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Conserved domains on  [gi|507077296|ref|WP_016148067|]
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helix-turn-helix transcriptional regulator [Butyricicoccus pullicaecorum]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
14-80 1.42e-12

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 56.93  E-value: 1.42e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507077296 14 GERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDRIVADYELEYLADAIGVTIYYLLGKE 80
Cdd:COG1396   9 GERLRELRKARGLTQEELAER-----LGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGA 70
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
14-80 1.42e-12

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 56.93  E-value: 1.42e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507077296 14 GERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDRIVADYELEYLADAIGVTIYYLLGKE 80
Cdd:COG1396   9 GERLRELRKARGLTQEELAER-----LGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGA 70
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 14-76 1.39e-09

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 48.70  E-value: 1.39e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507077296 14 GERVRAARERAGISQERLAYKIqiaglDITQKAISRIETGDRIVADYELEYLADAIGVTIYYL 76
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKL-----GVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
16-76 2.56e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 45.59  E-value: 2.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507077296   16 RVRAARERAGISQERLAYKIqiaglDITQKAISRIETGDRIVADYELEYLADAIGVTIYYL 76
Cdd:smart00530  1 RLKELREEKGLTQEELAEKL-----GVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 14-72 3.93e-07

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 42.52  E-value: 3.93e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507077296  14 GERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDRIVADYE-LEYLADAIGVT 72
Cdd:pfam13560  3 GARLRRLRERAGLSQEALARR-----LGVSRSTLSRLETGRRGRPSPAvVERLARALGVD 57
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 14-80 1.22e-06

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 43.96  E-value: 1.22e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507077296  14 GERVRAARERAGISQERLAYKIQIAGLDITQKAISRIETG-DRIVADyELEYLADAIGVTIYYLLGKE 80
Cdd:PRK13355   5 AERLKQAMKARGLKQEDLVHAAEARGVKLGKSHISQYVSGkTGPRRD-VLPFLAAILGVSEDWLLGGE 71
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
14-80 1.42e-12

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 56.93  E-value: 1.42e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507077296 14 GERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDRIVADYELEYLADAIGVTIYYLLGKE 80
Cdd:COG1396   9 GERLRELRKARGLTQEELAER-----LGVSRSTISRIERGRRNPSLETLLKLAKALGVSLDELLGGA 70
aMBF1 COG1813
Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and ...
 14-73 1.21e-10

Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441418 [Multi-domain]  Cd Length: 70  Bit Score: 51.86  E-value: 1.21e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507077296 14 GERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDRIVADYELEYLADAIGVTI 73
Cdd:COG1813  14 GERIREAREARGLSQEELAEK-----LGVSESTIRRIERGEATPSLDTLRKLEKALGISL 68
XRE COG1476
DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];
14-80 2.02e-10

DNA-binding transcriptional regulator, XRE-family HTH domain [Transcription];


Pssm-ID: 441085 [Multi-domain]  Cd Length: 68  Bit Score: 51.00  E-value: 2.02e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507077296 14 GERVRAARERAGISQERLAYKIqiaglDITQKAISRIETGDRIVADYELEYLADAIGVTIYYLLGKE 80
Cdd:COG1476   6 GNRLKELRKERGLTQEELAELL-----GVSRQTISAIENGKYNPSLELALKIARALGVSLEELFSLE 67
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 14-76 1.39e-09

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 48.70  E-value: 1.39e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 507077296 14 GERVRAARERAGISQERLAYKIqiaglDITQKAISRIETGDRIVADYELEYLADAIGVTIYYL 76
Cdd:cd00093   1 GERLKELRKEKGLTQEELAEKL-----GVSRSTISRIENGKRNPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
16-76 2.56e-08

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 45.59  E-value: 2.56e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 507077296   16 RVRAARERAGISQERLAYKIqiaglDITQKAISRIETGDRIVADYELEYLADAIGVTIYYL 76
Cdd:smart00530  1 RLKELREEKGLTQEELAEKL-----GVSRSTLSRIENGKRKPSLETLKKLAKALGVSLDEL 56
HTH_31 pfam13560
Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.
 14-72 3.93e-07

Helix-turn-helix domain; This domain is a helix-turn-helix domain that probably binds to DNA.


Pssm-ID: 433309 [Multi-domain]  Cd Length: 64  Bit Score: 42.52  E-value: 3.93e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507077296  14 GERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDRIVADYE-LEYLADAIGVT 72
Cdd:pfam13560  3 GARLRRLRERAGLSQEALARR-----LGVSRSTLSRLETGRRGRPSPAvVERLARALGVD 57
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 17-76 1.06e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 41.37  E-value: 1.06e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 507077296  17 VRAARERAGISQERLAykiqiAGLDITQKAISRIETGDRIVADYELEYLADAIGVTIYYL 76
Cdd:pfam01381  1 LKELREELGLSQEELA-----EKLGVSRSTISKIENGKREPSLETLKKLAEALGVSLDEL 55
PRK13355 PRK13355
bifunctional HTH-domain containing protein/aminotransferase; Provisional
 14-80 1.22e-06

bifunctional HTH-domain containing protein/aminotransferase; Provisional


Pssm-ID: 237361 [Multi-domain]  Cd Length: 517  Bit Score: 43.96  E-value: 1.22e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 507077296  14 GERVRAARERAGISQERLAYKIQIAGLDITQKAISRIETG-DRIVADyELEYLADAIGVTIYYLLGKE 80
Cdd:PRK13355   5 AERLKQAMKARGLKQEDLVHAAEARGVKLGKSHISQYVSGkTGPRRD-VLPFLAAILGVSEDWLLGGE 71
AF2118 COG3620
Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain ...
 14-77 2.41e-06

Predicted transcriptional regulator, contains an XRE-type HTH domain (archaeal members contain CBS pair) [Transcription];


Pssm-ID: 442838 [Multi-domain]  Cd Length: 95  Bit Score: 41.16  E-value: 2.41e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 507077296 14 GERVRAARERAGISQERLAykiQIAGldITQKAISRIETGDRIVADYELEYLADAIGVTIYYLL 77
Cdd:COG3620  19 GEALRLMRKELGLSQLPVA---ELVG--VSQSDILRIESGKRDPTVSTLEKIAEALGKELSAVL 77
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 14-80 2.39e-05

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 38.04  E-value: 2.39e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507077296  14 GERVRAARERAGISQERLAykiQIAGLDITQkaISRIETGDRIVADYELEYLADAIGVTIYYLLGKE 80
Cdd:pfam12844  1 GERLRKAREERGLTQEELA---ERLGISRSQ--LSAIENGKSVPPAETLYKIAELLGVPANWLLQGE 62
YiaG COG2944
DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];
12-55 6.55e-05

DNA-binding transcriptional regulator YiaG, XRE-type HTH domain [Transcription];


Pssm-ID: 442187 [Multi-domain]  Cd Length: 64  Bit Score: 36.84  E-value: 6.55e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 507077296 12 ISGERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDR 55
Cdd:COG2944   6 LTPEEIRALRERLGLSQAEFAAL-----LGVSVSTVRRWEQGRR 44
RodZ COG1426
Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell ...
 14-55 1.69e-03

Cytoskeletal protein RodZ, contains Xre-like HTH and DUF4115 domains [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441035 [Multi-domain]  Cd Length: 71  Bit Score: 33.62  E-value: 1.69e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 507077296 14 GERVRAARERAGISQERLAYKiqiagLDITQKAISRIETGDR 55
Cdd:COG1426   7 GELLRQAREAKGLSLEDVAER-----TKISVSYLEAIEEGDF 43
PRK09943 PRK09943
HTH-type transcriptional regulator PuuR;
14-53 2.67e-03

HTH-type transcriptional regulator PuuR;


Pssm-ID: 182158 [Multi-domain]  Cd Length: 185  Bit Score: 34.38  E-value: 2.67e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 507077296  14 GERVRAARERAGISQERLAykiQIAGLdiTQKAISRIETG 53
Cdd:PRK09943   9 GKRLSEIRQQQGLSQRRAA---ELSGL--THSAISTIEQD 43
PRK10856 PRK10856
cytoskeleton protein RodZ;
14-35 3.01e-03

cytoskeleton protein RodZ;


Pssm-ID: 236776 [Multi-domain]  Cd Length: 331  Bit Score: 34.23  E-value: 3.01e-03
                         10        20
                 ....*....|....*....|....*.
gi 507077296  14 GERVRAARERAGISQ----ERLAYKI 35
Cdd:PRK10856  16 GERLRQAREQLGLTQqavaERLCLKV 41
PRK08154 PRK08154
anaerobic benzoate catabolism transcriptional regulator; Reviewed
 14-80 7.03e-03

anaerobic benzoate catabolism transcriptional regulator; Reviewed


Pssm-ID: 236167 [Multi-domain]  Cd Length: 309  Bit Score: 33.39  E-value: 7.03e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 507077296  14 GERVRAARERAGISQERLAykiQIAGldITQKAISRIETGDRIVADYELEYLADAIGVTIYYLLGKE 80
Cdd:PRK08154  30 GERVRTLRARRGMSRKVLA---QASG--VSERYLAQLESGQGNVSILLLRRVARALGCSLADLLGDV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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