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Conserved domains on  [gi|1453176201|gb|AXO84348|]
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glycosyltransferase family 2 protein [Escherichia coli]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10118426)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  9445404|12691742

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 8-263 2.09e-66

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


:

Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 207.53  E-value: 2.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   8 LTVIILTFNEQLHIERCLKSLEGVNCNCIIIDSESTDDTVKIAKENNAIVYINKWpGNHAAQFQWALKNCKIEtpWLMKL 87
Cdd:cd02511     2 LSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWW-DGFGAQRNFALELATND--WVLSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  88 DADEYLTPELKKEINESLSELSPeiTGIYLKRRMYFMSKWIKRGGYYPTWLLRIWRINAGEMEERIMDEHIILKYGNTVN 167
Cdd:cd02511    79 DADERLTPELADEILALLATDDY--DGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201 168 FRGDIVDENLKGLAEWSSKHIRYAINEAIEtlnsmqkenknksvraslfgTQEQRKRFLKeiyIKFPLFLRPLTYFCWRY 247
Cdd:cd02511   157 LKGDILHYGYKSLEEFLEKHNRYSSLEAKD--------------------LAAKGKKRSL---LKGLLLGRPLLAFLKMY 213

                         250
                  ....*....|....*.
gi 1453176201 248 IIKLGFLDGKPGLIWH 263
Cdd:cd02511   214 ILKRGFLDGRAGFILA 229
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 8-263 2.09e-66

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 207.53  E-value: 2.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   8 LTVIILTFNEQLHIERCLKSLEGVNCNCIIIDSESTDDTVKIAKENNAIVYINKWpGNHAAQFQWALKNCKIEtpWLMKL 87
Cdd:cd02511     2 LSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWW-DGFGAQRNFALELATND--WVLSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  88 DADEYLTPELKKEINESLSELSPeiTGIYLKRRMYFMSKWIKRGGYYPTWLLRIWRINAGEMEERIMDEHIILKYGNTVN 167
Cdd:cd02511    79 DADERLTPELADEILALLATDDY--DGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201 168 FRGDIVDENLKGLAEWSSKHIRYAINEAIEtlnsmqkenknksvraslfgTQEQRKRFLKeiyIKFPLFLRPLTYFCWRY 247
Cdd:cd02511   157 LKGDILHYGYKSLEEFLEKHNRYSSLEAKD--------------------LAAKGKKRSL---LKGLLLGRPLLAFLKMY 213

                         250
                  ....*....|....*.
gi 1453176201 248 IIKLGFLDGKPGLIWH 263
Cdd:cd02511   214 ILKRGFLDGRAGFILA 229
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-147 8.04e-16

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 74.74  E-value: 8.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   5 NKLLTVIILTFNEQLHIERCLKSL---EGVNCNCIIIDSESTDDTVKIAKE-----NNAIVYINKWPGNHAAQFQWALKN 76
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLlaqTYPDFEIIVVDDGSTDGTAEILRElaakdPRIRVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1453176201  77 CKieTPWLMKLDADEYLTPELKKEINESLSELSPEI--TGIYLKRRMYFMSKWIKRGGYYPTWLLRIWRINAG 147
Cdd:COG0463    81 AR--GDYIAFLDADDQLDPEKLEELVAALEEGPADLvyGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSG 151
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 9-157 1.92e-12

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 64.34  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   9 TVIILTFNEQLHIERCLKSL---EGVNCNCIIIDSESTDDTVKIAKE-----NNAIVYINKWPGNHAAQFQWALKNCKie 80
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLlnqTYPNFEIIVVDDGSTDGTVEIAEEyakkdPRVRVIRLPENRGKAGARNAGLRAAT-- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1453176201  81 TPWLMKLDADEYLTPELKKEINESLSElsPEITGIYLKRRMYFMSKWIKRGGYYPTWLLRIWRINAGEMEERIMDEH 157
Cdd:pfam00535  79 GDYIAFLDADDEVPPDWLEKLVEALEE--DGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153
 
Name Accession Description Interval E-value
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 8-263 2.09e-66

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 207.53  E-value: 2.09e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   8 LTVIILTFNEQLHIERCLKSLEGVNCNCIIIDSESTDDTVKIAKENNAIVYINKWpGNHAAQFQWALKNCKIEtpWLMKL 87
Cdd:cd02511     2 LSVVIITKNEERNIERCLESVKWAVDEIIVVDSGSTDRTVEIAKEYGAKVYQRWW-DGFGAQRNFALELATND--WVLSL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  88 DADEYLTPELKKEINESLSELSPeiTGIYLKRRMYFMSKWIKRGGYYPTWLLRIWRINAGEMEERIMDEHIILKYGNTVN 167
Cdd:cd02511    79 DADERLTPELADEILALLATDDY--DGYYVPRRNFFLGRWIRHGGWYPDRQLRLFRRGKARFEDGRVHEQVVVDGGVGIV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201 168 FRGDIVDENLKGLAEWSSKHIRYAINEAIEtlnsmqkenknksvraslfgTQEQRKRFLKeiyIKFPLFLRPLTYFCWRY 247
Cdd:cd02511   157 LKGDILHYGYKSLEEFLEKHNRYSSLEAKD--------------------LAAKGKKRSL---LKGLLLGRPLLAFLKMY 213

                         250
                  ....*....|....*.
gi 1453176201 248 IIKLGFLDGKPGLIWH 263
Cdd:cd02511   214 ILKRGFLDGRAGFILA 229
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 5-147 8.04e-16

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 74.74  E-value: 8.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   5 NKLLTVIILTFNEQLHIERCLKSL---EGVNCNCIIIDSESTDDTVKIAKE-----NNAIVYINKWPGNHAAQFQWALKN 76
Cdd:COG0463     1 MPLVSVVIPTYNEEEYLEEALESLlaqTYPDFEIIVVDDGSTDGTAEILRElaakdPRIRVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1453176201  77 CKieTPWLMKLDADEYLTPELKKEINESLSELSPEI--TGIYLKRRMYFMSKWIKRGGYYPTWLLRIWRINAG 147
Cdd:COG0463    81 AR--GDYIAFLDADDQLDPEKLEELVAALEEGPADLvyGSRLIREGESDLRRLGSRLFNLVRLLTNLPDSTSG 151
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 9-157 1.92e-12

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 64.34  E-value: 1.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   9 TVIILTFNEQLHIERCLKSL---EGVNCNCIIIDSESTDDTVKIAKE-----NNAIVYINKWPGNHAAQFQWALKNCKie 80
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLlnqTYPNFEIIVVDDGSTDGTVEIAEEyakkdPRVRVIRLPENRGKAGARNAGLRAAT-- 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1453176201  81 TPWLMKLDADEYLTPELKKEINESLSElsPEITGIYLKRRMYFMSKWIKRGGYYPTWLLRIWRINAGEMEERIMDEH 157
Cdd:pfam00535  79 GDYIAFLDADDEVPPDWLEKLVEALEE--DGADVVVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLI 153
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 10-138 3.03e-11

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 60.60  E-value: 3.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  10 VIILTFNEQLHIERCLKSLEGV---NCNCIIIDSESTDDTVKIAKE-----NNAIVYINKWPGNHAAQFQWALKNCKIEt 81
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQtypNFEVIVVDDGSTDGTLEILEEyakkdPRVIRVINEENQGLAAARNAGLKAARGE- 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1453176201  82 pWLMKLDADEYLTPELKKEINESLsELSPEITGIY-LKRRMYFMSKWIKRGGYYPTWL 138
Cdd:cd00761    80 -YILFLDADDLLLPDWLERLVAEL-LADPEADAVGgPGNLLFRRELLEEIGGFDEALL 135
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 8-95 6.25e-09

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 55.90  E-value: 6.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   8 LTVIILTFNEQLHIERCLKSL-----EGVNCNCIIIDSESTDDTVKIAKE-----NNAIVYINKWPGNHAAQFQWALKNC 77
Cdd:COG1215    31 VSVIIPAYNEEAVIEETLRSLlaqdyPKEKLEVIVVDDGSTDETAEIARElaaeyPRVRVIERPENGGKAAALNAGLKAA 110

                          90
                  ....*....|....*...
gi 1453176201  78 KIEtpWLMKLDADEYLTP 95
Cdd:COG1215   111 RGD--IVVFLDADTVLDP 126
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
8-96 1.18e-07

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 51.15  E-value: 1.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   8 LTVIILTFNEQLHIERCLKSLE---GVNCNCIIIDSESTDDTVKIAKENNA--IVYI-NKWPGNHAAQFQWALKNCKieT 81
Cdd:COG1216     5 VSVVIPTYNRPELLRRCLESLLaqtYPPFEVIVVDNGSTDGTAELLAALAFprVRVIrNPENLGFAAARNLGLRAAG--G 82

                          90
                  ....*....|....*
gi 1453176201  82 PWLMKLDADEYLTPE 96
Cdd:COG1216    83 DYLLFLDDDTVVEPD 97
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 8-107 1.47e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 51.03  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   8 LTVIILTFNEQLHIERCLKSLEGVNCNC---IIIDSESTDDTVKIAKENNAIVyINKWPG-----NHAAQfqwalkncKI 79
Cdd:cd02522     1 LSIIIPTLNEAENLPRLLASLRRLNPLPleiIVVDGGSTDGTVAIARSAGVVV-ISSPKGrarqmNAGAA--------AA 71

                          90       100
                  ....*....|....*....|....*...
gi 1453176201  80 ETPWLMKLDADEYLTPELKKEINESLSE 107
Cdd:cd02522    72 RGDWLLFLHADTRLPPDWDAAIIETLRA 99
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 9-90 5.53e-07

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 49.92  E-value: 5.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   9 TVIILTFNEQLHIERCLKSL-----EGVNCNCIIIDSESTDDTVKIAKE----NNAIVYINKWPGNHAAQFQWALKNCKI 79
Cdd:cd02525     3 SIIIPVRNEEKYIEELLESLlnqsyPKDLIEIIVVDGGSTDGTREIVQEyaakDPRIRLIDNPKRIQSAGLNIGIRNSRG 82

                          90
                  ....*....|.
gi 1453176201  80 EtpWLMKLDAD 90
Cdd:cd02525    83 D--IIIRVDAH 91
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 9-62 3.20e-06

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 46.77  E-value: 3.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1453176201   9 TVIILTFNEQLHIERCLKSL---EGVNCNCIIIDSESTDDTVKIAKENNAivYINKW 62
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVlsqTYPNIEYIVIDGGSTDGTVDIIKKYED--KITYW 55
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 10-95 2.14e-05

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 44.14  E-value: 2.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  10 VIILTFNEQLHIERCLKSLegvnCNC-------IIIDSESTDDTVKIAKE-----NNAIVYINKWP-GNHAAQFQWALKN 76
Cdd:cd06423     1 IIVPAYNEEAVIERTIESL----LALdypklevIVVDDGSTDDTLEILEElaalyIRRVLVVRDKEnGGKAGALNAGLRH 76

                          90
                  ....*....|....*....
gi 1453176201  77 CKieTPWLMKLDADEYLTP 95
Cdd:cd06423    77 AK--GDIVVVLDADTILEP 93
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 10-144 2.46e-05

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 44.10  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  10 VIILTFNEQLHIERCLKSL-----EGVNCNCIIIDSESTDDTVKIAKENNAIVYINKW---PGN--HAAQFQWALKNCKi 79
Cdd:cd04179     1 VVIPAYNEEENIPELVERLlavleEGYDYEIIVVDDGSTDGTAEIARELAARVPRVRVirlSRNfgKGAAVRAGFKAAR- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1453176201  80 eTPWLMKLDAD-----EYLtPELKKEINESLSELspeITGIYLKRR----MYFMSKWIKRGGYYPTWLLRIWRI 144
Cdd:cd04179    80 -GDIVVTMDADlqhppEDI-PKLLEKLLEGGADV---VIGSRFVRGggagMPLLRRLGSRLFNFLIRLLLGVRI 148
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-90 1.11e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 39.58  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  10 VIILTFNEQLHIERCLKSLEGVNCN-----CIIIDSESTDDTVKI----AKENNAIVYI--NKWPGN--HAAQFQWALKN 76
Cdd:cd04192     1 VVIAARNEAENLPRLLQSLSALDYPkekfeVILVDDHSTDGTVQIlefaAAKPNFQLKIlnNSRVSIsgKKNALTTAIKA 80

                          90
                  ....*....|....
gi 1453176201  77 CKIEtpWLMKLDAD 90
Cdd:cd04192    81 AKGD--WIVTTDAD 92
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 10-90 1.14e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 39.08  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201  10 VIILTFNEQLHIERCLKSLE---GVNCNCIIIDSESTDDTVKIAKENNAIVYINKWPGN--HAAQFQWALKNCKieTPWL 84
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLaqtYPDFEVIVVDNASTDGSVELLRELFPEVRLIRNGENlgFGAGNNQGIREAK--GDYV 78


                  ....*.
gi 1453176201  85 MKLDAD 90
Cdd:cd04186    79 LLLNPD 84
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 9-80 9.03e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 36.84  E-value: 9.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1453176201   9 TVIILTFNEQLHIERCLKSL---EGVNCNCIIIDSESTDDTVKI----AKENNAIVYINKWPGNH--AAQFQWALKNCKI 79
Cdd:cd04196     1 AVLMATYNGEKYLREQLDSIlaqTYKNDELIISDDGSTDGTVEIikeyIDKDPFIIILIRNGKNLgvARNFESLLQAADG 80


                  .
gi 1453176201  80 E 80
Cdd:cd04196    81 D 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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