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Conserved domains on  [gi|1057949741|gb|AOE83816|]
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GDP-mannose dehydrogenase [Pseudomonas sp. TCU-HL1]

Protein Classification

nucleotide sugar dehydrogenase( domain architecture ID 11496319)

nucleotide sugar dehydrogenase such as GDP-mannose 6-dehydrogenase, which catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 1-421 1.34e-154

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


:

Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 443.59  E-value: 1.34e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVKSGRLRGTTDVAGAVRNTQVS 80
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADLGHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKALKAGRLRATTDYEEAIRDADVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLSLDYIEGVCREIGFALRDKAerhTVVVRSTVLPGTVKNVVIPIIEDcSGKKAGVDFGVAVNPEFLR 160
Cdd:TIGR03026  81 IICVPTPLKEDGSPDLSYVESAAETIAKHLRKGA---TVVLESTVPPGTTEEVVKPILER-SGLKLGEDFYLAYNPEFLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 161 ESTAIKDYDYPPMTVIGElDKAAGDVLETLYREL-DAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGR 239
Cdd:TIGR03026 157 EGNAVHDLLHPDRIVGGE-TEEAGEAVAELYSPIiDGPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGIDVY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 240 EVMDVVCQDNklNLSKYYMRPGFAFGGSCLPKDVRALNYRATSLDVDSPLIGSLMRSNAGQVQKAFDIIAGH----DKRK 315
Cdd:TIGR03026 236 EVIEAAGTDP--RIGFNFLNPGPGVGGHCIPKDPLALIAKAKELGYNPELIEAAREINDSQPDYVVEKIKDLlgplKGKT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 316 IALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDRNVEYARVHGANkdyieskiphvsslLDSNFDAVVNKADIIV 395
Cdd:TIGR03026 314 VLILGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPEEEVKGLP--------------SIDDLEEALKGADALV 379

                         410       420       430
                  ....*....|....*....|....*....|
gi 1057949741 396 LGNRDELFAPL----AQQAPAGKQVIDLVG 421
Cdd:TIGR03026 380 ILTDHSEFKDLdlekIKDLMKGKVVVDTRN 409
 
Name Accession Description Interval E-value
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 1-421 1.34e-154

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 443.59  E-value: 1.34e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVKSGRLRGTTDVAGAVRNTQVS 80
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADLGHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKALKAGRLRATTDYEEAIRDADVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLSLDYIEGVCREIGFALRDKAerhTVVVRSTVLPGTVKNVVIPIIEDcSGKKAGVDFGVAVNPEFLR 160
Cdd:TIGR03026  81 IICVPTPLKEDGSPDLSYVESAAETIAKHLRKGA---TVVLESTVPPGTTEEVVKPILER-SGLKLGEDFYLAYNPEFLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 161 ESTAIKDYDYPPMTVIGElDKAAGDVLETLYREL-DAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGR 239
Cdd:TIGR03026 157 EGNAVHDLLHPDRIVGGE-TEEAGEAVAELYSPIiDGPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGIDVY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 240 EVMDVVCQDNklNLSKYYMRPGFAFGGSCLPKDVRALNYRATSLDVDSPLIGSLMRSNAGQVQKAFDIIAGH----DKRK 315
Cdd:TIGR03026 236 EVIEAAGTDP--RIGFNFLNPGPGVGGHCIPKDPLALIAKAKELGYNPELIEAAREINDSQPDYVVEKIKDLlgplKGKT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 316 IALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDRNVEYARVHGANkdyieskiphvsslLDSNFDAVVNKADIIV 395
Cdd:TIGR03026 314 VLILGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPEEEVKGLP--------------SIDDLEEALKGADALV 379

                         410       420       430
                  ....*....|....*....|....*....|
gi 1057949741 396 LGNRDELFAPL----AQQAPAGKQVIDLVG 421
Cdd:TIGR03026 380 ILTDHSEFKDLdlekIKDLMKGKVVVDTRN 409
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
1-353 4.65e-130

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 382.06  E-value: 4.65e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVKSGRLRGTTDVAGAVRNTQVS 80
Cdd:COG1004     1 MKIAVIGTGYVGLVTAACLAELGHEVTCVDIDEEKIEALNAGEIPIYEPGLEELVARNVAAGRLRFTTDLAEAVAEADVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLSLDYIEGVCREIGFALRDkaeRHTVVVRSTVLPGTVKNVVIPIIEdcSGKKAGVDFGVAVNPEFLR 160
Cdd:COG1004    81 FIAVGTPSDEDGSADLSYVLAAARSIGEALKG---YKVVVTKSTVPVGTADRVRAIIAE--ELRGAGVDFDVVSNPEFLR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 161 ESTAIKDYDYPPMTVIGELDKAAGDVLETLYREL---DAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVD 237
Cdd:COG1004   156 EGSAVEDFLRPDRIVIGVDSERAAEVLRELYAPFvrnGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEKVGAD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 238 GREVMDVVCQDNKlnLSKYYMRPGFAFGGSCLPKDVRALNYRATSLDVDSPLIGSLMRSNAGQVQKAFDIIAGH-----D 312
Cdd:COG1004   236 VEEVARGIGLDSR--IGPKFLYAGIGYGGSCFPKDVRALIATARELGYDLRLLEAVEEVNERQKRRLVEKIREHlggdlK 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1057949741 313 KRKIALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYD 353
Cdd:COG1004   314 GKTIAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYD 354
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 1-190 1.15e-73

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 229.06  E-value: 1.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVkSGRLRGTTDVAGAVRNTQVS 80
Cdd:pfam03721   1 MKISVIGLGYVGLPTAACLAEIGHDVIGVDIDEEKVDKLNSGQIPIYEPGLDELVKANV-SGRLSFTTDYSTAIEEADVI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLS-LDYIEGVCREIGFALRdkaERHTVVVRSTVLPGTVKNVVIPIIEDCSGKKaGVDFGVAVNPEFL 159
Cdd:pfam03721  80 FIAVGTPSKKGGGAAdLKYVESAARSIAPHLK---KGKVVVVKSTVPVGTTENLVKPIIEEGGKKV-GVDFDVASNPEFL 155

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1057949741 160 RESTAIKDYDYPPMTVIGELDKAAGDVLETL 190
Cdd:pfam03721 156 REGSAVYDLFNPDRVVIGVTEKCAEAALEEL 186
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
 1-353 8.20e-41

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 149.40  E-value: 8.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGaVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGvkSGRLRGTTDVAGAVRNTqvS 80
Cdd:PRK15057    1 MKITISGTGYVG-LSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSD--KIHFNATLDKNEAYRDA--D 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSK---KNGDLSLDYIEGVCREIgFALRDKAerhTVVVRSTVlpgtvknvviPIIEDCSGKKAGVDFGVAVNPE 157
Cdd:PRK15057   76 YVIIATPTDydpKTNYFNTSSVESVIKDV-VEINPYA---VMVIKSTV----------PVGFTAAMHKKYRTENIIFSPE 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 158 FLRESTAIKDYDYPPMTVIGELDKAA---GDVLETLYRELDAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAV 234
Cdd:PRK15057  142 FLREGKALYDNLHPSRIVIGERSERAerfAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 235 GVDGREVMDVVCQDNKlnLSKYYMRPGFAFGGSCLPKDVRAL--NYRATSLDVDSPLIgslmrsNAGQVQKAF--DIIAG 310
Cdd:PRK15057  222 GLNTRQIIEGVCLDPR--IGNHYNNPSFGYGGYCLPKDTKQLlaNYQSVPNNLISAIV------DANRTRKDFiaDAILS 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1057949741 311 HDKRKIALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYD 353
Cdd:PRK15057  294 RKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYE 336
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
 317-424 5.34e-15

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 70.23  E-value: 5.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  317 ALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDrnveyarvhgankDYIESKIPHVSSLLDSNFDAVVNKADIIVL 396
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYD-------------PYAMEEAREYGLTYVSDLEEALKGADAVVI 67

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1057949741  397 GNRDELFAPLA----QQAPAGKQVIDLVGFMP 424
Cdd:smart00984  68 ATEHDEFRSLDpeelKDLMKKPVVVDGRNILD 99
 
Name Accession Description Interval E-value
NDP-sugDHase TIGR03026
nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent ...
 1-421 1.34e-154

nucleotide sugar dehydrogenase; Enzymes in this family catalyze the NAD-dependent alcohol-to-acid oxidation of nucleotide-linked sugars. Examples include UDP-glucose 6-dehydrogenase (1.1.1.22), GDP-mannose 6-dehydrogenase (1.1.1.132), UDP-N-acetylglucosamine 6-dehydrogenase (1.1.1.136), UDP-N-acetyl-D-galactosaminuronic acid dehydrogenase, and UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase. These enzymes are most often involved in the biosynthesis of polysaccharides and are often found in operons devoted to that purpose. All of these enzymes contain three Pfam domains, pfam03721, pfam00984, and pfam03720 for the N-terminal, central, and C-terminal regions respectively.


Pssm-ID: 274399 [Multi-domain]  Cd Length: 409  Bit Score: 443.59  E-value: 1.34e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVKSGRLRGTTDVAGAVRNTQVS 80
Cdd:TIGR03026   1 MKIAVIGLGYVGLPLAALLADLGHDVTGVDIDQEKVDKLNKGKSPIYEPGLDELLAKALKAGRLRATTDYEEAIRDADVI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLSLDYIEGVCREIGFALRDKAerhTVVVRSTVLPGTVKNVVIPIIEDcSGKKAGVDFGVAVNPEFLR 160
Cdd:TIGR03026  81 IICVPTPLKEDGSPDLSYVESAAETIAKHLRKGA---TVVLESTVPPGTTEEVVKPILER-SGLKLGEDFYLAYNPEFLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 161 ESTAIKDYDYPPMTVIGElDKAAGDVLETLYREL-DAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGR 239
Cdd:TIGR03026 157 EGNAVHDLLHPDRIVGGE-TEEAGEAVAELYSPIiDGPVLVTSIETAEMIKLAENTFRAVKIAFANELARICEALGIDVY 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 240 EVMDVVCQDNklNLSKYYMRPGFAFGGSCLPKDVRALNYRATSLDVDSPLIGSLMRSNAGQVQKAFDIIAGH----DKRK 315
Cdd:TIGR03026 236 EVIEAAGTDP--RIGFNFLNPGPGVGGHCIPKDPLALIAKAKELGYNPELIEAAREINDSQPDYVVEKIKDLlgplKGKT 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 316 IALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDRNVEYARVHGANkdyieskiphvsslLDSNFDAVVNKADIIV 395
Cdd:TIGR03026 314 VLILGLAFKPNTDDVRESPALDIIELLKEKGAKVKAYDPLVPEEEVKGLP--------------SIDDLEEALKGADALV 379

                         410       420       430
                  ....*....|....*....|....*....|
gi 1057949741 396 LGNRDELFAPL----AQQAPAGKQVIDLVG 421
Cdd:TIGR03026 380 ILTDHSEFKDLdlekIKDLMKGKVVVDTRN 409
Ugd COG1004
UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];
1-353 4.65e-130

UDP-glucose 6-dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440628 [Multi-domain]  Cd Length: 436  Bit Score: 382.06  E-value: 4.65e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVKSGRLRGTTDVAGAVRNTQVS 80
Cdd:COG1004     1 MKIAVIGTGYVGLVTAACLAELGHEVTCVDIDEEKIEALNAGEIPIYEPGLEELVARNVAAGRLRFTTDLAEAVAEADVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLSLDYIEGVCREIGFALRDkaeRHTVVVRSTVLPGTVKNVVIPIIEdcSGKKAGVDFGVAVNPEFLR 160
Cdd:COG1004    81 FIAVGTPSDEDGSADLSYVLAAARSIGEALKG---YKVVVTKSTVPVGTADRVRAIIAE--ELRGAGVDFDVVSNPEFLR 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 161 ESTAIKDYDYPPMTVIGELDKAAGDVLETLYREL---DAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVD 237
Cdd:COG1004   156 EGSAVEDFLRPDRIVIGVDSERAAEVLRELYAPFvrnGTPIIVTDLRSAELIKYAANAFLATKISFINEIANLCEKVGAD 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 238 GREVMDVVCQDNKlnLSKYYMRPGFAFGGSCLPKDVRALNYRATSLDVDSPLIGSLMRSNAGQVQKAFDIIAGH-----D 312
Cdd:COG1004   236 VEEVARGIGLDSR--IGPKFLYAGIGYGGSCFPKDVRALIATARELGYDLRLLEAVEEVNERQKRRLVEKIREHlggdlK 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1057949741 313 KRKIALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYD 353
Cdd:COG1004   314 GKTIAVLGLAFKPNTDDMRESPALDIIEALLEAGARVRAYD 354
WecC COG0677
UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];
3-396 4.89e-80

UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440441 [Multi-domain]  Cd Length: 413  Bit Score: 253.06  E-value: 4.89e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   3 ISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGlEELLQQGVKSGRLRGTTDVAgAVRNTQVSFI 82
Cdd:COG0677     2 IAVIGLGYVGLPLAVAFAKAGFRVIGFDINPERVEELNAGEDPILEPG-DELLAEAVAAGRLRATTDPE-ALAEADVVII 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  83 CVGTPSKKNGDLSLDYIEGVCREIGFALRdkaERHTVVVRSTVLPGTVKNVVIPIIEDCSGKKAGVDFGVAVNPEflRES 162
Cdd:COG0677    80 AVPTPLDEDKEPDLSYLESASETIAPHLK---PGDLVVLESTVYPGTTEEVCVPILEKRSGLKAGEDFFLAYSPE--RIN 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 163 TAIKDYD---YPpmTVIGELDKAAGDVLETLYRE-LDAPIIR-KDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVD 237
Cdd:COG0677   155 PGNKLHElrnIP--KVVGGITPESAERAAALYGSvVTAGVVPvSSIKVAEAAKLIENTYRDVNIALANELALICDRLGID 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 238 GREVMDVVcqdnklNLSKYYM--RPGFAFGGSCLPKDVRALNYRATSLDVDSPLIGSLMRSNAGQ----VQKAFDIIAGH 311
Cdd:COG0677   233 VWEVIEAA------NTKPGFLifYPGPGVGGHCIPVDPYYLTWKARELGYHPRLILAAREINDSMpeyvVERVVKALNEA 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 312 DKR----KIALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDRNVEYARVHGAnkdYIESkiphvsslldSNFDAV 387
Cdd:COG0677   307 GKSlkgaRVLVLGLAYKENVDDLRESPALDIIEELREYGAEVDVHDPYVDEEEVEGE---YGEL----------VDLEEA 373


                  ....*....
gi 1057949741 388 VNKADIIVL 396
Cdd:COG0677   374 LEGADAVVL 382
UDPG_MGDP_dh_N pfam03721
UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose ...
 1-190 1.15e-73

UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 397677 [Multi-domain]  Cd Length: 186  Bit Score: 229.06  E-value: 1.15e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVkSGRLRGTTDVAGAVRNTQVS 80
Cdd:pfam03721   1 MKISVIGLGYVGLPTAACLAEIGHDVIGVDIDEEKVDKLNSGQIPIYEPGLDELVKANV-SGRLSFTTDYSTAIEEADVI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLS-LDYIEGVCREIGFALRdkaERHTVVVRSTVLPGTVKNVVIPIIEDCSGKKaGVDFGVAVNPEFL 159
Cdd:pfam03721  80 FIAVGTPSKKGGGAAdLKYVESAARSIAPHLK---KGKVVVVKSTVPVGTTENLVKPIIEEGGKKV-GVDFDVASNPEFL 155

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1057949741 160 RESTAIKDYDYPPMTVIGELDKAAGDVLETL 190
Cdd:pfam03721 156 REGSAVYDLFNPDRVVIGVTEKCAEAALEEL 186
PRK15057 PRK15057
UDP-glucose 6-dehydrogenase; Provisional
 1-353 8.20e-41

UDP-glucose 6-dehydrogenase; Provisional


Pssm-ID: 185017 [Multi-domain]  Cd Length: 388  Bit Score: 149.40  E-value: 8.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGaVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGvkSGRLRGTTDVAGAVRNTqvS 80
Cdd:PRK15057    1 MKITISGTGYVG-LSNGLLIAQNHEVVALDILPSRVAMLNDRISPIVDKEIQQFLQSD--KIHFNATLDKNEAYRDA--D 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSK---KNGDLSLDYIEGVCREIgFALRDKAerhTVVVRSTVlpgtvknvviPIIEDCSGKKAGVDFGVAVNPE 157
Cdd:PRK15057   76 YVIIATPTDydpKTNYFNTSSVESVIKDV-VEINPYA---VMVIKSTV----------PVGFTAAMHKKYRTENIIFSPE 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 158 FLRESTAIKDYDYPPMTVIGELDKAA---GDVLETLYRELDAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEIGNIAKAV 234
Cdd:PRK15057  142 FLREGKALYDNLHPSRIVIGERSERAerfAALLQEGAIKQNIPTLFTDSTEAEAIKLFANTYLAMRVAYFNELDSYAESL 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 235 GVDGREVMDVVCQDNKlnLSKYYMRPGFAFGGSCLPKDVRAL--NYRATSLDVDSPLIgslmrsNAGQVQKAF--DIIAG 310
Cdd:PRK15057  222 GLNTRQIIEGVCLDPR--IGNHYNNPSFGYGGYCLPKDTKQLlaNYQSVPNNLISAIV------DANRTRKDFiaDAILS 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1057949741 311 HDKRKIALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYD 353
Cdd:PRK15057  294 RKPQVVGIYRLIMKSGSDNFRASSIQGIMKRIKAKGVEVIIYE 336
PLN02353 PLN02353
probable UDP-glucose 6-dehydrogenase
 1-362 5.50e-40

probable UDP-glucose 6-dehydrogenase


Pssm-ID: 177986 [Multi-domain]  Cd Length: 473  Bit Score: 149.06  E-value: 5.50e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVG----AVCAgcLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGvkSGR-LRGTTDVAGAVR 75
Cdd:PLN02353    2 VKICCIGAGYVGgptmAVIA--LKCPDIEVVVVDISVPRIDAWNSDQLPIYEPGLDEVVKQC--RGKnLFFSTDVEKHVA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  76 NTQVSFICVGTPSKKNG-------DLSldYIEGVCREIGFALR-DKaerhTVVVRSTVLPGTVKnvVIPIIEDCSGKkaG 147
Cdd:PLN02353   78 EADIVFVSVNTPTKTRGlgagkaaDLT--YWESAARMIADVSKsDK----IVVEKSTVPVKTAE--AIEKILTHNSK--G 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 148 VDFGVAVNPEFLRESTAIKDYDYPPMTVIGELDKAAG----DVLETLYRELDAP--IIRKDIEVAEMIKYTCNVWHAAKV 221
Cdd:PLN02353  148 INFQILSNPEFLAEGTAIEDLFKPDRVLIGGRETPEGqkavQALKDVYAHWVPEerIITTNLWSAELSKLAANAFLAQRI 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 222 TFANEIGNIAKAVGVDGREVMDVVCQDNKlnLSKYYMRPGFAFGGSCLPKDVRALNY--RATSLDVDSPLIGSLMRSNAG 299
Cdd:PLN02353  228 SSVNAMSALCEATGADVSQVSHAVGKDSR--IGPKFLNASVGFGGSCFQKDILNLVYicECNGLPEVAEYWKQVIKMNDY 305

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1057949741 300 Q--------VQKAFDIIAGhdkRKIALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDRNVEYARVH 362
Cdd:PLN02353  306 QksrfvnrvVSSMFNTVSG---KKIAVLGFAFKKDTGDTRETPAIDVCKGLLGDKAKLSIYDPQVTEEQIQ 373
UDPG_MGDP_dh pfam00984
UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose ...
 205-297 8.17e-33

UDP-glucose/GDP-mannose dehydrogenase family, central domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 460015 [Multi-domain]  Cd Length: 92  Bit Score: 119.02  E-value: 8.17e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 205 VAEMIKYTCNVWHAAKVTFANEIGNIAKAVGVDGREVMDVVCQDNklNLSKYYMRPGFAFGGSCLPKDVRALNYRATSLD 284
Cdd:pfam00984   1 SAELIKLAENAFLAVKISFINELANLCEALGADVWEVIEAAGTDP--RIGPKFLYPGPGVGGSCLPKDPRALIYLARELG 78

                          90
                  ....*....|...
gi 1057949741 285 VDSPLIGSLMRSN 297
Cdd:pfam00984  79 VPARLLEAAREVN 91
wecC PRK11064
UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional
 3-418 4.10e-29

UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional


Pssm-ID: 182940 [Multi-domain]  Cd Length: 415  Bit Score: 117.78  E-value: 4.10e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   3 ISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELLQQGVKSGRLRGTTDVAGAvrntQVSFI 82
Cdd:PRK11064    6 ISVIGLGYIGLPTAAAFASRQKQVIGVDINQHAVDTINRGEIHIVEPDLDMVVKTAVEGGYLRATTTPEPA----DAFLI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  83 CVGTPSKKNGDLSLDYIEGVCREIGFALRDKAerhTVVVRSTVLPGTVKNVVIPIIE---DCS-----GKKAGVDfgVAV 154
Cdd:PRK11064   82 AVPTPFKGDHEPDLTYVEAAAKSIAPVLKKGD---LVILESTSPVGATEQMAEWLAEarpDLTfpqqaGEQADIN--IAY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 155 NPE------FLREstAIKDyDyppmTVIGELDKAAGDVLETLYRE-LDAPIIRKDIEVAEMIKYTCNVWHAAKVTFANEI 227
Cdd:PRK11064  157 CPErvlpgqVMVE--LIKN-D----RVIGGMTPVCSARASELYKIfLEGECVVTNSRTAEMCKLTENSFRDVNIAFANEL 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 228 GNIAKAVGVDGREVMDVVCQDNKLNLskyyMRPGFAFGGSCL-----------PKDVRalnyratsldvdspLIGSLMRS 296
Cdd:PRK11064  230 SLICADQGINVWELIRLANRHPRVNI----LQPGPGVGGHCIavdpwfivaqnPQQAR--------------LIRTAREV 291

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 297 NAG-------QVQKAF-DIIAGHDKR----KIALLGLSFKAGTDDLRESPLVELAEMLigkgfdlsiydrnveyARVHGA 364
Cdd:PRK11064  292 NDGkphwvidQVKAAVaDCLAATDKRasevKIACFGLAFKPNIDDLRESPAMEIAELI----------------AQWHSG 355

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1057949741 365 NKDYIESKIPHVSSLLDS-----NFDAVVNKADIIVLGNRDELFAPLAQQAPAGKQVID 418
Cdd:PRK11064  356 ETLVVEPNIHQLPKKLDGlvtlvSLDEALATADVLVMLVDHSQFKAINGDNVHQQWVVD 414
PRK15182 PRK15182
Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;
1-388 3.99e-15

Vi polysaccharide biosynthesis UDP-N-acetylglucosamine C-6 dehydrogenase TviB;


Pssm-ID: 185104 [Multi-domain]  Cd Length: 425  Bit Score: 77.03  E-value: 3.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAgCLSARGHEVVGIDVSQTKIDLINNGKSPIVEPGLEELlqqgvKSGRLRGTTDVAGAVRNTQVS 80
Cdd:PRK15182    7 VKIAIIGLGYVGLPLA-VEFGKSRQVVGFDVNKKRILELKNGVDVNLETTEEEL-----REARYLKFTSEIEKIKECNFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  81 FICVGTPSKKNGDLSLDYIEGVCREIGFALRdkaERHTVVVRSTVLPGTVKNVVIPIIEDCSGKKAGVDFGVAVNPEFLR 160
Cdd:PRK15182   81 IITVPTPINTYKQPDLTPLIKASETVGTVLN---RGDIVVYESTVYPGCTEEECVPILARMSGMTFNQDFYVGYSPERIN 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 161 ES------TAIKDYDYPPMTVIGELdkaagdvLETLYRELDAPIIRK--DIEVAEMIKYTCNVWHAAKVTFANEIGNIAK 232
Cdd:PRK15182  158 PGdkkhrlTNIKKITSGSTAQIAEL-------IDEVYQQIISAGTYKaeSIKVAEAAKVIENTQRDLNIALVNELAIIFN 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 233 AVGVDGREVMDVVcqDNKLNLSKYymRPGFAfGGSCLPKDVRALNYRATSLDVDSPLI--GSLMRSNAGQ---------- 300
Cdd:PRK15182  231 RLNIDTEAVLRAA--GSKWNFLPF--RPGLV-GGHCIGVDPYYLTHKSQGIGYYPEIIlaGRRLNDNMGNyvseqlikam 305

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 301 VQKAFDIiaghDKRKIALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDRNVEYARVHGankdyiESKIPHVSSLL 380
Cdd:PRK15182  306 IKKGINV----EGSSVLILGFTFKENCPDIRNTRIIDVVKELGKYSCKVDIFDPWVDAEEVRR------EYGIIPVSEVK 375


                  ....*...
gi 1057949741 381 DSNFDAVV 388
Cdd:PRK15182  376 SSHYDAII 383
UDPG_MGDP_dh_C smart00984
UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes ...
 317-424 5.34e-15

UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenases are a small group of enzymes which possesses the ability to catalyse the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 214954 [Multi-domain]  Cd Length: 99  Bit Score: 70.23  E-value: 5.34e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741  317 ALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDrnveyarvhgankDYIESKIPHVSSLLDSNFDAVVNKADIIVL 396
Cdd:smart00984   1 AVLGLAFKPNTDDLRESPALDIIEELLEAGAEVVVYD-------------PYAMEEAREYGLTYVSDLEEALKGADAVVI 67

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1057949741  397 GNRDELFAPLA----QQAPAGKQVIDLVGFMP 424
Cdd:smart00984  68 ATEHDEFRSLDpeelKDLMKKPVVVDGRNILD 99
UDPG_MGDP_dh_C pfam03720
UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose ...
 317-396 2.06e-12

UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; The UDP-glucose/GDP-mannose dehydrogenaseses are a small group of enzymes which possesses the ability to catalyze the NAD-dependent 2-fold oxidation of an alcohol to an acid without the release of an aldehyde intermediate.


Pssm-ID: 427462 [Multi-domain]  Cd Length: 103  Bit Score: 62.98  E-value: 2.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741 317 ALLGLSFKAGTDDLRESPLVELAEMLIGKGFDLSIYDRNVEyarvhganKDYIESKIPHVSSLldSNFDAVVNKADIIVL 396
Cdd:pfam03720   1 AVLGLAFKPNTDDLRESPALDIIELLLEEGAEVKVYDPYVP--------EEAIEALGDGVTLV--DDLEEALKGADAIVI 70
MmsB COG2084
3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport ...
 1-131 2.81e-03

3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism];


Pssm-ID: 441687 [Multi-domain]  Cd Length: 285  Bit Score: 39.33  E-value: 2.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1057949741   1 MQISIFGLGYVGAVCAGCLSARGHEVVGIDVSQTKidlinngkspivepgLEELLQQGVksgrlRGTTDVAGAVRNTQVS 80
Cdd:COG2084     2 MKVGFIGLGAMGAPMARNLLKAGHEVTVWNRTPAK---------------AEALVAAGA-----RVAASPAEAAAAADVV 61

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1057949741  81 FICVGTPskkngdlslDYIEGVCREIGFALRDKAERHTVVVRSTVLPGTVK 131
Cdd:COG2084    62 ITMLPDD---------AAVEEVLLGEDGLLAALRPGAVVVDMSTISPETAR 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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