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Conserved domains on  [gi|1332745241|gb|AUS14696|]
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secreted cell wall DL-endopeptidase (plasmid) [Bacillus subtilis]

Protein Classification

bifunctional lytic transglycosylase/C40 family peptidase( domain architecture ID 12989902)

bifunctional lytic transglycosylase/C40 family peptidase may catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), and/or cleave peptide cross-bridges between glycan chains

Gene Ontology:  GO:0008233|GO:0016787|GO:0006508
MEROPS:  C40
PubMed:  12620121|11517925|8765311|7479697

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 112-243 1.97e-29

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


:

Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 109.71  E-value: 1.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 112 YGVPWNLLAAHHRVETRFSTIKNmVSPVGAVGHMQFMARTWvgwgypgdrlgdanipnevltnpkmiKKyggYGVDANGD 191
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAG-GSPAGAQGIAQFMPSTW--------------------------KA---YGVDGNGD 50

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1332745241 192 GKADPFDIEDAVFSAANYLAHNGAADG-----NIREAVFAYNHADW-YVEEVMGYAEK 243
Cdd:cd13399    51 GKADPFNPEDAIASAANYLCRHGWDLNaflgeDNFLALAAYNAGPGaYANAVLELAAT 108
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
264-388 2.70e-28

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 110.56  E-value: 2.70e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 264 ADVGRKWIGKsKYIFGGgRNKSdiaaGrFDCSSFVHWAFAQVGVDLGPlastSTETLKHLGKPVSPKKMKPGDVVFFDTY 343
Cdd:COG0791   104 VAAALSYLGT-PYVWGG-TSPS----G-FDCSGLVQYVYRQAGISLPR----TSADQAAAGTPVSRSELQPGDLVFFRTG 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1332745241 344 KTD-GHVGIYIGDGKFIGAQSS-TGVAIADMSKGYWKEKFNGrVKRI 388
Cdd:COG0791   173 GGGiSHVGIYLGNGKFIHASSSgKGVRISSLDSPYWKSRYVG-ARRV 218
 
Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 112-243 1.97e-29

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 109.71  E-value: 1.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 112 YGVPWNLLAAHHRVETRFSTIKNmVSPVGAVGHMQFMARTWvgwgypgdrlgdanipnevltnpkmiKKyggYGVDANGD 191
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAG-GSPAGAQGIAQFMPSTW--------------------------KA---YGVDGNGD 50

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1332745241 192 GKADPFDIEDAVFSAANYLAHNGAADG-----NIREAVFAYNHADW-YVEEVMGYAEK 243
Cdd:cd13399    51 GKADPFNPEDAIASAANYLCRHGWDLNaflgeDNFLALAAYNAGPGaYANAVLELAAT 108
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
264-388 2.70e-28

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 110.56  E-value: 2.70e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 264 ADVGRKWIGKsKYIFGGgRNKSdiaaGrFDCSSFVHWAFAQVGVDLGPlastSTETLKHLGKPVSPKKMKPGDVVFFDTY 343
Cdd:COG0791   104 VAAALSYLGT-PYVWGG-TSPS----G-FDCSGLVQYVYRQAGISLPR----TSADQAAAGTPVSRSELQPGDLVFFRTG 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1332745241 344 KTD-GHVGIYIGDGKFIGAQSS-TGVAIADMSKGYWKEKFNGrVKRI 388
Cdd:COG0791   173 GGGiSHVGIYLGNGKFIHASSSgKGVRISSLDSPYWKSRYVG-ARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 275-383 8.82e-28

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 105.44  E-value: 8.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 275 KYIFGGGRNKSdiaagrFDCSSFVHWAFAQVGVDLGPlastSTETLKHLG-KPVSPKKMKPGDVVFFDTYKTDGHVGIYI 353
Cdd:pfam00877   3 PYRWGGGSPSG------FDCSGLVRYAFAKVGIELPR----SSGQQYNAGkKTIPKSEPQRGDLVFFGTGKGISHVGIYL 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 1332745241 354 GDGKFIGAQSSTGVAIADMSKGYWKEKFNG 383
Cdd:pfam00877  73 GNGQMLHASTGGGVSISSLNGGYWQKRLVG 102
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
280-382 7.24e-22

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 92.14  E-value: 7.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 280 GGRNKSDIaagrfDCSSFVHWAF-AQVGVDLgplaSTSTETLKHLGKPVSPKKMKPGDVVFFDTYKTDGHVGIYIGDGKF 358
Cdd:PRK10838   85 GGSTKKGI-----DCSAFVQRTFrEQFGLEL----PRSTYEQQEMGKSVSRSKLRTGDLVLFRAGSTGRHVGIYIGNNQF 155

                          90       100
                  ....*....|....*....|....
gi 1332745241 359 IGAQSSTGVAIADMSKGYWKEKFN 382
Cdd:PRK10838  156 VHASTSSGVIISSMNEPYWKKRYN 179
wall_hydro_RipC NF038345
peptidoglycan hydrolase RipC; RipC is a peptidoglycan hydrolase, found in species such as ...
 271-375 3.60e-16

peptidoglycan hydrolase RipC; RipC is a peptidoglycan hydrolase, found in species such as Mycobacterium tuberculosis, that is activated by conformation change sent as a signal by the cell division-regulating transporter-like complex FtsEX. Members of this family are distinguished from more distant homologs by a Pro/Gly-rich region.


Pssm-ID: 468486 [Multi-domain]  Cd Length: 361  Bit Score: 79.01  E-value: 3.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 271 IGkSKYIFGGGrnksdiAAGRFDCSSFVHWAFAQVGVDLgplaSTSTETLKHLGKPVSPKKMKPGDVVFFdtYKTDGHVG 350
Cdd:NF038345  261 IG-SPYSWGGS------GPNAFDCSGLVMWAFQQAGISL----PHSSQALARGGQPVSLDDLQPGDVVTF--YSDASHAG 327

                          90       100
                  ....*....|....*....|....*.
gi 1332745241 351 IYIGDGKFIGAQS-STGVAIADMSKG 375
Cdd:NF038345  328 IYIGDGMMVHASTyGTPVRVAPISSA 353
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 98-247 1.63e-15

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 75.42  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241  98 PAKFIPIYKAAAKKYGVPWNLLAAHHRVETRFstIKNMVSPVGAVGHMQFMARTWVGWGYPGDRlgdanipnevltnpkm 177
Cdd:COG0741   100 PLPYLPLIEEAAKKYGVDPALVLALIRQESAF--NPNAVSPAGARGLMQLMPATARRLGLKLGL---------------- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 178 ikkyggygvdanGDGKADPFDIEDAVFSAANYLAH-NGAADGNIREAVFAYN--------------HADW---------- 232
Cdd:COG0741   162 ------------GPSPDDLFDPETNIRAGAAYLRElLDRFDGDLVLALAAYNagpgrvrrwlrrngDRDGeiipyaetrn 229

                         170
                  ....*....|....*
gi 1332745241 233 YVEEVMGYAEKYVKG 247
Cdd:COG0741   230 YVKKVLANYAIYRAG 244
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 106-228 3.23e-11

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 60.01  E-value: 3.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 106 KAAAKKYGVPWNLLAAHHRVETRFStiKNMVSPVGAVGHMQFMARTwvgwgypgdrlgdanipnevltnPKMIKKYGGYG 185
Cdd:pfam01464   2 IKAAQKYGVDPSLLLAIAQQESGFN--PKAVSKSGAVGLMQIMPST-----------------------AKRLGLRVNPG 56

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1332745241 186 VDangdgkaDPFDIEDAVFSAANYLAHN-GAADGNIREAVFAYN 228
Cdd:pfam01464  57 VD-------DLFDPEKNIKAGTKYLKELyKQYGGDLWLALAAYN 93
PRK10760 PRK10760
murein hydrolase B; Provisional
 177-214 1.95e-03

murein hydrolase B; Provisional


Pssm-ID: 236754 [Multi-domain]  Cd Length: 359  Bit Score: 40.11  E-value: 1.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1332745241 177 MIKKYGGYGVDANGDGKADPFDIEDAVFSAANYLAHNG 214
Cdd:PRK10760  225 MPSSFKQYAVDFNGDGHINLWDPVDAIGSVANYFKAHG 262
 
Name Accession Description Interval E-value
Slt35-like cd13399
Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic ...
 112-243 1.97e-29

Slt35-like lytic transglycosylase; Lytic transglycosylase similar to Escherichia coli lytic transglycosylase Slt35 and Pseudomonas aeruginosa Sltb1. Lytic transglycosylase (LT) catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this this family include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as the eukaryotic "goose-type" lysozymes (goose egg-white lysozyme; GEWL).


Pssm-ID: 381602 [Multi-domain]  Cd Length: 108  Bit Score: 109.71  E-value: 1.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 112 YGVPWNLLAAHHRVETRFSTIKNmVSPVGAVGHMQFMARTWvgwgypgdrlgdanipnevltnpkmiKKyggYGVDANGD 191
Cdd:cd13399     1 YGVPPGILAAILGVESGFGPNAG-GSPAGAQGIAQFMPSTW--------------------------KA---YGVDGNGD 50

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1332745241 192 GKADPFDIEDAVFSAANYLAHNGAADG-----NIREAVFAYNHADW-YVEEVMGYAEK 243
Cdd:cd13399    51 GKADPFNPEDAIASAANYLCRHGWDLNaflgeDNFLALAAYNAGPGaYANAVLELAAT 108
NlpC COG0791
Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];
264-388 2.70e-28

Cell wall-associated hydrolase, NlpC_P60 family [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440554 [Multi-domain]  Cd Length: 218  Bit Score: 110.56  E-value: 2.70e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 264 ADVGRKWIGKsKYIFGGgRNKSdiaaGrFDCSSFVHWAFAQVGVDLGPlastSTETLKHLGKPVSPKKMKPGDVVFFDTY 343
Cdd:COG0791   104 VAAALSYLGT-PYVWGG-TSPS----G-FDCSGLVQYVYRQAGISLPR----TSADQAAAGTPVSRSELQPGDLVFFRTG 172

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1332745241 344 KTD-GHVGIYIGDGKFIGAQSS-TGVAIADMSKGYWKEKFNGrVKRI 388
Cdd:COG0791   173 GGGiSHVGIYLGNGKFIHASSSgKGVRISSLDSPYWKSRYVG-ARRV 218
NLPC_P60 pfam00877
NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.
 275-383 8.82e-28

NlpC/P60 family; The function of this domain is unknown. It is found in several lipoproteins.


Pssm-ID: 395705 [Multi-domain]  Cd Length: 105  Bit Score: 105.44  E-value: 8.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 275 KYIFGGGRNKSdiaagrFDCSSFVHWAFAQVGVDLGPlastSTETLKHLG-KPVSPKKMKPGDVVFFDTYKTDGHVGIYI 353
Cdd:pfam00877   3 PYRWGGGSPSG------FDCSGLVRYAFAKVGIELPR----SSGQQYNAGkKTIPKSEPQRGDLVFFGTGKGISHVGIYL 72

                          90       100       110
                  ....*....|....*....|....*....|
gi 1332745241 354 GDGKFIGAQSSTGVAIADMSKGYWKEKFNG 383
Cdd:pfam00877  73 GNGQMLHASTGGGVSISSLNGGYWQKRLVG 102
spr PRK10838
bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;
280-382 7.24e-22

bifunctional murein DD-endopeptidase/murein LD-carboxypeptidase;


Pssm-ID: 236773 [Multi-domain]  Cd Length: 190  Bit Score: 92.14  E-value: 7.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 280 GGRNKSDIaagrfDCSSFVHWAF-AQVGVDLgplaSTSTETLKHLGKPVSPKKMKPGDVVFFDTYKTDGHVGIYIGDGKF 358
Cdd:PRK10838   85 GGSTKKGI-----DCSAFVQRTFrEQFGLEL----PRSTYEQQEMGKSVSRSKLRTGDLVLFRAGSTGRHVGIYIGNNQF 155

                          90       100
                  ....*....|....*....|....
gi 1332745241 359 IGAQSSTGVAIADMSKGYWKEKFN 382
Cdd:PRK10838  156 VHASTSSGVIISSMNEPYWKKRYN 179
wall_hydro_RipC NF038345
peptidoglycan hydrolase RipC; RipC is a peptidoglycan hydrolase, found in species such as ...
 271-375 3.60e-16

peptidoglycan hydrolase RipC; RipC is a peptidoglycan hydrolase, found in species such as Mycobacterium tuberculosis, that is activated by conformation change sent as a signal by the cell division-regulating transporter-like complex FtsEX. Members of this family are distinguished from more distant homologs by a Pro/Gly-rich region.


Pssm-ID: 468486 [Multi-domain]  Cd Length: 361  Bit Score: 79.01  E-value: 3.60e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 271 IGkSKYIFGGGrnksdiAAGRFDCSSFVHWAFAQVGVDLgplaSTSTETLKHLGKPVSPKKMKPGDVVFFdtYKTDGHVG 350
Cdd:NF038345  261 IG-SPYSWGGS------GPNAFDCSGLVMWAFQQAGISL----PHSSQALARGGQPVSLDDLQPGDVVTF--YSDASHAG 327

                          90       100
                  ....*....|....*....|....*.
gi 1332745241 351 IYIGDGKFIGAQS-STGVAIADMSKG 375
Cdd:NF038345  328 IYIGDGMMVHASTyGTPVRVAPISSA 353
MltE COG0741
Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin ...
 98-247 1.63e-15

Soluble lytic murein transglycosylase or regulatory protein s ( may contain LysM/invasin domain) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440504 [Multi-domain]  Cd Length: 244  Bit Score: 75.42  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241  98 PAKFIPIYKAAAKKYGVPWNLLAAHHRVETRFstIKNMVSPVGAVGHMQFMARTWVGWGYPGDRlgdanipnevltnpkm 177
Cdd:COG0741   100 PLPYLPLIEEAAKKYGVDPALVLALIRQESAF--NPNAVSPAGARGLMQLMPATARRLGLKLGL---------------- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 178 ikkyggygvdanGDGKADPFDIEDAVFSAANYLAH-NGAADGNIREAVFAYN--------------HADW---------- 232
Cdd:COG0741   162 ------------GPSPDDLFDPETNIRAGAAYLRElLDRFDGDLVLALAAYNagpgrvrrwlrrngDRDGeiipyaetrn 229

                         170
                  ....*....|....*
gi 1332745241 233 YVEEVMGYAEKYVKG 247
Cdd:COG0741   230 YVKKVLANYAIYRAG 244
PRK13914 PRK13914
invasion associated endopeptidase;
268-377 1.33e-12

invasion associated endopeptidase;


Pssm-ID: 237555 [Multi-domain]  Cd Length: 481  Bit Score: 69.06  E-value: 1.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 268 RKWIGKSkYIFGGGrnksdiAAGRFDCSSFVHWAFAQVGVDL-----GPLASTSTetlkhlgkpVSPKKMKPGDVVFFDT 342
Cdd:PRK13914  374 QKHLGKA-YSWGGN------GPTTFDCSGYTKYVFAKAGISLprtsgAQYASTTR---------ISESQAKPGDLVFFDY 437

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1332745241 343 YKTDGHVGIYIGDGKFIGAQSStGVAIADMSKGYW 377
Cdd:PRK13914  438 GSGISHVGIYVGNGQMINAQDN-GVKYDNIHGSGW 471
SLT pfam01464
Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found ...
 106-228 3.23e-11

Transglycosylase SLT domain; This family is distantly related to pfam00062. Members are found in phages, type II, type III and type IV secretion systems.


Pssm-ID: 396169 [Multi-domain]  Cd Length: 114  Bit Score: 60.01  E-value: 3.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 106 KAAAKKYGVPWNLLAAHHRVETRFStiKNMVSPVGAVGHMQFMARTwvgwgypgdrlgdanipnevltnPKMIKKYGGYG 185
Cdd:pfam01464   2 IKAAQKYGVDPSLLLAIAQQESGFN--PKAVSKSGAVGLMQIMPST-----------------------AKRLGLRVNPG 56

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1332745241 186 VDangdgkaDPFDIEDAVFSAANYLAHN-GAADGNIREAVFAYN 228
Cdd:pfam01464  57 VD-------DLFDPEKNIKAGTKYLKELyKQYGGDLWLALAAYN 93
SLT_2 pfam13406
Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.
 137-214 2.17e-08

Transglycosylase SLT domain; This family is related to the SLT domain pfam01464.


Pssm-ID: 404311 [Multi-domain]  Cd Length: 292  Bit Score: 54.86  E-value: 2.17e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1332745241 137 SPVGAVGHMQFMartwvgwgypgdrlgdaniPNEVLTnpkmikkyggYGVDANGDGKADPFD-IEDAVFSAANYLAHNG 214
Cdd:pfam13406 151 SWAGAMGQTQFM-------------------PSSYLA----------YAVDFDGDGRRDLWNsPPDALASVANYLKQHG 200
LT-like cd00254
lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble ...
 118-246 2.21e-08

lytic transglycosylase(LT)-like domain; Members include the soluble and insoluble membrane-bound LTs in bacteria and LTs in bacteriophage lambda. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381594 [Multi-domain]  Cd Length: 111  Bit Score: 51.83  E-value: 2.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 118 LLAAHHRVETRFStiKNMVSPVGAVGHMQFMARTWVGWGYpgdrlgdanipnevltnpkmikkyggygvdangDGKADPF 197
Cdd:cd00254     3 LVLAVIRVESGFN--PRAVSPAGARGLMQLMPGTARDLGR---------------------------------RGVDDLF 47

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1332745241 198 DIEDAVFSAANYLAHN-GAADGNIREAVFAYN-----HADWYVEEVMGYAE--KYVK 246
Cdd:cd00254    48 DPEENIRAGARYLRELlDRFGGDLELALAAYNagpgaVDRWGGGEVPPYKEtrNYVQ 104
MltF COG4623
Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, ...
 100-212 5.86e-08

Membrane-bound lytic murein transglycosylase MltF [Cell wall/membrane/envelope biogenesis, Signal transduction mechanisms];


Pssm-ID: 443662 [Multi-domain]  Cd Length: 421  Bit Score: 54.30  E-value: 5.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 100 KFIPIYKAAAKKYGVPWNLLAAHHRVETRFSTikNMVSPVGAVGHMQFMARTwvgwgypGDRlgdanipnevltnpkmik 179
Cdd:COG4623   263 PYDPLFEKYAEEYGLDWRLLAALAYQESHWNP--RARSPTGARGLMQLMPAT-------AKE------------------ 315

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1332745241 180 kyggYGVDangdgkaDPFDIEDAVFSAANYLAH 212
Cdd:COG4623   316 ----LGVD-------DRLDPEQSIRAGAKYLRW 337
MltB COG2951
Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];
107-214 6.66e-08

Membrane-bound lytic murein transglycosylase B [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442193 [Multi-domain]  Cd Length: 326  Bit Score: 53.63  E-value: 6.66e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 107 AAAKKYGVPWNLLAAHHRVETRFSTIK-----------------------------------------NMV-SPVGAVGH 144
Cdd:COG2951   105 RIEQRYGVPAEIIVAIWGVETNYGRYMgnfpvldalatlafdgrraeffrgeliaalkilqrgdidpdQMKgSWAGAMGQ 184

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1332745241 145 MQFMARTWVGwgypgdrlgdanipnevltnpkmikkyggYGVDANGDGKADPF-DIEDAVFSAANYLAHNG 214
Cdd:COG2951   185 TQFMPSSYLR-----------------------------YAVDFDGDGRRDLWnSPPDALASTANYLKKHG 226
MLTF-like cd13403
membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily ...
 106-151 1.84e-06

membrane-bound lytic murein transglycosylase F (MLTF) and similar proteins; This subfamily includes membrane-bound lytic murein transglycosylase F (MltF, murein lyase F) that degrades murein glycan strands. It is responsible for catalyzing the release of 1,6-anhydromuropeptides from peptidoglycan. Lytic transglycosylase catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc) as do goose-type lysozymes. However, in addition, it also makes a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381606 [Multi-domain]  Cd Length: 161  Bit Score: 47.53  E-value: 1.84e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1332745241 106 KAAAKKYGVPWNLLAA--HHrvETRFSTikNMVSPVGAVGHMQFMART 151
Cdd:cd13403     2 KKYAEKYGFDWRLLAAqaYQ--ESRFNP--NARSPAGARGLMQLMPST 45
Slt70-like cd13401
70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the ...
 101-183 3.83e-06

70kDa soluble lytic transglycosylase (Slt70) and similar proteins; Catalytic domain of the 70kda soluble lytic transglycosylase (LT)-like proteins, which also have an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda.


Pssm-ID: 381604 [Multi-domain]  Cd Length: 152  Bit Score: 46.32  E-value: 3.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241 101 FIPIYKAAAKKYGVPWNLLAAHHRVETRFSTikNMVSPVGAVGHMQFMART--WVgwgypGDRLGDANIPNEVLTNP--- 175
Cdd:cd13401     6 YRDLVERAAKKNGLDPALVYAIIRQESAFDP--DAVSPAGALGLMQLMPATakDV-----AKKLGLPYYSPRDLFDPeyn 78

                          90
                  ....*....|....*..
gi 1332745241 176 ---------KMIKKYGG 183
Cdd:cd13401    79 irlgsaylaELLDRFDG 95
LT_Slt70-like cd16896
uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized ...
 98-176 8.24e-06

uncharacterized lytic transglycosylase subfamily with similarity to Slt70; Uncharacterized lytic transglycosylase (LT) with a conserved sequence pattern suggesting similarity to the Slt70, a 70kda soluble lytic transglycosylase which also has an N-terminal U-shaped U-domain and a linker L-domain. LTs catalyze the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyl-D-glucosamine (GlcNAc), as do "goose-type" lysozymes. However, in addition to this, they also make a new glycosidic bond with the C6 hydroxyl group of the same muramic acid residue.


Pssm-ID: 381617 [Multi-domain]  Cd Length: 146  Bit Score: 45.19  E-value: 8.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1332745241  98 PAKFIPIYKAAAKKYGVPWNLLAAHHRVETRFSTikNMVSPVGAVGHMQFMART--WVgwgypGDRLGDANIPNEVLTNP 175
Cdd:cd16896     1 PLKYREYIEKYAKEYGVDPLLVAAVIKVESNFNP--NAVSSKGAIGLMQIMPETaeWI-----AEKLGLEDFSEDDLYDP 73


                  .
gi 1332745241 176 K 176
Cdd:cd16896    74 E 74
PRK10760 PRK10760
murein hydrolase B; Provisional
 177-214 1.95e-03

murein hydrolase B; Provisional


Pssm-ID: 236754 [Multi-domain]  Cd Length: 359  Bit Score: 40.11  E-value: 1.95e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1332745241 177 MIKKYGGYGVDANGDGKADPFDIEDAVFSAANYLAHNG 214
Cdd:PRK10760  225 MPSSFKQYAVDFNGDGHINLWDPVDAIGSVANYFKAHG 262
LT_MltC_MltE cd16893
membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and ...
 103-151 3.18e-03

membrane-bound lytic murein transglycosylases MltC and MltE, and similar proteins; MltC and MltE are periplasmic, outer membrane attached lytic transglycosylases (LTs), which cleave beta-1,4-glycosidic bonds joining N-acetylmuramic acid and N-acetylglucosamine in the cell wall peptidoglycan, yielding 1,6-anhydromuropeptides. Proteins similar to this family include the soluble and insoluble membrane-bound LTs in bacteria and the LTs in bacteriophage lambda


Pssm-ID: 381614 [Multi-domain]  Cd Length: 162  Bit Score: 37.92  E-value: 3.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1332745241 103 PIYKAAAKKYGVPWNLLAAHHRVETRFSTikNMVSPVGAVGHMQFMART 151
Cdd:cd16893     1 PIVEKYAKKYGVDPALILAIIETESSFNP--YAVSHSPAYGLMQIVPST 47
Lyz-like cd00442
lysozyme-like domains; This family contains several members, including soluble lytic ...
 124-156 3.86e-03

lysozyme-like domains; This family contains several members, including soluble lytic transglycosylases (SLT), goose egg-white lysozymes (GEWL), hen egg-white lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, chitosanases, and pesticin. Typical members are involved in the hydrolysis of beta-1,4- linked polysaccharides.


Pssm-ID: 381596 [Multi-domain]  Cd Length: 59  Bit Score: 35.46  E-value: 3.86e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1332745241 124 RVETRFSTIKNMVSPVGAVGHMQFMARTWVGWG 156
Cdd:cd00442     7 GQESGGNKPANAGSGSGAAGLFQFMPGTWKAYG 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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