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Conserved domains on  [gi|844790481|ref|WP_047939476|]
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MULTISPECIES: type I restriction-modification system subunit M [Corynebacterium]

Protein Classification

type I restriction-modification system subunit M( domain architecture ID 13779125)

type I restriction-modification system modification (M) subunit (HsdM), together with specificity (S) subunit (HsdS), forms a methyltransferase that methylates two adenine residues in complementary strands of a bipartite DNA recognition sequence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
120-368 7.05e-100

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


:

Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 299.41  E-value: 7.05e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 120 EGLGNLYEGLLEKNANEKKSGAGQYFTPRVLIDVMVRLIDPQPGERCNDPACGTFGFMIAASEYVRRNTDNhysldgDRA 199
Cdd:COG0286    1 DVLGDAYEYLLRKFAEESGKKAGEFYTPREVVRLMVELLDPKPGETVYDPACGSGGFLVEAAEYLKEHGGD------ERK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 200 EFQvkeaFTGVELVHDTHRLALMNAMLHNIEAP-IYLGDTLSPLGKGLNGYDVVLTNPPFGTKRGGERATRDDL------ 272
Cdd:COG0286   75 KLS----LYGQEINPTTYRLAKMNLLLHGIGDPnIELGDTLSNDGDELEKFDVVLANPPFGGKWKKEELKDDLLgrfgyg 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 273 TFPTSNKQLNFLQHIYRSLKRGGRAAVVLPDNVLFAdGDGRRIREDLMNKCNMHTILRLPTGIFYANGVKTNVLFFERGt 352
Cdd:COG0286  151 LPPKSNADLLFLQHILSLLKPGGRAAVVLPDGVLFR-GAEKEIRKKLLENDLLEAIIGLPSNLFYNTGIPTCILFLTKG- 228

                        250
                 ....*....|....*.
gi 844790481 353 tDKENTKEVWFYDLRT 368
Cdd:COG0286  229 -KPERTGKVLFIDASK 243
HsdM_N pfam12161
HsdM N-terminal domain; This domain is found at the N-terminus of the methylase subunit of ...
 6-109 4.31e-12

HsdM N-terminal domain; This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. The family is found in association with pfam02384. Mutations in this region of EcoKI methyltransferase abolish the normally strong preference of this system for methylating hemimethylated substrate. The structure of this domain has been shown to be all alpha-helical.


:

Pssm-ID: 463478  Cd Length: 123  Bit Score: 63.09  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481    6 IVAKLWNLCNVLRDDgITYHQYVTELTYLLFLKM--AKETDTEK---------------YLPEGFRWDDLR-VLEGIELK 67
Cdd:pfam12161   1 LESFLWNAADILRGD-VDASEYKEYILPLLFLKRldDVLEEREEevleliepldsgfgfYIPSELRWSKLAnNLDNDELG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 844790481   68 KFYQDMLRELGEGSTSRVREIYTGAQTNI--DEPKNLKKIIDAI 109
Cdd:pfam12161  80 ENLNDAFPGLEELNPDLRGVFMKDARGIItlKSPDLLKKVIQKF 123
 
Name Accession Description Interval E-value
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
120-368 7.05e-100

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 299.41  E-value: 7.05e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 120 EGLGNLYEGLLEKNANEKKSGAGQYFTPRVLIDVMVRLIDPQPGERCNDPACGTFGFMIAASEYVRRNTDNhysldgDRA 199
Cdd:COG0286    1 DVLGDAYEYLLRKFAEESGKKAGEFYTPREVVRLMVELLDPKPGETVYDPACGSGGFLVEAAEYLKEHGGD------ERK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 200 EFQvkeaFTGVELVHDTHRLALMNAMLHNIEAP-IYLGDTLSPLGKGLNGYDVVLTNPPFGTKRGGERATRDDL------ 272
Cdd:COG0286   75 KLS----LYGQEINPTTYRLAKMNLLLHGIGDPnIELGDTLSNDGDELEKFDVVLANPPFGGKWKKEELKDDLLgrfgyg 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 273 TFPTSNKQLNFLQHIYRSLKRGGRAAVVLPDNVLFAdGDGRRIREDLMNKCNMHTILRLPTGIFYANGVKTNVLFFERGt 352
Cdd:COG0286  151 LPPKSNADLLFLQHILSLLKPGGRAAVVLPDGVLFR-GAEKEIRKKLLENDLLEAIIGLPSNLFYNTGIPTCILFLTKG- 228

