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Conserved domains on  [gi|916807007|ref|WP_051414063|]
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polynucleotide adenylyltransferase PcnB [Pseudoxanthomonas suwonensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
pcnB super family cl36036
poly(A) polymerase I; Provisional
 1-391 1.72e-161

poly(A) polymerase I; Provisional


The actual alignment was detected with superfamily member PRK11623:

Pssm-ID: 236939 [Multi-domain]  Cd Length: 472  Bit Score: 463.84  E-value: 1.72e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   1 MNPQALPQPVLRIIPRDQHILSRRDVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRN 80
Cdd:PRK11623  26 EAEQAVARPQMTVIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  81 CRLIGRRFRLAHVVYGREIIEVATFRANSDDGSGDR----EVEDGRLVRDNVYGTIEEDAVRRDFTCNALYYAIEDFSVR 156
Cdd:PRK11623 106 CRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNESDRntsqRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVR 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 157 DYVGGYEDVQARVMRLIGDPETRYREDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGH 236
Cdd:PRK11623 186 DYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGY 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 237 AVASFEGLERHGLLAALMPETAAALRSNRSGALRRMLLQGLANTDARVAADEPVSPAFLFALLLW-PAYCRALAGLQAQG 315
Cdd:PRK11623 266 GYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWyPLLEHAQKIAQESG 345

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916807007 316 MHAEEAQRRAADRVTLHQVQTIALPKRFSLPMQEIWLLQSRFSGRQRKRVFRLLAHPRFRAAYDFLVLRQAAADSH 391
Cdd:PRK11623 346 LAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVENNA 421
 
Name Accession Description Interval E-value
pcnB PRK11623
poly(A) polymerase I; Provisional
 1-391 1.72e-161

poly(A) polymerase I; Provisional


Pssm-ID: 236939 [Multi-domain]  Cd Length: 472  Bit Score: 463.84  E-value: 1.72e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   1 MNPQALPQPVLRIIPRDQHILSRRDVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRN 80
Cdd:PRK11623  26 EAEQAVARPQMTVIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  81 CRLIGRRFRLAHVVYGREIIEVATFRANSDDGSGDR----EVEDGRLVRDNVYGTIEEDAVRRDFTCNALYYAIEDFSVR 156
Cdd:PRK11623 106 CRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNESDRntsqRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVR 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 157 DYVGGYEDVQARVMRLIGDPETRYREDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGH 236
Cdd:PRK11623 186 DYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGY 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 237 AVASFEGLERHGLLAALMPETAAALRSNRSGALRRMLLQGLANTDARVAADEPVSPAFLFALLLW-PAYCRALAGLQAQG 315
Cdd:PRK11623 266 GYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWyPLLEHAQKIAQESG 345

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916807007 316 MHAEEAQRRAADRVTLHQVQTIALPKRFSLPMQEIWLLQSRFSGRQRKRVFRLLAHPRFRAAYDFLVLRQAAADSH 391
Cdd:PRK11623 346 LAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVENNA 421
pcnB TIGR01942
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ...
 13-417 6.50e-157

poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).


Pssm-ID: 130997 [Multi-domain]  Cd Length: 410  Bit Score: 450.02  E-value: 6.50e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   13 IIPRDQHILSRRDVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRNCRLIGRRFRLAH 92
Cdd:TIGR01942   1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   93 VVYGREIIEVATFRAnsddGSGDREVEDGRLVRDNVYGTIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQARVMRL 172
Cdd:TIGR01942  81 VSFGRQIIEVATFRS----GHKSSVNAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRRLRL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  173 IGDPETRYREDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGHAVASFEGLERHGLLAA 252
Cdd:TIGR01942 157 IGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQLLEP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  253 LMPETAAALRSNRSGALRRMLLQGLANTDARVAADEPVSPAFLFALLLWPAYCRALAGLQAQGMHAEEAQRRAADRVTLH 332
Cdd:TIGR01942 237 LFPSVAYALRESPKFESAFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQGVMPYPAVFDAIRDFVEE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  333 QVQTIALPKRFSLPMQEIWLLQSRFSGRQRKRVFRLLAHPRFRAAYDFLVLRQAAADSHAADVEFWRTAQQVSGDELAAS 412
Cdd:TIGR01942 317 QCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRENAVLGEWWTPYQLASEEERTEM 396


                  ....*
gi 916807007  413 LEAGA 417
Cdd:TIGR01942 397 TRSAA 401
PcnB COG0617
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ...
 25-411 4.24e-111

tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440382 [Multi-domain]  Cd Length: 391  Bit Score: 332.55  E-value: 4.24e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  25 DVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFR---NCRLIGRRFRLAHVVYGREIIE 101
Cdd:COG0617    1 RLSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGGEKIE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 102 VATFRAnsddgsgDREVEDGRLvRDNVYG-TIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQARVMRLIGDPETRY 180
Cdd:COG0617   81 VATART-------ERYYGDGRR-PFVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEERF 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 181 REDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGHAVASFEGLERHGLLAALmpetaaa 260
Cdd:COG0617  153 REDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL------- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 261 lrsnrsgalrrmllqglantdarvaadepvspAFLFALLLWPAYCRAlagLQAQGMHAEEAQRRAADRVTLHQVQTIALP 340
Cdd:COG0617  226 --------------------------------ALRLAALLHDLGKPA---TREDGLPTFHGHEEAGAELAEALLKRLRLP 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 341 KRFSLPMQEIWLLQSRFSGRQRKR---VFRLLAHpRFRAAYDFLVLRQAAAD--------SHAADVEFWRTAQQVSGDEL 409
Cdd:COG0617  271 NRERKLVRELVELHLRFHGLGELRdsaVRRLLER-GPEALEDLLLLRENGLEypelqerlAELLEAAWRRFQPPVDGEDL 349


                 ..
gi 916807007 410 AA 411
Cdd:COG0617  350 MA 351
PolyA_pol pfam01743
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ...
 44-171 4.10e-45

Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.


Pssm-ID: 396348 [Multi-domain]  Cd Length: 126  Bit Score: 152.82  E-value: 4.10e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   44 AYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRNCRLI----GRRFRLAHVVYGREIIEVATFRANSDDgsgdrevE 119
Cdd:pfam01743   1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVhllsGIEFGTIHVIFGNQILEVATFRIEFDE-------S 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 916807007  120 DGRLVRDNVY-GTIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQARVMR 171
Cdd:pfam01743  74 DFRNPRSEEYtGTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
NT_ClassII-CCAase cd05398
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ...
 27-167 2.99e-41

Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.


Pssm-ID: 143388 [Multi-domain]  Cd Length: 139  Bit Score: 143.12  E-value: 2.99e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  27 SPNALRVLYRLREA-GFGAYLVGGAVRDLLLGLHPKDFDVATDA-TPEQVKQLFR--NCRLIGR--RFRLAHVVYGREII 100
Cdd:cd05398    1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKkiGGRVVGLgeEFGTATVVINGLTI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 916807007 101 EVATFRansddgsGDREVEDGRLVRDNVYgTIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQA 167
Cdd:cd05398   81 DVATLR-------TETYTDPGRRPPVVGF-TIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
 
Name Accession Description Interval E-value
pcnB PRK11623
poly(A) polymerase I; Provisional
 1-391 1.72e-161

poly(A) polymerase I; Provisional


Pssm-ID: 236939 [Multi-domain]  Cd Length: 472  Bit Score: 463.84  E-value: 1.72e-161
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   1 MNPQALPQPVLRIIPRDQHILSRRDVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRN 80
Cdd:PRK11623  26 EAEQAVARPQMTVIPREQHAISRKDISENALKVLYRLNKAGYEAYLVGGGVRDLLLGKKPKDFDVTTNATPEQVRKLFRN 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  81 CRLIGRRFRLAHVVYGREIIEVATFRANSDDGSGDR----EVEDGRLVRDNVYGTIEEDAVRRDFTCNALYYAIEDFSVR 156
Cdd:PRK11623 106 CRLVGRRFRLAHVMFGPEIIEVATFRGHHEGNESDRntsqRGQNGMLLRDNIFGSIEEDAQRRDFTINSLYYSVADFTVR 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 157 DYVGGYEDVQARVMRLIGDPETRYREDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGH 236
Cdd:PRK11623 186 DYVGGMKDLKEGVIRLIGNPETRYREDPVRMLRAVRFAAKLDMRISPETAEPIPRLATLLNDIPPARLFEESLKLLQAGY 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 237 AVASFEGLERHGLLAALMPETAAALRSNRSGALRRMLLQGLANTDARVAADEPVSPAFLFALLLW-PAYCRALAGLQAQG 315
Cdd:PRK11623 266 GYETYKLLCEYHLFQPLFPTITRYFTENGDSPMERIIEQVLKNTDTRIHNDMRVNPAFLFAAMFWyPLLEHAQKIAQESG 345

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 916807007 316 MHAEEAQRRAADRVTLHQVQTIALPKRFSLPMQEIWLLQSRFSGRQRKRVFRLLAHPRFRAAYDFLVLRQAAADSH 391
Cdd:PRK11623 346 LAYYDAFALAMNDVLDEACRSLAIPKRLTTLTRDIWQLQLRMSRRQGKRAWKLMEHPKFRAAYDLLALRAEVENNA 421
pcnB TIGR01942
poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as ...
 13-417 6.50e-157

poly(A) polymerase; This model describes the pcnB family of poly(A) polymerases (also known as plasmid copy number protein). These enzymes sequentially add adenosine nucleotides to the 3' end of RNAs, targeting them for degradation by the cell. This was originally described for anti-sense RNAs, but was later demonstrated for mRNAs as well. Members of this family are as yet limited to the gamma- and beta-proteobacteria, with putative members in the Chlamydiacae and spirochetes. This family has homology to tRNA nucleotidyltransferase (cca).


Pssm-ID: 130997 [Multi-domain]  Cd Length: 410  Bit Score: 450.02  E-value: 6.50e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   13 IIPRDQHILSRRDVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRNCRLIGRRFRLAH 92
Cdd:TIGR01942   1 VIPESEHNIPRQSFSAHALNVVERLKGAGYQAYIVGGAVRDLLLGIEPKDFDVVTSATPEEVRKLFRNSRIVGRRFRLVH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   93 VVYGREIIEVATFRAnsddGSGDREVEDGRLVRDNVYGTIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQARVMRL 172
Cdd:TIGR01942  81 VSFGRQIIEVATFRS----GHKSSVNAEGRILKDNVYGTLEEDAWRRDFTVNALYYDPSREVIIDYVGGMEDLKNRRLRL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  173 IGDPETRYREDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGHAVASFEGLERHGLLAA 252
Cdd:TIGR01942 157 IGDPRSRYQEDPVRMLRALRFSVKLEFTIDESTARPIRESAPLLKGIPPARLFEEILKLLFSGRSAALFRMLCGYQLLEP 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  253 LMPETAAALRSNRSGALRRMLLQGLANTDARVAADEPVSPAFLFALLLWPAYCRALAGLQAQGMHAEEAQRRAADRVTLH 332
Cdd:TIGR01942 237 LFPSVAYALRESPKFESAFTVQALVNDTDFRVKRDKPVTPAFLYAALLWPGLVFRVADAPDQGVMPYPAVFDAIRDFVEE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  333 QVQTIALPKRFSLPMQEIWLLQSRFSGRQRKRVFRLLAHPRFRAAYDFLVLRQAAADSHAADVEFWRTAQQVSGDELAAS 412
Cdd:TIGR01942 317 QCAPISIPKRFSIPTREIWQMQLRLERRSGMRARKLLGHARFRAAYDLLLLREVCGRENAVLGEWWTPYQLASEEERTEM 396


                  ....*
gi 916807007  413 LEAGA 417
Cdd:TIGR01942 397 TRSAA 401
PcnB COG0617
tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and ...
 25-411 4.24e-111

tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; tRNA nucleotidyltransferase/poly(A) polymerase is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440382 [Multi-domain]  Cd Length: 391  Bit Score: 332.55  E-value: 4.24e-111
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  25 DVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFR---NCRLIGRRFRLAHVVYGREIIE 101
Cdd:COG0617    1 RLSPNALKVLEALEEAGFEAYLVGGAVRDLLLGRPPKDIDIVTVATPEEVAALFRkalRTVPVGRDFGTVTVVFGGEKIE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 102 VATFRAnsddgsgDREVEDGRLvRDNVYG-TIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQARVMRLIGDPETRY 180
Cdd:COG0617   81 VATART-------ERYYGDGRR-PFVEFGdTLEEDLARRDFTINALAYDLNDGELIDPFGGLADLEARVIRTVGDPEERF 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 181 REDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGHAVASFEGLERHGLLAALmpetaaa 260
Cdd:COG0617  153 REDPLRILRAVRFAARLGFTIEPETLAAIREMAGLLDRLSAERVWDELLKLLLSPHPSRGLELLRETGLLEVL------- 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 261 lrsnrsgalrrmllqglantdarvaadepvspAFLFALLLWPAYCRAlagLQAQGMHAEEAQRRAADRVTLHQVQTIALP 340
Cdd:COG0617  226 --------------------------------ALRLAALLHDLGKPA---TREDGLPTFHGHEEAGAELAEALLKRLRLP 270

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 341 KRFSLPMQEIWLLQSRFSGRQRKR---VFRLLAHpRFRAAYDFLVLRQAAAD--------SHAADVEFWRTAQQVSGDEL 409
Cdd:COG0617  271 NRERKLVRELVELHLRFHGLGELRdsaVRRLLER-GPEALEDLLLLRENGLEypelqerlAELLEAAWRRFQPPVDGEDL 349


                 ..
gi 916807007 410 AA 411
Cdd:COG0617  350 MA 351
PRK13299 PRK13299
tRNA CCA-pyrophosphorylase; Provisional
 30-244 8.00e-55

tRNA CCA-pyrophosphorylase; Provisional


Pssm-ID: 237339 [Multi-domain]  Cd Length: 394  Bit Score: 186.97  E-value: 8.00e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  30 ALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRNCRLIGRRFRLAHVVYGREIIEVATFRANS 109
Cdd:PRK13299   9 ALPILEKIKEAGFEAYFVGGSVRDYLLGRPIHDVDIATSAYPEEVKAIFPRTVDVGIEHGTVLVLENGEEYEVTTFRTES 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 110 ddgsgdrEVEDGR------LVRDnvygtIEEDAVRRDFTCNALyyAI-EDFSVRDYVGGYEDVQARVMRLIGDPETRYRE 182
Cdd:PRK13299  89 -------EYVDYRrpsevtFVRS-----LEEDLKRRDFTINAI--AMdENGEIIDLFDGLEDLKNRLIRAVGNAEERFQE 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916807007 183 DPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGHAVASFEGL 244
Cdd:PRK13299 155 DALRMMRAVRFASQLGFDLETETFEAMKTQAPLLEKISVERIFVEFEKLLLGPFWRKGLKLL 216
PolyA_pol pfam01743
Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, ...
 44-171 4.10e-45

Poly A polymerase head domain; This family includes nucleic acid independent RNA polymerases, such as Poly(A) polymerase, which adds the poly (A) tail to mRNA EC:2.7.7.19. This family also includes the tRNA nucleotidyltransferase that adds the CCA to the 3' of the tRNA EC:2.7.7.25. This family is part of the nucleotidyltransferase superfamily.


Pssm-ID: 396348 [Multi-domain]  Cd Length: 126  Bit Score: 152.82  E-value: 4.10e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007   44 AYLVGGAVRDLLLGLHPKDFDVATDATPEQVKQLFRNCRLI----GRRFRLAHVVYGREIIEVATFRANSDDgsgdrevE 119
Cdd:pfam01743   1 LYIVGGAVRDLLLGKTPKDVDIATDATPEQVATLFRRRRIVhllsGIEFGTIHVIFGNQILEVATFRIEFDE-------S 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 916807007  120 DGRLVRDNVY-GTIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQARVMR 171
Cdd:pfam01743  74 DFRNPRSEEYtGTLEEDAKRRDFTINALAYNPNSGEVIDYFGGIKDLKSGVIR 126
NT_ClassII-CCAase cd05398
Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the ...
 27-167 2.99e-41

Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; CCA-adding enzymes add the sequence [cytidine(C)-cytidine-adenosine (A)], one nucleotide at a time, onto the 3' end of tRNA, in a template-independent reaction. This Class II group is comprised mainly of eubacterial and eukaryotic enzymes and includes Bacillus stearothermophilus CCAase, Escherichia coli poly(A) polymerase I, human mitochondrial CCAase, and Saccharomyces cerevisiae CCAase (CCA1). CCA-adding enzymes have a single catalytic pocket, which recognizes both ATP and CTP substrates. Included in this subgroup are CC- and A-adding enzymes from various ancient species of bacteria such as Aquifex aeolicus; these enzymes collaborate to add CCA to tRNAs. This family belongs to the Pol beta-like NT superfamily. In the majority of enzymes in this superfamily, two carboxylates, Dx[D/E], together with a third more distal carboxylate, coordinate two divalent metal cations involved in a two-metal ion mechanism of nucleotide addition. These carboxylate residues are fairly well conserved in this family. Escherichia coli CCAase is related to this group but has not been included in this alignment as this enzyme lacks the N-terminal helix conserved in the remainder of the NT superfamily.


Pssm-ID: 143388 [Multi-domain]  Cd Length: 139  Bit Score: 143.12  E-value: 2.99e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  27 SPNALRVLYRLREA-GFGAYLVGGAVRDLLLGLHPKDFDVATDA-TPEQVKQLFR--NCRLIGR--RFRLAHVVYGREII 100
Cdd:cd05398    1 TPELLKLLRELKKAlGYEAYLVGGAVRDLLLGRPPKDIDIATDAdGPEFAEALFKkiGGRVVGLgeEFGTATVVINGLTI 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 916807007 101 EVATFRansddgsGDREVEDGRLVRDNVYgTIEEDAVRRDFTCNALYYAIEDFSVRDYVGGYEDVQA 167
Cdd:cd05398   81 DVATLR-------TETYTDPGRRPPVVGF-TIEEDLLRRDFTINAMAYDLDDGELIDPFGGLKDLEN 139
PolyA_pol_arg_C pfam12626
Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is ...
 314-418 3.13e-35

Polymerase A arginine-rich C-terminus; The C-terminus of polymerase A in E coli is arginine-rich and is necessary for full functioning of the enzyme.


Pssm-ID: 463647 [Multi-domain]  Cd Length: 116  Bit Score: 126.55  E-value: 3.13e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  314 QGMHAEEAQRRAADRVTLHQVQTIALPKRFSLPMQEIWLLQSRFSGRQRKRVFRLLAHPRFRAAYDFLVLRQAAADSHAA 393
Cdd:pfam12626   1 QGLPPYDALQLAADEVLDEQCQRVAIPRRFTAPMREIWLLQPRLEKRQGKRPFRLLEHPRFRAAYDFLLLRAESGEVLQE 80

                          90       100
                  ....*....|....*....|....*
gi 916807007  394 DVEFWRTAQQVSGDELAASLEAGAA 418
Cdd:pfam12626  81 LAEWWTRFQEADEAEREAMIAELGA 105
PolyA_pol_RNAbd pfam12627
Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA ...
 198-261 1.96e-20

Probable RNA and SrmB- binding site of polymerase A; This region encompasses much of the RNA and SrmB binding motifs on polymerase A.


Pssm-ID: 463648 [Multi-domain]  Cd Length: 64  Bit Score: 84.46  E-value: 1.96e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 916807007  198 GFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGHAVASFEGLERHGLLAALMPETAAAL 261
Cdd:pfam12627   1 GFTIEPETREAIRKLAPLLKKISPERIFEELLKLLLSGHPERGLELLRETGLLEYLFPELAAAL 64
PRK13297 PRK13297
tRNA CCA-pyrophosphorylase; Provisional
 40-256 3.63e-17

tRNA CCA-pyrophosphorylase; Provisional


Pssm-ID: 139469 [Multi-domain]  Cd Length: 364  Bit Score: 82.74  E-value: 3.63e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  40 AGFGAYLVGGAVRDLLLGLHPKDFD-VATDATPEQVKQlfRNCRLIGRRFRLahVVYGREIIEVATFRANSDDGSGDRev 118
Cdd:PRK13297  10 AGLQVYIVGGAVRDALLGLPAGDRDwVVVGATPEDMAR--RGFIPVGGDFPV--FLHPRTKEEYALARTERKSGRGYK-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 119 edGRLVRDNVYGTIEEDAVRRDFTCNALYYAIEDfSVRDYVGGYEDVQARVMRLIGDPetrYREDPVRMLRAVRLAAKLG 198
Cdd:PRK13297  84 --GFTFYTGADVTLEQDLQRRDLTVNAIARTPQG-ELVDPLDGVADVRARVLRHVGEA---FAEDPVRILRLGRFAARFG 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 916807007 199 -FSIEPATAAPIPLLAPlLGEA---APARLFEEMLKLFLSGHAVASFEGLERHGLLAALMPE 256
Cdd:PRK13297 158 dFSIAPETMQLCRRMVE-AGEAdalVPERVWKEVSRGLMAQAPSRMLDVLARAGALARVMPE 218
cca PRK10885
multifunctional CCA addition/repair protein;
45-256 1.88e-16

multifunctional CCA addition/repair protein;


Pssm-ID: 182810 [Multi-domain]  Cd Length: 409  Bit Score: 80.67  E-value: 1.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  45 YLVGGAVRDLLLGLHPKDFD-VATDATPEQ-VKQLFRNcrlIGRRFRL-AHVVYGREiieVATFRANSDDGSG------- 114
Cdd:PRK10885   4 YLVGGAVRDALLGLPVKDRDwVVVGATPEEmLAQGYQQ---VGKDFPVfLHPKTHEE---YALARTERKSGRGytgftcy 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 115 -DREVedgrlvrdnvygTIEEDAVRRDFTCNALYYAiEDFSVRDYVGGYEDVQARVMRLIGDPetrYREDPVRMLRAVRL 193
Cdd:PRK10885  78 aAPDV------------TLEEDLIRRDLTINAMAQD-DDGELIDPYGGQRDLEARLLRHVSPA---FAEDPLRVLRVARF 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 916807007 194 AAK---LGFSIEPATAApipLLAPLL--GEAA---PARLFEEMLKLFLSGHAVASFEGLERHGLLAALMPE 256
Cdd:PRK10885 142 AARfahLGFRIAPETLA---LMREMVasGELDaltPERVWKETERALMERNPQVFFQVLRDCGALAVLLPE 209
PRK13298 PRK13298
tRNA CCA-pyrophosphorylase; Provisional
 45-256 2.13e-15

tRNA CCA-pyrophosphorylase; Provisional


Pssm-ID: 237338 [Multi-domain]  Cd Length: 417  Bit Score: 77.85  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  45 YLVGGAVRDLLLGLHPKDFD-VATDATPEQVkqLFRNCRLIGRRFRLAHVVYGREiiEVATFRANSDDGSGdrevEDGRL 123
Cdd:PRK13298   4 YLVGGAVRDSLLNLPVKDKDwVVVGGTPKIL--LSINFQQVGKDFPVFLHPETHE--EYALARTERKSGVG----YTGFI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 124 VRDNVYGTIEEDAVRRDFTCNALYYAiEDFSVRDYVGGYEDVQARVMRLIGDPetrYREDPVRMLRAVRLAAK---LGFS 200
Cdd:PRK13298  76 TDTSSDVTLEEDLIRRDLTINAIAQD-ENGNYIDPFQGKKDIQLRLLRHVSES---FIEDPLRVLRVARFAALlvhLGFK 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 916807007 201 IEPATAAPIPLLAPL--LGEAAPARLFEEMLKLFLSGHAVASFEGLERHGLLAALMPE 256
Cdd:PRK13298 152 IAKETMILMCIMVKKheLLYLTPERIWNETEKALKTDNPHVYFQVLYECNALKFLFPE 209
PRK13296 PRK13296
CCA tRNA nucleotidyltransferase;
45-205 4.21e-12

CCA tRNA nucleotidyltransferase;


Pssm-ID: 106256 [Multi-domain]  Cd Length: 360  Bit Score: 67.32  E-value: 4.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007  45 YLVGGAVRDLLLGLHPKDFD-VATDATPEQ-VKQLFRNcrlIGRRFRLahVVYGREIIEVATFRANSDDGSGDREVEdgr 122
Cdd:PRK13296   4 YLVGGAVRDMLLGITPKDKDwVVVGATEDEmLANGFIK---IAANFPV--FIHPQTKQEYALARSEKKTASGYHGFE--- 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 123 lVRDNVYGTIEEDAVRRDFTCNALyyAIE-DFSVRDYVGGYEDVQARVMRligDPETRYREDPVRMLRAVRLAAKLG--- 198
Cdd:PRK13296  76 -VNFSKYITLEDDLKRRDLTINSI--AIDqNNKVIDPFNGQADLQNRILR---HTSIAFIEDPLRVVRLARFKAQLSnfn 149


                 ....*..
gi 916807007 199 FSIEPAT 205
Cdd:PRK13296 150 FSIAQEM 156
PHA01806 PHA01806
hypothetical protein
 12-77 1.12e-05

hypothetical protein


Pssm-ID: 222838  Cd Length: 200  Bit Score: 46.03  E-value: 1.12e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 916807007  12 RIIPRDQHILSRrDVSPNALRVLYRLREAGFGAYLVGGAVRDLLLGLHPKDFDVATDA-TPEQVKQL 77
Cdd:PHA01806   7 DLLEGTKEIPEG-LIAKALLLRLYSDARHSEGVALAGGAARDLMHGAEPKDIDIALYGmDDRQAELL 72
PRK03381 PRK03381
PII uridylyl-transferase; Provisional
 179-259 7.95e-03

PII uridylyl-transferase; Provisional


Pssm-ID: 235123 [Multi-domain]  Cd Length: 774  Bit Score: 38.82  E-value: 7.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 916807007 179 RYREDPVRMLRAVRLAAKLGFSIEPATAAPIPLLAPLLGEAAPARLFEEMLKLFLSGH-AVASFEGLERHGLLAALMPET 257
Cdd:PRK03381 325 RPARDPGLVLRVAAAAATTGLPIAAATLSRLAASAPPLPTPWPAEARDDLLVLLGAGPaAVAVIEALDRTGLWGRLLPEW 404


                 ..
gi 916807007 258 AA 259
Cdd:PRK03381 405 EA 406
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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