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Conserved domains on  [gi|1328813490|ref|XP_023397791|]
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arylsulfatase E-like [Loxodonta africana]

Protein Classification

Sulfatase_C domain-containing protein( domain architecture ID 10631472)

Sulfatase_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfatase_C pfam14707
C-terminal region of aryl-sulfatase;
1-129 2.82e-53

C-terminal region of aryl-sulfatase;


:

Pssm-ID: 405407 [Multi-domain]  Cd Length: 122  Bit Score: 163.64  E-value: 2.82e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490   1 MHYCEGFLHAARWYQrstgtvWKVHFTTPKFHPEGAGACYGRGVCpcsgagVIHHDPPVLFNLSRDPSEAHPLTPATePL 80
Cdd:pfam14707   7 FHYCGAALHAVRWGP------YKAHFFTPSFDPPGAEGCYGSKVP------VTHHDPPLLFDLERDPSEKYPLSPDS-PE 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1328813490  81 FHQVMERVAQAVKEHQQTLTPAPLQLDSLNNIWRPWLQPCCGVFPLCWC 129
Cdd:pfam14707  74 YPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCCPTFPACTC 122
 
Name Accession Description Interval E-value
Sulfatase_C pfam14707
C-terminal region of aryl-sulfatase;
1-129 2.82e-53

C-terminal region of aryl-sulfatase;


Pssm-ID: 405407 [Multi-domain]  Cd Length: 122  Bit Score: 163.64  E-value: 2.82e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490   1 MHYCEGFLHAARWYQrstgtvWKVHFTTPKFHPEGAGACYGRGVCpcsgagVIHHDPPVLFNLSRDPSEAHPLTPATePL 80
Cdd:pfam14707   7 FHYCGAALHAVRWGP------YKAHFFTPSFDPPGAEGCYGSKVP------VTHHDPPLLFDLERDPSEKYPLSPDS-PE 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1328813490  81 FHQVMERVAQAVKEHQQTLTPAPLQLDSLNNIWRPWLQPCCGVFPLCWC 129
Cdd:pfam14707  74 YPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCCPTFPACTC 122
ES cd16159
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ...
 2-107 1.10e-43

Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.


Pssm-ID: 293778 [Multi-domain]  Cd Length: 521  Bit Score: 149.75  E-value: 1.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490   2 HYCEGFLHAARWYQRSTGTVWKVHFTTPKFHPEGAGaCYGRGVCPCSGAGVIHHDPPVLFNLSRDPSEAHPLTPATEPlF 81
Cdd:cd16159   417 HYCGAELHAVRYRPRDGGAVWKAHYFTPNFYPGTEG-CCGTLLCRCFGDSVTHHDPPLLFDLSADPSESNPLDPTDEP-Y 494

                          90       100
                  ....*....|....*....|....*.
gi 1328813490  82 HQVMERVAQAVKEHQQTLTPAPLQLD 107
Cdd:cd16159   495 QEIIKKILEAVAEHQSSIEPVESQLS 520
 
Name Accession Description Interval E-value
Sulfatase_C pfam14707
C-terminal region of aryl-sulfatase;
1-129 2.82e-53

C-terminal region of aryl-sulfatase;


Pssm-ID: 405407 [Multi-domain]  Cd Length: 122  Bit Score: 163.64  E-value: 2.82e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490   1 MHYCEGFLHAARWYQrstgtvWKVHFTTPKFHPEGAGACYGRGVCpcsgagVIHHDPPVLFNLSRDPSEAHPLTPATePL 80
Cdd:pfam14707   7 FHYCGAALHAVRWGP------YKAHFFTPSFDPPGAEGCYGSKVP------VTHHDPPLLFDLERDPSEKYPLSPDS-PE 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1328813490  81 FHQVMERVAQAVKEHQQTLTPAPLQLDSLNNIWRPWLQPCCGVFPLCWC 129
Cdd:pfam14707  74 YPEVLAEIKAAVEEHKATLVPVPNQLSKGNYLWDPWLQPCCPTFPACTC 122
ES cd16159
Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of ...
 2-107 1.10e-43

Estrone sulfatase; Human estrone sulfatase (ES) is responsible for maintaining high levels of the active estrogen in tumor cells. ES catalyzes the hydrolysis of E1 sulfate, which is a component of the three-enzyme system that has been implicated in intracrine biosynthesis of estradiol. It is associated with the membrane of the endoplasmic reticulum (ER). The structure of ES consisting of two antiparallel alpha helices that protrude from the roughly spherical molecule. These highly hydrophobic helices anchor the functional domain on the membrane surface facing the ER lumen.


Pssm-ID: 293778 [Multi-domain]  Cd Length: 521  Bit Score: 149.75  E-value: 1.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490   2 HYCEGFLHAARWYQRSTGTVWKVHFTTPKFHPEGAGaCYGRGVCPCSGAGVIHHDPPVLFNLSRDPSEAHPLTPATEPlF 81
Cdd:cd16159   417 HYCGAELHAVRYRPRDGGAVWKAHYFTPNFYPGTEG-CCGTLLCRCFGDSVTHHDPPLLFDLSADPSESNPLDPTDEP-Y 494

                          90       100
                  ....*....|....*....|....*.
gi 1328813490  82 HQVMERVAQAVKEHQQTLTPAPLQLD 107
Cdd:cd16159   495 QEIIKKILEAVAEHQSSIEPVESQLS 520
GALNS cd16157
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
 54-107 4.03e-10

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293776 [Multi-domain]  Cd Length: 466  Bit Score: 56.32  E-value: 4.03e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1328813490  54 HHDPPVLFNLSRDPSEAHPLTPATePLFHQVMERVAQAVKEHQQTLTPAPLQLD 107
Cdd:cd16157   407 HTKLPLLFHLGRDPGEKYPISFKS-AEYKQAMPRISKVVQQHQKTLVPGEPQLN 459
spARS_like cd16160
sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its ...
 3-88 7.83e-10

sea urchin arylsulfatase-like; This family includes sea urchin arylsulfatase and its homologous proteins. Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293779 [Multi-domain]  Cd Length: 445  Bit Score: 55.51  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490   3 YCEGFLHAARwYQRstgtvWKVHFTTPKFHPEGAGACYGRGVCP---------CSGAGVIHHDPPVLFNLSRDPSEAHPL 73
Cdd:cd16160   354 YCCSRLMAVR-YGS-----YKIHFKTQPLPSQESLDPNCDGGGPlsdyivcydCEDECVTKHNPPLIFDVEKDPGEQYPL 427

                          90
                  ....*....|....*
gi 1328813490  74 TPATEPLFHQVMERV 88
Cdd:cd16160   428 QPSVYEHMLEAVEKL 442
ARSA cd16158
Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely ...
 10-121 1.81e-07

Arylsulfatase A or cerebroside-sulfatase; Arylsulfatase A breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. It is a member of the sulfatase family. The arylsulfatase A was located in lysosome-like structures and transported to dense lysosomes in a mannose 6-phosphate receptor-dependent manner. Deficiency of arylsulfatase A leads to the accumulation of cerebroside sulfate, which causes a lethal progressive demyelination. Arylsulfatase A requires the posttranslational oxidation of the -CH2SH group of a conserved cysteine to an aldehyde, yielding a formylglycine to be in an active form.


Pssm-ID: 293777 [Multi-domain]  Cd Length: 479  Bit Score: 48.60  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490  10 AARWYQrstgtvWKVHF-TTPKFHPEGAG--ACYGRgvcpcsgAGVIHHDPPVLFNLSRDPSEAHPLTPATEplFHQVME 86
Cdd:cd16158   369 AVRWGK------YKAHFyTQGAAHSGTTPdkDCHPS-------AELTSHDPPLLFDLSQDPSENYNLLGLPE--YNQVLK 433

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1328813490  87 RVAQAVKEHQQTLTPAPLQLDSLNNiwrPWLQPCC 121
Cdd:cd16158   434 QIQQVKERFEASMKFGESEINKGED---PALEPCC 465
GALNS_like cd16026
galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal ...
 2-74 3.38e-06

galactosamine-6-sulfatase; also known as N-acetylgalactosamine-6-sulfatase (GALNS); Lysosomal galactosamine-6-sulfatase removes sulfate groups from a terminal N-acetylgalactosamine-6-sulfate (or galactose-6-sulfate) in mucopolysaccharides such as keratan sulfate and chondroitin-6-sulfate. Defects in GALNS lead to accumulation of substrates, resulting in the development of the lysosomal storage disease mucopolysaccharidosis IV A.


Pssm-ID: 293750 [Multi-domain]  Cd Length: 399  Bit Score: 44.86  E-value: 3.38e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1328813490   2 HYCEGFLHAARWyQRstgtvWKVHFTTPKFHPEGAGACYGrgvcpcsgagvIHHDPPVLFNLSRDPSEAHPLT 74
Cdd:cd16026   344 YYDGGDLQAVRS-GR-----WKLHLPTTYRTGTDPGGLDP-----------TKLEPPLLYDLEEDPGETYNVA 399
ARSG cd16161
arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze ...
 22-74 8.20e-05

arylsulfatase G; Arylsulfatase G is a subfamily of sulfatases which specifically hydrolyze sulfate esters in a wide variety of substrates such as glycosaminoglycans, steroid sulfates, or sulfolipids. ARSG has arylsulfatase activity toward different pseudosubstrates like p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. An active site Cys is post-translationally converted to the critical active site C(alpha)-formylglycine. ARSG mRNA expression was found to be tissue-specific with highest expression in liver, kidney, and pancreas, suggesting a metabolic role of ARSG that might be associated with a non-classified lysosomal storage disorder.


Pssm-ID: 293780 [Multi-domain]  Cd Length: 383  Bit Score: 40.92  E-value: 8.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1328813490  22 WKVHFTTpkfhpEGAGACYGrgvcpcSGAGVIHHDPPVLFNLSRDPSEAHPLT 74
Cdd:cd16161   342 YKAHYAT-----GGALACCG------STGPKLYHDPPLLFDLEVDPAESFPLT 383
ARS_like cd16142
uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters ...
 5-74 2.39e-04

uncharacterized arylsulfatase subfamily; Sulfatases catalyze the hydrolysis of sulfate esters from wide range of substrates, including steroids, carbohydrates and proteins. Sulfate esters may be formed from various alcohols and amines. The biological roles of sulfatase includes the cycling of sulfur in the environment, in the degradation of sulfated glycosaminoglycans and glycolipids in the lysosome, and in remodeling sulfated glycosaminoglycans in the extracellular space. The sulfatases are essential for human metabolism. At least eight human monogenic diseases are caused by the deficiency of individual sulfatases.


Pssm-ID: 293761 [Multi-domain]  Cd Length: 372  Bit Score: 39.44  E-value: 2.39e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1328813490   5 EGFLHAARWYQrstgtvWKVHFTTpkFHPEGAGACYGRGVCPCsgagvihhdpPVLFNLSRDPSEAHPLT 74
Cdd:cd16142   321 EGELGAVRWKN------WKVHFKA--QEDTGGPTGEPFYVLTF----------PLIFNLRRDPKERYDVT 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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