NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|62857605|ref|NP_001016865|]
View 

BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone [Xenopus tropicalis]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 201-353 1.96e-104

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


:

Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 305.82  E-value: 1.96e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 201 IVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSDGSLSDDRLNHLLSVAPQQSIIL 280
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62857605 281 LEDVDAAFVSRDLTKENPTAYQGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDVKQYV 353
Cdd:cd19510  81 LEDIDAAFESREHNKKNPSAYGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 24-191 5.56e-85

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


:

Pssm-ID: 214980  Cd Length: 170  Bit Score: 256.77  E-value: 5.56e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605     24 GVGTALALARKGAQFGMIAFRRHYMITLEVPSKDKSYQWLLSWISHY--AKNTQHLSVETSYLQHESGRISTKFDFVPSP 101
Cdd:smart01024   2 LLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQpfRQRSRHLSVETSYTQHDNGKSSTSFSFVPGP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    102 GNHFIWYKSKWIRIERNREKQMIDLHTGTPWESVTFTALGTKRDIFFNILQEARELALKQQVGKTVMYNAVGAEWRQFgF 181
Cdd:smart01024  82 GTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF-A 160

                          170
                   ....*....|
gi 62857605    182 PRRRRPLSSV 191
Cdd:smart01024 161 PRRKRPLSSV 170
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 201-353 1.96e-104

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 305.82  E-value: 1.96e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 201 IVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSDGSLSDDRLNHLLSVAPQQSIIL 280
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62857605 281 LEDVDAAFVSRDLTKENPTAYQGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDVKQYV 353
Cdd:cd19510  81 LEDIDAAFESREHNKKNPSAYGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 24-191 5.56e-85

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 256.77  E-value: 5.56e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605     24 GVGTALALARKGAQFGMIAFRRHYMITLEVPSKDKSYQWLLSWISHY--AKNTQHLSVETSYLQHESGRISTKFDFVPSP 101
Cdd:smart01024   2 LLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQpfRQRSRHLSVETSYTQHDNGKSSTSFSFVPGP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    102 GNHFIWYKSKWIRIERNREKQMIDLHTGTPWESVTFTALGTKRDIFFNILQEARELALKQQVGKTVMYNAVGAEWRQFgF 181
Cdd:smart01024  82 GTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF-A 160

                          170
                   ....*....|
gi 62857605    182 PRRRRPLSSV 191
Cdd:smart01024 161 PRRKRPLSSV 170
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 25-191 2.33e-53

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 175.90  E-value: 2.33e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    25 VGTALALARKGAQFGMIAFRRHYMITLEVPSKDKSYQWLLSWISHY--AKNTQHLSVETSYLQH------ESGRISTKFD 96
Cdd:pfam08740   1 LGALLAALRRGLRSLWSLLRRRFLSTVEIRSDDESYDWVLAWLSQQpfWRRSRSLSAETRTNSRsdddddDDGSKKKPLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    97 FVPSPGNHFIWYKSKWIRIERNREKQMIDLHTGTPWESVTFTALGTKRDIFFNILQEARELALKQQVGKTVMYNAV---- 172
Cdd:pfam08740  81 YTPGFGTHYFWYKGRWFAVSRERESSSSDLATGSPRETLTLSCLGRSPEPLKELLEEARELYLKKDEGKTVIYRAWrdgy 160

                         170
                  ....*....|....*....
gi 62857605   173 GAEWRQFGfPRRRRPLSSV 191
Cdd:pfam08740 161 GGSWRRVG-SRPKRPLSTV 178
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 226-355 2.89e-26

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 102.67  E-value: 2.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   226 YLLYGPPGCGKSSFITALAGELEYSICLMSLSD-----GSLSDDRLNHLLSVAPQQ--SIILLEDVDAAFVSRDltkenp 298
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSElvskyVGESEKRLRELFEAAKKLapCVIFIDEIDALAGSRG------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 62857605   299 TAYQGMGRLTFSGLLNALDGVASTEAR-IVFMTTNHIDRLDPALIrpGRVDVKQYVGY 355
Cdd:pfam00004  75 SGGDSESRRVVNQLLTELDGFTSSNSKvIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 193-354 3.44e-22

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 96.23  E-value: 3.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 193 LEEGVSEkIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD------GSlSDDRL 266
Cdd:COG1222  83 LDEQIEE-IREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSElvskyiGE-GARNV 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 267 NHLL----SVAPqqSIILLEDVDAAFVSRDLTKENptayqGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALI 342
Cdd:COG1222 161 REVFelarEKAP--SIIFIDEIDAIAARRTDDGTS-----GEVQRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALL 233

                       170
                ....*....|..
gi 62857605 343 RPGRVDVKQYVG 354
Cdd:COG1222 234 RPGRFDRVIEVP 245
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 199-350 2.09e-15

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 77.50  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  199 EKIVQDVKGFID----NPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMS--------LSDGSlsdDRL 266
Cdd:PTZ00361 189 EQQIQEIKEAVElpltHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVgseliqkyLGDGP---KLV 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  267 NHLLSVAPQQ--SIILLEDVDAAFVSR-DLTKENPTAYQgmgrLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIR 343
Cdd:PTZ00361 266 RELFRVAEENapSIVFIDEIDAIGTKRyDATSGGEKEIQ----RTMLELLNQLDGFDSRGDVKVIMATNRIESLDPALIR 341


                 ....*..
gi 62857605  344 PGRVDVK 350
Cdd:PTZ00361 342 PGRIDRK 348
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 193-348 1.16e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 73.02  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   193 LEEGVsEKIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELE---YSIC---LMSLSDGSlSDDRL 266
Cdd:TIGR01243 183 LKEAK-EKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGayfISINgpeIMSKYYGE-SEERL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   267 NHLLSVAPQQ--SIILLEDVDAAFVSRD-LTKEnptayqgMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIR 343
Cdd:TIGR01243 261 REIFKEAEENapSIIFIDEIDAIAPKREeVTGE-------VEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRR 333


                  ....*
gi 62857605   344 PGRVD 348
Cdd:TIGR01243 334 PGRFD 338
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 223-357 4.60e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 48.91  E-value: 4.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    223 RRGYLLYGPPGCGKSSFITALAGEL---EYSICLMSLSDGSLSDDRLNHLLSV---------------------APQQSI 278
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEEVLDQLLLIIVggkkasgsgelrlrlalalarKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62857605    279 ILLEDVDAAFVSRDLtkenptayqgmGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPgRVDVKQYVGYCT 357
Cdd:smart00382  82 LILDEITSLLDAEQE-----------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
cell_div_CdvC NF041006
cell division protein CdvC;
224-248 5.35e-04

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 42.03  E-value: 5.35e-04
                         10        20
                 ....*....|....*....|....*
gi 62857605  224 RGYLLYGPPGCGKSSFITALAGELE 248
Cdd:NF041006 135 RGILLYGPPGCGKTMLAAAVANEID 159
 
Name Accession Description Interval E-value
RecA-like_BCS1 cd19510
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ...
 201-353 1.96e-104

Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410918 [Multi-domain]  Cd Length: 153  Bit Score: 305.82  E-value: 1.96e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 201 IVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSDGSLSDDRLNHLLSVAPQQSIIL 280
Cdd:cd19510   1 IIDDLKDFIKNEDWYNDRGIPYRRGYLLYGPPGTGKSSFIAALAGELDYDICDLNLSEVVLTDDRLNHLLNTAPKQSIIL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62857605 281 LEDVDAAFVSRDLTKENPTAYQGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDVKQYV 353
Cdd:cd19510  81 LEDIDAAFESREHNKKNPSAYGGLSRVTFSGLLNALDGVASSEERIVFMTTNHIERLDPALIRPGRVDMKIYM 153
BCS1_N smart01024
This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import ...
 24-191 5.56e-85

This domain is found at the N terminal of the mitochondrial ATPase BCS1. It encodes the import and intramitochondrial sorting for the protein;


Pssm-ID: 214980  Cd Length: 170  Bit Score: 256.77  E-value: 5.56e-85
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605     24 GVGTALALARKGAQFGMIAFRRHYMITLEVPSKDKSYQWLLSWISHY--AKNTQHLSVETSYLQHESGRISTKFDFVPSP 101
Cdd:smart01024   2 LLGAAGAFLRRGISVAASLIRRRFLVTLEVPSKDESYAWLLEWLSQQpfRQRSRHLSVETSYTQHDNGKSSTSFSFVPGP 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    102 GNHFIWYKSKWIRIERNREKQMIDLHTGTPWESVTFTALGTKRDIFFNILQEARELALKQQVGKTVMYNAVGAEWRQFgF 181
Cdd:smart01024  82 GTHWFWYKGRWIWVTREREKTMADMRTGSPFETLTLTTLGRDRDVFKELLEEARELALKRTEGKTVIYTADGPEWRRF-A 160

                          170
                   ....*....|
gi 62857605    182 PRRRRPLSSV 191
Cdd:smart01024 161 PRRKRPLSSV 170
BCS1_N pfam08740
BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It ...
 25-191 2.33e-53

BCS1 N terminal; This domain is found at the N terminal of the mitochondrial ATPase BSC1. It encodes the import and intramitochondrial sorting for the protein.


Pssm-ID: 462583  Cd Length: 178  Bit Score: 175.90  E-value: 2.33e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    25 VGTALALARKGAQFGMIAFRRHYMITLEVPSKDKSYQWLLSWISHY--AKNTQHLSVETSYLQH------ESGRISTKFD 96
Cdd:pfam08740   1 LGALLAALRRGLRSLWSLLRRRFLSTVEIRSDDESYDWVLAWLSQQpfWRRSRSLSAETRTNSRsdddddDDGSKKKPLR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    97 FVPSPGNHFIWYKSKWIRIERNREKQMIDLHTGTPWESVTFTALGTKRDIFFNILQEARELALKQQVGKTVMYNAV---- 172
Cdd:pfam08740  81 YTPGFGTHYFWYKGRWFAVSRERESSSSDLATGSPRETLTLSCLGRSPEPLKELLEEARELYLKKDEGKTVIYRAWrdgy 160

                         170
                  ....*....|....*....
gi 62857605   173 GAEWRQFGfPRRRRPLSSV 191
Cdd:pfam08740 161 GGSWRRVG-SRPKRPLSTV 178
RecA-like_protease cd19481
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ...
 201-353 1.13e-40

proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410889 [Multi-domain]  Cd Length: 158  Bit Score: 142.04  E-value: 1.13e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 201 IVQDVKGFIDNPKWYSD---RGIPYRRGYLLYGPPGCGKSSFITALAGELeySICLMSLSDGSL-------SDDRLNHLL 270
Cdd:cd19481   1 LKASLREAVEAPRRGSRlrrYGLGLPKGILLYGPPGTGKTLLAKALAGEL--GLPLIVVKLSSLlskyvgeSEKNLRKIF 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 271 SVAPQQ--SIILLEDVDAAFVSRDLTKENptayqGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19481  79 ERARRLapCILFIDEIDAIGRKRDSSGES-----GELRRVLNQLLTELDGVNSRSKVLVIAATNRPDLLDPALLRPGRFD 153


                ....*
gi 62857605 349 VKQYV 353
Cdd:cd19481 154 EVIEF 158
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 226-355 2.89e-26

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 102.67  E-value: 2.89e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   226 YLLYGPPGCGKSSFITALAGELEYSICLMSLSD-----GSLSDDRLNHLLSVAPQQ--SIILLEDVDAAFVSRDltkenp 298
Cdd:pfam00004   1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSElvskyVGESEKRLRELFEAAKKLapCVIFIDEIDALAGSRG------ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 62857605   299 TAYQGMGRLTFSGLLNALDGVASTEAR-IVFMTTNHIDRLDPALIrpGRVDVKQYVGY 355
Cdd:pfam00004  75 SGGDSESRRVVNQLLTELDGFTSSNSKvIVIAATNRPDKLDPALL--GRFDRIIEFPL 130
RPT1 COG1222
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ...
 193-354 3.44e-22

ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440835 [Multi-domain]  Cd Length: 326  Bit Score: 96.23  E-value: 3.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 193 LEEGVSEkIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD------GSlSDDRL 266
Cdd:COG1222  83 LDEQIEE-IREAVELPLKNPELFRKYGIEPPKGVLLYGPPGTGKTLLAKAVAGELGAPFIRVRGSElvskyiGE-GARNV 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 267 NHLL----SVAPqqSIILLEDVDAAFVSRDLTKENptayqGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALI 342
Cdd:COG1222 161 REVFelarEKAP--SIIFIDEIDAIAARRTDDGTS-----GEVQRTVNQLLAELDGFESRGDVLIIAATNRPDLLDPALL 233

                       170
                ....*....|..
gi 62857605 343 RPGRVDVKQYVG 354
Cdd:COG1222 234 RPGRFDRVIEVP 245
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 184-355 2.77e-20

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 91.90  E-value: 2.77e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 184 RRRPLSSVVLEEGVSEKIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD----- 258
Cdd:COG0464 152 REAILDDLGGLEEVKEELRELVALPLKRPELREEYGLPPPRGLLLYGPPGTGKTLLARALAGELGLPLIEVDLSDlvsky 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 259 -GSlSDDRLNHLLSVAPQQS--IILLEDVDAAFVSRDLTKEnptayqGMGRLTFSGLLNALDGVasTEARIVFMTTNHID 335
Cdd:COG0464 232 vGE-TEKNLREVFDKARGLApcVLFIDEADALAGKRGEVGD------GVGRRVVNTLLTEMEEL--RSDVVVIAATNRPD 302

                       170       180
                ....*....|....*....|
gi 62857605 336 RLDPALIRpgRVDVKQYVGY 355
Cdd:COG0464 303 LLDPALLR--RFDEIIFFPL 320
RecA-like_NVL_r1-like cd19518
first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 209-348 1.72e-18

first of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410926 [Multi-domain]  Cd Length: 169  Bit Score: 82.45  E-value: 1.72e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 209 IDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEysICLMSLSDGSL-------SDDRLNHLLSVAPQQS--II 279
Cdd:cd19518  20 ILPPEYFQHLGVEPPRGVLLHGPPGCGKTMLANAIAGELK--VPFLKISATEIvsgvsgeSEEKIRELFDQAISNApcIV 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62857605 280 LLEDVDAAFVSRDltkenpTAYQGMGRLTFSGLLNALDGV----ASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19518  98 FIDEIDAITPKRE------SAQREMERRIVSQLLTCMDELnnekTAGGPVLVIGATNRPDSLDPALRRAGRFD 164
RecA-like_CDC48_NLV2_r1-like cd19503
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ...
 211-348 4.13e-18

first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410911 [Multi-domain]  Cd Length: 165  Bit Score: 81.18  E-value: 4.13e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 211 NPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELeySICLMSLSDGSL-------SDDRLNHLLSVAP--QQSIILL 281
Cdd:cd19503  22 YPELFRALGLKPPRGVLLHGPPGTGKTLLARAVANEA--GANFLSISGPSIvskylgeSEKNLREIFEEARshAPSIIFI 99

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62857605 282 EDVDAAFVSRDLTKEnptayqGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19503 100 DEIDALAPKREEDQR------EVERRVVAQLLTLMDGMSSRGKVVVIAATNRPDAIDPALRRPGRFD 160
RecA-like_FtsH cd19501
ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc ...
 193-353 2.46e-17

ATP-dependent zinc metalloprotease FtsH; FtsH ATPase is a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. It is anchored to the cytoplasmic membrane such that the amino- and carboxy-termini are exposed to the cytoplasm. It presents a membrane-bound hexameric structure that is able to unfold and degrade protein substrates. It is comprised of an N-terminal transmembrane region and the larger C-terminal cytoplasmic region, which consists of an ATPase domain and a protease domain. This RecA-Like FTsH subfamily represents the ATPase domain, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410909 [Multi-domain]  Cd Length: 171  Bit Score: 79.20  E-value: 2.46e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 193 LEEGVSEkiVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD-----GSLSDDRLN 267
Cdd:cd19501   9 CEEAKEE--LKEVVEFLKNPEKFTKLGAKIPKGVLLVGPPGTGKTLLAKAVAGEAGVPFFSISGSDfvemfVGVGASRVR 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 268 HLLSVAPQQS--IILLEDVDAAFVSRD--LTKENPTAYQgmgrlTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIR 343
Cdd:cd19501  87 DLFEQAKKNApcIVFIDEIDAVGRKRGagLGGGHDEREQ-----TLNQLLVEMDGFESNTGVIVIAATNRPDVLDPALLR 161

                       170
                ....*....|
gi 62857605 344 PGRVDVKQYV 353
Cdd:cd19501 162 PGRFDRQVYV 171
RecA-like_CDC48_r2-like cd19511
second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase ...
 197-353 1.60e-16

second of two ATPase domains of CDC48/p97, PEX1 and -6, VAT and NVL, and similar ATPase domains; This subfamily includes the second of two ATPase domains of the molecular chaperone CDC48 in yeast and p97 or VCP in metazoans, Peroxisomal biogenesis factor 1 (PEX1) and -6 (PEX6), Valosin-containing protein-like ATPase (VAT), and nuclear VCP-like protein (NVL). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410919 [Multi-domain]  Cd Length: 159  Bit Score: 76.55  E-value: 1.60e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 197 VSEKIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSIC------LMSLSDGSlSDDRLNHLL 270
Cdd:cd19511   1 VKRELKEAVEWPLKHPDAFKRLGIRPPKGVLLYGPPGCGKTLLAKALASEAGLNFIsvkgpeLFSKYVGE-SERAVREIF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 271 SVAPQQ--SIILLEDVDAAFVSRDLTKENptayqGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19511  80 QKARQAapCIIFFDEIDSLAPRRGQSDSS-----GVTDRVVSQLLTELDGIESLKGVVVIAATNRPDMIDPALLRPGRLD 154


                ....*
gi 62857605 349 VKQYV 353
Cdd:cd19511 155 KLIYV 159
RecA-like_PAN_like cd19502
proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily ...
 196-350 5.11e-16

proteasome activating nucleotidase PAN and related proteasome subunits; This subfamily contains ATPase subunits of the eukaryotic 26S proteasome, and of the archaeal proteasome which carry out ATP-dependent degradation of substrates of the ubiquitin-proteasome pathway. The eukaryotic 26S proteasome consists of a proteolytic 20S core particle (CP), and a 19S regulatory particle (RP) which provides the ATP-dependence and the specificity for ubiquitinated proteins. In the archaea the RP is a homohexameric complex of proteasome-activating nucleotidase (PAN). This subfamily also includes various eukaryotic 26S subunits including, proteasome 26S subunit, ATPase 2 (PSMC2, also known as S7 and MSS1) which is a member of the 19S RP and has a chaperone like activity; and proteasome 20S subunit alpha 6 (PSMA6, also known as IOTA, p27K, and PROS27) which is a member of the 20S CP. This RecA-like_PAN subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410910 [Multi-domain]  Cd Length: 171  Bit Score: 75.45  E-value: 5.11e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 196 GVSEKIvQDVKGFID----NPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLS--------DGSlsd 263
Cdd:cd19502   7 GLDEQI-REIREVVElplkHPELFEELGIEPPKGVLLYGPPGTGKTLLAKAVANHTDATFIRVVGSelvqkyigEGA--- 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 264 dRLNH-LLSVAPQQ--SIILLEDVDAAFVSRdlTKENPTAYQGMGRlTFSGLLNALDGVASTEARIVFMTTNHIDRLDPA 340
Cdd:cd19502  83 -RLVReLFEMAREKapSIIFIDEIDAIGAKR--FDSGTGGDREVQR-TMLELLNQLDGFDPRGNIKVIMATNRPDILDPA 158

                       170
                ....*....|
gi 62857605 341 LIRPGRVDVK 350
Cdd:cd19502 159 LLRPGRFDRK 168
PTZ00361 PTZ00361
26 proteosome regulatory subunit 4-like protein; Provisional
 199-350 2.09e-15

26 proteosome regulatory subunit 4-like protein; Provisional


Pssm-ID: 185575 [Multi-domain]  Cd Length: 438  Bit Score: 77.50  E-value: 2.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  199 EKIVQDVKGFID----NPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMS--------LSDGSlsdDRL 266
Cdd:PTZ00361 189 EQQIQEIKEAVElpltHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVgseliqkyLGDGP---KLV 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  267 NHLLSVAPQQ--SIILLEDVDAAFVSR-DLTKENPTAYQgmgrLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIR 343
Cdd:PTZ00361 266 RELFRVAEENapSIVFIDEIDAIGTKRyDATSGGEKEIQ----RTMLELLNQLDGFDSRGDVKVIMATNRIESLDPALIR 341


                 ....*..
gi 62857605  344 PGRVDVK 350
Cdd:PTZ00361 342 PGRIDRK 348
RecA-like_CDC48_r2-like cd19528
second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or ...
 197-353 2.31e-14

second of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP in metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the second of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r2-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410936 [Multi-domain]  Cd Length: 161  Bit Score: 70.23  E-value: 2.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 197 VSEKIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSIC------LMSLSDGSlSDDRLNHLL 270
Cdd:cd19528   1 VKRELQELVQYPVEHPDKFLKFGMTPSKGVLFYGPPGCGKTLLAKAIANECQANFIsvkgpeLLTMWFGE-SEANVRDIF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 271 SVAPQQS--IILLEDVDAAFVSRDltkENPTAYQGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19528  80 DKARAAApcVLFFDELDSIAKARG---GNIGDAGGAADRVINQILTEMDGMNTKKNVFIIGATNRPDIIDPAILRPGRLD 156


                ....*
gi 62857605 349 VKQYV 353
Cdd:cd19528 157 QLIYI 161
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 193-348 1.16e-13

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 73.02  E-value: 1.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   193 LEEGVsEKIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELE---YSIC---LMSLSDGSlSDDRL 266
Cdd:TIGR01243 183 LKEAK-EKIREMVELPMKHPELFEHLGIEPPKGVLLYGPPGTGKTLLAKAVANEAGayfISINgpeIMSKYYGE-SEERL 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   267 NHLLSVAPQQ--SIILLEDVDAAFVSRD-LTKEnptayqgMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIR 343
Cdd:TIGR01243 261 REIFKEAEENapSIIFIDEIDAIAPKREeVTGE-------VEKRVVAQLLTLMDGLKGRGRVIVIGATNRPDALDPALRR 333


                  ....*
gi 62857605   344 PGRVD 348
Cdd:TIGR01243 334 PGRFD 338
RecA-like_VCP_r2 cd19529
second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ...
 197-353 1.78e-13

second of two ATPase domains of Valosin-containing protein-like ATPase (VAT) and similar ATPase domains; The Valosin-containing protein-like ATPase of Thermoplasma acidophilum (VAT), is an archaeal homolog of the ubiquitous Cdc48/p97. It is a protein unfoldase that functions in concert with the 20S proteasome by unfolding proteasome substrates and passing them on for degradation. VAT forms a homohexamer, each monomer contains two tandem ATPase domains, referred to as D1 and D2, and an N-terminal domain. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410937 [Multi-domain]  Cd Length: 159  Bit Score: 67.91  E-value: 1.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 197 VSEKIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSIC------LMSLSDGSlSDDRLNHLL 270
Cdd:cd19529   1 VKQELKEAVEWPLLKPEVFKRLGIRPPKGILLYGPPGTGKTLLAKAVATESNANFIsvkgpeLLSKWVGE-SEKAIREIF 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 271 SVAPQQS--IILLEDVDAAFVSRDLTKENptayqGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19529  80 RKARQVApcVIFFDEIDSIAPRRGTTGDS-----GVTERVVNQLLTELDGLEEMNGVVVIAATNRPDIIDPALLRAGRFD 154


                ....*
gi 62857605 349 VKQYV 353
Cdd:cd19529 155 RLIYI 159
RecA-like_CDC48_r1-like cd19519
first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP ...
 212-348 2.88e-13

first of two ATPase domains of CDC48 and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. CDC48's roles include in the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis, and in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). This RecA-like_cdc48_r1-like subfamily belongs to the RecA-like family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410927 [Multi-domain]  Cd Length: 166  Bit Score: 67.46  E-value: 2.88e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 212 PKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELE---YSIC---LMSLSDGSlSDDRLNHLLSVAPQQ--SIILLED 283
Cdd:cd19519  23 PELFKAIGIKPPRGILLYGPPGTGKTLIARAVANETGaffFLINgpeIMSKLAGE-SESNLRKAFEEAEKNapAIIFIDE 101

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 62857605 284 VDAAFVSRDLTkenptayQG-MGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19519 102 IDAIAPKREKT-------HGeVERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFD 160
RecA-like_NVL_r2-like cd19530
second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL ...
 209-353 1.99e-12

second of two ATPase domains of NVL (nuclear VCP-like protein) and similar ATPase domains; NVL exists in two forms with N-terminal extensions of different lengths in mammalian cells. NVL has two alternatively spliced isoforms, a short form, NVL1, and a long form, NVL2. NVL2, the major species, is mainly present in the nucleolus, whereas NVL1 is nucleoplasmic. Each has an N-terminal domain, followed by two tandem ATPase domains; this subfamily includes the first of the two ATPase domains. NVL2 is involved in the biogenesis of the 60S ribosome subunit by associating specifically with ribosome protein L5 and modulating the function of DOB1. NVL2 is also required for telomerase assembly and the regulation of telomerase activity, and is involved in pre-rRNA processing. The role of NVL1 is unclear. This RecA-like_NVL_r1-like subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410938 [Multi-domain]  Cd Length: 161  Bit Score: 64.82  E-value: 1.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 209 IDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSicLMSLSDGSL-------SDDRLNHLLSVAPQQS--II 279
Cdd:cd19530  16 IKRPDIYKALGIDLPTGVLLYGPPGCGKTLLAKAVANESGAN--FISVKGPELlnkyvgeSERAVRQVFQRARASApcVI 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62857605 280 LLEDVDAAFVSRDlTKENptayQGMGRLTfSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDVKQYV 353
Cdd:cd19530  94 FFDEVDALVPKRG-DGGS----WASERVV-NQLLTEMDGLEERSNVFVIAATNRPDIIDPAMLRPGRLDKTLYV 161
hflB PRK10733
ATP-dependent zinc metalloprotease FtsH;
202-354 2.08e-12

ATP-dependent zinc metalloprotease FtsH;


Pssm-ID: 182683 [Multi-domain]  Cd Length: 644  Bit Score: 68.91  E-value: 2.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  202 VQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD---------GSLSDDRLNHLLSV 272
Cdd:PRK10733 164 VAELVEYLREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDfvemfvgvgASRVRDMFEQAKKA 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  273 APqqSIILLEDVDAAFVSRDltkenptayQGMG------RLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGR 346
Cdd:PRK10733 244 AP--CIIFIDEIDAVGRQRG---------AGLGgghderEQTLNQMLVEMDGFEGNEGIIVIAATNRPDVLDPALLRPGR 312


                 ....*...
gi 62857605  347 VDVKQYVG 354
Cdd:PRK10733 313 FDRQVVVG 320
RecA-like_PEX1_r2 cd19526
second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as ...
 212-348 3.06e-12

second of two ATPase domains of Peroxisomal biogenesis factor 1 (PEX1); PEX1(also known as Peroxin-1)/PEX6 is a protein unfoldase; PEX1 and PEX6 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. PEX-1 is required for stability of PEX5. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410934 [Multi-domain]  Cd Length: 158  Bit Score: 64.37  E-value: 3.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 212 PKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSIC------LMSLSDGSlSDDRLNHLLSVA--PQQSIILLED 283
Cdd:cd19526  16 PKIFASSPLRLRSGILLYGPPGCGKTLLASAIASECGLNFIsvkgpeLLNKYIGA-SEQNVRDLFSRAqsAKPCILFFDE 94

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 62857605 284 VDAAFVSR--DLTkenptayqGMGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19526  95 FDSIAPKRghDST--------GVTDRVVNQLLTQLDGVEGLDGVYVLAATSRPDLIDPALLRPGRLD 153
COG1223 COG1223
Predicted ATPase, AAA+ superfamily [General function prediction only];
188-343 5.45e-12

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 440836 [Multi-domain]  Cd Length: 246  Bit Score: 65.29  E-value: 5.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 188 LSSVVLEEGVSEKIVQDVKGF--IDNPKWYsdrGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLS--DGSLSD 263
Cdd:COG1223   1 LDDVVGQEEAKKKLKLIIKELrrRENLRKF---GLWPPRKILFYGPPGTGKTMLAEALAGELKLPLLTVRLDslIGSYLG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 264 D---RLNHLLSVAPQQ-SIILLEDVDAAFVSRDLTKENPTayqgMGRLTfSGLLNALDGVASteaRIVFM-TTNHIDRLD 338
Cdd:COG1223  78 EtarNLRKLFDFARRApCVIFFDEFDAIAKDRGDQNDVGE----VKRVV-NALLQELDGLPS---GSVVIaATNHPELLD 149


                ....*
gi 62857605 339 PALIR 343
Cdd:COG1223 150 SALWR 154
RecA-like_PEX6_r2 cd19527
second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as ...
 197-353 9.87e-12

second of two ATPase domains of Peroxisomal biogenesis factor 6 (PEX6); PEX6(also known as Peroxin61)/PEX1 is a protein unfoldase; PEX6 and PEX1 form a heterohexameric Type-2 AAA-ATPase complex and are essential for peroxisome biogenesis as they are required for the import of folded proteins into the peroxisomal matrix. This subfamily represents the second ATPase domain of PEX6. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410935 [Multi-domain]  Cd Length: 160  Bit Score: 62.92  E-value: 9.87e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 197 VSEKIVQDVKGFIDNPKWYSDrGIPYRRGYLLYGPPGCGKSSFITALAgeLEYSICLMSLSDGSL-------SDDRLNHL 269
Cdd:cd19527   1 VKKEILDTIQLPLEHPELFSS-GLRKRSGILLYGPPGTGKTLLAKAIA--TECSLNFLSVKGPELinmyigeSEANVREV 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 270 LSVAPQQS--IILLEDVDAAFVSRDLTKENPTAyqgMGRLTfSGLLNALDGVASTEARI-VFMTTNHIDRLDPALIRPGR 346
Cdd:cd19527  78 FQKARDAKpcVIFFDELDSLAPSRGNSGDSGGV---MDRVV-SQLLAELDGMSSSGQDVfVIGATNRPDLLDPALLRPGR 153


                ....*..
gi 62857605 347 VDVKQYV 353
Cdd:cd19527 154 FDKLLYL 160
PTZ00454 PTZ00454
26S protease regulatory subunit 6B-like protein; Provisional
 212-350 2.57e-11

26S protease regulatory subunit 6B-like protein; Provisional


Pssm-ID: 240423 [Multi-domain]  Cd Length: 398  Bit Score: 64.78  E-value: 2.57e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  212 PKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMS--------LSDG-SLSDDRLNHLLSVAPqqSIILLE 282
Cdd:PTZ00454 168 PELYEQIGIDPPRGVLLYGPPGTGKTMLAKAVAHHTTATFIRVVgsefvqkyLGEGpRMVRDVFRLARENAP--SIIFID 245

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 62857605  283 DVDAAFVSR-DltkenptAYQGMGR---LTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVDVK 350
Cdd:PTZ00454 246 EVDSIATKRfD-------AQTGADRevqRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRK 310
CDC48 TIGR01243
AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two ...
 193-353 1.42e-10

AAA family ATPase, CDC48 subfamily; This subfamily of the AAA family ATPases includes two members each from three archaeal species. It also includes yeast CDC48 (cell division control protein 48) and the human ortholog, transitional endoplasmic reticulum ATPase (valosin-containing protein). These proteins in eukaryotes are involved in the budding and transfer of membrane from the transitional endoplasmic reticulum to the Golgi apparatus.


Pssm-ID: 273521 [Multi-domain]  Cd Length: 733  Bit Score: 63.39  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   193 LEEgVSEKIVQDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSIC------LMSLSDGSlSDDRL 266
Cdd:TIGR01243 458 LEE-VKQELREAVEWPLKHPEIFEKMGIRPPKGVLLFGPPGTGKTLLAKAVATESGANFIavrgpeILSKWVGE-SEKAI 535

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605   267 NHLLSVAPQQS--IILLEDVDAAFVSRDLTKENPTAYQGMGRLtfsglLNALDGVASTEARIVFMTTNHIDRLDPALIRP 344
Cdd:TIGR01243 536 REIFRKARQAApaIIFFDEIDAIAPARGARFDTSVTDRIVNQL-----LTEMDGIQELSNVVVIAATNRPDILDPALLRP 610


                  ....*....
gi 62857605   345 GRVDVKQYV 353
Cdd:TIGR01243 611 GRFDRLILV 619
RecA-like_NSF-SEC18_r1-like cd19504
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ...
 185-350 1.81e-10

first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410912 [Multi-domain]  Cd Length: 177  Bit Score: 59.43  E-value: 1.81e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 185 RRPLSSVVLEEGVSEKIvqdvkgfidnpkwysdrGIPYRRGYLLYGPPGCGKSSFITALAGEL---EYSIC----LMSLS 257
Cdd:cd19504  14 RRAFASRVFPPEIVEQL-----------------GCKHVKGILLYGPPGTGKTLMARQIGKMLnarEPKIVngpeILNKY 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 258 DGSlSDDRLNHLLSVAPQQS----------IILLEDVDAAFVSRDLTKENptayQGMGRLTFSGLLNALDGVASTEARIV 327
Cdd:cd19504  77 VGE-SEANIRKLFADAEEEQrrlgansglhIIIFDEIDAICKQRGSMAGS----TGVHDTVVNQLLSKIDGVEQLNNILV 151

                       170       180
                ....*....|....*....|...
gi 62857605 328 FMTTNHIDRLDPALIRPGRVDVK 350
Cdd:cd19504 152 IGMTNRKDLIDEALLRPGRLEVQ 174
RecA-like_VPS4-like cd19509
ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This ...
 214-343 9.63e-10

ATPase domain of VPS4, ATAD1, K, KTNA1, Spastin, FIGL-1 and similar ATPase domains; This subfamily includes the ATPase domains of vacuolar protein sorting-associated protein 4 (VPS4), ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase), Katanin p60 ATPase-containing subunit A1 (KTNA1), Spastin, and Fidgetin-Like 1 (FIGL-1). This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410917 [Multi-domain]  Cd Length: 163  Bit Score: 56.98  E-value: 9.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 214 WYSDRGIPyrRGYLLYGPPGCGKSSFITALAGELeySICLMSLSDGSL-------SDDRLNHLLSVAP--QQSIILLEDV 284
Cdd:cd19509  25 FPGLRGPP--RGILLYGPPGTGKTLLARAVASES--GSTFFSISASSLvskwvgeSEKIVRALFALARelQPSIIFIDEI 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62857605 285 DAAFVSRDLTKENPTAyqgmgRLTfSGLLNALDGV-ASTEARIVFM-TTNHIDRLDPALIR 343
Cdd:cd19509 101 DSLLSERGSGEHEASR-----RVK-TEFLVQMDGVlNKPEDRVLVLgATNRPWELDEAFLR 155
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 221-355 1.25e-09

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 56.39  E-value: 1.25e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 221 PYRRGYLLYGPPGCGKSSFITALAGEL---EYSICLMSLSD-----------GSLSDDRLNHLLSVApQQSIILLEDVDA 286
Cdd:cd00009  17 PPPKNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASDlleglvvaelfGHFLVRLLFELAEKA-KPGVLFIDEIDS 95

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 62857605 287 afvsrdltkenptayqgMGRLTFSGLLNAL----DGVASTEARIVFMTTNHIDRLDPALIRPGRVDVKQYVGY 355
Cdd:cd00009  96 -----------------LSRGAQNALLRVLetlnDLRIDRENVRVIGATNRPLLGDLDRALYDRLDIRIVIPL 151
RecA-like_Ycf46-like cd19507
ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of ...
 219-348 2.68e-09

ATPase domain of Ycf46 and similar ATPase domains; Ycf46 may play a role in the regulation of photosynthesis in cyanobacteria, especially in CO2 uptake and utilization. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410915 [Multi-domain]  Cd Length: 161  Bit Score: 55.84  E-value: 2.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 219 GIPYRRGYLLYGPPGCGKSSFITALAGELEysICLMSLSDGSL-------SDDRLNHLLSVAPQQS--IILLEDVDAAFV 289
Cdd:cd19507  27 GLPTPKGLLLVGIQGTGKSLTAKAIAGVWQ--LPLLRLDMGRLfgglvgeSESRLRQMIQTAEAIApcVLWIDEIEKGFS 104

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 62857605 290 SRDLTKENPTAyqgmGRLtFSGLLNALdgvaSTEARIVFM--TTNHIDRLDPALIRPGRVD 348
Cdd:cd19507 105 NADSKGDSGTS----SRV-LGTFLTWL----QEKKKPVFVvaTANNVQSLPPELLRKGRFD 156
ftsH CHL00176
cell division protein; Validated
 203-348 4.02e-09

cell division protein; Validated


Pssm-ID: 214386 [Multi-domain]  Cd Length: 638  Bit Score: 58.52  E-value: 4.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  203 QDVKGFIDNPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELE---YSIclmslsDGS--------LSDDRLNHLLS 271
Cdd:CHL00176 196 EEVVSFLKKPERFTAVGAKIPKGVLLVGPPGTGKTLLAKAIAGEAEvpfFSI------SGSefvemfvgVGAARVRDLFK 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  272 VAPQQS--IILLEDVDAafVSRDLTKenptayqGMG------RLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIR 343
Cdd:CHL00176 270 KAKENSpcIVFIDEIDA--VGRQRGA-------GIGggnderEQTLNQLLTEMDGFKGNKGVIVIAATNRVDILDAALLR 340


                 ....*
gi 62857605  344 PGRVD 348
Cdd:CHL00176 341 PGRFD 345
RecA-like_Yta7-like cd19517
ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces ...
 212-348 1.31e-08

ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains; Saccharomyces cerevisiae Yta7 is a chromatin-associated AAA-ATPase involved in regulation of chromatin dynamics. Its human ortholog ANCCA/ATAD2 transcriptionally activates pathways of malignancy in a broad range of cancers. The RecA-like_Yta7 subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410925 [Multi-domain]  Cd Length: 170  Bit Score: 54.05  E-value: 1.31e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 212 PKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEY------------SICLMSLSDGSLSDDRLNHLLSVAPQQSII 279
Cdd:cd19517  23 PEVFAKFKITPPRGVLFHGPPGTGKTLMARALAAECSKggqkvsffmrkgADCLSKWVGEAERQLRLLFEEAYRMQPSII 102

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62857605 280 LLEDVDAAFVSRDLTKENPTAYqgmgrlTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:cd19517 103 FFDEIDGLAPVRSSKQEQIHAS------IVSTLLALMDGLDNRGQVVVIGATNRPDALDPALRRPGRFD 165
PRK03992 PRK03992
proteasome-activating nucleotidase; Provisional
 211-348 2.19e-08

proteasome-activating nucleotidase; Provisional


Pssm-ID: 179699 [Multi-domain]  Cd Length: 389  Bit Score: 55.61  E-value: 2.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  211 NPKWYSDRGIPYRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD--------GSlsddRLNH-LLSVAPQQ--SII 279
Cdd:PRK03992 153 KPELFEEVGIEPPKGVLLYGPPGTGKTLLAKAVAHETNATFIRVVGSElvqkfigeGA----RLVReLFELAREKapSII 228

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  280 LLEDVDAAFVSRdlTKENPTAYQGMGRlTFSGLLNALDGVAST-EARIVfMTTNHIDRLDPALIRPGRVD 348
Cdd:PRK03992 229 FIDEIDAIAAKR--TDSGTSGDREVQR-TLMQLLAEMDGFDPRgNVKII-AATNRIDILDPAILRPGRFD 294
HflB COG0465
ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];
193-348 6.28e-08

ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440233 [Multi-domain]  Cd Length: 583  Bit Score: 54.66  E-value: 6.28e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 193 LEEGVSEkiVQDVKGFIDNPKWYSDRG--IPyrRGYLLYGPPGCGKssfiT----ALAGELE---YSIclmSLSD----- 258
Cdd:COG0465 147 VDEAKEE--LQEIVDFLKDPEKFTRLGakIP--KGVLLVGPPGTGK----TllakAVAGEAGvpfFSI---SGSDfvemf 215

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 259 -GslsddrlnhllsvapqqsiilledVDAAFVsRDL---TKEN-PT--------AyqgMGRLTFSGL----------LNA 315
Cdd:COG0465 216 vG------------------------VGASRV-RDLfeqAKKNaPCiifideidA---VGRQRGAGLggghdereqtLNQ 267

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 62857605 316 L----DGVASTEARIVFMTTNHIDRLDPALIRPGRVD 348
Cdd:COG0465 268 LlvemDGFEGNEGVIVIAATNRPDVLDPALLRPGRFD 304
RecA-like_ATAD1 cd19520
ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ...
 224-343 4.24e-07

ATPase domain of ATPase family AAA domain-containing protein 1 and similar ATPase domains; ATPase family AAA domain-containing protein 1 (ATAD1, also known as Thorase) is an ATPase that plays a critical role in regulating the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, thereby regulating synaptic plasticity, learning and memory. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410928 [Multi-domain]  Cd Length: 166  Bit Score: 49.73  E-value: 4.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 224 RGYLLYGPPGCGKSSFITALAGELEYSicLMSLSDGSLSD------DRL-NHLLSVAP--QQSIILLEDVDAAFVSRDLT 294
Cdd:cd19520  36 KGVLLYGPPGCGKTMLAKATAKEAGAR--FINLQVSSLTDkwygesQKLvAAVFSLASklQPSIIFIDEIDSFLRQRSST 113

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 62857605 295 KENPTAyqgMGRLTFSGLLNALDgvASTEARIVFM-TTNHIDRLDPALIR 343
Cdd:cd19520 114 DHEATA---MMKAEFMSLWDGLS--TDGNCRVIVMgATNRPQDLDEAILR 158
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 223-357 4.60e-07

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 48.91  E-value: 4.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605    223 RRGYLLYGPPGCGKSSFITALAGEL---EYSICLMSLSDGSLSDDRLNHLLSV---------------------APQQSI 278
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEEVLDQLLLIIVggkkasgsgelrlrlalalarKLKPDV 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 62857605    279 ILLEDVDAAFVSRDLtkenptayqgmGRLTFSGLLNALDGVASTEARIVFMTTNHIDRLDPALIRPgRVDVKQYVGYCT 357
Cdd:smart00382  82 LILDEITSLLDAEQE-----------ALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRR-RFDRRIVLLLIL 148
RecA-like_VPS4 cd19521
ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein ...
 195-353 4.47e-06

ATPase domain of vacuolar protein sorting-associated protein 4; Vacuolar protein sorting-associated protein 4 (Vps4) is believed to be involved in intracellular protein transport out of a prevacuolar endosomal compartment. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410929 [Multi-domain]  Cd Length: 170  Bit Score: 46.78  E-value: 4.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 195 EGVSEKIVQDVKGFIDNPKWYSDRGIPYRrGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD------GSlSDDRLNH 268
Cdd:cd19521  13 EGAKEALKEAVILPVKFPHLFTGNRKPWS-GILLYGPPGTGKSYLAKAVATEANSTFFSVSSSDlvskwmGE-SEKLVKQ 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 269 LLSVAPQQ--SIILLEDVDAAFVSRDlTKENPTAyqgmgRLTFSGLLNALDGVASTEARI-VFMTTNHIDRLDPALIRpg 345
Cdd:cd19521  91 LFAMARENkpSIIFIDEVDSLCGTRG-EGESEAS-----RRIKTELLVQMNGVGNDSQGVlVLGATNIPWQLDSAIRR-- 162


                ....*...
gi 62857605 346 RVDVKQYV 353
Cdd:cd19521 163 RFEKRIYI 170
ycf46 CHL00195
Ycf46; Provisional
 216-348 5.82e-06

Ycf46; Provisional


Pssm-ID: 177094 [Multi-domain]  Cd Length: 489  Bit Score: 48.48  E-value: 5.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605  216 SDRGIPYRRGYLLYGPPGCGKSsfITALAGELEYSICLMSLSDGSL-------SDDRLNHLLSVAPQQS--IILLEDVDA 286
Cdd:CHL00195 252 SNYGLPTPRGLLLVGIQGTGKS--LTAKAIANDWQLPLLRLDVGKLfggivgeSESRMRQMIRIAEALSpcILWIDEIDK 329

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 62857605  287 AFVSRDLTKENPTAYQGMGrlTFSGLLnaldgvaSTEARIVFM--TTNHIDRLDPALIRPGRVD 348
Cdd:CHL00195 330 AFSNSESKGDSGTTNRVLA--TFITWL-------SEKKSPVFVvaTANNIDLLPLEILRKGRFD 384
RecA-like_spastin cd19524
ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in ...
 224-343 1.65e-05

ATPase domain of spastin; Spastin is an ATP-dependent microtubule-severing protein involved in microtubule dynamics; it specifically recognizes and cuts microtubules that are polyglutamylated. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410932 [Multi-domain]  Cd Length: 164  Bit Score: 44.84  E-value: 1.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 224 RGYLLYGPPGCGKSSFITALAGELE---YSICLMSLSDGSLSDDR--LNHLLSVAP--QQSIILLEDVDAAFVSRDlTKE 296
Cdd:cd19524  34 RGLLLFGPPGNGKTMLAKAVAAESNatfFNISAASLTSKYVGEGEklVRALFAVARelQPSIIFIDEVDSLLSERS-EGE 112

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 62857605 297 NPTAyqgmgRLTFSGLLNALDGVAST-EARIVFM-TTNHIDRLDPALIR 343
Cdd:cd19524 113 HEAS-----RRLKTEFLIEFDGVQSNgDDRVLVMgATNRPQELDDAVLR 156
PRK04195 PRK04195
replication factor C large subunit; Provisional
 186-258 1.98e-05

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 46.45  E-value: 1.98e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 62857605  186 RP--LSSVVleegVSEKIVQDVKGFIDNpkWysDRGIPyRRGYLLYGPPGCGKSSFITALAGELEYSICLMSLSD 258
Cdd:PRK04195   9 RPktLSDVV----GNEKAKEQLREWIES--W--LKGKP-KKALLLYGPPGVGKTSLAHALANDYGWEVIELNASD 74
RecA-like_KTNA1 cd19522
Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is ...
 212-353 1.67e-04

Katanin p60 ATPase-containing subunit A1; Katanin p60 ATPase-containing subunit A1 (KTNA1) is the catalytic subunit of the Katanin complex which is severs microtubules in an ATP-dependent manner, and is implicated in multiple aspects of microtubule dynamics. In addition to the p60 catalytic ATPase subunit, Katanin contains an accessory subunit (p80 or p80-like). The microtubule-severing activity of the ATPase is essential for female meiotic spindle assembly, and male gamete production; and the katanin complex severing microtubules is under tight regulation during the transition from the meiotic to mitotic stage to allow proper embryogenesis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410930 [Multi-domain]  Cd Length: 170  Bit Score: 41.89  E-value: 1.67e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 212 PKWYSD--RGI--PYRrGYLLYGPPGCGKSSFITALAGELEYSicLMSLSDGSLS------DDRLNHLL-----SVAPqq 276
Cdd:cd19522  19 PMWMPEffKGIrrPWK-GVLMVGPPGTGKTLLAKAVATECGTT--FFNVSSSTLTskyrgeSEKLVRLLfemarFYAP-- 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 277 SIILLEDVDAAFVSRDLTKENPTAyqgmgRLTFSGLLNALDGVASTEAR-------IVFMTTNHIDRLDPALIRpgRVDV 349
Cdd:cd19522  94 TTIFIDEIDSICSRRGTSEEHEAS-----RRVKSELLVQMDGVGGASENddpskmvMVLAATNFPWDIDEALRR--RLEK 166


                ....
gi 62857605 350 KQYV 353
Cdd:cd19522 167 RIYI 170
RecA-like_Figl-1 cd19525
ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; ...
 218-343 2.31e-04

ATPase domain of Fidgetin-Like 1 (FIGL-1); FIGL-1 may participate in DNA repair in the nucleus; it may be involved in DNA double-strand break repair via homologous recombination. Caenorhabditis elegans FIGL-1 is a nuclear protein and controls the mitotic progression in the germ line and mouse FIGL-1 may be involved in the control of male meiosis. human FIGL-1 has been shown to be a centrosome protein involved in ciliogenesis perhaps as a microtubule-severing protein. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410933 [Multi-domain]  Cd Length: 186  Bit Score: 41.90  E-value: 2.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 218 RGIPyrRGYLLYGPPGCGKSSF---ITALAGELEYSICLMSLSDGSLSDDR--LNHLLSVA--PQQSIILLEDVDAAFVS 290
Cdd:cd19525  52 RGPP--KGILLFGPPGTGKTLIgkcIASQSGATFFSISASSLTSKWVGEGEkmVRALFSVArcKQPAVIFIDEIDSLLSQ 129

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 62857605 291 RDLTKENPTayqgmgRLTFSGLLNALDGV--ASTEARIVFMTTNHIDRLDPALIR 343
Cdd:cd19525 130 RGEGEHESS------RRIKTEFLVQLDGAttSSEDRILVVGATNRPQEIDEAARR 178
cell_div_CdvC NF041006
cell division protein CdvC;
224-248 5.35e-04

cell division protein CdvC;


Pssm-ID: 468935 [Multi-domain]  Cd Length: 371  Bit Score: 42.03  E-value: 5.35e-04
                         10        20
                 ....*....|....*....|....*
gi 62857605  224 RGYLLYGPPGCGKSSFITALAGELE 248
Cdd:NF041006 135 RGILLYGPPGCGKTMLAAAVANEID 159
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
225-286 4.01e-03

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 38.80  E-value: 4.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 62857605 225 GYLLYGPPGCGKSSFITALAGEL------EYSIC---------------LMSLSDGSLSDDR-------LNHLLSVAPQQ 276
Cdd:COG0470  20 ALLLHGPPGIGKTTLALALARDLlcenpeGGKACgqchsrlmaagnhpdLLELNPEEKSDQIgidqireLGEFLSLTPLE 99

                        90
                ....*....|...
gi 62857605 277 S---IILLEDVDA 286
Cdd:COG0470 100 GgrkVVIIDEADA 112
RNA_helicase pfam00910
RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding ...
 227-253 7.27e-03

RNA helicase; This family includes RNA helicases thought to be involved in duplex unwinding during viral RNA replication. Members of this family are found in a variety of single stranded RNA viruses.


Pssm-ID: 459992  Cd Length: 102  Bit Score: 36.04  E-value: 7.27e-03
                          10        20
                  ....*....|....*....|....*..
gi 62857605   227 LLYGPPGCGKSSFITALAGELEYSICL 253
Cdd:pfam00910   2 WLYGPPGCGKSTLAKYLARALLKKLGL 28
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 227-249 9.43e-03

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 38.14  E-value: 9.43e-03
                         10        20
                 ....*....|....*....|...
gi 62857605  227 LLYGPPGCGKSSFITALAGELEY 249
Cdd:PRK13342  40 ILWGPPGTGKTTLARIIAGATDA 62
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH