NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1061225919|gb|AOH83560|]
View 

glycerol-3-phosphate dehydrogenase [Sphingomonas panacis]

Protein Classification

similar to glycerol-3-phosphate dehydrogenase( domain architecture ID 11415519)

protein similar to glycerol-3-phosphate dehydrogenase

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 1-321 8.34e-142

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


:

Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 403.65  E-value: 8.34e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRASDDLAAA-AETDLILVVTPA 79
Cdd:COG0240     1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEAlAGADLVLLAVPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLRDLPRH---GQPLLLCSKGIEAGSHKLLSEVAAEEHPAS-PIGVLSGPTFAGEVARGLPTAVTLAMADADAAA 155
Cdd:COG0240    81 QALREVLEQLAPLlppGAPVVSATKGIEPGTGLLMSEVIAEELPGAlRIAVLSGPSFAEEVARGLPTAVVVASEDEEVAE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 156 RMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGL 235
Cdd:COG0240   161 RLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 236 GDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLA-GAEVGAVIGT 314
Cdd:COG0240   241 GDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYeGKSPREAVEA 320


                  ....*..
gi 1061225919 315 LLARPLT 321
Cdd:COG0240   321 LMARPLK 327
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 1-321 8.34e-142

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 403.65  E-value: 8.34e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRASDDLAAA-AETDLILVVTPA 79
Cdd:COG0240     1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEAlAGADLVLLAVPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLRDLPRH---GQPLLLCSKGIEAGSHKLLSEVAAEEHPAS-PIGVLSGPTFAGEVARGLPTAVTLAMADADAAA 155
Cdd:COG0240    81 QALREVLEQLAPLlppGAPVVSATKGIEPGTGLLMSEVIAEELPGAlRIAVLSGPSFAEEVARGLPTAVVVASEDEEVAE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 156 RMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGL 235
Cdd:COG0240   161 RLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 236 GDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLA-GAEVGAVIGT 314
Cdd:COG0240   241 GDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYeGKSPREAVEA 320


                  ....*..
gi 1061225919 315 LLARPLT 321
Cdd:COG0240   321 LMARPLK 327
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-318 1.30e-141

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 402.91  E-value: 1.30e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRASDDLAAA-AETDLILVVTPA 79
Cdd:PRK00094    2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEAlADADLILVAVPS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLR---DLPRHGQPLLLCSKGIEAGSHKLLSEVAAEEHPA-SPIGVLSGPTFAGEVARGLPTAVTLAMADADAAA 155
Cdd:PRK00094   82 QALREVLKqlkPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDlAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 156 RMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGL 235
Cdd:PRK00094  162 RVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAGL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 236 GDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLA-GAEVGAVIGT 314
Cdd:PRK00094  242 GDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYeGKDPREAVED 321


                  ....
gi 1061225919 315 LLAR 318
Cdd:PRK00094  322 LMGR 325
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 173-305 1.25e-56

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 179.89  E-value: 1.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 173 DVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGLGDLVLTCSSTSSRNFSL 252
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1061225919 253 GLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLAG 305
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYE 133
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 2-279 1.96e-55

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 183.70  E-value: 1.96e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   2 NIGILGGGAWGTALAQVMAAGG--------HTVRLWAREPEVVAA-----INDTHANPLFLPGVELSPAIRASDDLAAAA 68
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWVFEEEIEGRnlteiINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  69 E-TDLILVVTPAQHARAVLRDLPRH---GQPLLLCSKGIE--AGSHKLLSEVAaEEHPASPIGVLSGPTFAGEVARGLPT 142
Cdd:TIGR03376  81 KgADILVFVIPHQFLEGICKQLKGHvkpNARAISCIKGLEvsKDGVKLLSDII-EEELGIPCGVLSGANLANEVAKEKFS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 143 AVTLAMADADAAARMAEALA----LPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRF 218
Cdd:TIGR03376 160 ETTVGYRDPADFDVDARVLKalfhRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKF 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061225919 219 GLA--RGSRAETLAGLSGLGDLVLTCSstSSRNFSLGLGLGQ-GRKAAELMAD--RRTVAEGAFTA 279
Cdd:TIGR03376 240 ARMffPTGEVTFTFESCGVADLITTCL--GGRNFKVGRAFAKtGKSLEELEKEllNGQSLQGVATA 303
 
Name Accession Description Interval E-value
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 1-321 8.34e-142

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 403.65  E-value: 8.34e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRASDDLAAA-AETDLILVVTPA 79
Cdd:COG0240     1 MKIAVLGAGSWGTALAKVLARNGHEVTLWGRDPEVAEEINETRENPRYLPGVKLPENLRATSDLEEAlAGADLVLLAVPS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLRDLPRH---GQPLLLCSKGIEAGSHKLLSEVAAEEHPAS-PIGVLSGPTFAGEVARGLPTAVTLAMADADAAA 155
Cdd:COG0240    81 QALREVLEQLAPLlppGAPVVSATKGIEPGTGLLMSEVIAEELPGAlRIAVLSGPSFAEEVARGLPTAVVVASEDEEVAE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 156 RMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGL 235
Cdd:COG0240   161 RLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGVALGARPETFMGLAGL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 236 GDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLA-GAEVGAVIGT 314
Cdd:COG0240   241 GDLVLTCTSDLSRNRRFGLALGKGKSLEEALAEMGMVAEGVYTAKAVYELAEKLGVEMPITEAVYAVLYeGKSPREAVEA 320


                  ....*..
gi 1061225919 315 LLARPLT 321
Cdd:COG0240   321 LMARPLK 327
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
1-318 1.30e-141

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 402.91  E-value: 1.30e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRASDDLAAA-AETDLILVVTPA 79
Cdd:PRK00094    2 MKIAVLGAGSWGTALAIVLARNGHDVTLWARDPEQAAEINADRENPRYLPGIKLPDNLRATTDLAEAlADADLILVAVPS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLR---DLPRHGQPLLLCSKGIEAGSHKLLSEVAAEEHPA-SPIGVLSGPTFAGEVARGLPTAVTLAMADADAAA 155
Cdd:PRK00094   82 QALREVLKqlkPLLPPDAPIVWATKGIEPGTGKLLSEVLEEELPDlAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 156 RMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGL 235
Cdd:PRK00094  162 RVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVALGANPETFLGLAGL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 236 GDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLA-GAEVGAVIGT 314
Cdd:PRK00094  242 GDLVLTCTSPLSRNRRFGLALGQGKSLEEALAEIGMVAEGVRTAKAVYELAKKLGVEMPITEAVYAVLYeGKDPREAVED 321


                  ....
gi 1061225919 315 LLAR 318
Cdd:PRK00094  322 LMGR 325
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 2-305 3.21e-72

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 226.97  E-value: 3.21e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   2 NIGILGGGAWGTALAQVMAAGGHTVrLWAREPEVVAAINDTHANPLFLP-GVELSPAIRASDDLA-AAAETDLILVVTPA 79
Cdd:PRK12439    9 KVVVLGGGSWGTTVASICARRGPTL-QWVRSAETADDINDNHRNSRYLGnDVVLSDTLRATTDFAeAANCADVVVMGVPS 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLRDLPRHGQ---PLLLCSKGIEAGSHKLLSEVAAEEHPASPIGVLSGPTFAGEVARGLPTAVTLAMADADAAAR 156
Cdd:PRK12439   88 HGFRGVLTELAKELRpwvPVVSLVKGLEQGTNMRMSQIIEEVLPGHPAGILAGPNIAREVAEGYAAAAVLAMPDQHLATR 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 157 MAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGLG 236
Cdd:PRK12439  168 LSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMTKLGVAMGGNPETFAGLAGMG 247

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061225919 237 DLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLAG 305
Cdd:PRK12439  248 DLIVTCTSQRSRNRHVGEQLGAGKPIDEIIASMNQVAEGVKAASVVMEFADEYGLNMPIAREVDAVINH 316
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-303 2.85e-68

