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Conserved domains on  [gi|1678495840|gb|QCX38472|]
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TetR/AcrR family transcriptional regulator [Aureibaculum algae]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TetR_C_37 pfam18665
Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor ...
 82-197 2.07e-36

Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.


:

Pssm-ID: 408446  Cd Length: 117  Bit Score: 123.15  E-value: 2.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678495840  82 CKSDLESLINNLFSRKWNQYFDDGVFYSCYALIYRNKAFNDSFKHYLLQLHSVLNSKLIEAYDNKVIYNNDIKNLSEIIF 161
Cdd:pfam18665   2 SIDDLYQFIERLFSRKWNLLFDDGVFYSCYALVFREKAIKSKYKKILDSLRETLSDILKECNDEGLIKLKNPDDTANLIF 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1678495840 162 ALIDGSYYYMGMFDlNNEAHQKQLTIYIKHCLSLFK 197
Cdd:pfam18665  82 VLLDGAYYYLSLEE-DKEAYEERLNQYKDQAYSLLG 116
TetR_C_11 super family cl23808
Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional ...
 5-67 5.98e-07

Tetracyclin repressor-like, C-terminal domain; This family of bacterial transcriptional repressors is characterized by the short approximately 50 amino acid stretch of residues constituting the helix-turn-helix DNA binding motif, around the YRFhY motif. The target proteins that are repressed are involved in the transcriptional control of multi-drug efflux pumps, pathways for the biosynthesis of antibiotics, response to osmotic stress and toxic chemicals, control of catabolic pathways, differentiation processes, and pathogenicity.


The actual alignment was detected with superfamily member PRK00767:

Pssm-ID: 474063 [Multi-domain]  Cd Length: 197  Bit Score: 47.91  E-value: 5.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678495840   5 KLG--ETRKLEIIKSFYLVAKKNGLENASIAKVADAMGISNGLVMHYFNTKDELLIGLNEYILNQ 67
Cdd:PRK00767    3 KVGmePIRRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQ 67
 
Name Accession Description Interval E-value
TetR_C_37 pfam18665
Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor ...
 82-197 2.07e-36

Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.


Pssm-ID: 408446  Cd Length: 117  Bit Score: 123.15  E-value: 2.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678495840  82 CKSDLESLINNLFSRKWNQYFDDGVFYSCYALIYRNKAFNDSFKHYLLQLHSVLNSKLIEAYDNKVIYNNDIKNLSEIIF 161
Cdd:pfam18665   2 SIDDLYQFIERLFSRKWNLLFDDGVFYSCYALVFREKAIKSKYKKILDSLRETLSDILKECNDEGLIKLKNPDDTANLIF 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1678495840 162 ALIDGSYYYMGMFDlNNEAHQKQLTIYIKHCLSLFK 197
Cdd:pfam18665  82 VLLDGAYYYLSLEE-DKEAYEERLNQYKDQAYSLLG 116
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
3-166 6.72e-11

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.99  E-value: 6.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678495840   3 RKKLGETRKlEIIKSFYLVAKKNGLENASIAKVADAMGISNGLVMHYFNTKDELLIGLNEYILNQHLHVMTssnsKIIKC 82
Cdd:COG1309     1 RRRREATRE-RILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE----EALAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678495840  83 KSDLESLInNLFSRKWNQYFDDGVFYS-CYALIYRNKAFNDSFKHYLLQLHSVLNSKLIEAYDNKVIynnDIKNLSEIIF 161
Cdd:COG1309    76 EDPRERLR-ALLRAYLEFLAENPALARlLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADV---DPDALARALL 151


                  ....*
gi 1678495840 162 ALIDG 166
Cdd:COG1309   152 ALLDG 156
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 5-67 5.98e-07

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 47.91  E-value: 5.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678495840   5 KLG--ETRKLEIIKSFYLVAKKNGLENASIAKVADAMGISNGLVMHYFNTKDELLIGLNEYILNQ 67
Cdd:PRK00767    3 KVGmePIRRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQ 67
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
7-72 2.63e-04

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 40.31  E-value: 2.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1678495840   7 GETRKLEIIKSFYLVAKKNGLENASIAKVADAMGISNGLVMHYFNTKDELLIGLNEYILNQHLHVM 72
Cdd:COG3226     6 GEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARL 71
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
24-57 1.26e-03