                        250
                 ....*....|....*.
gi 844790481 353 tDKENTKEVWFYDLRT 368
Cdd:COG0286  229 -KPERTGKVLFIDASK 243
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 122-423 6.47e-88

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 271.12  E-value: 6.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  122 LGNLYEGLLEKNANEKKSGAGQYFTPRVLIDVMVRLIDPQPGERCNDPACGTFGFMIAASEYVrrntdnhYSLDGDRAEF 201
Cdd:pfam02384   5 FGDAYEYLLRKFAPNAGKSGGEFFTPREVSKLIVELLDPKPGESIYDPACGSGGFLIQAEKFV-------KEHDGDTNDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  202 QvkeaFTGVELVHDTHRLALMNAMLHNIEAP---IYLGDTL-SPLGKGLNGYDVVLTNPPFGTKRGGERATRDDLTF--- 274
Cdd:pfam02384  78 S----IYGQEKNPTTYRLARMNMILHGIEYDdfhIRHGDTLtSPKFEDDKKFDVVVANPPFSDKWDANDTLENDPRFrpa 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  275 ----PTSNKQLNFLQHIYRSLKRGGRAAVVLPDNVLFADGDGRRIREDLMNKCNMHTILRLPTGIFYANGVKTNVLFFER 350
Cdd:pfam02384 154 ygvaPKSNADLAFLQHIIYYLAPGGRAAVVLPNGVLFRGGAEGKIRKALVDKDLVETVIALPPNLFYNTSIPTCILFLTK 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 844790481  351 GTTDKenTKEVWFYDLRTNMPSFGKRTPLTKEHFAGFAAAYTStdrttlvDDRLSHF----TRAEIAAKDDSLDLGL 423
Cdd:pfam02384 234 NKAER--KGKVLFIDASNEFKKEGKLNILTDEHIEKIIDTFGE-------FKDVDGFsksaTLEEIAANDYNLNVGR 301
HsdM_N pfam12161
HsdM N-terminal domain; This domain is found at the N-terminus of the methylase subunit of ...
 6-109 4.31e-12

HsdM N-terminal domain; This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. The family is found in association with pfam02384. Mutations in this region of EcoKI methyltransferase abolish the normally strong preference of this system for methylating hemimethylated substrate. The structure of this domain has been shown to be all alpha-helical.


Pssm-ID: 463478  Cd Length: 123  Bit Score: 63.09  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481    6 IVAKLWNLCNVLRDDgITYHQYVTELTYLLFLKM--AKETDTEK---------------YLPEGFRWDDLR-VLEGIELK 67
Cdd:pfam12161   1 LESFLWNAADILRGD-VDASEYKEYILPLLFLKRldDVLEEREEevleliepldsgfgfYIPSELRWSKLAnNLDNDELG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 844790481   68 KFYQDMLRELGEGSTSRVREIYTGAQTNI--DEPKNLKKIIDAI 109
Cdd:pfam12161  80 ENLNDAFPGLEELNPDLRGVFMKDARGIItlKSPDLLKKVIQKF 123
 
Name Accession Description Interval E-value
HsdM COG0286
Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];
120-368 7.05e-100

Type I restriction-modification system, DNA methylase subunit [Defense mechanisms];


Pssm-ID: 440055 [Multi-domain]  Cd Length: 243  Bit Score: 299.41  E-value: 7.05e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 120 EGLGNLYEGLLEKNANEKKSGAGQYFTPRVLIDVMVRLIDPQPGERCNDPACGTFGFMIAASEYVRRNTDNhysldgDRA 199
Cdd:COG0286    1 DVLGDAYEYLLRKFAEESGKKAGEFYTPREVVRLMVELLDPKPGETVYDPACGSGGFLVEAAEYLKEHGGD------ERK 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 200 EFQvkeaFTGVELVHDTHRLALMNAMLHNIEAP-IYLGDTLSPLGKGLNGYDVVLTNPPFGTKRGGERATRDDL------ 272
Cdd:COG0286   75 KLS----LYGQEINPTTYRLAKMNLLLHGIGDPnIELGDTLSNDGDELEKFDVVLANPPFGGKWKKEELKDDLLgrfgyg 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 273 TFPTSNKQLNFLQHIYRSLKRGGRAAVVLPDNVLFAdGDGRRIREDLMNKCNMHTILRLPTGIFYANGVKTNVLFFERGt 352
Cdd:COG0286  151 LPPKSNADLLFLQHILSLLKPGGRAAVVLPDGVLFR-GAEKEIRKKLLENDLLEAIIGLPSNLFYNTGIPTCILFLTKG- 228

                        250
                 ....*....|....*.
gi 844790481 353 tDKENTKEVWFYDLRT 368
Cdd:COG0286  229 -KPERTGKVLFIDASK 243
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 122-423 6.47e-88

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 271.12  E-value: 6.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  122 LGNLYEGLLEKNANEKKSGAGQYFTPRVLIDVMVRLIDPQPGERCNDPACGTFGFMIAASEYVrrntdnhYSLDGDRAEF 201
Cdd:pfam02384   5 FGDAYEYLLRKFAPNAGKSGGEFFTPREVSKLIVELLDPKPGESIYDPACGSGGFLIQAEKFV-------KEHDGDTNDL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  202 QvkeaFTGVELVHDTHRLALMNAMLHNIEAP---IYLGDTL-SPLGKGLNGYDVVLTNPPFGTKRGGERATRDDLTF--- 274
Cdd:pfam02384  78 S----IYGQEKNPTTYRLARMNMILHGIEYDdfhIRHGDTLtSPKFEDDKKFDVVVANPPFSDKWDANDTLENDPRFrpa 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  275 ----PTSNKQLNFLQHIYRSLKRGGRAAVVLPDNVLFADGDGRRIREDLMNKCNMHTILRLPTGIFYANGVKTNVLFFER 350
Cdd:pfam02384 154 ygvaPKSNADLAFLQHIIYYLAPGGRAAVVLPNGVLFRGGAEGKIRKALVDKDLVETVIALPPNLFYNTSIPTCILFLTK 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 844790481  351 GTTDKenTKEVWFYDLRTNMPSFGKRTPLTKEHFAGFAAAYTStdrttlvDDRLSHF----TRAEIAAKDDSLDLGL 423
Cdd:pfam02384 234 NKAER--KGKVLFIDASNEFKKEGKLNILTDEHIEKIIDTFGE-------FKDVDGFsksaTLEEIAANDYNLNVGR 301
HsdM_N pfam12161
HsdM N-terminal domain; This domain is found at the N-terminus of the methylase subunit of ...
 6-109 4.31e-12

HsdM N-terminal domain; This domain is found at the N-terminus of the methylase subunit of Type I DNA methyltransferases. This domain family is found in bacteria and archaea, and is typically between 123 and 138 amino acids in length. The family is found in association with pfam02384. Mutations in this region of EcoKI methyltransferase abolish the normally strong preference of this system for methylating hemimethylated substrate. The structure of this domain has been shown to be all alpha-helical.


Pssm-ID: 463478  Cd Length: 123  Bit Score: 63.09  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481    6 IVAKLWNLCNVLRDDgITYHQYVTELTYLLFLKM--AKETDTEK---------------YLPEGFRWDDLR-VLEGIELK 67
Cdd:pfam12161   1 LESFLWNAADILRGD-VDASEYKEYILPLLFLKRldDVLEEREEevleliepldsgfgfYIPSELRWSKLAnNLDNDELG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 844790481   68 KFYQDMLRELGEGSTSRVREIYTGAQTNI--DEPKNLKKIIDAI 109
Cdd:pfam12161  80 ENLNDAFPGLEELNPDLRGVFMKDARGIItlKSPDLLKKVIQKF 123
YtxK COG0827
Adenine-specific DNA N6-methylase [Replication, recombination and repair];
88-396 1.28e-10

Adenine-specific DNA N6-methylase [Replication, recombination and repair];


Pssm-ID: 440589 [Multi-domain]  Cd Length: 327  Bit Score: 62.66  E-value: 1.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  88 IYTGAQTNIDEPKNLKKIIDAINDLDWYS-AREEGLGNLYEGLLeKNANEKKSGAGQYfTPRVLIDVMVRLID---PQPG 163
Cdd:COG0827   39 LLDGEVEGKPTEEAKKKLKKNYQKLQLESlSKEEIRKALQLALL-KGMKESVQPNHQM-TPDAIGLLIGYLVEkftKKEG 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 164 ERCNDPACGTFGFMIAASEYVRRNTDNHysldgdraefqvkeaftGVELvhDTH--RLALMNAMLHNIEAPIYLGDTLSP 241
Cdd:COG0827  117 LRILDPAVGTGNLLTTVLNQLKKKVNAY-----------------GVEV--DDLliRLAAVLANLQGHPVELFHQDALQP 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 242 LgkgLNG-YDVVLTNPPFGTKRGGERATRDDLTFPTSNKQLNFL---QHIyRSLKRGGRAAVVLPDNvLFADGDGRRIRE 317
Cdd:COG0827  178 L---LIDpVDVVISDLPVGYYPNDERAKRFKLKADEGHSYAHHLfieQSL-NYLKPGGYLFFLVPSN-LFESDQAAQLRE 252

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 844790481 318 DLMNKCNMHTILRLPTGIFYANGVKTNVLFFERGTTDKENTKEVWFYDLrtnmPSFgKRTPLTKEHFAGFAAAYTSTDR 396
Cdd:COG0827  253 FLKEKAHIQGLIQLPESLFKNEAAAKSILILQKKGEGTKQPKEVLLAQL----PSF-KNPEAMKKFLEQINKWFKENKK 326
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 153-309 1.60e-09

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 56.98  E-value: 1.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  153 VMVRLIDPQPGERCNDPACGTFGFMI-AASEYVRRNTDNHysldgdraEFQVKEAFTGVELVHDTHRLALMNAMLHNIEA 231
Cdd:pfam01170  19 AMVNLAGWKPGDPLLDPMCGSGTILIeAALMGANIAPGKF--------DARVRAPLYGSDIDRRMVQGARLNAENAGVGD 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481  232 PIYLGDTL-SPLGKGLNGYDVVLTNPPFGTKRGGERAtrddltfptsNKQL--NFLQHIYRSLKRGGRAAVVLPDNVLFA 308
Cdd:pfam01170  91 LIEFVQADaADLPLLEGSVDVIVTNPPYGIRLGSKGA----------LEALypEFLREAKRVLRGGGWLVLLTAENKDFE 160


                  .
gi 844790481  309 D 309
Cdd:pfam01170 161 K 161
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 153-303 4.08e-06

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 46.87  E-value: 4.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 153 VMVRLIDPQPGERCNDPACGTFGFMIAASEYVRRntdnhySLDGDRAEFQVkeaftgvelvhdthRLALMNAMLHNIEAP 232
Cdd:COG1041   17 ALVNLAGAKEGDTVLDPFCGTGTILIEAGLLGRR------VIGSDIDPKMV--------------EGARENLEHYGYEDA 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 844790481 233 -IYLGDTLS-PLGKGLngYDVVLTNPPFGTKRGGERATRDDLTfptsnkqLNFLQHIYRSLKRGGRAAVVLPD 303
Cdd:COG1041   77 dVIRGDARDlPLADES--VDAIVTDPPYGRSSKISGEELLELY-------EKALEEAARVLKPGGRVVIVTPR 140
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 219-300 2.09e-05

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 45.18  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 219 LALMNAMLHNIE-APIYLGDTLSPLGKGlnGYDVVLTNPPFgtKRGgeRATRDDLTfptsnkqLNFLQHIYRSLKRGGRA 297
Cdd:COG2813   88 LARANAAANGLEnVEVLWSDGLSGVPDG--SFDLILSNPPF--HAG--RAVDKEVA-------HALIADAARHLRPGGEL 154


                 ...
gi 844790481 298 AVV 300
Cdd:COG2813  155 WLV 157
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
143-267 2.09e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 42.20  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 143 QYFTPRVLIDVMVRLIDPQ---PGERCNDPACGTFGFMIAASeyvrrntdnhySLDGDRAefqvkeafTGVELVHDTHRL 219
Cdd:COG2263   23 QYPTPAELAAELLHLAYLRgdiEGKTVLDLGCGTGMLAIGAA-----------LLGAKKV--------VGVDIDPEALEI 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 844790481 220 ALMNAMLHNIEAPIYLGDTLSPLGKGlnGYDVVLTNPPFGT-KRGGERA 267
Cdd:COG2263   84 ARENAERLGVRVDFIRADVTRIPLGG--SVDTVVMNPPFGAqRRHADRP 130
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 207-302 1.68e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 40.13  E-value: 1.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 207 FTGVELVHDTHRLALMNAMLHNIEAPI--YLGD--TLSPLGKGlNGYDVVLTNPPF---GTKRGGERATR------DDLT 273
Cdd:COG4123   64 ITGVEIQPEAAELARRNVALNGLEDRItvIHGDlkEFAAELPP-GSFDLVVSNPPYfkaGSGRKSPDEARaiarheDALT 142

                         90       100
                 ....*....|....*....|....*....
gi 844790481 274 FPTsnkqlnFLQHIYRSLKRGGRAAVVLP 302
Cdd:COG4123  143 LED------LIRAAARLLKPGGRFALIHP 165
YhdJ COG0863
DNA modification methylase [Replication, recombination and repair];
233-387 3.63e-03

DNA modification methylase [Replication, recombination and repair];


Pssm-ID: 440623  Cd Length: 236  Bit Score: 38.75  E-value: 3.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 233 IYLGDTLSPLgKGLNG--YDVVLTNPPFGTKRGGERATRDDLTFPTSNKQLNFL----QHIYRSLKRGGRAAVVLPDNVL 306
Cdd:COG0863    2 LICGDCLEVL-KELPDesVDLIVTDPPYNLGKKYGLGRREIGNELSFEEYLEFLrewlAECYRVLKPGGSLYVNIGDRYI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 307 F-----ADGDGRRIREDL-MNKCNMhtiLRLPTGIFYANGVKTnVLFFERGTTDKENTKEVWFYDLRTNMPSF----GKR 376
Cdd:COG0863   81 SrliaaLRDAGFKLRNEIiWRKPNG---VPGPSKRRFRNSHEY-ILWFTKGKKYTFNVDAVKSIEDGRNPSDVwdipGVT 156

                        170
                 ....*....|.
gi 844790481 377 TPLTKEHFAGF 387
Cdd:COG0863  157 PKERKGHPTQK 167
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 148-257 9.25e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 38.23  E-value: 9.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 844790481 148 RVLIDVMVRLIDPQPGER-----CndpACGTFGFMIAAseyvrrntdnhysldgdraefQVKEAfTGVELVHDTHRLALM 222
Cdd:COG2265  219 EALYAAALEWLDLTGGERvldlyC---GVGTFALPLAR---------------------RAKKV-IGVEIVPEAVEDARE 273

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 844790481 223 NAMLHNIE-APIYLGDTLSPLGKGLNG--YDVVLTNPP 257
Cdd:COG2265  274 NARLNGLKnVEFVAGDLEEVLPELLWGgrPDVVVLDPP 311
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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