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 216.24  E-value: 2.85e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRAS---DDLAAAAETDLILVVt 77
Cdd:PRK14620    1 MKISILGAGSFGTAIAIALSSKKISVNLWGRNHTTFESINTKRKNLKYLPTCHLPDNISVKsaiDEVLSDNATCIILAV- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  78 PAQHARAVLRDLprHGQ------PLLLCSKGIEAGSHKLLSEVAAEEHPASPIGVLSGPTFAGEVARGLPTAVTLAMADA 151
Cdd:PRK14620   80 PTQQLRTICQQL--QDChlkkntPILICSKGIEKSSLKFPSEIVNEILPNNPIAILSGPSFAKEIAEKLPCSIVLAGQNE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 152 DAAARMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAE--TL 229
Cdd:PRK14620  158 TLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLYSAKNGSIDlnTL 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1061225919 230 AGLSGLGDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALL 303
Cdd:PRK14620  238 IGPSCLGDLILTCTTLHSRNMSFGFKIGNGFNINQILSEGKSVIEGFSTVKPLISLAKKLNIELPICESIYNLL 311
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-323 8.62e-67

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 211.77  E-value: 8.62e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWARepevvaaindthanplflpgvelspaiRASDDLAAA-AETDLILVVTPA 79
Cdd:PRK14619    5 KTIAILGAGAWGSTLAGLASANGHRVRVWSR---------------------------RSGLSLAAVlADADVIVSAVSM 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLRDLPRHGQP----LLLCSKGIEAGSHKLLSEVAAEEHPASPIGVLSGPTFAGEVARGLPTAVTLAMADADAAA 155
Cdd:PRK14619   58 KGVRPVAEQVQALNLPpetiIVTATKGLDPETTRTPSQIWQAAFPNHPVVVLSGPNLSKEIQQGLPAATVVASRDLAAAE 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 156 RMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGL 235
Cdd:PRK14619  138 TVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPEMIRVGTHLGAQTETFYGLSGL 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 236 GDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLAGAEV-GAVIGT 314
Cdd:PRK14619  218 GDLLATCTSPLSRNYQVGYGLAQGKSLEQILAELEGTAEGVNTANVLVQLAQQQNIAVPITEQVYRLLQGEITpQQALEE 297


                  ....*....
gi 1061225919 315 LLARPLTRE 323
Cdd:PRK14619  298 LMERDLKPE 306
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-305 9.61e-63

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 202.02  E-value: 9.61e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRASDDLA-AAAETDLILVVTPA 79
Cdd:PRK14618    5 MRVAVLGAGAWGTALAVLAASKGVPVRLWARRPEFAAALAAERENREYLPGVALPAELYPTADPEeALAGADFAVVAVPS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  80 QHARAVLRDLPRhGQPLLLCSKGIEAGSHKLLSEVAA-EEHPASPIGVLSGPTFAGEVARGLPTAVTLAMADADAAARMA 158
Cdd:PRK14618   85 KALRETLAGLPR-ALGYVSCAKGLAPDGGRLSELARVlEFLTQARVAVLSGPNHAEEIARFLPAATVVASPEPGLARRVQ 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 159 EALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGLGDL 238
Cdd:PRK14618  164 AAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMVRFGVALGAEEATFYGLSGLGDL 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1061225919 239 VLTCSSTSSRNFSLGLGLGQGRKAAELMAdRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLAG 305
Cdd:PRK14618  244 IATATSPHSRNRAAGEAIVRGVDREHLEA-GGKVVEGLYTVKALDAWAKAHGHDLPIVEAVARVARG 309
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 173-305 1.25e-56

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 179.89  E-value: 1.25e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 173 DVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFGLARGSRAETLAGLSGLGDLVLTCSSTSSRNFSL 252
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGAKPETFFGLAGLGDLIVTCTSGLSRNRRF 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1061225919 253 GLGLGQGRKAAELMADRRTVAEGAFTAPVLCAAAAAADVAMPVSEAVAALLAG 305
Cdd:pfam07479  81 GEALGKGKSLEEAEKELGQVAEGVYTAKAVYELAKKLGVEMPIFEAVYRILYE 133
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 2-279 1.96e-55

