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Conserved domains on  [gi|486711287|gb|EOG48772|]
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acyl carrier protein [Enterococcus faecalis EnGen0196]

Protein Classification

acyl carrier protein( domain architecture ID 10011594)

acyl carrier protein functions as the carrier of the growing fatty acid chain in fatty acid biosynthesis

Gene Ontology:  GO:0009245|GO:0000036|GO:0000035
PubMed:  20662770

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 3-78 9.67e-25

acyl carrier protein; Provisional


:

Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 87.53  E-value: 9.67e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 486711287  3 REEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 3-78 9.67e-25

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 87.53  E-value: 9.67e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 486711287  3 REEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 1.28e-18

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 72.19  E-value: 1.28e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 486711287  1 MTREEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:COG0236   1 MPREELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 5-78 4.64e-16

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 65.50  E-value: 4.64e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 486711287   5 EVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:TIGR00517  3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 8-70 1.25e-05

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 38.70  E-value: 1.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 486711287   8 QKVAKIISNHFDIEADQVTDQLNIkDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGA 70
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
 
Name Accession Description Interval E-value
acpP PRK00982
acyl carrier protein; Provisional
 3-78 9.67e-25

acyl carrier protein; Provisional


Pssm-ID: 179197 [Multi-domain]  Cd Length: 78  Bit Score: 87.53  E-value: 9.67e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 486711287  3 REEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:PRK00982  1 MSEIFEKVKKIIVEQLGVDEEEVTPEASFVDDLGADSLDTVELVMALEEEFGIEIPDEDAEKIKTVGDAVDYIEKH 76
PTZ00171 PTZ00171
acyl carrier protein; Provisional
 4-78 6.64e-19

acyl carrier protein; Provisional


Pssm-ID: 240304  Cd Length: 148  Bit Score: 74.73  E-value: 6.64e-19
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 486711287   4 EEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:PTZ00171  69 EDVLTRVKKVVKNFEKVDASKITPESNFVKDLGADSLDVVELLIAIEQEFNLTIPDHDAEKIKTVQDAIDYIEQN 143
AcpP COG0236
Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the ...
 1-78 1.28e-18

Acyl carrier protein [Lipid transport and metabolism]; Acyl carrier protein is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440006 [Multi-domain]  Cd Length: 80  Bit Score: 72.19  E-value: 1.28e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 486711287  1 MTREEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:COG0236   1 MPREELEERLAEIIAEVLGVDPEEITPDDSFFEDLGLDSLDAVELIAALEEEFGIELPDTELFEYPTVADLADYLEEK 78
PRK12449 PRK12449
acyl carrier protein; Provisional
 1-76 3.34e-16

acyl carrier protein; Provisional


Pssm-ID: 183533 [Multi-domain]  Cd Length: 80  Bit Score: 66.27  E-value: 3.34e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 486711287  1 MTREEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIV 76
Cdd:PRK12449  1 MTREEIFERLINLIQKQRSYLSLAITEQTHLKDDLAVDSIELVEFIINVEDEFHIAIPDEDVEDMVSMGDLLDYLV 76
acyl_carrier TIGR00517
acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser ...
 5-78 4.64e-16

acyl carrier protein; This small protein has phosphopantetheine covalently bound to a Ser residue. It acts as a carrier of the growing fatty acid chain, which is bound to the prosthetic group, during fatty acid biosynthesis. Homologous phosphopantetheine-binding domains are found in longer proteins. Acyl carrier proteins scoring above the noise cutoff but below the trusted cutoff may be specialized versions. These include those involved in mycolic acid biosynthesis in the Mycobacteria, lipid A biosynthesis in Rhizobium, actinorhodin polyketide synthesis in Streptomyces coelicolor, etc. This protein is not found in the Archaea.Gene name acpP.S (Ser) at position 37 in the seed alignment, in the motif DSLD, is the phosphopantetheine attachment site. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 213536 [Multi-domain]  Cd Length: 77  Bit Score: 65.50  E-value: 4.64e-16
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 486711287   5 EVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSN 78
Cdd:TIGR00517  3 EIFEKVKAIIKEQLNVDEDQITTDARFVEDLGADSLDTVELVMALEEEFDIEIPDEEAEKIATVGDAVNYIEEN 76
acpP CHL00124
acyl carrier protein; Validated
 1-79 2.21e-14

acyl carrier protein; Validated


Pssm-ID: 177047 [Multi-domain]  Cd Length: 82  Bit Score: 61.58  E-value: 2.21e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 486711287  1 MTREEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYIVSNS 79
Cdd:CHL00124  1 MTKNDIFEKVQSIVAEQLGIEKSEVTLDANFTRDLGADSLDVVELVMAIEEKFDIEIPDEDAEKISTLQEAVDFISQKI 79
PRK05350 PRK05350
acyl carrier protein; Provisional
 1-75 5.49e-07

acyl carrier protein; Provisional


Pssm-ID: 180033  Cd Length: 82  Bit Score: 42.67  E-value: 5.49e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 486711287  1 MTREEVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGAAVDYI 75
Cdd:PRK05350  2 MTREEILERLRAILVELFEIDPEDITPEANLYEDLDLDSIDAVDLVVHLQKLTGKKIKPEEFKSVRTVQDVVDAV 76
PP-binding pfam00550
Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached ...
 8-70 1.25e-05

Phosphopantetheine attachment site; A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.


Pssm-ID: 425746 [Multi-domain]  Cd Length: 62  Bit Score: 38.70  E-value: 1.25e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 486711287   8 QKVAKIISNHFDIEADQVTDQLNIkDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETVGA 70
Cdd:pfam00550  1 ERLRELLAEVLGVPAEEIDPDTDL-FDLGLDSLLAVELIARLEEEFGVEIPPSDLFEHPTLAE 62
PRK08172 PRK08172
acyl carrier protein;
5-68 1.30e-04

acyl carrier protein;


Pssm-ID: 181266  Cd Length: 82  Bit Score: 36.79  E-value: 1.30e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 486711287  5 EVLQKVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDEDAEKIETV 68
Cdd:PRK08172  4 DIEARVKKVITSCIAVDVDSINGQTHLVEDLYADSLDLIDIVFGLSEEFDISCNENDLPDMTTF 67
PRK07639 PRK07639
petrobactin biosynthesis protein AsbD;
1-75 3.23e-04

petrobactin biosynthesis protein AsbD;


Pssm-ID: 181065  Cd Length: 86  Bit Score: 35.49  E-value: 3.23e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 486711287  1 MTREEVLQKVAKIISNHFDIEA-DQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDE--DAEKIETVGAAVDYI 75
Cdd:PRK07639  1 MRREALKNAVLKIMEEKLELKNvTHLEETMRLNEDLYIDSVMMLQLIVYIEMDVKLCVPEDevDPKAFLTVGSLLDFM 78
PRK06508 PRK06508
acyl carrier protein; Provisional
 9-60 8.76e-04

acyl carrier protein; Provisional


Pssm-ID: 180597  Cd Length: 93  Bit Score: 34.79  E-value: 8.76e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 486711287  9 KVAKIISNHFDIEADQVTDQLNIKDDLNADSISVMEFVLELEDEFGTEISDE 60
Cdd:PRK06508  7 KVADIIAETSDIPRDTITPESHTIDDLGIDSLDFLDIVFAIDKAFGIKLPLE 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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