMATIVVYTTSMYCVREGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIAVTSLLYI 397
Cdd:COG2271 275 IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLA 354
|
....*....
gi 1821117515 398 LATFKKEKK 406
Cdd:COG2271 355 LLLLRETRK 363
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
13-363 |
7.11e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 63.07 E-value: 7.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 13 LFTFLSLYIAQTIPMSFFSTILPVLMRQQDYSLETIGMLQFLK-LPWVL-KFLWSPAIDRSchtlnDYKRWIFSSELIYA 90
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYlLGAALgAPLAGRLADRF-----GRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 91 VIILAISFLdleTNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHKLGW 170
Cdd:COG2814 87 LGSLLCALA---PSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 171 NQLLPYLAIFVVVALIPLMLFKkkqveePQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVD- 249
Cdd:COG2814 164 RWVFLVNAVLALLALLLLLRLL------PESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEv 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 250 YGYSMKQIGVMSGVIGTSiGCVGSLTGGFIVRKIGcyiPRIVFAVFILATTVYFYLLVthLAVNTATLHLGITLLWGSYG 329
Cdd:COG2814 238 LGLSASAAGLLLALFGLG-GVLGALLAGRLADRFG---RRRLLLIGLLLLALGLLLLA--LAGSLWLLLLALFLLGFGFG 311
|
330 340 350
....*....|....*....|....*....|....
gi 1821117515 330 MATIVVYTTSMYCVREGYEGTDFTLQTVITHLSG 363
Cdd:COG2814 312 LLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| ampG |
PRK11010 |
muropeptide MFS transporter AmpG; |
17-398 |
8.15e-11 |
|
muropeptide MFS transporter AmpG;
Pssm-ID: 182898 [Multi-domain] Cd Length: 491 Bit Score: 63.51 E-value: 8.15e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 17 LSLYIAQTIPMSFFSTILPVLMRQQDYSLETIGMLQFLKLPWVLKFLWSPAIDRSCHTLNDYKR-WIFSSELIYAVIILA 95
Cdd:PRK11010 18 LILGFASGLPLALTSGTLQAWMTVENIDLKTIGFFSLVGQAYVFKFLWSPLMDRYTPPFLGRRRgWLLATQLLLLVAIAA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 96 ISFLDLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHK-LGWNQLL 174
Cdd:PRK11010 98 MGFLEPGTQLRWLAALAVVIAFCSASQDIVFDAWKTDVLPAEERGAGAAISVLGYRLAMLVSGGLALWLADRyLGWQGMY 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 175 PYLAIFVVVALIPLMLFKKKQVEEPQERKKY----APphpddLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLV-D 249
Cdd:PRK11010 178 WLMAALLIPCIIATLLAPEPTDTIPVPKTLEqavvAP-----LRDFFGRNNAWLILLLIVLYKLGDAFAMSLTTTFLIrG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 250 YGYSMKQIGVMSGVIGTSIGCVGSLTGGFIVRKIGCYIPRIVFAVFILATTV-YFYLLVTHLAVNTATLHLGITLLWGsy 328
Cdd:PRK11010 253 VGFDAGEVGLVNKTLGLLATIVGALYGGILMQRLSLFRALMIFGILQGVSNAgYWLLSITDKNLYSMGAAVFFENLCG-- 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821117515 329 GMATIVVYTTSMYCVREGYEGTDFTLqtvithLSGmLMAAG---AGKIAG----MYGYANLFLFESCIAVTSLLYIL 398
Cdd:PRK11010 331 GMGTAAFVALLMTLCNKSFSATQFAL------LSA-LSAVGrvyVGPVAGwfveAHGWPTFYLFSVAAAVPGLLLLL 400
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
78-407 |
6.63e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 60.25 E-value: 6.63e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 78 YKRWIFSSELIYAVIILAISFLdleTNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQ---SVGSFAGA 154
Cdd:COG0738 72 YKRGLLLGLLLMALGLLLFALA---PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHaffSLGALLGP 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 155 MIGGgvlLLLYHKLGWNQLLPYLAIFVVVALIPLMLFKKKqVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYA 234
Cdd:COG0738 149 LLGG---LLILLGLSLSWHLPYLILAVLLLLLALLFLRSK-LPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVG 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 235 GLIGTLAMLKPMLVDY-GYSMKQIGVMSGVIGTSIgCVGSLTGGFIVRKIGcyiPRIVFAVFILATTVYFYLLVThlaVN 313
Cdd:COG0738 225 AEGAIGDWLPLYLKDVlGLSEATAALGLSLFWGGM-TIGRFLGGFLLKRFG---PVRLLRLSALLAAVGLLLALL---AP 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 314 TATLHLGITLLWG---SYGMATIVVYTTSMYcvrEGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIA 390
Cdd:COG0738 298 GPWLALIGLALVGlglSLMFPTIFSLALDGL---GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCY 374
|
330
....*....|....*..
gi 1821117515 391 VTSLLYILATFKKEKKD 407
Cdd:COG0738 375 LLILLLALALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
78-398 |
9.87e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.90 E-value: 9.87e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 78 YKRWIFSSELIYAVIILAISFLdleTNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDK----SLVNSMQSVGSFAG 153
Cdd:cd17325 60 RKRLLLLGLLLLAVSTLLFAFA---TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERgramGIFSSAIGLGFLIG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 154 AMIGGgvllLLYHKLGWNQLLPYLAIFVVVALIPLMLFKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYY 233
Cdd:cd17325 137 PLLGG----LLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLA 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 234 AGLIGTLAMLKPMLVD-YGYSMKQIGVMSGVIGtSIGCVGSLTGGFIVRKIGCYIPrIVFAVFILATTVYFYLLVTHLav 312
Cdd:cd17325 213 FAFGALEPFLPLYAAElGGLSPAQIGLLFGAQG-LASALSQPPAGKLSDRIGRKPL-ILIGLLLSAVALLLLPLATSF-- 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 313 ntATLHLGITLLWGSYGMATIVVYTTSMYCVREGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIAVT 392
Cdd:cd17325 289 --WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
....*.
gi 1821117515 393 SLLYIL 398
Cdd:cd17325 367 AAVLFL 372
|
|
| MFS_FBT |
cd17484 |
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The ... |
45-401 |
5.58e-09 |
|
Folate-biopterin transporter of the Major Facilitator Superfamily of transporters; The Folate-biopterin transporter (FBT) family includes folate carriers related to those of trypanosomatids in higher plant plastids and cyanobacteria. FBT mediates folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The FBT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341037 [Multi-domain] Cd Length: 399 Bit Score: 57.62 E-value: 5.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 45 LETIGMLQFLKLPWVLKFLWSPAIDrschTLN--DYKRW--IFSSELIYAVIILAISFLDLeTNIYTIIILIVFAFTASA 120
Cdd:cd17484 33 ASVQALTSIASLPWAIKPLYGLLSD----SVPifGYRRKpyLILAGALGALSWLALALVSN-SSLALALLLLLLASLGVA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 121 TQDIATDALAVLSFSKKDKSLVNSMQSVGSFA---GAMIG---GGVLLLLYHKLGwnqllpylaIFVVVALIPLML---- 190
Cdd:cd17484 108 FSDVVIDALVVEASRGAPQSLAGDLQSLCWGSsaiGGIVGsyfSGYLLELLGPRT---------VFAVTSFFPLLLliva 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 191 -FKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVDYGYSMKQIGVMSgVIGTSIG 269
Cdd:cd17484 179 fFVKEERVPPHRTKENFDEQLKALWETVKQPSIWLPALFIFLYQATPSSGSAMFYFMTNELGFSPEFLGRLR-VIGSIAS 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 270 CVGSLTGGFIVRKIGcyIPRIVFAVFILATTVYF--YLLVTHLAVNtatlhLGIT----LLWGSyGMATIVVYTTSM--- 340
Cdd:cd17484 258 LLGVLLYNRFLKHVP--FRKIFFWTTVLLVLLGLtdLILVTRWNLK-----LGIPdhafVLGDD-AVVTVIGEILFMpil 329
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 341 -YCVR---EGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYG-----YANLFLFESCIAVTSLLYILATF 401
Cdd:cd17484 330 vLAARlcpPGIEGTVFALLMSISNLGSLTSSFLGALLTKALGvtstnFDNLWLLILICNLSRLLPLLFLF 399
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
87-337 |
1.31e-08 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 56.42 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 87 LIYAVIILAISFL--DLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKdKSLVNSMQSVGSFAGAMIGGGVLLLL 164
Cdd:COG2807 86 LLLALLLLAAGLLlrSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPL 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 165 YHKLGWNQLLPYLAIFVVVALIPLMLFKKKQVEEPQerkkyAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLK 244
Cdd:COG2807 165 AAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA-----AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLP 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 245 PMLVDYGYSMKQIGVMSGVIgTSIGCVGSLTGGFIVRKIGCyiPRIVFAVFILATTVYFYLLvthLAVNTATLHLGITLL 324
Cdd:COG2807 240 PILRDAGLSAATAGLLLSLF-QLAGIPGSLLVPLLADRLGD--RRPLLLLLGLLGLAGLLGL---LLAPGSLPWLWAVLL 313
|
250
....*....|...
gi 1821117515 325 WGSYGMATIVVYT 337
Cdd:COG2807 314 GLGQGGLFPLALT 326
|
|
| Acatn |
pfam13000 |
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to ... |
19-149 |
4.06e-08 |
|
Acetyl-coenzyme A transporter 1; The mouse Acatn is a 61 kDa hydrophobic protein with six to 10 transmembrane domains. It appears to promote 9-O-acetylation in gangliosides.
Pssm-ID: 372424 [Multi-domain] Cd Length: 543 Bit Score: 55.06 E-value: 4.06e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 19 LYIAQTIPMSF-FSTIlPVLMR--QQDYSLETIGMLQFLKLPWVLKFLWSPAIDrSCHTLNDYKR--WIFSSELIYAVII 93
Cdd:pfam13000 7 LYFLQGIPVGLaFGTI-PFLLKsmAKETSFTSLGIFSMATYPYSLKILWSPIVD-SIYSKKIGRRrsWIIPVQLVSGIML 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821117515 94 LAISFL---------------------DLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVG 149
Cdd:pfam13000 85 IILGYCiskglifpgvddafhgrlskgVLNVNITTLTWYFGILVFLCATQDIAVDGWALTILSKQSLSYASTAQTVG 161
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
16-398 |
5.93e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 54.16 E-value: 5.93e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 16 FLSLYIAQTIPM---SFFSTILPVLMRQQDYSLETIGMLQFLK-LPWVLKFLWSPAI-DRSchtlnDYKRWIFSSELIYA 90
Cdd:cd06173 1 FRLLWLAQLLSAlgdWIFTVALPWLVLQLTGSALLVGLVLAAFfLPFLLFSPFAGVLaDRF-----DRRRLLILADLLRA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 91 VIILAISFLdLETNIYTIIILIVFAF---TASATQDIATDALAVLSFSKKDK----SLVNSMQSVGSFAGAMIGGgvllL 163
Cdd:cd06173 76 LLAAVLALL-ALLGSLSLWLLLVLAFllgIASAFFGPARQALLPELVPKEQLvranALNSLATQLARIIGPALGG----L 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 164 LYHKLGWNQLLPYLAIFVVVALIPLMLFKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAML 243
Cdd:cd06173 151 LVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 244 KPMLVD--YGYSMKQIGVMSGVIGtsigcVGSLTGGFIVRKIGCYIPRIVFaVFILATTVYFYLLVTHLAVNTATLHLGI 321
Cdd:cd06173 231 LPLLAKevLGGGAAGYGLLLAAFG-----VGALLGALLLGRLSKRRRRGRL-LLIGALLLGLALLVLGLSPSLWLLLAAL 304
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821117515 322 TLLWGSYGMATIVVYTTSMYCVREGYEGTDFTLQTVITHLSGMLMAAGAGKIAGMYGYANLFLFESCIAVTSLLYIL 398
Cdd:cd06173 305 FLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
27-398 |
6.58e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 6.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 27 MSFFSTILPVLMRQQDYSLETIGMLQFLKLpwVLKFLWSPAIDRschtLNDYKRWIFSSELIYAVIILAISFLDLETNIY 106
Cdd:cd17478 12 QGFLPALLPLLIAKLGLSYAQAGLLVSVFS--ITSSLLQPLFGY----LADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 107 TIIILIVFAFTASAT-QDIATDALAVLSFSKKDK--SLVNSMQSVGSFAGAMIGGGVLLLLYhklgwnqLLPYLAIFVVV 183
Cdd:cd17478 86 LLLLLVALAGIGSAAfHPEGARLASQAAGGRRGLamSIFSVGGNLGFALGPLIAAALVALFG-------GLGLLILLIIP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 184 ALIPLMLFKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPMLVDYGYSMKQIGVMSGV 263
Cdd:cd17478 159 GLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 264 IgTSIGCVGSLTGGFIVRKIGcyiPRIVFAVFILATTVYFYL-LVTHLAVNTATLHLGITLLWGSygMATIVVYTTSMYC 342
Cdd:cd17478 239 F-LFAGAIGTLIGGPLSDRFG---RRRVIIASLLLAAPFLLLfLLTPGIWSYILLVLAGFLLFAS--FPVTVVLAQELLP 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1821117515 343 VREG-----YEGTDFTLqtvithlsGMLMAAGAGKIAGMYGYANLFLFESCIAVTSLLYIL 398
Cdd:cd17478 313 GNVGlasglMMGLSFGL--------GGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
90-321 |
5.80e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.00 E-value: 5.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 90 AVIILAISFLDLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQ---SVGSFAGAMIGGgvlLLLYH 166
Cdd:cd17333 69 LLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESSATRLNVLHgffGLGALIGPLIAT---SLLTS 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 167 KLGWNQLLPYLAIFVVVALIPLMLFKKKQVEEPQERKKYAPPHPDDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLKPM 246
Cdd:cd17333 146 ELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSY 225
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1821117515 247 LVDYGYSMKQIGVMSGVIGTSIGCVGSLTGGFIVRKIGC--YIPRIVFAVFILATTVYFYLLVTHLAVNTATLHLGI 321
Cdd:cd17333 226 LVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPhtLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM 302
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
87-379 |
1.09e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.18 E-value: 1.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 87 LIYAVIILAISFLDLETNIYTIIILIVFAFTASATQDIATdALAVLSFSKKdKSLVNSMQSVGSFAGAMIGGGVLLLLYH 166
Cdd:cd17355 76 LLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFA-TVAAWWFERR-RGLALGILTAGGGLGSLVFLPLGAALIE 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 167 KLGWNQLLPYLAIFVVVALIPLMLFKKKQVEEPQERKKYAPPHPDD---LLGFFKQKGIWKQILFLFLYYAGLIGTLAML 243
Cdd:cd17355 154 AFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPgstLKEALRSASFWLLALAFFLCGFAVVGLIVHL 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 244 KPMLVDYGYSMKQIGVMSGVIGTSiGCVGSLTGGFIVRKIGcyIPRIVFAVFILATTVYFYLLVTHLAVNTATLH-LGIT 322
Cdd:cd17355 234 VPYLADRGISPAAAAVALALIGLF-NIVGRLLSGWLGDRYS--PRRLLAASYALRALGLALLLLLPFPPLALLLFaALFG 310
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1821117515 323 LLWGSYgMATIVVYTTSMYCVREGyeGTDFTLQTVITHLSGMLMAAGAGKIAGMYGY 379
Cdd:cd17355 311 LGWGAT-VPLTAALAARYFGARSY--GTLFGLVFAPHQLGSALGPWLGGLLYDRTGS 364
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
105-379 |
5.21e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 41.82 E-value: 5.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 105 IYTIIILIVFAFTASATqDIATDAL-AVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHKLGW-NQLLPYL---AI 179
Cdd:cd17332 100 IYALITYILLDLLYTLV-NIPYTALiPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGgNASRGYFltaLI 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 180 FVVVALIPLMLFKKKQVEEPQERKKYAPPHP--DDLLGFFKQKGIWKQILFLFLYYAGLIGTLAMLkPMLVDYGYSMKQI 257
Cdd:cd17332 179 IGIIGIILLLICFFGTRERVVPPEEEKSKLPllKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVL-VYYFKYVLGGRAE 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 258 GVMSGVIGTSIGCVGSLTGGFIVRKIGcyiPRIVFAVFILATTVYFYLLVTHLAVNTATLHLGITLlwGSYGMATIVVYT 337
Cdd:cd17332 258 LVLLLLLILSGALLALLPWPPLKKRFG---KKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVL--AGIGYGGANLLP 332
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1821117515 338 TSMY--CVREGY-------EGTDFTLQTVITHLSGMLMAAGAGKIAGMYGY 379
Cdd:cd17332 333 WAMLadVIDYGElktgkrrEGIFYSVMTFFRKLGLALAGALVGLILSLAGY 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
20-197 |
5.42e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.78 E-value: 5.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 20 YIAQTIPMSFFSTILPV-LMRQQDYSLETIGMLQFLklPWVLKFLWSPAIDRSCHTLNDYKRWIFSseLIYAVIILAISF 98
Cdd:COG2271 189 YFLVYFALYGFLTWLPTyLVEVRGLSLAQAGLLLSL--PFLAGIVGSLLGGWLSDRLGRRRKLVLA--IGLLLAALALLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821117515 99 LDLETNIYTIIILIVFAFTASATQDIATDALAVLSFSKKDKSLVNSMQSVGSFAGAMIGGGVLLLLYHKLGWNQLLPYLA 178
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLA 344
|
170
....*....|....*....
gi 1821117515 179 IFVVVALIPLMLFKKKQVE 197
Cdd:COG2271 345 ALALLAALLALLLLRETRK 363
|
|
| |