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 183.70  E-value: 1.96e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   2 NIGILGGGAWGTALAQVMAAGG--------HTVRLWAREPEVVAA-----INDTHANPLFLPGVELSPAIRASDDLAAAA 68
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENAralpelfeESVRMWVFEEEIEGRnlteiINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  69 E-TDLILVVTPAQHARAVLRDLPRH---GQPLLLCSKGIE--AGSHKLLSEVAaEEHPASPIGVLSGPTFAGEVARGLPT 142
Cdd:TIGR03376  81 KgADILVFVIPHQFLEGICKQLKGHvkpNARAISCIKGLEvsKDGVKLLSDII-EEELGIPCGVLSGANLANEVAKEKFS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 143 AVTLAMADADAAARMAEALA----LPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRF 218
Cdd:TIGR03376 160 ETTVGYRDPADFDVDARVLKalfhRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKF 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1061225919 219 GLA--RGSRAETLAGLSGLGDLVLTCSstSSRNFSLGLGLGQ-GRKAAELMAD--RRTVAEGAFTA 279
Cdd:TIGR03376 240 ARMffPTGEVTFTFESCGVADLITTCL--GGRNFKVGRAFAKtGKSLEELEKEllNGQSLQGVATA 303
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 3-146 1.62e-52

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 170.07  E-value: 1.62e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   3 IGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPLFLPGVELSPAIRASDDLAAAAE-TDLILVVTPAQH 81
Cdd:pfam01210   2 IAVLGAGSWGTALAKVLADNGHEVRLWGRDEELIEEINTTHENVRYLPGIKLPENLKATTDLAEALKgADIIVIVVPSQA 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1061225919  82 ARAVLRDL---PRHGQPLLLCSKGIEAGSHKLLSEVAAEEHP-ASPIGVLSGPTFAGEVARGLPTAVTL 146
Cdd:pfam01210  82 LREVLKQLkglLKPDAILVSLSKGIEPGTLKLLSEVIEEELGiQPPIAVLSGPSHAEEVAQGLPTATVI 150
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 3-242 1.10e-31

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 121.67  E-value: 1.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   3 IGILGGGAWGTALAQVMAAGGH-------TVRLWAREPEV-----VAAINDTHANPLFLPGVELSPAIRASDDLAAAAE- 69
Cdd:PTZ00345   14 VSVIGSGNWGSAISKVVGENTQrnyifhnEVRMWVLEEIVegeklSDIINTKHENVKYLPGIKLPDNIVAVSDLKEAVEd 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919  70 TDLILVVTPAQHARAVLR------DLPRHGQPLLLcSKGI--EAGSHKLLSEVAaEEHPASPIGVLSGPTFAGEVARGLP 141
Cdd:PTZ00345   94 ADLLIFVIPHQFLESVLSqikennNLKKHARAISL-TKGIivENGKPVLCSDVI-EEELGIPCCALSGANVANDVAREEF 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919 142 TAVTLAMADADAAARMAEALALPTFRPYASDDVIGAEIGGAVKNVLAIACGVVEGAGLGQNARAALIARGFAEMTRFG-- 219
Cdd:PTZ00345  172 SEATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLFGki 251

                         250       260
                  ....*....|....*....|...
gi 1061225919 220 LARGSRAETLAGLSGLGDLVLTC 242
Cdd:PTZ00345  252 FFPNVMDETFFESCGLADLITTC 274
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 233-299 3.42e-14

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 66.37  E-value: 3.42e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1061225919 233 SGLGDLVLTCSSTSSRNFSLGLGLGQGRKAAELMADrrTVAEGAFTA-PVLCAAAAAADVAMPVSEAV 299
Cdd:pfam20618   1 AGLGDLVLTCTSDLSRNRTFGLLLGKGMTLAEAGNG--QVAEGVRTAkAVAAILARAHNVEMPILEAV 66
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 1-92 3.07e-10

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 60.25  E-value: 3.07e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGA----WGTALAQvmaaGGHTVRLWAREPEVVAAINdthANPLFLPGVELSPAIRASDDLAAAAETDLILVV 76
Cdd:PRK06522    1 MKIAILGAGAigglFGAALAQ----AGHDVTLVARRGAHLDALN---ENGLRLEDGEITVPVLAADDPAELGPQDLVILA 73

                          90
                  ....*....|....*.
gi 1061225919  77 TPAQHARAVLRDLPRH 92
Cdd:PRK06522   74 VKAYQLPAALPSLAPL 89
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 1-92 1.88e-09

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 57.94  E-value: 1.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWARePEVVAAINDTHANPLFLPGVELSPAIRASDDLAAAAETDLILVVTPAQ 80
Cdd:COG1893     1 MKIAILGAGAIGGLLGARLARAGHDVTLVAR-GAHAEALRENGLRLESPDGDRTTVPVPAVTDPEELGPADLVLVAVKAY 79

                          90
                  ....*....|..
gi 1061225919  81 HARAVLRDLPRH 92
Cdd:COG1893    80 DLEAAAEALAPL 91
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
3-92 6.10e-07

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 49.40  E-value: 6.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   3 IGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDthanplflpgvELSPAIRASDDLAAAAETDLILVVTPAQHA 82
Cdd:COG2085     1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKAAALAA-----------ELGPGARAGTNAEAAAAADVVVLAVPYEAV 69

                          90
                  ....*....|
gi 1061225919  83 RAVLRDLPRH 92
Cdd:COG2085    70 PDVLESLGDA 79
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 1-73 9.89e-06

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 46.26  E-value: 9.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHAN---------PLFLPGVELSPA-IRASDDLAAAAET 70
Cdd:COG1250     3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKlldklvkkgKLTEEEADAALArITPTTDLAALADA 82


                  ...
gi 1061225919  71 DLI 73
Cdd:COG1250    83 DLV 85
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
 3-92 2.04e-05

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 43.76  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   3 IGILGGGAWGTALAQVMAAGGHTVRLWAREPEvVAAINDTHANPLFLPGVELSPAIRASDDLAAAAETDLILVVTPAQHA 82
Cdd:pfam02558   1 IAILGAGAIGSLLGARLAKAGHDVTLILRGAE-LAAIKKNGLRLTSPGGERIVPPPAVTSASESLGPIDLVIVTVKAYQT 79

                          90
                  ....*....|
gi 1061225919  83 RAVLRDLPRH 92
Cdd:pfam02558  80 EEALEDIAPL 89
PRK08655 PRK08655
prephenate dehydrogenase; Provisional
 1-120 9.01e-04

prephenate dehydrogenase; Provisional


Pssm-ID: 236326 [Multi-domain]  Cd Length: 437  Bit Score: 40.74  E-value: 9.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGG----GAWgtaLAQVMAAGGHTVRLWAREPEVVAAIndthANPLflpGVELspairASDDLAAAAETDLILVV 76
Cdd:PRK08655    1 MKISIIGGtgglGKW---FARFLKEKGFEVIVTGRDPKKGKEV----AKEL---GVEY-----ANDNIDAAKDADIVIIS 65

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1061225919  77 TPAQHARAVLRDLPRH---GQPLL-LCSkgIEAGSHKLLSEVAAEE------HP 120
Cdd:PRK08655   66 VPINVTEDVIKEVAPHvkeGSLLMdVTS--VKERPVEAMEEYAPEGveilptHP 117
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 1-93 2.60e-03

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 39.02  E-value: 2.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   1 MNIGILGGGAWGTALAQVMAAGGHTVRlwarepeVVAAINDTHANPLflpgVELSPAIRASDDLAAAAETDLILVVTPAQ 80
Cdd:COG5495     4 MKIGIIGAGRVGTALAAALRAAGHEVV-------GVYSRSPASAERA----AALLGAVPALDLEELAAEADLVLLAVPDD 72

                          90
                  ....*....|...
gi 1061225919  81 HARAVLRDLPRHG 93
Cdd:COG5495    73 AIAEVAAGLAAAG 85
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
4-91 2.76e-03

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 36.44  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   4 GILGGGAWGTALA-QVMAAGGHTVRL-WAREPEVVAAINDthanplflpgvELSPAIRASDDLAAAAETDLILVVTPAQH 81
Cdd:pfam03807   1 GFIGAGNMGEALArGLVAAGPHEVVVaNSRNPEKAEELAE-----------EYGVGATAVDNEEAAEEADVVFLAVKPED 69

                          90
                  ....*....|
gi 1061225919  82 ARAVLRDLPR 91
Cdd:pfam03807  70 APDVLSELSD 79
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 2-73 3.93e-03

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 37.52  E-value: 3.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1061225919   2 NIGILGGGAWGTALAQVMAAGGHTVRLWAREPEVVAAINDTHANPL-------FLPGVELSPA---IRASDDLAAAAETD 71
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLerlvekgRITEEEVDAAlarISFTTDLAAAVDAD 80


                  ..
gi 1061225919  72 LI 73
Cdd:pfam02737  81 LV 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH