NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|198036241|emb|CAR52137|]
View 

conserved hypothetical protein [Burkholderia cenocepacia J2315]

Protein Classification

cephalosporin hydroxylase family protein( domain architecture ID 10007503)

cephalosporin hydroxylase family protein similar to mycobacterial rhamnosyl O-methyltransferase that catalyzes the O-methylation of the hydroxyl group on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p-hydroxybenzoic acid derivatives (p-HBAD)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CmcI COG3510
Cephalosporin hydroxylase [Defense mechanisms];
1-228 6.72e-112

Cephalosporin hydroxylase [Defense mechanisms];


:

Pssm-ID: 442733  Cd Length: 239  Bit Score: 320.30  E-value: 6.72e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241   1 MSERPSARMRDINIEWLTRAAEFGHLFQTHWLGERFFHLPGDMLALQELIWRERPDCIVQTGIAAGGGVVFTASMLELAG 80
Cdd:COG3510   12 ASLGSDEALDDLSEEWLRASYKNKYSYNFSWLGRPIIQYPQDMVAYQEIIWELKPDLIIETGIAHGGSLIFSASMLALLG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241  81 NHGRVVAIEPRLRDEVRQRLQSHRLADRMVLIEGESCAPDTLASVRTQIDDGARVMAILDLTHTHAHVLRELECYAPFVT 160
Cdd:COG3510   92 MKGKVLGIDIDIRPHNRAAIEAHPLAPRIELIEGSSTAPEIVEQVKALAKPGERVMVILDSNHTHEHVLAELEAYAPLVT 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 198036241 161 RGCYAIVMDTIMEYLPESMFDGKPYGRGNNPATATREFLARDDRFEVDHDIEDRVLMTLSPGGFLKRV 228
Cdd:COG3510  172 PGSYLVVFDTIIEDLPVDMFPDRPWGPGNNPKTAVEEYLKEHPEFEIDKSIEHKLLITVAPDGYLKRI 239
 
Name Accession Description Interval E-value
CmcI COG3510
Cephalosporin hydroxylase [Defense mechanisms];
1-228 6.72e-112

Cephalosporin hydroxylase [Defense mechanisms];


Pssm-ID: 442733  Cd Length: 239  Bit Score: 320.30  E-value: 6.72e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241   1 MSERPSARMRDINIEWLTRAAEFGHLFQTHWLGERFFHLPGDMLALQELIWRERPDCIVQTGIAAGGGVVFTASMLELAG 80
Cdd:COG3510   12 ASLGSDEALDDLSEEWLRASYKNKYSYNFSWLGRPIIQYPQDMVAYQEIIWELKPDLIIETGIAHGGSLIFSASMLALLG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241  81 NHGRVVAIEPRLRDEVRQRLQSHRLADRMVLIEGESCAPDTLASVRTQIDDGARVMAILDLTHTHAHVLRELECYAPFVT 160
Cdd:COG3510   92 MKGKVLGIDIDIRPHNRAAIEAHPLAPRIELIEGSSTAPEIVEQVKALAKPGERVMVILDSNHTHEHVLAELEAYAPLVT 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 198036241 161 RGCYAIVMDTIMEYLPESMFDGKPYGRGNNPATATREFLARDDRFEVDHDIEDRVLMTLSPGGFLKRV 228
Cdd:COG3510  172 PGSYLVVFDTIIEDLPVDMFPDRPWGPGNNPKTAVEEYLKEHPEFEIDKSIEHKLLITVAPDGYLKRI 239
CmcI pfam04989
Cephalosporin hydroxylase; Members of this family are about 220 amino acids long. The CmcI ...
 24-228 4.34e-72

Cephalosporin hydroxylase; Members of this family are about 220 amino acids long. The CmcI protein is presumed to represent the cephalosporin-7--hydroxylase. However this has not been experimentally verified.


Pssm-ID: 428241  Cd Length: 206  Bit Score: 218.42  E-value: 4.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241   24 GHLFQTHWLGERFFHLPGDMLALQELIWRERPDCIVQTGIAAGGGVVFTASMLELAGNHGRVVAIEPRLRDEVRQRLQSH 103
Cdd:pfam04989   2 KYSYNFSWLGRPIIQYPQDMWAYQEIIFELKPDLIIETGIAHGGSAIFSASILALLGSPRKVLGVDIDIRAHNRAAIEAH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241  104 RLADRMVLIEGESCAPDTLASVRTQIDDGARVMAILDLTHTHAHVLRELECYAPFVTRGCYAIVMDTIMEYLPESMFDGK 183
Cdd:pfam04989  82 PMAPRIEMIEGSSTDPEIIEQVRSLANEPGKILVILDSDHTHDHVLAELEAYAPLVSAGSYCVVFDTNIEDLPVLFFPDP 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 198036241  184 PYGRGNNPATATREFLARDDRFEVDHDIEDRVLMTLSPGGFLKRV 228
Cdd:pfam04989 162 PWGPGNNPKTAVEEYLATFPEFEIDKEIENKLLITVAPDGFLKRI 206
 
Name Accession Description Interval E-value
CmcI COG3510
Cephalosporin hydroxylase [Defense mechanisms];
1-228 6.72e-112

Cephalosporin hydroxylase [Defense mechanisms];


Pssm-ID: 442733  Cd Length: 239  Bit Score: 320.30  E-value: 6.72e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241   1 MSERPSARMRDINIEWLTRAAEFGHLFQTHWLGERFFHLPGDMLALQELIWRERPDCIVQTGIAAGGGVVFTASMLELAG 80
Cdd:COG3510   12 ASLGSDEALDDLSEEWLRASYKNKYSYNFSWLGRPIIQYPQDMVAYQEIIWELKPDLIIETGIAHGGSLIFSASMLALLG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241  81 NHGRVVAIEPRLRDEVRQRLQSHRLADRMVLIEGESCAPDTLASVRTQIDDGARVMAILDLTHTHAHVLRELECYAPFVT 160
Cdd:COG3510   92 MKGKVLGIDIDIRPHNRAAIEAHPLAPRIELIEGSSTAPEIVEQVKALAKPGERVMVILDSNHTHEHVLAELEAYAPLVT 171

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 198036241 161 RGCYAIVMDTIMEYLPESMFDGKPYGRGNNPATATREFLARDDRFEVDHDIEDRVLMTLSPGGFLKRV 228
Cdd:COG3510  172 PGSYLVVFDTIIEDLPVDMFPDRPWGPGNNPKTAVEEYLKEHPEFEIDKSIEHKLLITVAPDGYLKRI 239
CmcI pfam04989
Cephalosporin hydroxylase; Members of this family are about 220 amino acids long. The CmcI ...
 24-228 4.34e-72

Cephalosporin hydroxylase; Members of this family are about 220 amino acids long. The CmcI protein is presumed to represent the cephalosporin-7--hydroxylase. However this has not been experimentally verified.


Pssm-ID: 428241  Cd Length: 206  Bit Score: 218.42  E-value: 4.34e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241   24 GHLFQTHWLGERFFHLPGDMLALQELIWRERPDCIVQTGIAAGGGVVFTASMLELAGNHGRVVAIEPRLRDEVRQRLQSH 103
Cdd:pfam04989   2 KYSYNFSWLGRPIIQYPQDMWAYQEIIFELKPDLIIETGIAHGGSAIFSASILALLGSPRKVLGVDIDIRAHNRAAIEAH 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198036241  104 RLADRMVLIEGESCAPDTLASVRTQIDDGARVMAILDLTHTHAHVLRELECYAPFVTRGCYAIVMDTIMEYLPESMFDGK 183
Cdd:pfam04989  82 PMAPRIEMIEGSSTDPEIIEQVRSLANEPGKILVILDSDHTHDHVLAELEAYAPLVSAGSYCVVFDTNIEDLPVLFFPDP 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 198036241  184 PYGRGNNPATATREFLARDDRFEVDHDIEDRVLMTLSPGGFLKRV 228
Cdd:pfam04989 162 PWGPGNNPKTAVEEYLATFPEFEIDKEIENKLLITVAPDGFLKRI 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH