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Conserved domains on  [gi|1370451951|ref|XP_024309028|]
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zinc finger protein 648 isoform X1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 12142424)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  22803940|11361095|11179890|12665246|10940247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-494 1.31e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 307 YQCSFCDKAYTWSSDHRKHIRTHTG-EKPYPCPDCGKAFVRSSDLRKHQRNMH---SNNKPFPCSE--CGLTFNKPLSLL 380
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALK 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 381 RHQRTHLGAKPFRCPA--CDREFAVASRMVEHQRVH-----SGERPFPC--PTCGKCFTKSSNLSEHQTLHTGQRP--FK 449
Cdd:COG5048   341 RHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370451951 450 CADCGVAFAQPSRLVRHQRIHTGERPFpCTQCGQAFARSSTLKRH 494
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-317 1.18e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....
gi 1370451951 294 LQQHRRLHTGERPYQCSFCDKAYT 317
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-543 3.15e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370451951 518 ELAQHIRMHNGERPYQCEDCGQAFTR 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-494 1.31e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 307 YQCSFCDKAYTWSSDHRKHIRTHTG-EKPYPCPDCGKAFVRSSDLRKHQRNMH---SNNKPFPCSE--CGLTFNKPLSLL 380
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALK 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 381 RHQRTHLGAKPFRCPA--CDREFAVASRMVEHQRVH-----SGERPFPC--PTCGKCFTKSSNLSEHQTLHTGQRP--FK 449
Cdd:COG5048   341 RHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370451951 450 CADCGVAFAQPSRLVRHQRIHTGERPFpCTQCGQAFARSSTLKRH 494
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-346 4.57e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 4.57e-06
                          10        20
                  ....*....|....*....|....
gi 1370451951 323 RKHIRTHTGEKPYPCPDCGKAFVR 346
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-317 1.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....
gi 1370451951 294 LQQHRRLHTGERPYQCSFCDKAYT 317
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-543 3.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370451951 518 ELAQHIRMHNGERPYQCEDCGQAFTR 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
307-494 1.31e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 307 YQCSFCDKAYTWSSDHRKHIRTHTG-EKPYPCPDCGKAFVRSSDLRKHQRNMH---SNNKPFPCSE--CGLTFNKPLSLL 380
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSVNhsgESLKPFSCPYslCGKLFSRNDALK 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 381 RHQRTHLGAKPFRCPA--CDREFAVASRMVEHQRVH-----SGERPFPC--PTCGKCFTKSSNLSEHQTLHTGQRP--FK 449
Cdd:COG5048   341 RHILLHTSISPAKEKLlnSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1370451951 450 CADCGVAFAQPSRLVRHQRIHTGERPFpCTQCGQAFARSSTLKRH 494
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-461 3.62e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 3.62e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 250 YRCLRGGRAFQKPSKPLSPAETRGGAAKRYACELCGKAYSHRGTLQQHRR--LHTGE--RPYQC--SFCDKAYTWSSDHR 323
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALK 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 324 KHIRTHTGEKPYPCP--DCGKAFVRSSDLRKHQRNMHSNNkpfpcsecgltfnkplslLRHQRTHLGAKPFRCPACDREF 401
Cdd:COG5048   341 RHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD------------------LKNDKKSETLSNSCIRNFKRDS 402

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370451951 402 AVAsrmvEHQRVHSGERP--FPCPTCGKCFTKSSNLSEHQTLHTGQRPFKCADCGVAFAQPS 461
Cdd:COG5048   403 NLS----LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
310-554 8.72e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 8.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 310 SFCDKAYTWSSDHRkHIRTHTGEKPYPCPDCGKAFVRSSDLRKHQRNMHSNNkPFPCSECGLTFNKPLSLLRHQRTHLGA 389
Cdd:COG5048   175 SLSKDPSSNLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 390 KPFRCPACDREFAVASRMVEHQRVHSGER-------PFPCPTCGKCFTKSSNLSEHQ--TLHTGQ--RPFKC--ADCGVA 456
Cdd:COG5048   253 SSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKL 332

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 457 FAQPSRLVRHQRIHTGERPFPC--TQCGQAFARSSTLKRHQQIH-----SGEKGFLCA--ECGRAFRIASELAQHIRMHN 527
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHL 412

                         250       260
                  ....*....|....*....|....*....
gi 1370451951 528 GERPYQCED--CGQAFTRSNHLQRHRAKH 554
Cdd:COG5048   413 SFRPYNCKNppCSKSFNRHYNLIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
323-346 4.57e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.13  E-value: 4.57e-06
                          10        20
                  ....*....|....*....|....
gi 1370451951 323 RKHIRTHTGEKPYPCPDCGKAFVR 346
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
279-550 2.08e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 279 YACELCGKAYSHRGTLQQHRRLHTGERPYQCSFC---DKAYTWSSDHRkHIRTHTGEKPYPCPDCGKAFVRSSDLRKHQR 355
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSgcdKSFSRPLELSR-HLRTHHNNPSDLNSKSLPLSNSKASSSSLSS 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 356 NMHSNNKPFPCSECGLTFNKPLSLLR--HQRTHLGAKPfrCPACDREFavasrmveHQRVHSGERPFPCPTCGKCFTKSS 433
Cdd:COG5048   113 SSSNSNDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNP--LPGNNSSS--------VNTPQSNSLHPPLPANSLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 434 NLSE--HQTLHTGQRPFKCADCGVAFAQPSRLVRHQRIHTGERPFPCTQCGQAFARSSTLKRHQQIHSGEKGFLCAECGR 511
Cdd:COG5048   183 NLSLliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1370451951 512 AFRI--ASELAQHIRMHNGER-----PYQCEDCGQAFTRSNHLQRH 550
Cdd:COG5048   263 SSLPtaSSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRH 308
zf-H2C2_2 pfam13465
Zinc-finger double domain;
462-487 4.84e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.84e-05
                          10        20
                  ....*....|....*....|....*.
gi 1370451951 462 RLVRHQRIHTGERPFPCTQCGQAFAR 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-317 1.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.18e-04
                          10        20
                  ....*....|....*....|....
gi 1370451951 294 LQQHRRLHTGERPYQCSFCDKAYT 317
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
518-543 3.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 1370451951 518 ELAQHIRMHNGERPYQCEDCGQAFTR 543
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 532-554 6.69e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.69e-04
                          10        20
                  ....*....|....*....|...
gi 1370451951 532 YQCEDCGQAFTRSNHLQRHRAKH 554
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 331-401 8.94e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 8.94e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370451951 331 GEKPYPCP--DCGKAFVRSSDLRKHQRNMHSNNKPFPCSecgltfnkplSLLRHQRTHLGAKPFRCPACDREF 401
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENP----------SPEKMNIFSAKDKPYRCEVCDKRY 408
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 335-355 1.01e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|.
gi 1370451951 335 YPCPDCGKAFVRSSDLRKHQR 355
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLR 21
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-402 1.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|....*
gi 1370451951 378 SLLRHQRTHLGAKPFRCPACDREFA 402
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
406-431 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370451951 406 RMVEHQRVHSGERPFPCPTCGKCFTK 431
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 476-498 2.17e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.17e-03
                          10        20
                  ....*....|....*....|...
gi 1370451951 476 FPCTQCGQAFARSSTLKRHQQIH 498
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-459 2.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.31e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370451951 434 NLSEHQTLHTGQRPFKCADCGVAFAQ 459
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 420-442 3.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|...
gi 1370451951 420 FPCPTCGKCFTKSSNLSEHQTLH 442
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 298-358 4.09e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370451951 298 RRLHT-GERPYQCSF--CDKAYTWSSD---HRKH-----IRTHT-----------GEKPYPCPDCGKAFVRSSDLRKHQR 355
Cdd:COG5189   340 RMLKVkDGKPYKCPVegCNKKYKNQNGlkyHMLHghqnqKLHENpspekmnifsaKDKPYRCEVCDKRYKNLNGLKYHRK 419


                  ...
gi 1370451951 356 NMH 358
Cdd:COG5189   420 HSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
445-499 4.82e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 4.82e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1370451951 445 QRPFKCADCGVAFAQPSRLVRHQRIHTGERPFPCTQCGQAFARSST--LKRHQQIHS 499
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHH 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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