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 35.46  E-value: 1.26e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1678495840  24 KNGLENASIAKVADAMGISNGLVMHYFNTKDELL 57
Cdd:pfam00440  11 ERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
 
Name Accession Description Interval E-value
TetR_C_37 pfam18665
Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor ...
 82-197 2.07e-36

Tetracyclin repressor-like, C-terminal domain; IcaR belongs to the tetracycline repressor (TetR) family of proteins, which are involved in a wide variety of gene regulations. It binds to a 42 bp region immediately upstream of the icaA gene. This entry represents the C-terminal domain which is involved in dimerization.


Pssm-ID: 408446  Cd Length: 117  Bit Score: 123.15  E-value: 2.07e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678495840  82 CKSDLESLINNLFSRKWNQYFDDGVFYSCYALIYRNKAFNDSFKHYLLQLHSVLNSKLIEAYDNKVIYNNDIKNLSEIIF 161
Cdd:pfam18665   2 SIDDLYQFIERLFSRKWNLLFDDGVFYSCYALVFREKAIKSKYKKILDSLRETLSDILKECNDEGLIKLKNPDDTANLIF 81

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1678495840 162 ALIDGSYYYMGMFDlNNEAHQKQLTIYIKHCLSLFK 197
Cdd:pfam18665  82 VLLDGAYYYLSLEE-DKEAYEERLNQYKDQAYSLLG 116
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
3-166 6.72e-11

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 57.99  E-value: 6.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678495840   3 RKKLGETRKlEIIKSFYLVAKKNGLENASIAKVADAMGISNGLVMHYFNTKDELLIGLNEYILNQHLHVMTssnsKIIKC 82
Cdd:COG1309     1 RRRREATRE-RILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKEELLLAVLERLLEELLAALE----EALAA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1678495840  83 KSDLESLInNLFSRKWNQYFDDGVFYS-CYALIYRNKAFNDSFKHYLLQLHSVLNSKLIEAYDNKVIynnDIKNLSEIIF 161
Cdd:COG1309    76 EDPRERLR-ALLRAYLEFLAENPALARlLLAEAAELPELRAALRALLRRLRALLAELLRAGGLLADV---DPDALARALL 151


                  ....*
gi 1678495840 162 ALIDG 166
Cdd:COG1309   152 ALLDG 156
PRK00767 PRK00767
transcriptional regulator BetI; Validated
 5-67 5.98e-07

transcriptional regulator BetI; Validated


Pssm-ID: 179115 [Multi-domain]  Cd Length: 197  Bit Score: 47.91  E-value: 5.98e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1678495840   5 KLG--ETRKLEIIKSFYLVAKKNGLENASIAKVADAMGISNGLVMHYFNTKDELLIGLNEYILNQ 67
Cdd:PRK00767    3 KVGmePIRRQQLIDATLRAIGEVGLLDATIAQIARRAGVSTGIISHYFGGKDGLLEATMRHLLRQ 67
YbjK COG3226
DNA-binding transcriptional regulator YbjK [Transcription];
7-72 2.63e-04

DNA-binding transcriptional regulator YbjK [Transcription];


Pssm-ID: 442459 [Multi-domain]  Cd Length: 191  Bit Score: 40.31  E-value: 2.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1678495840   7 GETRKLEIIKSFYLVAKKNGLENASIAKVADAMGISNGLVMHYFNTKDELLIGLNEYILNQHLHVM 72
Cdd:COG3226     6 GEERRERILEAALRVIARDGVRGVTHRAVAAEAGVPLGSTTYYFRTRDELLAAAFERLAEREAARL 71
TetR_N pfam00440
Bacterial regulatory proteins, tetR family;
24-57 1.26e-03

Bacterial regulatory proteins, tetR family;


Pssm-ID: 425684 [Multi-domain]  Cd Length: 47  Bit Score: 35.46  E-value: 1.26e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1678495840  24 KNGLENASIAKVADAMGISNGLVMHYFNTKDELL 57
Cdd:pfam00440  11 ERGYDATTVREIAKRAGVSKGALYRYFGSKEELL 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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