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Conserved domains on  [gi|1606559788|dbj|BBH87663|]
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MarR family transcriptional regulator [Thermosporothrix sp. COM3]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-144 2.29e-30

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 106.98  E-value: 2.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606559788   4 EEHDGHKELNIYQQLVRAYVLLDDSDSRFFSDYGLSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKL 83
Cdd:COG1846     2 SDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1606559788  84 VKRQPMVQDRRVTLITLTPKGKKLRDEIEQQHRLRIRELIGVLPPERQGFFLECLETIAQH 144
Cdd:COG1846    82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-144 2.29e-30

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 106.98  E-value: 2.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606559788   4 EEHDGHKELNIYQQLVRAYVLLDDSDSRFFSDYGLSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKL 83
Cdd:COG1846     2 SDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1606559788  84 VKRQPMVQDRRVTLITLTPKGKKLRDEIEQQHRLRIRELIGVLPPERQGFFLECLETIAQH 144
Cdd:COG1846    82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-131 2.42e-20

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 79.95  E-value: 2.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606559788   31 RFFSDYGLSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQDRRVTLITLTPKGKKLRDE 110
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1606559788  111 IEQQHRLRIRELIGVLPPERQ 131
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-94 1.71e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 53.36  E-value: 1.71e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1606559788  36 YGLSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQDRR 94
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 43-116 3.55e-04

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 38.96  E-value: 3.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1606559788  43 FWTLSHLDEKEGHSM--IDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQDRRVTLITLTPKGKK-LRDEIEQQHR 116
Cdd:PRK10870   58 FMALITLESQENHSIqpSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEfLREVLPPQHN 134
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-144 2.29e-30

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 106.98  E-value: 2.29e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606559788   4 EEHDGHKELNIYQQLVRAYVLLDDSDSRFFSDYGLSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKL 83
Cdd:COG1846     2 SDEPDPAEERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGL 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1606559788  84 VKRQPMVQDRRVTLITLTPKGKKLRDEIEQQHRLRIRELIGVLPPERQGFFLECLETIAQH 144
Cdd:COG1846    82 VEREPDPEDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
31-131 2.42e-20

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 79.95  E-value: 2.42e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606559788   31 RFFSDYGLSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQDRRVTLITLTPKGKKLRDE 110
Cdd:smart00347   1 EELKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|.
gi 1606559788  111 IEQQHRLRIRELIGVLPPERQ 131
Cdd:smart00347  81 LLEARSETLAELLAGLTAEEQ 101
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 36-94 1.71e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 53.36  E-value: 1.71e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1606559788  36 YGLSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQDRR 94
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 38-96 4.71e-10

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 52.16  E-value: 4.71e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1606559788  38 LSPRQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQDRRVT 96
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK10870 PRK10870
transcriptional repressor MprA; Provisional
 43-116 3.55e-04

transcriptional repressor MprA; Provisional


Pssm-ID: 182795  Cd Length: 176  Bit Score: 38.96  E-value: 3.55e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1606559788  43 FWTLSHLDEKEGHSM--IDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQDRRVTLITLTPKGKK-LRDEIEQQHR 116
Cdd:PRK10870   58 FMALITLESQENHSIqpSELSCALGSSRTNATRIADELEKRGWIERRESDNDRRCLHLQLTEKGHEfLREVLPPQHN 134
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
18-117 3.24e-03

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 36.03  E-value: 3.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1606559788  18 LVRAYVLLDDSDSRFFSDYgLSP-----RQFWTLSHLDEKEGHSMIDLSRLILTDKSNMTGIIDRLEKMKLVKRQPMVQD 92
Cdd:PRK11512   14 LGRLIHMVNQKKDRLLNEY-LSPlditaAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPND 92

                          90       100
                  ....*....|....*....|....*
gi 1606559788  93 RRVTLITLTPKGKKLrdeIEQQHRL 117
Cdd:PRK11512   93 KRGVLVKLTTSGAAI---CEQCHQL 114
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
45-117 4.11e-03

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 35.56  E-value: 4.11e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1606559788  45 TLSHLDEKEGH-SMIDLSRLILTDKSNMTGIIDRLEKMKLVKRQPmvqDRRvtlITLTPKGKKLRDEIEQQHRL 117
Cdd:COG1321    14 AIYELSEEGGPvRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEP---YGG---ITLTEEGRELALRIVRRHRL 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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