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Conserved domains on  [gi|247547209|gb|ACT04228|]
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two component transcriptional regulator, AraC family [Paenibacillus sp. JDR-2]

Protein Classification

response regulator( domain architecture ID 1000931)

two-component system response regulator contains a phosphoacceptor receiver (REC) domain and a helix-turn-helix (HTH) DNA-binding output domain; similar to YesN/AraC family transcriptional regulators

Gene Ontology:  GO:0000160|GO:0043565|GO:0003700
PubMed:  20226724

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
5-123 5.93e-48

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


:

Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 162.51  E-value: 5.93e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVQ 123
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKP-VDEEELEEALEKAKE 118
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
449-530 6.11e-23

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 92.62  E-value: 6.11e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   449 VTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQ 528
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81

                   ..
gi 247547209   529 AY 530
Cdd:smart00342  82 EY 83
 
Name Accession Description Interval E-value
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
5-123 5.93e-48

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 162.51  E-value: 5.93e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVQ 123
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKP-VDEEELEEALEKAKE 118
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
4-106 1.96e-38

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 136.44  E-value: 1.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILE-WEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIIL 79
                         90       100
                 ....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:COG4753   80 SGYSDFEYAQEAIKLGADDYLLK 102
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
5-119 2.21e-29

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 111.86  E-value: 2.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209    5 VLLVDDEPLVRNDLRSLLdfRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL--EKEGYVV-AEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILT 77
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 247547209   85 SYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLE 119
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSK-PFDPDELLAAIR 111
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
449-530 6.11e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 92.62  E-value: 6.11e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   449 VTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQ 528
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81

                   ..
gi 247547209   529 AY 530
Cdd:smart00342  82 EY 83
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
410-530 4.32e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.00  E-value: 4.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 410 LQSFYGVLLILLKEHHATGSYSRHVSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAA 489
Cdd:COG2207  130 LLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERA 209
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 247547209 490 RRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:COG2207  210 KRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEY 250
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
4-126 1.19e-20

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 90.47  E-value: 1.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFrAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:PRK10651   8 TILLIDDHPMLRTGVKQLISM-APDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVF 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVqAGK 126
Cdd:PRK10651  87 SVSNHEEDVVTALKRGADGYLLKD-MEPEDLLKALQQAA-AGE 127
HTH_18 pfam12833
Helix-turn-helix domain;
455-530 2.71e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.56  E-value: 2.71e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247547209  455 AGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLL-ESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:pfam12833   2 AAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEY 78
PRK10371 PRK10371
transcriptional regulator MelR;
429-530 5.65e-14

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 72.93  E-value: 5.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 429 SYSRH----VSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVS 504
Cdd:PRK10371 184 SVSRHaqfyVSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIA 263
                         90       100
                 ....*....|....*....|....*.
gi 247547209 505 DQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:PRK10371 264 LTAGFRSSSRFYSTFGKYVGMSPQQY 289
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
3-60 2.08e-12

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 61.82  E-value: 2.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 247547209     3 YRVLLVDDEPLVRNDLRSLLdfRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMP 60
Cdd:smart00448   1 MRILVVDDDPLLRELLKALL--EKEGYEV-DEATDGEEALELLKEEKPDLILLDIMMP 55
 
Name Accession Description Interval E-value
REC_YesN-like cd17536
phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response ...
5-123 5.93e-48

phosphoacceptor receiver (REC) domain of YesN and related helix-turn-helix containing response regulators; This family is composed of uncharacterized response regulators that contain a REC domain and a AraC family helix-turn-helix (HTH) DNA-binding output domain, including Bacillus subtilis uncharacterized transcriptional regulatory protein YesN and Staphylococcus aureus uncharacterized response regulatory protein SAR0214. YesN is a member of the two-component regulatory system YesM/YesN and SAR0214 is a member of the probable two-component regulatory system SAR0215/SAR0214. Also included in this family is the AlgR-like group of LytTR/AlgR family response, which includes Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR and Bacillus subtilis sensory transduction protein LytT, among others. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381091 [Multi-domain]  Cd Length: 121  Bit Score: 162.51  E-value: 5.93e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17536    1 VLIVDDEPLIREGLKKLIDWEELGFEVVGEAENGEEALELIEEHKPDIVITDIRMPGMDGLELIEKIRELYPDIKIIILS 80
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVQ 123
Cdd:cd17536   81 GYDDFEYAQKAIRLGVVDYLLKP-VDEEELEEALEKAKE 118
YesN COG4753
Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding ...
4-106 1.96e-38

Two-component response regulator, YesN/AraC family, consists of REC and AraC-type DNA-binding domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443786 [Multi-domain]  Cd Length: 103  Bit Score: 136.44  E-value: 1.96e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:COG4753    1 KVLIVDDEPLIREGLKRILE-WEAGFEVVGEAENGEEALELLEEHKPDLVITDINMPGMDGLELLEAIRELDPDTKIIIL 79
                         90       100
                 ....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:COG4753   80 SGYSDFEYAQEAIKLGADDYLLK 102
REC_NarL-like cd17535
phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family ...
5-124 2.78e-33

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381090 [Multi-domain]  Cd Length: 117  Bit Score: 122.62  E-value: 2.78e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17535    1 VLIVDDHPLVREGLRRLLE-SEPDIEVVGEAADGEEALALLRELRPDVVLMDLSMPGMDGIEALRRLRRRYPDLKVIVLT 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLkhrldKDTLLAMLEKAVQA 124
Cdd:cd17535   80 AHDDPEYVLRALKAGAAGYLL-----KDSSPEELIEAIRA 114
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
1-139 7.51e-33

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 122.39  E-value: 7.51e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT 80
Cdd:COG4565    2 KMIRVLIVEDDPMVAELLRRYLE-RLPGFEVVGVASSGEEALALLAEHRPDLILLDIYLPDGDGLELLRELRARGPDVDV 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 247547209  81 IMLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAGKSSEAASEADESSH 139
Cdd:COG4565   81 IVITAARDPETVREALRAGVVDYLIK-PFTFERLREALERYLEYRRLLREDQEEDLPEA 138
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
1-136 1.67e-29

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 120.45  E-value: 1.67e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT 80
Cdd:COG2204    1 SMARILVVDDDPDIRRLLKELL--ERAGYEVE-TAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPV 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 247547209  81 IMLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAGKSSEAASEADE 136
Cdd:COG2204   78 ILLTGYGDVETAVEAIKAGAFDYLTK-PFDLEELLAAVERALERRRLRRENAEDSG 132
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
5-119 2.21e-29

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 111.86  E-value: 2.21e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209    5 VLLVDDEPLVRNDLRSLLdfRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLL--EKEGYVV-AEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRRRDPTTPVIILT 77
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 247547209   85 SYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLE 119
Cdd:pfam00072  78 AHGDEDDAVEALEAGADDFLSK-PFDPDELLAAIR 111
LytT COG3279
DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction ...
2-140 5.28e-29

DNA-binding response regulator, LytR/AlgR family [Transcription, Signal transduction mechanisms];


Pssm-ID: 442510 [Multi-domain]  Cd Length: 235  Bit Score: 114.91  E-value: 5.28e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:COG3279    1 MMKILIVDDEPLARERLERLLE-KYPDLEVVGEASNGEEALELLEEHKPDLVFLDIQMPGLDGFELARQLRELDPPPPII 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209  82 MLSSYDdyDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQ-AGKSSEAASEADESSHF 140
Cdd:COG3279   80 FTTAYD--EYALEAFEVNAVDYLLK-PIDEERLAKALEKAKErLEAKAAAEASPEEKDRI 136
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
6-106 2.57e-27

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 105.77  E-value: 2.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   6 LLVDDEPLVRNDLRSLLdfRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLSS 85
Cdd:cd00156    1 LIVDDDPAIRELLKSLL--EREGYEV-DTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRELPPDIPVIVLTA 77
                         90       100
                 ....*....|....*....|.
gi 247547209  86 YDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd00156   78 KADEEDAVRALELGADDYLVK 98
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
1-127 3.06e-27

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 106.47  E-value: 3.06e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQR--YPAV 78
Cdd:COG0784    4 GGKRILVVDDNPDNRELLRRLL--ERLGYEVT-TAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALprLPDI 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 247547209  79 QTIMLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAGKS 127
Cdd:COG0784   81 PIIALTAYADEEDRERALEAGADDYLTK-PVDPEELLEALRRLLARASA 128
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
4-123 8.18e-25

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 102.55  E-value: 8.18e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT--I 81
Cdd:COG3437    8 TVLIVDDDPENLELLRQLL--RTLGYDVV-TAESGEEALELLLEAPPDLILLDVRMPGMDGFELLRLLRADPSTRDIpvI 84
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVQ 123
Cdd:COG3437   85 FLTALADPEDRERALEAGADDYLTKP-FDPEELLARVRNALE 125
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
2-125 9.60e-25

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 101.14  E-value: 9.60e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT- 80
Cdd:COG3706    1 PARILVVDDDPTNRKLLRRLL--EAAGYEVV-EAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADIp 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 247547209  81 -IMLSSYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVQAG 125
Cdd:COG3706   78 iIFLTALDDEEDRARALEAGADDYLTKP-FDPEELLARVDLVARYG 122
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
2-106 2.14e-24

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 100.80  E-value: 2.14e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:COG0745    1 MPRILVVEDDPDIRELLADAL--EREGYEVD-TAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRARPSDIPII 77
                         90       100
                 ....*....|....*....|....*
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:COG0745   78 MLTARDDEEDRVRGLEAGADDYLTK 102
REC_CheY cd17542
phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response ...
3-122 1.03e-23

phosphoacceptor receiver (REC) domain of chemotaxis protein CheY; The chemotaxis response regulator CheY contains a stand-alone REC domain. Chemotaxis is a behavior known for motile bacteria that directs their movement in response to chemical gradients. CheY is involved in transmitting sensory signals from chemoreceptors to the flagellar motors. Phosphorylated CheY interacts with the flagella switch components FliM and FliY, which causes counterclockwise rotation of the flagella, resulting in smooth swimming. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381097 [Multi-domain]  Cd Length: 117  Bit Score: 96.19  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLLDfrAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:cd17542    1 KKVLIVDDAAFMRMMLKDILT--KAGYEVVGEAANGEEAVEKYKELKPDLVTMDITMPEMDGIEALKEIKKIDPNAKVIM 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAV 122
Cdd:cd17542   79 CSAMGQEEMVKEAIKAGAKDFIVK-PFQPERVLEAVEKVL 117
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
449-530 6.11e-23

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 92.62  E-value: 6.11e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   449 VTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQ 528
Cdd:smart00342   2 LTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTPS 81

                   ..
gi 247547209   529 AY 530
Cdd:smart00342  82 EY 83
REC_PdtaR-like cd19932
phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes ...
4-122 1.64e-22

phosphoacceptor receiver (REC) domain of PdtaR and similar proteins; This subfamily includes Mycobacterium tuberculosis PdtaR, also called Rv1626, and similar proteins containing a REC domain and an ANTAR (AmiR and NasR transcription antitermination regulators) RNA-binding output domain. PdtaR is a response regulator that acts at the level of transcriptional antitermination and is a member of the PdtaR/PdtaS two-component regulatory system. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381159 [Multi-domain]  Cd Length: 118  Bit Score: 92.86  E-value: 1.64e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAvQTIML 83
Cdd:cd19932    2 RVLIAEDEALIRMDLREML--EEAGYEVVGEASDGEEAVELAKKHKPDLVIMDVKMPRLDGIEAAKIITSENIA-PIVLL 78
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLKHRLDKDtLLAMLEKAV 122
Cdd:cd19932   79 TAYSQQDLVERAKEAGAMAYLVKPFSESD-LIPAIEMAI 116
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
410-530 4.32e-22

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 96.00  E-value: 4.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 410 LQSFYGVLLILLKEHHATGSYSRHVSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAA 489
Cdd:COG2207  130 LLRALELLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERA 209
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 247547209 490 RRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:COG2207  210 KRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPSEY 250
REC_CheB-like cd17541
phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate ...
3-106 6.39e-22

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381096 [Multi-domain]  Cd Length: 125  Bit Score: 91.30  E-value: 6.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPaVQTIM 82
Cdd:cd17541    1 IRVLIVDDSAVMRKLLSRILE-SDPDIEVVGTARDGEEALEKIKELKPDVITLDIEMPVMDGLEALRRIMAERP-TPVVM 78
                         90       100
                 ....*....|....*....|....*.
gi 247547209  83 LSSY--DDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17541   79 VSSLteEGAEITLEALELGAVDFIAK 104
Spo0F COG5803
Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, ...
1-106 8.66e-22

Stage 0 sporulation initiation response regulator Spo0F [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444505 [Multi-domain]  Cd Length: 119  Bit Score: 90.62  E-value: 8.66e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLldFRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT 80
Cdd:COG5803    1 MMKKILIVDDQAGIRMLLKEV--LKKEGYEVF-QAANGKEALEKVKELKPDLVLLDMKMPGMDGIEILKEIKEIDPDIPV 77
                         90       100
                 ....*....|....*....|....*.
gi 247547209  81 IMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:COG5803   78 IMMTAYGELDMVEEAKELGAKGYFTK 103
REC_HupR-like cd17569
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar ...
3-123 1.89e-21

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381113 [Multi-domain]  Cd Length: 118  Bit Score: 89.77  E-value: 1.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLldFRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:cd17569    1 PTILLVDDEPNILKALKRL--LRREGYEVL-TATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRERYPDTVRIL 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKHRLDKDTLLAMLEKAVQ 123
Cdd:cd17569   78 LTGYADLDAAIEAINEGEIYRFLTKPWDDEELKETIRQALE 118
REC_citrate_TCS cd19925
phosphoacceptor receiver (REC) domain of citrate family two-component system response ...
3-106 3.64e-21

phosphoacceptor receiver (REC) domain of citrate family two-component system response regulators; This family includes Lactobacillus paracasei MaeR, Escherichia coli DcuR and DpiA, Klebsiella pneumoniae CitB, as well as Bacillus DctR, MalR, and CitT. These are all response regulators of two-component systems (TCSs) from the citrate family, and are involved in the transcriptional regulation of genes associated with L-malate catabolism (MaeRK), citrate-specific fermentation (DpiAB, CitAB), plasmid inheritance (DpiAB), anaerobic fumarate respiratory system (DcuRS), and malate transport/utilization (MalKR). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381152 [Multi-domain]  Cd Length: 118  Bit Score: 88.84  E-value: 3.64e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:cd19925    1 INVLIVEDDPMVAEIHRAYVE-QVPGFTVIGTAGTGEEALKLLKERQPDLILLDIYLPDGNGLDLLRELRAAGHDVDVIV 79
                         90       100
                 ....*....|....*....|....
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd19925   80 VTAANDVETVREALRLGVVDYLIK 103
AmiR COG3707
Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding ...
1-123 5.89e-21

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 442921 [Multi-domain]  Cd Length: 194  Bit Score: 90.79  E-value: 5.89e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAvQT 80
Cdd:COG3707    2 RGLRVLVVDDEPLRRADLREGL--REAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPA-PV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 247547209  81 IMLSSYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVQ 123
Cdd:COG3707   79 ILLTAYSDPELIERALEAGVSAYLVKP-LDPEDLLPALELALA 120
PRK10651 PRK10651
transcriptional regulator NarL; Provisional
4-126 1.19e-20

transcriptional regulator NarL; Provisional


Pssm-ID: 182619 [Multi-domain]  Cd Length: 216  Bit Score: 90.47  E-value: 1.19e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFrAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:PRK10651   8 TILLIDDHPMLRTGVKQLISM-APDITVVGEASNGEQGIELAESLDPDLILLDLNMPGMNGLETLDKLREKSLSGRIVVF 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVqAGK 126
Cdd:PRK10651  87 SVSNHEEDVVTALKRGADGYLLKD-MEPEDLLKALQQAA-AGE 127
CitB COG2197
DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal ...
2-71 2.55e-20

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 441799 [Multi-domain]  Cd Length: 131  Bit Score: 86.87  E-value: 2.55e-20
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTI 71
Cdd:COG2197    1 MIRVLIVDDHPLVREGLRALLE-AEPDIEVVGEAADGEEALELLEELRPDVVLLDIRMPGMDGLEALRRL 69
REC_LytTR_AlgR-like cd17532
phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; ...
5-121 3.76e-20

phosphoacceptor receiver (REC) domain of LytTR/AlgR family response regulators similar to AlgR; Members of the LytTR/AlgR family of response regulators contain a REC domain and a unique LytTR DNA-binding output domain that lacks the helix-turn-helix motif and consists mostly of beta-strands. Transcriptional regulators with the LytTR-type output domains are involved in biosynthesis of extracellular polysaccharides, fimbriation, expression of exoproteins, including toxins, and quorum sensing. Included in this AlgR-like group of LytTR/AlgR family response regulators are Streptococcus agalactiae sensory transduction protein LytR, Pseudomonas aeruginosa positive alginate biosynthesis regulatory protein AlgR, Bacillus subtilis sensory transduction protein LytT, and Escherichia coli transcriptional regulatory protein BtsR, which are members of two-component regulatory systems. LytR and LytT are components of regulatory systems that regulate genes involved in cell wall metabolism. AlgR positively regulates the algD gene, which codes for a GDP-mannose dehydrogenase, a key enzyme in the alginate biosynthesis pathway. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381087 [Multi-domain]  Cd Length: 118  Bit Score: 86.05  E-value: 3.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRY--PAVqtIM 82
Cdd:cd17532    1 ALIVDDEPLAREELRYLLE-EHPDIEIVGEAENGEEALEAIEELKPDVVFLDIQMPGLDGLELAKKLSKLAkpPLI--VF 77
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 247547209  83 LSSYDdyDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKA 121
Cdd:cd17532   78 VTAYD--EYAVEAFELNAVDYLLK-PFSEERLAEALAKL 113
REC_DC-like cd17534
phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; ...
4-122 8.48e-20

phosphoacceptor receiver (REC) domain of modulated diguanylate cyclase and similar domains; This groups includes a modulated diguanylate cyclase containing a PAS sensor domain from Desulfovibrio desulfuricans G20. Members of this group contain N-terminal REC domains and various output domains including the GGDEF, histidine kinase, and helix-turn-helix (HTH) DNA binding domains. Also included in this family is Mycobacterium tuberculosis PdtaR, a transcriptional antiterminator that contains a REC domain and an ANTAR RNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381089 [Multi-domain]  Cd Length: 117  Bit Score: 84.77  E-value: 8.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPG-MNGVDLNRTIKQRYPaVQTIM 82
Cdd:cd17534    2 KILIVEDEAIIALDLKEIL--ESLGYEVVGIADSGEEAIELAEENKPDLILMDINLKGdMDGIEAAREIREKFD-IPVIF 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAV 122
Cdd:cd17534   79 LTAYSDEETLERAKETNPYGYLVK-PFNERELKAAIELAL 117
REC_OmpR cd17574
phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins ...
6-106 1.21e-19

phosphoacceptor receiver (REC) domain of OmpR family response regulators; OmpR-like proteins are one of the most widespread transcriptional regulators. OmpR family members contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domain. They are involved in the control of environmental stress tolerance (such as the oxidative, osmotic and acid stress response), motility, virulence, outer membrane biogenesis and other processes. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381116 [Multi-domain]  Cd Length: 99  Bit Score: 84.00  E-value: 1.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   6 LLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLSS 85
Cdd:cd17574    1 LVVEDDEEIAELLSDYL--EKEGYEVD-TAADGEEALELAREEQPDLIILDVMLPGMDGFEVCRRLREKGSDIPIIMLTA 77
                         90       100
                 ....*....|....*....|..
gi 247547209  86 YDD-YDYVRdCLKNGSVDYLLK 106
Cdd:cd17574   78 KDEeEDKVL-GLELGADDYITK 98
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
411-530 9.68e-19

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 87.14  E-value: 9.68e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 411 QSFYGVLLILLKEHHATgsysrhVSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAAR 490
Cdd:COG4977  195 QAQFSPLLVPLGHRDPR------LARAQAWMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERAR 268
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 247547209 491 RLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:COG4977  269 RLLETTDLSIEEIAAACGFGSASHFRRAFRRRFGVSPSAY 308
REC_NarL cd19931
phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate ...
5-123 9.74e-19

phosphoacceptor receiver (REC) domain of Nitrate/Nitrite response regulator L (NarL); Nitrate/nitrite response regulator protein NarL contains an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. Escherichia coli NarL activates the expression of the nitrate reductase (narGHJI) and formate dehydrogenase-N (fdnGHI) operons, and represses the transcription of the fumarate reductase (frdABCD) operon in response to a nitrate/nitrite induction signal. Phosphorylation of the NarL REC domain releases the C-terminal HTH output domain that subsequently binds specific DNA promoter sites to repress or activate gene expression. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381158 [Multi-domain]  Cd Length: 117  Bit Score: 82.01  E-value: 9.74e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFrAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd19931    1 VLLIDDHPLLRKGIKQLIEL-DPDFTVVGEASSGEEGIELAERLDPDLILLDLNMKGMSGLDTLKALREEGVSARIVILT 79
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKHrLDKDTLLAMLEKAVQ 123
Cdd:cd19931   80 VSDAEDDVVTALRAGADGYLLKD-MEPEDLLEALKQAAS 117
PRK15369 PRK15369
two component system response regulator;
1-127 1.14e-18

two component system response regulator;


Pssm-ID: 185267 [Multi-domain]  Cd Length: 211  Bit Score: 84.75  E-value: 1.14e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLDFRAHgFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT 80
Cdd:PRK15369   2 KNYKILLVDDHELIINGIKNMLAPYPR-YKIVGQVDNGLEVYNACRQLEPDIVILDLGLPGMNGLDVIPQLHQRWPAMNI 80
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 247547209  81 IMLSSYDDYDYVRDCLKNGSVDYLLKHRlDKDTLLAMLeKAVQAGKS 127
Cdd:PRK15369  81 LVLTARQEEHMASRTLAAGALGYVLKKS-PQQILLAAI-QTVAVGKR 125
HTH_18 pfam12833
Helix-turn-helix domain;
455-530 2.71e-18

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 79.56  E-value: 2.71e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 247547209  455 AGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLL-ESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:pfam12833   2 AAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARRLLlEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEY 78
REC_RssB-like cd17555
phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; ...
4-125 2.75e-18

phosphoacceptor receiver (REC) domain of Pseudomonas aeruginosa RssB and similar domains; Pseudomonas aeruginosa RssB is an orphan atypical response regulator containing a REC domain and a PP2C-type protein phosphatase output domain. Its function is still unknown. Escherichia RssB, which is not included in this subfamily, is a ClpX adaptor protein which alters ClpX specificity by mediating a specific interaction between ClpX and the substrates such as RpoS, an RNA polymerase sigma factor. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381107 [Multi-domain]  Cd Length: 116  Bit Score: 80.71  E-value: 2.75e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDfrAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:cd17555    2 TILVIDDDEVVRESIAAYLE--DSGFQVL-QAADGRQGLELFRSEQPDLVLCDLRMPEMDGLEVLKQITKESPDTPVIVV 78
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLKHRLDkdtlLAMLEKAVQAG 125
Cdd:cd17555   79 SGAGVMSDAVEALRLGAWDYLTKPIED----LAVLEHAVRRA 116
REC_DesR-like cd19930
phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of ...
5-108 1.42e-17

phosphoacceptor receiver (REC) domain of DesR and similar proteins; This group is composed of Bacillus subtilis DesR, Streptococcus pneumoniae response regulator spr1814, and similar proteins, all containing an N-terminal REC domain and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. DesR is a response regulator that, together with its cognate sensor kinase DesK, comprises a two-component regulatory system that controls membrane fluidity. Phosphorylation of the REC domain of DesR is allosterically coupled to two distinct exposed surfaces of the protein, controlling noncanonical dimerization/tetramerization, cooperative activation, and DesK binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381157 [Multi-domain]  Cd Length: 117  Bit Score: 78.47  E-value: 1.42e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd19930    1 VLIAEDQEMVRGALAALLE-LEDDLEVVAQASNGQEALRLVLKHSPDVAILDIEMPGRTGLEVAAELREELPDTKVLIVT 79
                         90       100
                 ....*....|....*....|....
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKHR 108
Cdd:cd19930   80 TFGRPGYFRRALAAGVDGYVLKDR 103
FixJ COG4566
DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal ...
5-168 4.29e-17

DNA-binding response regulator, FixJ family, consists of REC and HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443623 [Multi-domain]  Cd Length: 196  Bit Score: 79.76  E-value: 4.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLL---DFRAHGFEicgeaqSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:COG4566    2 VYIVDDDEAVRDSLAFLLesaGLRVETFA------SAEAFLAALDPDRPGCLLLDVRMPGMSGLELQEELAARGSPLPVI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAgksSEAASEADESSHFNAELVRS------QISDL-AR 154
Cdd:COG4566   76 FLTGHGDVPMAVRAMKAGAVDFLEK-PFDDQALLDAVRRALAR---DRARRAERARRAELRARLASltprerEVLDLvVA 151
                        170
                 ....*....|....*.
gi 247547209 155 GKA--EAARELEGSIR 168
Cdd:COG4566  152 GLSnkQIARELGISPR 167
REC_TrrA-like cd17554
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and ...
4-90 8.78e-17

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator TrrA and similar domains; Thermotoga maritima contains a two-component signal transduction system (TCS) composed of the ThkA sensory histidine kinase (HK) and its cognate response regulator (RR) TrrA; the specific function of the system is unknown. TCSs couple environmental stimuli to adaptive responses. TrrA is a stand-alone RR containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381106 [Multi-domain]  Cd Length: 113  Bit Score: 76.11  E-value: 8.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPlvrnDLRSLLD--FRAHGFEICGeAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:cd17554    2 KILVVDDEE----NIRELYKeeLEDEGYEVVT-AGNGEEALEKLESEDPDLVILDIKMPGMDGLETLRKIREKKPDLPVI 76

                 ....*....
gi 247547209  82 MLSSYDDYD 90
Cdd:cd17554   77 ICTAYSEYK 85
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
4-121 2.65e-16

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 76.88  E-value: 2.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGeAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:COG4567    6 SLLLVDDDEAFARVLARAL--ERRGFEVTT-AASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRERDPDARIVVL 82
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKA 121
Cdd:COG4567   83 TGYASIATAVEAIKLGADDYLAK-PADADDLLAALERA 119
PRK00742 PRK00742
chemotaxis-specific protein-glutamate methyltransferase CheB;
1-128 3.07e-16

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 234828 [Multi-domain]  Cd Length: 354  Bit Score: 80.19  E-value: 3.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPaVQT 80
Cdd:PRK00742   2 MKIRVLVVDDSAFMRRLISEILN-SDPDIEVVGTAPDGLEAREKIKKLNPDVITLDVEMPVMDGLDALEKIMRLRP-TPV 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 247547209  81 IMLSS--YDDYDYVRDCLKNGSVDYLLK----HRLDKDTLLAML-EKAVQAGKSS 128
Cdd:PRK00742  80 VMVSSltERGAEITLRALELGAVDFVTKpflgISLGMDEYKEELaEKVRAAARAR 134
REC_PA4781-like cd19920
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar ...
5-106 3.56e-16

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381147 [Multi-domain]  Cd Length: 103  Bit Score: 74.08  E-value: 3.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPlvrNDLRSLLDF-RAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQ--RYPAVQTI 81
Cdd:cd19920    1 ILIVDDVP---DNLRLLSELlRAAGYRV-LVATDGQQALQRAQAEPPDLILLDVMMPGMDGFEVCRRLKAdpATRHIPVI 76
                         90       100
                 ....*....|....*....|....*
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd19920   77 FLTALTDTEDKVKGFELGAVDYITK 101
REC_DctD-like cd17549
phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and ...
5-124 3.72e-16

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381101 [Multi-domain]  Cd Length: 130  Bit Score: 74.83  E-value: 3.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLL---DFRAHGFEicgeaqSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:cd17549    1 VLLVDDDADVREALQQTLelaGFRVRAFA------DAEEALAALSPDFPGVVISDIRMPGMDGLELLAQIRELDPDLPVI 74
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQA 124
Cdd:cd17549   75 LITGHGDVPMAVEAMRAGAYDFLEK-PFDPERLLDVVRRALEK 116
REC_D1_PleD-like cd17538
first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar ...
4-106 5.19e-16

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381093 [Multi-domain]  Cd Length: 104  Bit Score: 73.69  E-value: 5.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTI-- 81
Cdd:cd17538    1 KILVVDDEPANRELLEALL--SAEGYEVL-TADSGQEALALAEEELPDLILLDVMMPGMDGFEVCRRLKED-PETRHIpv 76
                         90       100
                 ....*....|....*....|....*..
gi 247547209  82 -MLSSYDD-YDYVRDcLKNGSVDYLLK 106
Cdd:cd17538   77 iMITALDDrEDRIRG-LEAGADDFLSK 102
REC_NtrX-like cd17550
phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and ...
5-123 6.84e-16

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381102 [Multi-domain]  Cd Length: 115  Bit Score: 73.69  E-value: 6.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17550    1 ILIVDDEEDIRESLSGILE--DEGYEV-DTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELLKEIKEKYPDLPVIMIS 77
                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQ 123
Cdd:cd17550   78 GHGTIETAVKATKLGAYDFIEK-PLSLDRLLLTIERALE 115
REC_2_GGDEF cd17544
second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This ...
4-106 1.01e-15

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381098 [Multi-domain]  Cd Length: 122  Bit Score: 73.32  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIgEQRPDV--AILDVNMPGMNGVDLNRTIKQRYP----A 77
Cdd:cd17544    2 KVLVVDDSATSRNHLRALL--RRHNFQVL-EAANGQEALEVL-EQHPDIklVITDYNMPEMDGFELVREIRKKYSrdqlA 77
                         90       100
                 ....*....|....*....|....*....
gi 247547209  78 VqtIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17544   78 I--IGISASGDNALSARFIKAGANDFLTK 104
PRK09483 PRK09483
response regulator; Provisional
2-133 2.12e-15

response regulator; Provisional


Pssm-ID: 236538 [Multi-domain]  Cd Length: 217  Bit Score: 75.14  E-value: 2.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:PRK09483   1 MINVLLVDDHELVRAGIRRILE-DIKGIKVVGEACCGEDAVKWCRTNAVDVVLMDMNMPGIGGLEATRKILRYTPDVKII 79
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKHRLDKDTLLAMleKAVQAGK---SSEAASE 133
Cdd:PRK09483  80 MLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAI--RSVHSGQryiASDIAQQ 132
REC_hyHK_CKI1_RcsC-like cd17546
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators ...
5-118 6.30e-15

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinases/response regulators similar to Arabidopsis thaliana CKI1 and Escherichia coli RcsC; This family is composed of hybrid sensor histidine kinases/response regulators that are sensor histidine kinases (HKs) fused with a REC domain, similar to the sensor histidine kinase CKI1 from Arabidopsis thaliana, which is involved in multi-step phosphorelay (MSP) signaling that mediates responses to a variety of important stimuli in plants. MSP involves a signal being transferred from HKs via histidine phosphotransfer proteins (AHP1-AHP5) to nuclear response regulators. The CKI1 REC domain specifically interacts with the downstream signaling protein AHP2, AHP3 and AHP5. The plant MSP system has evolved from the prokaryotic two-component system (TCS), which allows organisms to sense and respond to changes in environmental conditions. This family also includes bacterial hybrid sensor HKs such as Escherichia coli RcsC, which is a component of the Rcs signalling pathway that controls a variety of physiological functions like capsule synthesis, cell division, and motility. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381099 [Multi-domain]  Cd Length: 113  Bit Score: 70.96  E-value: 6.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT---I 81
Cdd:cd17546    1 VLVVDDNPVNRKVLKKLL--EKLGYE-VDVAENGQEALELLKEEPFDLVLMDLQMPVMDGLEATRRIRELEGGGRRtpiI 77
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAML 118
Cdd:cd17546   78 ALTANALEEDREKCLEAGMDDYLSK-PVKLDQLKEVL 113
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
4-106 1.19e-14

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 70.36  E-value: 1.19e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDfRAhGFEiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIK--QRYPAVQTI 81
Cdd:cd17618    2 TILIVEDEPAIREMIAFNLE-RA-GFD-VVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKrdEMTRDIPII 78
                         90       100
                 ....*....|....*....|....*.
gi 247547209  82 MLSSY-DDYDYVRdCLKNGSVDYLLK 106
Cdd:cd17618   79 MLTARgEEEDKVR-GLEAGADDYITK 103
PRK10403 PRK10403
nitrate/nitrite response regulator protein NarP;
3-134 1.44e-14

nitrate/nitrite response regulator protein NarP;


Pssm-ID: 182431 [Multi-domain]  Cd Length: 215  Bit Score: 72.96  E-value: 1.44e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLLDFRAhGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:PRK10403   7 FQVLIVDDHPLMRRGVRQLLELDP-GFEVVAEAGDGASAIDLANRLDPDVILLDLNMKGMSGLDTLNALRRDGVTAQIII 85
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKHRlDKDTLLAMLEKAVQAGKS-SEAASEA 134
Cdd:PRK10403  86 LTVSDASSDVFALIDAGADGYLLKDS-DPEVLLEAIRAGAKGSKVfSERVNQY 137
REC_FixJ cd17537
phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response ...
5-121 1.62e-14

phosphoacceptor receiver (REC) domain of FixJ family response regulators; FixJ family response regulators contain an N-terminal receiver domain (REC) and a C-terminal LuxR family helix-turn-helix (HTH) DNA-binding output domain. The Sinorhizobium meliloti two-component system FixL/FixJ regulates nitrogen fixation in response to oxygen during symbiosis. Under microaerobic conditions, the kinase FixL phosphorylates the response regulator FixJ resulting in the regulation of nitrogen fixation genes such as nifA and fixK. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381092 [Multi-domain]  Cd Length: 116  Bit Score: 69.93  E-value: 1.62e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICGEAqSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17537    3 VYVVDDDEAVRDSLAFLL--RSVGLAVKTFT-SASAFLAAAPPDQPGCLVLDVRMPGMSGLELQDELLARGSNIPIIFIT 79
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKHRLDKDtLLAMLEKA 121
Cdd:cd17537   80 GHGDVPMAVEAMKAGAVDFLEKPFRDQV-LLDAIEQA 115
REC_RegA-like cd17563
phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; ...
4-106 1.65e-14

phosphoacceptor receiver (REC) domain of photosynthetic apparatus regulatory protein RegA; Rhodobacter sphaeroides RegA, also called response regulator PrrA, is the DNA binding regulatory protein of a redox-responsive two-component regulatory system RegB/RegA that is involved in transactivating anaerobic expression of the photosynthetic apparatus. It contains a REC domain and a DNA-binding helix-turn-helix output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381111 [Multi-domain]  Cd Length: 112  Bit Score: 69.78  E-value: 1.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDL-RSLldfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:cd17563    2 SLLLVDDDEVFAERLaRAL---ERRGFEVE-TAHSVEEALALAREEKPDYAVLDLRLGGDSGLDLIPPLRALQPDARIVV 77
                         90       100
                 ....*....|....*....|....
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17563   78 LTGYASIATAVEAIKLGADDYLAK 101
PRK11697 PRK11697
two-component system response regulator BtsR;
2-114 2.56e-14

two-component system response regulator BtsR;


Pssm-ID: 236956 [Multi-domain]  Cd Length: 238  Bit Score: 72.57  E-value: 2.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTI-KQRYPAVqt 80
Cdd:PRK11697   1 MIKVLIVDDEPLAREELRELLQ-EEGDIEIVGECSNAIEAIGAIHRLKPDVVFLDIQMPRISGLELVGMLdPEHMPYI-- 77
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 247547209  81 IMLSSYDDYdYVRdCLKNGSVDYLLK----HRLDKdTL 114
Cdd:PRK11697  78 VFVTAFDEY-AIK-AFEEHAFDYLLKpidpARLAK-TL 112
REC_typeB_ARR-like cd17584
phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and ...
5-106 2.68e-14

phosphoacceptor receiver (REC) domain of type B Arabidopsis response regulators (ARRs) and similar domains; Type-B ARRs (Arabidopsis response regulators) are a class of MYB-type transcription factors that act as major players in the transcriptional activation of cytokinin-responsive genes. They directly regulate the expression of type-A ARR genes and other downstream target genes. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Cytokinin signaling involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-B ARRs contain a receiver (REC) domain and a large C-terminal extension that has characteristics of an effector or output domain, with a Myb-like DNA binding domain referred to as the GARP domain. The GARP domain is a motif specific to plant transcription factors. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381121 [Multi-domain]  Cd Length: 115  Bit Score: 69.19  E-value: 2.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFRAHGFEICGEAqsaETALDMIGEQRP--DVAILDVNMPGMNGVDLNRTIKQRyPAVQTIM 82
Cdd:cd17584    1 VLVVDDDPTCLAILKRMLLRCGYQVTTCTDA---EEALSMLRENKDefDLVITDVHMPDMDGFEFLELIRLE-MDLPVIM 76
                         90       100
                 ....*....|....*....|....
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17584   77 MSADGSTSTVMKGLAHGACDYLLK 100
PRK11361 PRK11361
acetoacetate metabolism transcriptional regulator AtoC;
3-123 4.10e-14

acetoacetate metabolism transcriptional regulator AtoC;


Pssm-ID: 183099 [Multi-domain]  Cd Length: 457  Bit Score: 74.50  E-value: 4.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLldFRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:PRK11361   5 NRILIVDDEDNVRRMLSTA--FALQGFETH-CANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSHETRTPVIL 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQ 123
Cdd:PRK11361  82 MTAYAEVETAVEALRCGAFDYVIK-PFDLDELNLIVQRALQ 121
glnG PRK10923
nitrogen regulation protein NR(I); Provisional
5-163 4.90e-14

nitrogen regulation protein NR(I); Provisional


Pssm-ID: 182842 [Multi-domain]  Cd Length: 469  Bit Score: 74.52  E-value: 4.90e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:PRK10923   6 VWVVDDDSSIRWVLERALA--GAGLT-CTTFENGNEVLEALASKTPDVLLSDIRMPGMDGLALLKQIKQRHPMLPVIIMT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQ-------------AGKSSEAASEA---DESSHFNAELVRSQ 148
Cdd:PRK10923  83 AHSDLDAAVSAYQQGAFDYLPK-PFDIDEAVALVERAIShyqeqqqprniqvNGPTTDIIGEApamQDVFRIIGRLSRSS 161
                        170
                 ....*....|....*
gi 247547209 149 ISDLARGKAEAAREL 163
Cdd:PRK10923 162 ISVLINGESGTGKEL 176
PRK10371 PRK10371
transcriptional regulator MelR;
429-530 5.65e-14

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 72.93  E-value: 5.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 429 SYSRH----VSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVS 504
Cdd:PRK10371 184 SVSRHaqfyVSQMLGFIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIA 263
                         90       100
                 ....*....|....*....|....*.
gi 247547209 505 DQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:PRK10371 264 LTAGFRSSSRFYSTFGKYVGMSPQQY 289
REC_OmpR_KdpE-like cd17620
phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a ...
5-106 7.31e-14

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381135 [Multi-domain]  Cd Length: 99  Bit Score: 67.57  E-value: 7.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQrYPAVQTIMLS 84
Cdd:cd17620    1 ILVIEDEPQIRRFLRTAL--EAHGYR-VFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIRRLRE-WSAVPVIVLS 76
                         90       100
                 ....*....|....*....|..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17620   77 ARDEESDKIAALDAGADDYLTK 98
REC_DivK-like cd17548
phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus ...
4-73 1.25e-13

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381100 [Multi-domain]  Cd Length: 115  Bit Score: 67.18  E-value: 1.25e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQ 73
Cdd:cd17548    1 KILIVEDNPLNMKLARDLL--ESAGYEVL-EAADGEEALEIARKEKPDLILMDIQLPGMDGLEATRLLKE 67
REC_RpfG-like cd17551
phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator ...
4-106 1.32e-13

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381103 [Multi-domain]  Cd Length: 118  Bit Score: 67.47  E-value: 1.32e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEP----LVRNDLRSLLDFRAHGFeicgeaQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQR--YPA 77
Cdd:cd17551    2 RILIVDDNPtnllLLEALLRSAGYLEVVSF------TDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALpgLED 75
                         90       100
                 ....*....|....*....|....*....
gi 247547209  78 VQTIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17551   76 VPIVMITADTDREVRLRALEAGATDFLTK 104
REC_2_DhkD-like cd17580
second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal ...
5-83 1.59e-13

second phosphoacceptor receiver (REC) domain of Dictyostelium discoideum hybrid signal transduction histidine kinase D and similar domains; Dictyostelium discoideum hybrid signal transduction histidine kinase D (DhkD) is a large protein that contains two histidine kinase (HK) and two REC domains on the intracellular side of a single pass transmembrane domain, and extracellular PAS and PAC domains that likely are involved in ligand binding. This model represents the second REC domain and similar domains. DhkD activates the cAMP phosphodiesterase RegA to ensure proper prestalk and prespore patterning, tip formation, and the vertical elongation of the mound into a finger, in Dictyostelium discoideum. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381118 [Multi-domain]  Cd Length: 112  Bit Score: 67.10  E-value: 1.59e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICGeAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTIML 83
Cdd:cd17580    1 ILVVDDNEDAAEMLALLL--ELEGAEVTT-AHSGEEALEAAQRFRPDVILSDIGMPGMDGYELARRLREL-PWLANTPA 75
REC_NtrC cd19919
phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; ...
4-122 6.78e-13

phosphoacceptor receiver (REC) domain of DNA-binding transcriptional regulator NtrC; DNA-binding transcriptional regulator NtrC is also called nitrogen regulation protein NR(I) or nitrogen regulator I (NRI). It contains an N-terminal receiver (REC) domain, followed by a sigma-54 interaction domain, and a C-terminal helix-turn-helix DNA-binding domain. It is part of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. DNA-binding response regulator NtrC is phosphorylated by NtrB; phosphorylation of the N-terminal REC domain activates the central sigma-54 interaction domain and leads to the transcriptional activation from promoters that require sigma(54)-containing RNA polymerase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381146 [Multi-domain]  Cd Length: 116  Bit Score: 65.37  E-value: 6.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLD---FRAHGFEicgeaqSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQT 80
Cdd:cd19919    2 TVWIVDDDSSIRWVLERALAgagLTVTSFE------NAQEALAALASSQPDVLISDIRMPGMDGLALLAQIKQRHPDLPV 75
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 247547209  81 IMLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAV 122
Cdd:cd19919   76 IIMTAHSDLDSAVSAYQGGAFEYLPK-PFDIDEAVALVERAI 116
fixJ PRK09390
response regulator FixJ; Provisional
3-152 1.17e-12

response regulator FixJ; Provisional


Pssm-ID: 181815 [Multi-domain]  Cd Length: 202  Bit Score: 66.95  E-value: 1.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLLDfrAHGFEICGEAqSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:PRK09390   4 GVVHVVDDDEAMRDSLAFLLD--SAGFEVRLFE-SAQAFLDALPGLRFGCVVTDVRMPGIDGIELLRRLKARGSPLPVIV 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAGKSSeAASEADesshfnAELVRSQISDL 152
Cdd:PRK09390  81 MTGHGDVPLAVEAMKLGAVDFIEK-PFEDERLIGAIERALAQAPEA-AKSEAV------AADIRARIASL 142
REC smart00448
cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar ...
3-60 2.08e-12

cheY-homologous receiver domain; CheY regulates the clockwise rotation of E. coli flagellar motors. This domain contains a phosphoacceptor site that is phosphorylated by histidine kinase homologues.


Pssm-ID: 214668 [Multi-domain]  Cd Length: 55  Bit Score: 61.82  E-value: 2.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 247547209     3 YRVLLVDDEPLVRNDLRSLLdfRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMP 60
Cdd:smart00448   1 MRILVVDDDPLLRELLKALL--EKEGYEV-DEATDGEEALELLKEEKPDLILLDIMMP 55
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
434-530 2.24e-12

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 68.54  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 434 VSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQyTIKQVSDQVGFTTHN 513
Cdd:COG2169   86 VARACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQTGL-SVTDAAYAAGFGSLS 164
                         90
                 ....*....|....*..
gi 247547209 514 YFFKVFKEVTGMTPQAY 530
Cdd:COG2169  165 RFYEAFKKLLGMTPSAY 181
REC_OmpR_PmrA-like cd17624
phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This ...
5-106 2.90e-12

phosphoacceptor receiver (REC) domain of PmrA-like OmpR family response regulators; This subfamily contains various OmpR family response regulators including PmrA, BasR, QseB, tctD, and RssB, which are components of two-component regulatory systems (TCSs). The PmrA/PmrB TCS controls transcription of genes that are involved in lipopolysaccharide modification in the outer membrane of bacteria, increasing bacterial resistance to host-derived antimicrobial peptides. The BasS/BasR TCS functions as an iron- and zinc-sensing transcription regulator. The QseB/QseC TCS activates the flagella regulon by activating transcription of FlhDC. The RssA/RssB TCS regulates swarming behavior in Serratia marcescens. OmpR family DNA-binding response regulators contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381139 [Multi-domain]  Cd Length: 115  Bit Score: 63.27  E-value: 2.90e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17624    1 ILLVEDDALLGDGLKTGL--RKAGYAVD-WVRTGAEAEAALASGPYDLVILDLGLPDGDGLDLLRRWRRQGQSLPVLILT 77
                         90       100
                 ....*....|....*....|..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17624   78 ARDGVDDRVAGLDAGADDYLVK 99
REC_NtrC1-like cd17572
phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex ...
5-126 3.03e-12

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381114 [Multi-domain]  Cd Length: 121  Bit Score: 63.37  E-value: 3.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17572    1 VLLVEDSPSLAALYQEYL--SDEGYKVT-HVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVIT 77
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAGK 126
Cdd:cd17572   78 AHGSVDIAVEAMRLGAYDFLEK-PFDADRLRVTVRNALKHRK 118
REC_OmpR_PrrA-like cd17627
phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The ...
5-106 3.21e-12

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381142 [Multi-domain]  Cd Length: 116  Bit Score: 63.17  E-value: 3.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFraHGFEICGEAQSAEtALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd17627    1 ILVVDDDRAVRESLRRSLRF--EGYEVETAVDGAE-ALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLT 77
                         90       100
                 ....*....|....*....|..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17627   78 ARDSVSDRVAGLDAGADDYLVK 99
REC_Spo0F-like cd17553
phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone ...
4-123 3.58e-12

phosphoacceptor receiver (REC) domain of Spo0F and similar domains; Spo0F, a stand-alone response regulator containing only a REC domain with no output/effector domain, controls sporulation in Bacillus subtilis through the exchange of a phosphoryl group. Bacillus subtilis forms spores when conditions for growth become unfavorable. The initiation of sporulation is controlled by a phosphorelay (an expanded version of the two-component system) that consists of four main components: a histidine kinase (KinA), a secondary messenger (Spo0F), a phosphotransferase (Spo0B), and a transcription factor (Spo0A). REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381105 [Multi-domain]  Cd Length: 117  Bit Score: 63.34  E-value: 3.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEplvrNDLRSLLD--FRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:cd17553    2 KILIVDDQ----YGIRILLNevFNKEGYQTF-QAANGLQALDIVTKERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVI 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQ 123
Cdd:cd17553   77 IMTAYGELDMIQESKELGALTHFAK-PFDIDEIRDAVKKYLP 117
REC_HupR cd17596
phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of ...
4-123 5.49e-12

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381127 [Multi-domain]  Cd Length: 133  Bit Score: 63.15  E-value: 5.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLL--DFRAHgfeicgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:cd17596    2 TILVVDDEVRSLEALRRTLeeDFDVL------TAASAEEALAILEEEWVQVILCDQRMPGTTGVEFLKEVRERWPEVVRI 75
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 247547209  82 MLSSYDDYDYVRDCLKNGSV-DYLLKhRLDKDTLLAMLEKAVQ 123
Cdd:cd17596   76 IISGYTDSEDIIAGINEAGIyQYLTK-PWHPDQLLLTVRNAAR 117
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
3-88 6.52e-12

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 62.40  E-value: 6.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLldFRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTIM 82
Cdd:cd17619    1 PHILIVEDEPVTRATLKSY--FEQEGYDV-SEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELREQ-SEVGIIL 76

                 ....*.
gi 247547209  83 LSSYDD 88
Cdd:cd17619   77 VTGRDD 82
REC_CheY_CheY3 cd19923
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY ...
4-122 6.64e-12

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY3 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY3, Escherichia coli CheY, and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381150 [Multi-domain]  Cd Length: 119  Bit Score: 62.36  E-value: 6.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIK--QRYPAVQTI 81
Cdd:cd19923    2 KVLVVDDFSTMRRIIKNLL--KELGFNNVEEAEDGVDALEKLKAGGFDFVITDWNMPNMDGLELLKTIRadGALSHLPVL 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAV 122
Cdd:cd19923   80 MVTAEAKKENVIAAAQAGVNNYIVK-PFTAATLKEKLEKIF 119
REC_hyHK_blue-like cd18161
phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators ...
5-106 7.31e-12

phosphoacceptor receiver (REC) domain of hybrid sensor histidine kinase/response regulators similar to Pseudomonas savastanoi blue-light-activated histidine kinase; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase (HK)/response regulators contain all the elements of a classical TCS in a single polypeptide chain. Pseudomonas savastanoi blue-light-activated histidine kinase is a photosensitive HK and RR that is involved in increased bacterial virulence upon exposure to light. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381145 [Multi-domain]  Cd Length: 102  Bit Score: 61.98  E-value: 7.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFRAHgfeICGEAQSAETALDMIGEQ-RPDVAILDVNMPG-MNGVDLNRTIKQRYPAVQTIM 82
Cdd:cd18161    1 VLVVEDDPDVRRLTAEVLEDLGY---TVLEAASGDEALDLLESGpDIDLLVTDVIMPGgMNGSQLAEEARRRRPDLKVLL 77
                         90       100
                 ....*....|....*....|....
gi 247547209  83 LSSYDDYDYVRDCLKNGsVDYLLK 106
Cdd:cd18161   78 TSGYAENAIEGGDLAPG-VDVLSK 100
PRK10430 PRK10430
two-component system response regulator DcuR;
2-106 9.96e-12

two-component system response regulator DcuR;


Pssm-ID: 182454 [Multi-domain]  Cd Length: 239  Bit Score: 65.13  E-value: 9.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRnDLRSLLDFRAHGFEICGEAQSAETALDMI--GEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQ 79
Cdd:PRK10430   1 MINVLIVDDDAMVA-ELNRRYVAQIPGFQCCGTASTLEQAKEIIfnSDTPIDLILLDIYMQQENGLDLLPVLHEAGCKSD 79
                         90       100
                 ....*....|....*....|....*..
gi 247547209  80 TIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:PRK10430  80 VIVISSAADAATIKDSLHYGVVDYLIK 106
PRK09958 PRK09958
acid-sensing system DNA-binding response regulator EvgA;
6-121 1.86e-11

acid-sensing system DNA-binding response regulator EvgA;


Pssm-ID: 182168 [Multi-domain]  Cd Length: 204  Bit Score: 63.38  E-value: 1.86e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   6 LLVDDEPLVRNDLRSLLDfrAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLSS 85
Cdd:PRK09958   4 IIIDDHPLAIAAIRNLLI--KNDIEILAELTEGGSAVQRVETLKPDIVIIDVDIPGVNGIQVLETLRKRQYSGIIIIVSA 81
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 247547209  86 YDDYDYVRDCLKNGSVDYLLKHRlDKDTLLAMLEKA 121
Cdd:PRK09958  82 KNDHFYGKHCADAGANGFVSKKE-GMNNIIAAIEAA 116
PRK10365 PRK10365
sigma-54-dependent response regulator transcription factor ZraR;
5-140 2.23e-11

sigma-54-dependent response regulator transcription factor ZraR;


Pssm-ID: 182412 [Multi-domain]  Cd Length: 441  Bit Score: 65.82  E-value: 2.23e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:PRK10365   8 ILVVDDDISHCTILQALL--RGWGYNV-ALANSGRQALEQVREQVFDLVLCDVRMAEMDGIATLKEIKALNPAIPVLIMT 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAGKSSEAASEADESSHF 140
Cdd:PRK10365  85 AYSSVETAVEALKTGALDYLIK-PLDFDNLQATLEKALAHTHSIDAETPAVTASQF 139
REC_OmpR_MtPhoP-like cd17615
phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; ...
4-106 2.40e-11

phosphoacceptor receiver (REC) domain of MtPhoP-like OmpR family response regulators; Mycobacterium tuberculosis PhoP (MtPhoP) is part of the PhoP/PhoR two-component system that is involved in phosphate control by stimulating expression of genes involved in scavenging, transport and mobilization of phosphate, and repressing the utilization of nitrogen sources. Also included in this subfamily is Mycobacterium tuberculosis transcriptional regulatory protein TcrX, part of the two-component regulatory system TcrY/TcrX that may be involved in virulence. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381131 [Multi-domain]  Cd Length: 118  Bit Score: 60.83  E-value: 2.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRahGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:cd17615    1 RVLVVDDEPNITELLSMALRYE--GWDV-ETAADGAEALAAAREFRPDAVVLDIMLPDMDGLEVLRRLRADGPDVPVLFL 77
                         90       100
                 ....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17615   78 TAKDSVEDRIAGLTAGGDDYVTK 100
PRK12555 PRK12555
chemotaxis-specific protein-glutamate methyltransferase CheB;
4-76 2.95e-11

chemotaxis-specific protein-glutamate methyltransferase CheB;


Pssm-ID: 237135 [Multi-domain]  Cd Length: 337  Bit Score: 64.90  E-value: 2.95e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRAhGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYP 76
Cdd:PRK12555   2 RIGIVNDSPLAVEALRRALARDP-DHEVVWVATDGAQAVERCAAQPPDVILMDLEMPRMDGVEATRRIMAERP 73
REC_OmpR_kpRstA-like cd17622
phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; ...
4-106 3.24e-10

phosphoacceptor receiver (REC) domain of kpRstA-like OmpR family response regulators; Klebsiella pneumoniae RstA (kpRstA) is part of the RstA/RstB two-component regulatory system that may play a regulatory role in virulence. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381137 [Multi-domain]  Cd Length: 116  Bit Score: 57.77  E-value: 3.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAeTALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:cd17622    2 RILLVEDDPKLARLIADFL--ESHGFNVVVEHRGD-RALEVIAREKPDAVLLDIMLPGIDGLTLCRDLRPKYQGPILLLT 78
                         90       100
                 ....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDcLKNGSVDYLLK 106
Cdd:cd17622   79 ALDSDIDHILG-LELGADDYVVK 100
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
5-106 9.68e-10

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 56.30  E-value: 9.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAETALDMIgEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTIMLS 84
Cdd:cd17594    2 VLVVDDDAAMRHLLILYL--RERGFDVTAAADGAEEARLML-HRRVDLVLLDLRLGQESGLDLLRTIRAR-SDVPIIIIS 77
                         90       100
                 ....*....|....*....|...
gi 247547209  85 SYDDYDYVRDC-LKNGSVDYLLK 106
Cdd:cd17594   78 GDRRDEIDRVVgLELGADDYLAK 100
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
6-106 3.04e-09

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 54.97  E-value: 3.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   6 LLVDDEPlvrnDLRSLLDF--RAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQ--RYPAVQTI 81
Cdd:cd19937    1 LVVDDEE----DIVELLKYnlEKEGYEVV-TAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSdpKTSSIPII 75
                         90       100
                 ....*....|....*....|....*.
gi 247547209  82 MLSSYDD-YDYVRDcLKNGSVDYLLK 106
Cdd:cd19937   76 MLTAKGEeFDKVLG-LELGADDYITK 100
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
5-106 3.17e-09

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 54.37  E-value: 3.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFeICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd19935    1 ILVVEDEKKLAEYLKKGL--TEEGY-AVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGKQTPVLMLT 77
                         90       100
                 ....*....|....*....|...
gi 247547209  85 SYDD-YDYVRDcLKNGSVDYLLK 106
Cdd:cd19935   78 ARDSvEDRVKG-LDLGADDYLVK 99
REC_OmpR_CpxR cd17623
phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is ...
5-106 3.32e-09

phosphoacceptor receiver (REC) domain of CpxR-like OmpR family response regulators; CpxR is part of the CpxA/CpxR two-component regulatory system that mediates envelope stress responses that is key for virulence and antibiotic resistance in several Gram negative pathogens. CpxR is a transcription factor/response regulator that controls the expression of numerous genes, including those of the classical porins OmpF and OmpC. It belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381138 [Multi-domain]  Cd Length: 115  Bit Score: 54.62  E-value: 3.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTIMLS 84
Cdd:cd17623    1 ILLIDDDRELTELLTEYLE--MEGFNV-RAAHDGEQGLAALLEGSPDLVVLDVMLPKMNGLDVLKELRKT-SQVPVLMLT 76
                         90       100
                 ....*....|....*....|...
gi 247547209  85 SY-DDYDYVRDcLKNGSVDYLLK 106
Cdd:cd17623   77 ARgDDIDRILG-LELGADDYLPK 98
PRK14084 PRK14084
DNA-binding response regulator;
4-145 4.54e-09

DNA-binding response regulator;


Pssm-ID: 184495 [Multi-domain]  Cd Length: 246  Bit Score: 57.07  E-value: 4.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:PRK14084   2 KALIVDDEPLARNELTYLLN-EIGGFEEINEAENVKETLEALLINQYDIIFLDINLMDESGIELAAKIQKMKEPPAIIFA 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 247547209  84 SSYDdyDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQA-GKSSEAASEADESSHFNAELV 145
Cdd:PRK14084  81 TAHD--QFAVKAFELNATDYILK-PFEQKRIEQAVNKVRATkAKDDNNASAIANDMSANFDQS 140
REC_OmpR_ChvI-like cd19936
phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; ...
5-106 5.04e-09

phosphoacceptor receiver (REC) domain of ChvI-like OmpR family response regulators; Sinorhizobium meliloti ChvI is part of the ExoS/ChvI two-component regulatory system (TCS) that is required for nitrogen-fixing symbiosis and exopolysaccharide synthesis. ExoS/ChvI also play important roles in regulating biofilm formation, motility, nutrient utilization, and the viability of free-living bacteria. ChvI belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381163 [Multi-domain]  Cd Length: 99  Bit Score: 53.60  E-value: 5.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEplvRNDLRSLLD-FRAHGFEICGEAqSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTIML 83
Cdd:cd19936    1 IALVDDD---RNILTSVSMaLEAEGFSVETYT-DGASALDGLNARPPDLAILDIKMPRMDGMELLQRLRQK-STLPVIFL 75
                         90       100
                 ....*....|....*....|....
gi 247547209  84 SSYDD-YDYVRDcLKNGSVDYLLK 106
Cdd:cd19936   76 TSKDDeIDEVFG-LRMGADDYITK 98
REC_CheV-like cd19924
phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This ...
5-106 5.14e-09

phosphoacceptor receiver (REC) domain of chemotaxis protein CheV and similar proteins; This subfamily includes the REC domains of Bacillus subtilis chemotaxis protein CheV, Myxococcus xanthus gliding motility regulatory protein FrzE, and similar proteins. CheV is a hybrid protein with an N-terminal CheW-like domain and a C-terminal CheY-like REC domain. The CheV pathway is one of three systems employed by B. subtilis for sensory adaptation that contribute to chemotaxis. It is involved in the transmission of sensory signals from chemoreceptors to flagellar motors. Together with CheW, it is involved in the coupling of methyl-accepting chemoreceptors to the central two-component histidine kinase CheA. FrzE is a hybrid sensor histidine kinase/response regulator that is part of the Frz pathway that controls cell reversal frequency to support directional motility during swarming and fruiting body formation. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381151 [Multi-domain]  Cd Length: 111  Bit Score: 53.92  E-value: 5.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEICgEAQSAETALDMIGEQRP---------DVAILDVNMPGMNGVDLNRTIKQ-- 73
Cdd:cd19924    1 ILVVDDSPTARKQLRDLLK--NLGFEIA-EAVDGEEALNKLENLAKegndlskelDLIITDIEMPKMDGYELTFELRDdp 77
                         90       100       110
                 ....*....|....*....|....*....|...
gi 247547209  74 RYPAVQTIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd19924   78 RLANIPVILNSSLSGEFSRARGKKVGADAYLAK 110
Spo0A COG5801
Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell ...
1-85 5.16e-09

Stage 0 sporulation initiation regulator Spo0A (response regulator, REC-HTH domains) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444503 [Multi-domain]  Cd Length: 264  Bit Score: 57.12  E-value: 5.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMY--RVLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVD----LNRTIKQR 74
Cdd:COG5801    1 MMEkiKVLIADDNREFCELLEEYLS-SQPDMEVVGVAYNGLEALELIEEKKPDVVILDIIMPHLDGLGvlekLREMNLEK 79
                         90
                 ....*....|.
gi 247547209  75 YPAVqtIMLSS 85
Cdd:COG5801   80 RPKV--IMLTA 88
REC_GlnL-like cd17565
phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar ...
7-103 8.00e-09

phosphoacceptor receiver (REC) domain of transcriptional regulatory protein GlnL and similar proteins; Bacillus subtilis GlnL is part of the GlnK-GlnL (formerly YcbA-YcbB) two-component system that positively regulates the expression of the glsA-glnT (formerly ybgJ-ybgH) operon in response to glutamine. It contains a REC domain and a DNA-binding output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381112 [Multi-domain]  Cd Length: 103  Bit Score: 53.43  E-value: 8.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   7 LVDDEPLVRNDLRSLLDFRAHGfEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLSSY 86
Cdd:cd17565    3 IVDDDKNIIKILSDIIEDDDLG-EVVGEADNGAQAYDEILFLQPDIVLIDLLMPGMDGIQLVRKLKDTGSNGKFIMISQV 81
                         90
                 ....*....|....*..
gi 247547209  87 DDYDYVRDCLKNGsVDY 103
Cdd:cd17565   82 SDKEMIGKAYQAG-IEF 97
REC_OmpR_DrrD-like cd17625
phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a ...
6-106 8.95e-09

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381140 [Multi-domain]  Cd Length: 115  Bit Score: 53.38  E-value: 8.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   6 LLVDDEPLVRNDLRSLLDFRAHGFEICGEAqsaETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLSS 85
Cdd:cd17625    1 LVVEDEKDLSEAITKHLKKEGYTVDVCFDG---EEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTA 77
                         90       100
                 ....*....|....*....|..
gi 247547209  86 YDD-YDYVRDcLKNGSVDYLLK 106
Cdd:cd17625   78 LDAvEDRVKG-LDLGADDYLPK 98
REC_RR468-like cd17552
phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and ...
4-81 1.32e-08

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381104 [Multi-domain]  Cd Length: 121  Bit Score: 53.32  E-value: 1.32e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRAhGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDlnrTIK--QRYPAVQTI 81
Cdd:cd17552    3 RILVIDDEEDIREVVQACLEKLA-GWEVL-TASSGQEGLEKAATEQPDAILLDVMMPDMDGLA---TLKklQANPETQSI 77
PRK11083 PRK11083
DNA-binding response regulator CreB; Provisional
1-88 1.57e-08

DNA-binding response regulator CreB; Provisional


Pssm-ID: 236838 [Multi-domain]  Cd Length: 228  Bit Score: 55.35  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLdfRAHGF--EICGEAQSAetaLDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAV 78
Cdd:PRK11083   2 QQPTILLVEDEQAIADTLVYAL--QSEGFtvEWFERGLPA---LDKLRQQPPDLVILDVGLPDISGFELCRQLLAFHPAL 76
                         90
                 ....*....|
gi 247547209  79 QTIMLSSYDD 88
Cdd:PRK11083  77 PVIFLTARSD 86
psREC_PRR cd17582
pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response ...
5-106 1.57e-08

pseudo receiver domain of pseudo-response regulators; In Arabidopsis, five pseudo-response regulators (PRRs), also called APRRs, comprise a core group of clock components that controls the pace of the central oscillator of the circadian clock, an endogenous time-keeping mechanism that enables organisms to adapt to external daily cycles. The coordinated sequential expression of PRR9 (APRR9), PRR7 (APRR7), PRR5 (APRR5), PRR3 (APRR3), and PRR1 (APRR1) results in circadian waves that may be at the basis of the endogenous circadian clock. PRRs contain an N-terminal pseudo receiver (psREC) domain that resembles the receiver domain of a two-component response regulator, but lacks an aspartate residue that accepts a phosphoryl group from the sensor kinase, and a CCT motif at the C-terminus that contains a putative nuclear localization signal. The psREC domain is involved in protein-protein interactions.


Pssm-ID: 381120 [Multi-domain]  Cd Length: 104  Bit Score: 52.40  E-value: 1.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAIL--DVNMPGMNGVDL-----NRTIKQRYPa 77
Cdd:cd17582    1 VLLVENDDSTRQIVTALL--RKCSYEVT-AASDGLQAWDVLEDEQNEIDLIltEVDLPVSSGFKLlsyimRHKICKNIP- 76
                         90       100
                 ....*....|....*....|....*....
gi 247547209  78 vqTIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17582   77 --VIMMSSQDSVGVVFKCLSKGAADYLVK 103
PRK10360 PRK10360
transcriptional regulator UhpA;
2-125 2.01e-08

transcriptional regulator UhpA;


Pssm-ID: 182408 [Multi-domain]  Cd Length: 196  Bit Score: 54.60  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLDFRAHgFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLnrtIKQRYPAVQTI 81
Cdd:PRK10360   1 MITVALIDDHLIVRSGFAQLLGLEPD-LQVVAEFGSGREALAGLPGRGVQVCICDISMPDISGLEL---LSQLPKGMATI 76
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQAG 125
Cdd:PRK10360  77 MLSVHDSPALVEQALNAGARGFLSK-RCSPDELIAAVHTVATGG 119
REC_hyHK cd17598
phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase ...
5-106 2.20e-08

phosphoacceptor receiver (REC) domain of uncharacterized hybrid sensor histidine kinase/response regulators; Typically, two-component regulatory systems (TCSs) consist of a sensor (histidine kinase) that responds to specific input(s) by modifying the output of a cognate response regulator (RR). TCSs allow organisms to sense and respond to changes in environmental conditions. Hybrid sensor histidine kinase/response regulators contain all the elements of a classical TCS in a single polypeptide chain. RRs share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381128 [Multi-domain]  Cd Length: 118  Bit Score: 52.33  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIK--QRYPAVQTIM 82
Cdd:cd17598    1 ILIVEDSPTQAEQLKHILE--EQGYKV-QVARNGREALAMLAEHRPTLVISDIVMPEMDGYELCRKIKsdPDLKDIPVIL 77
                         90       100
                 ....*....|....*....|....*
gi 247547209  83 LSSYDD-YDYVRDcLKNGSVDYLLK 106
Cdd:cd17598   78 LTTLSDpRDVIRG-LECGADNFITK 101
REC_OmpR_BfmR-like cd19939
phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; ...
4-106 2.24e-08

phosphoacceptor receiver (REC) domain of BfmR-like OmpR family response regulators; Acinetobacter baumannii BfmR is part of the BfmR/S two-component system that functions as the master regulator of biofilm initiation. BfmR confers resistance to complement-mediated bactericidal activity, independent of capsular polysaccharide, and also increases resistance to the clinically important antimicrobials meropenem and colistin, making it a potential antimicrobial target. Its inhibition would have the dual benefit of significantly decreasing in vivo survival and increasing sensitivity to selected antimicrobials. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381166 [Multi-domain]  Cd Length: 116  Bit Score: 52.38  E-value: 2.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDfrAHGFEiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYpAVQTIML 83
Cdd:cd19939    1 RILIVEDELELARLTRDYLI--KAGLE-VSVFTDGQRAVRRIIDEQPSLVVLDIMLPGMDGLTVCREVREHS-HVPILML 76
                         90       100
                 ....*....|....*....|....
gi 247547209  84 SS-YDDYDYVRDcLKNGSVDYLLK 106
Cdd:cd19939   77 TArTEEMDRVLG-LEMGADDYLCK 99
REC_OmpR_MtrA-like cd17626
phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is ...
4-106 3.29e-08

phosphoacceptor receiver (REC) domain of MtrA-like OmpR family response regulators; MtrA is part of MtrA/MtrB (or MtrAB), a highly conserved two-component system (TCS) implicated in the regulation of cell division in the actinobacteria. In unicellular Mycobacterium tuberculosis, MtrAB coordinates DNA replication with cell division and regulates the transcription of resuscitation-promoting factor B. In filamentous Streptomyces venezuelae, it links antibiotic production to sporulation. MtrA belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381141 [Multi-domain]  Cd Length: 115  Bit Score: 51.70  E-value: 3.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFE--ICGEAQSAetaLDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTI 81
Cdd:cd17626    2 RILVVDDDAALAEMIGIVL--RGEGFDpaFCGDGTQA---LAAFREVRPDLVLLDLMLPGIDGIEVCRQIRAE-SGVPIV 75
                         90       100
                 ....*....|....*....|....*
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17626   76 MLTAKSDTVDVVLGLESGADDYVAK 100
REC_OmpR_YycF-like cd17614
phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF ...
5-106 4.25e-08

phosphoacceptor receiver (REC) domain of YrcF-like OmpR family response regulators; YycF appears to play an important role in cell wall integrity in a wide range of gram-positive bacteria, and may also modulate cell membrane integrity. It functions as part of a phosphotransfer system that ultimately controls the levels of competence within the bacteria. YycF belongs to the OmpR family of response regulators, which are characterized by a REC domain and a winged helix-turn-helix effector domain involved in DNA binding. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381130 [Multi-domain]  Cd Length: 115  Bit Score: 51.66  E-value: 4.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRslLDFRAHGFEI-CgeAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYpAVQTIML 83
Cdd:cd17614    1 ILVVDDEKPISDILK--FNLTKEGYEVvT--AYDGREALEKVEEEQPDLILLDLMLPEKDGLEVCREVRKTS-NVPIIML 75
                         90       100
                 ....*....|....*....|....
gi 247547209  84 SSYD-DYDYVRDcLKNGSVDYLLK 106
Cdd:cd17614   76 TAKDsEVDKVLG-LELGADDYVTK 98
REC_Rcp-like cd17557
phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and ...
4-106 5.34e-08

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381108 [Multi-domain]  Cd Length: 129  Bit Score: 51.65  E-value: 5.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPlvrNDLRSLLD-FRAHGF--EICgEAQSAETALDMI-------GEQRPDVAILDVNMPGMNGVDLNRTIKQ 73
Cdd:cd17557    1 TILLVEDNP---GDAELIQEaFKEAGVpnELH-VVRDGEEALDFLrgegeyaDAPRPDLILLDLNMPRMDGFEVLREIKA 76
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 247547209  74 RyPAVQTI---MLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17557   77 D-PDLRRIpvvVLTTSDAEEDIERAYELGANSYIVK 111
REC_CheC-like cd17593
phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC ...
4-120 5.86e-08

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381124 [Multi-domain]  Cd Length: 117  Bit Score: 51.00  E-value: 5.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDL-RSLLDFRAHgfEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:cd17593    2 KVLICDDSSMARKQLaRALPADWDV--EIT-FAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIV 78
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEK 120
Cdd:cd17593   79 VSGDVQPEAKERVLELGALAFLKK-PFDPEKLAQLLEE 115
PRK13435 PRK13435
response regulator; Provisional
1-75 9.81e-08

response regulator; Provisional


Pssm-ID: 184052 [Multi-domain]  Cd Length: 145  Bit Score: 51.21  E-value: 9.81e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLDfrAHGFEICGEAQSAETALDMIGEQRPDVAILDVN-MPGMNGVDLNRTIKQRY 75
Cdd:PRK13435   4 RQLKVLIVEDEALIALELEKLVE--EAGHEVVGIAMSSEQAIALGRRRQPDVALVDVHlADGPTGVEVARRLSADG 77
PRK10766 PRK10766
two-component system response regulator TorR;
1-88 1.05e-07

two-component system response regulator TorR;


Pssm-ID: 182711 [Multi-domain]  Cd Length: 221  Bit Score: 52.73  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLldFRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQT 80
Cdd:PRK10766   1 MSYHILVVEDEPVTRARLQGY--FEQEGYTVS-EAASGAGMREIMQNQHVDLILLDINLPGEDGLMLTRELRSR-STVGI 76

                 ....*...
gi 247547209  81 IMLSSYDD 88
Cdd:PRK10766  77 ILVTGRTD 84
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
465-530 1.20e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 53.37  E-value: 1.20e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247547209 465 LSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:PRK13501 209 LKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDY 274
REC_CheY4-like cd17562
phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY ...
4-84 1.73e-07

phosphoacceptor receiver (REC) domain of chemotaxis response regulator CheY4 and similar CheY family proteins; CheY family chemotaxis response regulators (RRs) comprise about 17% of bacterial RRs and almost half of all RRs in archaea. This subfamily contains Vibrio cholerae CheY4 and similar CheY family RRs. CheY proteins control bacterial motility and participate in signaling phosphorelays and in protein-protein interactions. CheY RRs contain only the REC domain with no output/effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381110 [Multi-domain]  Cd Length: 118  Bit Score: 49.99  E-value: 1.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQ--RYPAVQTI 81
Cdd:cd17562    2 KILAVDDSASIRQMVSFTL--RGAGYEVV-EAADGRDALSKAQSKKFDLIITDQNMPNMDGIELIKELRKlpAYKFTPIL 78

                 ...
gi 247547209  82 MLS 84
Cdd:cd17562   79 MLT 81
orf27 CHL00148
Ycf27; Reviewed
3-106 2.15e-07

Ycf27; Reviewed


Pssm-ID: 214376 [Multi-domain]  Cd Length: 240  Bit Score: 52.03  E-value: 2.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   3 YRVLLVDDEPLVRNDLRSLLDFRahGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKqRYPAVQTIM 82
Cdd:CHL00148   7 EKILVVDDEAYIRKILETRLSII--GYEVI-TASDGEEALKLFRKEQPDLVILDVMMPKLDGYGVCQEIR-KESDVPIIM 82
                         90       100
                 ....*....|....*....|....*..
gi 247547209  83 LSSYDDydyVRDCLKN---GSVDYLLK 106
Cdd:CHL00148  83 LTALGD---VSDRITGlelGADDYVVK 106
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
465-538 2.50e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 52.36  E-value: 2.50e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247547209 465 LSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPqAYWNSLGDGK 538
Cdd:PRK13502 209 LRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMTP-SQWRHLSNQS 281
PRK10701 PRK10701
DNA-binding transcriptional regulator RstA; Provisional
2-106 2.66e-07

DNA-binding transcriptional regulator RstA; Provisional


Pssm-ID: 236738 [Multi-domain]  Cd Length: 240  Bit Score: 51.95  E-value: 2.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQsAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAvQTI 81
Cdd:PRK10701   1 MNKIVFVEDDAEVGSLIAAYL--AKHDIDVTVEPR-GDRAEATILREQPDLVLLDIMLPGKDGMTICRDLRPKWQG-PIV 76
                         90       100
                 ....*....|....*....|....*.
gi 247547209  82 MLSSYD-DYDYVRDcLKNGSVDYLLK 106
Cdd:PRK10701  77 LLTSLDsDMNHILA-LEMGACDYILK 101
REC_PFxFATGY cd17586
phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response ...
5-74 3.37e-07

phosphoacceptor receiver (REC) domain of PFxFATGY motif single-domain (stand-alone) response regulators; This subfamily is composed of stand-alone response regulators (RRs) containing the PFxFATG[G/Y] motif; RRs with such a motif are also called ''FAT GUY'' response regulators. Included in this subfamily are Sphingomonas melonis SdrG, Sinorhizobium meliloti Sma0114, and Erythrobacter litoralis EL_LovR. SdrG is involved in the control of the general stress response. Sma0114 is part of the Sma0113/Sma0114 two-component system (TCS) that is involved in catabolite repression and polyhydroxy butyrate synthesis. EL_LovR is involved in a light-regulated TCS. PFxFATG[G/Y] RRs are typically associated with histidine-tryptophan-glutamate (HWE) histidine kinases that constitute a subclass of the larger histidine kinase superfamily characterized by an altered ATP binding site, which lacks the F-box that is normally an integral component of the ATP lid. The PFxFATG[G/Y] motif is involved in conformational changes after phosphorylation that results in the activation of the RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381122 [Multi-domain]  Cd Length: 111  Bit Score: 49.00  E-value: 3.37e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQR 74
Cdd:cd17586    1 VLVLEDEPLIAMNLEDALE--DLGGKEVVTAATCAEALRSLADGPIDIAILDVNLGGETSIPVADALKRR 68
PRK15115 PRK15115
response regulator GlrR; Provisional
4-137 4.99e-07

response regulator GlrR; Provisional


Pssm-ID: 185070 [Multi-domain]  Cd Length: 444  Bit Score: 52.15  E-value: 4.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPlvrnDLRSLLDFR--AHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTI 81
Cdd:PRK15115   7 HLLLVDDDP----GLLKLLGMRltSEGYSVV-TAESGQEALRVLNREKVDLVISDLRMDEMDGMQLFAEIQKVQPGMPVI 81
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAVQagkssEAASEADES 137
Cdd:PRK15115  82 ILTAHGSIPDAVAATQQGVFSFLTK-PVDRDALYKAIDDALE-----QSAPATDER 131
REC_PilR cd19926
phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR ...
5-106 5.15e-07

phosphoacceptor receiver (REC) domain of type 4 fimbriae expression regulatory protein PilR and similar proteins; Pseudomonas aeruginosa PilR is the response regulator of the PilS/PilR two-component regulatory system (PilSR TCS) that acts in conjunction with sigma-54 to regulate the expression of type 4 pilus (T4P) major subunit PilA. In addition, the PilSR TCS regulates flagellum-dependent swimming motility and pilus-dependent twitching motility. PilR contains an N-terminal REC domain, a central sigma-54 interaction domain, and a C-terminal Fis-type helix-turn-helix DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381153 [Multi-domain]  Cd Length: 100  Bit Score: 47.92  E-value: 5.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPlvrnDLRSLLDFRAHGFEI-CGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:cd19926    1 VLVVDDEP----DIRELLEITLGRMGLdVRSARNVKEARELLASEPYDLCLTDMRLPDGSGLELVQHIQQRLPQTPVAVI 76
                         90       100
                 ....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd19926   77 TAYGSLDTAIEALKAGAFDFLTK 99
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
465-538 5.32e-07

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 51.64  E-value: 5.32e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247547209 465 LSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPqAYWNSLGDGK 538
Cdd:PRK13500 239 LRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTP-SQWRHLNSQK 311
PRK11173 PRK11173
two-component response regulator; Provisional
3-74 6.12e-07

two-component response regulator; Provisional


Pssm-ID: 183013 [Multi-domain]  Cd Length: 237  Bit Score: 50.78  E-value: 6.12e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 247547209   3 YRVLLVDDEPLVRNDLRSLldFRAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQR 74
Cdd:PRK11173   4 PHILIVEDELVTRNTLKSI--FEAEGYDVF-EATDGAEMHQILSENDINLVIMDINLPGKNGLLLARELREQ 72
PRK10529 PRK10529
DNA-binding transcriptional activator KdpE; Provisional
2-106 6.56e-07

DNA-binding transcriptional activator KdpE; Provisional


Pssm-ID: 182522 [Multi-domain]  Cd Length: 225  Bit Score: 50.57  E-value: 6.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLDfrAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQrYPAVQTI 81
Cdd:PRK10529   1 MTNVLIVEDEQAIRRFLRTALE--GDGMRVF-EAETLQRGLLEAATRKPDLIILDLGLPDGDGIEFIRDLRQ-WSAIPVI 76
                         90       100
                 ....*....|....*....|....*
gi 247547209  82 MLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:PRK10529  77 VLSARSEESDKIAALDAGADDYLSK 101
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
434-530 7.17e-07

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 51.13  E-value: 7.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 434 VSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHN 513
Cdd:PRK10572 185 VREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQLGISVLRWREDQRISRAKLLLQTTRMPIATIGRNVGYDDQL 264
                         90
                 ....*....|....*..
gi 247547209 514 YFFKVFKEVTGMTPQAY 530
Cdd:PRK10572 265 YFSRVFKKCTGASPSEF 281
REC_OmpR_EcPhoP-like cd19934
phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; ...
5-106 7.48e-07

phosphoacceptor receiver (REC) domain of EcPhoP-like OmpR family response regulators; Escherichia coli PhoP (EcPhoP) is part of the PhoQ/PhoP two-component system (TCS) that regulates virulence genes and plays an essential role in the response of the bacteria to the environment of their mammalian hosts, sensing several stimuli such as extracellular magnesium limitation, low pH, the presence of cationic antimicrobial peptides, and osmotic upshift. This subfamily also includes Brucella suis FeuP, part of the FeuPQ TCS that is involved in the regulation of iron uptake, and Microchaete diplosiphon RcaC, which is required for chromatic adaptation. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381161 [Multi-domain]  Cd Length: 117  Bit Score: 48.05  E-value: 7.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd19934    1 LLLVEDDALLAAQLKEQL--SDAGYV-VDVAEDGEEALFQGEEEPYDLVVLDLGLPGMDGLSVLRRWRSEGRATPVLILT 77
                         90       100
                 ....*....|....*....|..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd19934   78 ARDSWQDKVEGLDAGADDYLTK 99
PRK13557 PRK13557
histidine kinase; Provisional
4-88 8.68e-07

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 51.60  E-value: 8.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRAHGFEIcgeAQSAETALDMI-GEQRPDVAILDVNMPG-MNGVDLNRTIKQRYPAVQTI 81
Cdd:PRK13557 417 TILIVDDRPDVAELARMILEDFGYRTLV---ASNGREALEILdSHPEVDLLFTDLIMPGgMNGVMLAREARRRQPKIKVL 493

                 ....*..
gi 247547209  82 MLSSYDD 88
Cdd:PRK13557 494 LTTGYAE 500
REC_RocR cd17530
phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR ...
4-87 1.20e-06

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381086 [Multi-domain]  Cd Length: 123  Bit Score: 47.82  E-value: 1.20e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRAHGFeiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:cd17530    2 RVLVLDDDPFQCMMAATILEDLGPGN--VDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFLRHLAESHSNAAVILM 79

                 ....
gi 247547209  84 SSYD 87
Cdd:cd17530   80 SGLD 83
REC_CpdR_CckA-like cd18160
phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; ...
4-86 1.44e-06

phosphoacceptor receiver (REC) domain of Brucella abortus CpdR and CckA, and similar domains; Two-component systems (TCSs), consisting of a sensor and a response regulator, are used by bacteria to adapt to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis and membrane transport. Response regulators share the common phosphoacceptor REC domain and differ output domains such as DNA, RNA, ligand, and protein-binding, or enzymatic domain. CpdR is a stand-alone REC protein. CckA is a sensor histidine kinase containing N-terminal PAS domains and a C-terminal REC domain. CpdR and CckA are components of a regulatory phosphorelay system (composed of CckA, ChpT, CtrA and CpdR) that controls Brucella abortus cell growth, division, and intracellular survival inside mammalian host cells. CckA autophosphorylates in the presence of ATP and transfers a phosphoryl group to the conserved aspartic acid residue on its C-terminal REC domain, which is relayed to the ChpT phosphotransferase. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381144 [Multi-domain]  Cd Length: 103  Bit Score: 46.73  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRahGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:cd18160    1 TILLADDEPSVRKFIVTTLKKA--GYAVTEAESGAEALEKLQQGKDIDIVVTDIVMPEMDGIELAREARKIDPDVKILFI 78

                 ...
gi 247547209  84 SSY 86
Cdd:cd18160   79 SGG 81
REC_Spo0A cd17561
phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the ...
4-106 1.53e-06

phosphoacceptor receiver (REC) domain of Spo0A; Spo0A is a response regulator of the phosphorelay system in the early stage of spore formation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress and may act in the with sigma factor spo0H to control the expression of some genes that are critical to the sporulation process. Spo0A contains a regulatory N-terminal REC domain and a C-terminal DNA-binding transcription activation domain as its effector/output domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381109 [Multi-domain]  Cd Length: 108  Bit Score: 46.83  E-value: 1.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRAhGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGV----DLNRtiKQRYPAVQ 79
Cdd:cd17561    3 KVLIADDNREFVQLLEEYLNSQP-DMEVVGVAHNGQEALELIEEKEPDVLLLDIIMPHLDGIgvleKLRR--MRLEKRPK 79
                         90       100
                 ....*....|....*....|....*..
gi 247547209  80 TIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17561   80 IIMLTAFGQEDITQRAVELGASYYILK 106
REC_typeA_ARR cd17581
phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and ...
5-106 2.11e-06

phosphoacceptor receiver (REC) domain of type A Arabidopsis response regulators (ARRs) and similar proteins; Type-A response regulators of Arabidopsis (ARRs) are involved in cytokinin signaling, which involves a phosphorelay cascade by histidine kinase receptors (AHKs), histidine phosphotransfer proteins (AHPs) and downstream ARRs. Cytokinin is a plant hormone implicated in many growth and development processes including shoot organogenesis, leaf senescence, sink/source relationships, vascular development, lateral bud release, and photomorphogenic development. Type-A ARRs function downstream of and are regulated by type-B ARRs, which are a class of MYB-type transcription factors. As primary cytokinin response genes, type-A ARRs act as redundant negative feedback regulators of cytokinin signaling by inactivating the phosphorelay. ARRs are divided into two groups, type-A and -B, according to their sequence and domain structure. Type-A ARRs are similar in domain structure to CheY, in that they lack a typical output domain and only contain a stand-alone receiver (REC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381119 [Multi-domain]  Cd Length: 122  Bit Score: 46.98  E-value: 2.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICGeAQSAETALDMIG----EQRPDVAILDVN-------MPGMNGVDLNRTIKQ 73
Cdd:cd17581    1 VLAVDDSLVDRKVIERLL--RISSCRVTA-VDSGKRALEFLGledeEDSSNFNEPKVNmiitdycMPGMTGYDLLKKVKE 77
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 247547209  74 --RYPAVQTIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17581   78 ssALKEIPVVIMSSENIPTRISRCLEEGAEDFLLK 112
pleD PRK09581
response regulator PleD; Reviewed
1-106 2.53e-06

response regulator PleD; Reviewed


Pssm-ID: 236577 [Multi-domain]  Cd Length: 457  Bit Score: 49.90  E-value: 2.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPL-VRndlrsLLDFR--AHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIK--QRY 75
Cdd:PRK09581   1 MTARILVVDDIPAnVK-----LLEAKllAEYYTVL-TASSGAEAIAICEREQPDIILLDVMMPGMDGFEVCRRLKsdPAT 74
                         90       100       110
                 ....*....|....*....|....*....|..
gi 247547209  76 PAVQTIMLSSYDD-YDYVRDcLKNGSVDYLLK 106
Cdd:PRK09581  75 THIPVVMVTALDDpEDRVRG-LEAGADDFLTK 105
REC_Ycf29 cd19927
phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a ...
5-75 2.84e-06

phosphoacceptor receiver (REC) domain of probable transcriptional regulator Ycf29; Ycf29 is a probable response regulator of a two-component system (TCS), typically consisting a sensor and a response regulator, that functions in adaptation to changing environments. Processes regulated by TCSs in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Ycf29 contains an N-terminal REC domain and a LuxR-type helix-turn-helix DNA-binding output domain. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381154 [Multi-domain]  Cd Length: 102  Bit Score: 45.83  E-value: 2.84e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFRahGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRY 75
Cdd:cd19927    1 ILLVDDDPGIRLAVKDYLEDQ--GFTVI-AASNGLEALDLLNQYIPDLIISDIIMPGVDGYSLLGKLRKNA 68
REC_OmpR_RegX3-like cd17621
phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is ...
5-106 3.32e-06

phosphoacceptor receiver (REC) domain of RegX3-like OmpR family response regulators; RegX3 is a member of the SenX3-RegX3 two-component system that is involved in phosphate-sensing signal transduction. Phosphorylated RegX3 functions as a transcriptional activator of phoA. It induces transcription in phosphate limiting environment and also controls expression of several critical metabolic enzymes in aerobic condition. RegX3 belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381136 [Multi-domain]  Cd Length: 99  Bit Score: 45.65  E-value: 3.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRyPAVQTIMLS 84
Cdd:cd17621    1 VLVVEDEESFSDPLAYLL--RKEGFEV-TVATDGPAALAEFDRAGADIVLLDLMLPGLSGTEVCRQLRAR-SNVPVIMVT 76
                         90       100
                 ....*....|....*....|...
gi 247547209  85 SYDD-YDYVRDcLKNGSVDYLLK 106
Cdd:cd17621   77 AKDSeIDKVVG-LELGADDYVTK 98
REC_OmpR_NsrR-like cd18159
phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family ...
5-116 3.33e-06

phosphoacceptor receiver (REC) domain of Streptococcus agalactiae NsrR-like OmpR family response regulators; Streptococcus agalactiae NsrR is a lantibiotic resistance-associated response regulator and is part of the nisin resistance operon. It is a member of the NsrRK two-component system (TCS) that is involved in the regulation of lantibiotic resistance genes such as a membrane-associated lipoprotein of LanI, and the nsr gene cluster which encodes for the resistance protein NSR and the ABC transporter NsrFP, both conferring resistance against nisin. This subfamily also includes Staphylococcus epidermidis GraR, part of the GraR/GraS TCS involved in resistance against cationic antimicrobial peptides, and Bacillus subtilis BceR, part of the BceS/BceR TCS involved in the regulation of bacitracin resistance. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381143 [Multi-domain]  Cd Length: 113  Bit Score: 46.12  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFEICGeAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPaVQTIMLS 84
Cdd:cd18159    1 ILIVEDDETIASLLKKHL--EKWGYEVVL-IEDFEDVLEEFLQFKPDLVLLDINLPYFDGFYWCREIRQISN-VPIIFIS 76
                         90       100       110
                 ....*....|....*....|....*....|...
gi 247547209  85 SYDD-YDYVRdCLKNGSVDYLLKhRLDKDTLLA 116
Cdd:cd18159   77 SRDDnMDQVM-AINMGGDDYITK-PFDLDVLLA 107
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
4-106 3.41e-06

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 46.22  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAEtALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKqRYPAVQTIML 83
Cdd:cd19938    1 RILIVEDEPKLAQLLIDYL--RAAGYAPTLLAHGDQ-VLPYVRHTPPDLILLDLMLPGTDGLTLCREIR-RFSDVPIIMV 76
                         90       100
                 ....*....|....*....|....
gi 247547209  84 SS-YDDYDYVRDcLKNGSVDYLLK 106
Cdd:cd19938   77 TArVEEIDRLLG-LELGADDYICK 99
REC_PhyR cd17540
phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is ...
4-84 5.12e-06

phosphoacceptor receiver (REC) domain of response regulator PhyR and similar proteins; PhyR is a hybrid stress regulator that contains an N-terminal sigma-like (SL) domain and a C-terminal REC domain. Phosphorylation of the REC domain is known to promote binding of the SL domain to an anti-sigma factor. PhyR thus functions as an anti-anti-sigma factor in its phosphorylated state. It is involved in the general stress response. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381095 [Multi-domain]  Cd Length: 117  Bit Score: 45.70  E-value: 5.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMP-GMNGVDlnrtikqrypAVQTIM 82
Cdd:cd17540    2 RVLIIEDEPLIAMDLEQIV--EDLGHQVVGIARTRDEAVALARRERPDLILADIQLAdGSSGID----------AVNEIL 69

                 ..
gi 247547209  83 LS 84
Cdd:cd17540   70 TT 71
PRK10693 PRK10693
two-component system response regulator RssB;
34-118 7.74e-06

two-component system response regulator RssB;


Pssm-ID: 182652 [Multi-domain]  Cd Length: 303  Bit Score: 48.06  E-value: 7.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209  34 EAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLSSYDDYDYVRDCLKNGSVDYLLK-----HR 108
Cdd:PRK10693   2 LAANGVDALELLGGFTPDLIICDLAMPRMNGIEFVEHLRNRGDQTPVLVISATENMADIAKALRLGVQDVLLKpvkdlNR 81
                         90
                 ....*....|
gi 247547209 109 LdKDTLLAML 118
Cdd:PRK10693  82 L-REMVFACL 90
PRK10955 PRK10955
envelope stress response regulator transcription factor CpxR;
2-138 8.39e-06

envelope stress response regulator transcription factor CpxR;


Pssm-ID: 182864 [Multi-domain]  Cd Length: 232  Bit Score: 47.10  E-value: 8.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPLVRNDLRSLLDFRahGFEICgEAQSAETALDMIgEQRPDVAILDVNMPGMNGVDLNRTIKQRYpavQT- 80
Cdd:PRK10955   1 MNKILLVDDDRELTSLLKELLEME--GFNVI-VAHDGEQALDLL-DDSIDLLLLDVMMPKKNGIDTLKELRQTH---QTp 73
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209  81 -IMLSSY-DDYDYVRDcLKNGSVDYLLKHRLDKDtLLAMLEKAVQAGKSSEAASEADESS 138
Cdd:PRK10955  74 vIMLTARgSELDRVLG-LELGADDYLPKPFNDRE-LVARIRAILRRSHWSEQQQNNDNGS 131
PRK11091 PRK11091
aerobic respiration control sensor protein ArcB; Provisional
4-79 1.37e-05

aerobic respiration control sensor protein ArcB; Provisional


Pssm-ID: 236842 [Multi-domain]  Cd Length: 779  Bit Score: 48.01  E-value: 1.37e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRAHGFEIcgeAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQ 79
Cdd:PRK11091 527 NILLVEDIELNVIVARSVLEKLGNSVDV---AMTGKEALEMFDPDEYDLVLLDIQLPDMTGLDIARELRERYPRED 599
REC_OmpR_CtrA cd17616
phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is ...
5-122 1.54e-05

phosphoacceptor receiver (REC) domain of CtrA-like OmpR family response regulators; CtrA is part of the CckA-ChpT-CtrA phosphorelay that is conserved in alphaproteobacteria and is important in orchestrating the cell cycle, polar development, and flagellar biogenesis. CtrA is the master regulator of flagella synthesis genes and also regulates genes involved in the cell cycle, exopolysaccharide synthesis, and cyclic-di-GMP signaling. CtrA is active as a transcription factor when phosphorylated. It is a member of the OmpR family of DNA-binding response regulators, characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381132 [Multi-domain]  Cd Length: 114  Bit Score: 44.32  E-value: 1.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLdfRAHGFeICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIkqRYPAVQT--IM 82
Cdd:cd17616    1 VLLIEDDSATAQSIELML--KSEGF-NVYTTDLGEEGLDLGKLYDYDIILLDLNLPDMSGYEVLRTL--RLAKVKTpiLI 75
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLKhRLDKDTLLAMLEKAV 122
Cdd:cd17616   76 LSGLADIEDKVKGLGFGADDYMTK-PFHKDELVARIHAIV 114
PRK10610 PRK10610
chemotaxis protein CheY;
4-72 1.77e-05

chemotaxis protein CheY;


Pssm-ID: 170568 [Multi-domain]  Cd Length: 129  Bit Score: 44.58  E-value: 1.77e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247547209   4 RVLLVDDEPLVRNDLRSLLdfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIK 72
Cdd:PRK10610   7 KFLVVDDFSTMRRIVRNLL--KELGFNNVEEAEDGVDALNKLQAGGFGFVISDWNMPNMDGLELLKTIR 73
REC_TrxB cd17595
phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase ...
5-106 2.27e-05

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381126 [Multi-domain]  Cd Length: 135  Bit Score: 44.25  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVrndLRSLL-DFRAH---GFEICgEAQSAETALDMIGEQR---PDVAIL--DVNMPGMNGVDLNRTIKQRY 75
Cdd:cd17595    3 ILTVDDDPQV---LRAVArDLRRQygkDYRVL-RADSGAEALDALKELKlrgEAVALFlvDQRMPEMDGVEFLEKAMELF 78
                         90       100       110
                 ....*....|....*....|....*....|..
gi 247547209  76 PAVQTIMLSSYDDYDYVRDCLKNGSVD-YLLK 106
Cdd:cd17595   79 PEAKRVLLTAYADTDAAIRAINDVQLDyYLLK 110
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
417-527 2.47e-05

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 46.21  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 417 LLILLKEH-HATGSY--SRHVSQAIGFILERYSGIVTLELAAGFIGLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLL 493
Cdd:PRK13503 153 LLVLLRKSsLQENGEnsDARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRLLKARHLL 232
                         90       100       110
                 ....*....|....*....|....*....|....
gi 247547209 494 ESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTP 527
Cdd:PRK13503 233 RHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSP 266
REC_PatA-like cd17602
phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) ...
5-106 2.81e-05

phosphoacceptor receiver (REC) domain of PatA and similar domains; Nostoc sp. (or Anabaena sp.) PatA is necessary for proper patterning of heterocysts along filaments. PatA contains phosphoacceptor REC domain at its C-terminus and an N-terminal PATAN (PatA N-terminus) domain, which was proposed in a bioinformatics study to mediate protein-protein interactions. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays. Some members of this group may have an inactive REC domain, lacking canonical metal-binding and active site residues.


Pssm-ID: 381129 [Multi-domain]  Cd Length: 102  Bit Score: 43.13  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEICGeAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIK--QRYPAVQTIM 82
Cdd:cd17602    1 VACVDDRPSIQKMIEYFLE--KQGFRVVV-IDDPLRALTTLLNSKPDLILIDIDMPDLDGYELCSLLRksSALKDTPIIM 77
                         90       100
                 ....*....|....*....|....*
gi 247547209  83 LSSYDDY-DYVRDCLKnGSVDYLLK 106
Cdd:cd17602   78 LTGKDGLvDRIRAKMA-GASGYLTK 101
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
414-530 3.93e-05

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 45.76  E-value: 3.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 414 YGVLLILLKEHHATGSYSRHVSQAIGFILERYSGIVT--------LELAAGFIGLNASYLSRIFKDETqSTFSEYVNRVR 485
Cdd:PRK15185 180 YFLLFLLTAFLRLPESYEIILSSAQITLKERVYNIISsspsrqwkLTDVADHIFMSTSTLKRKLAEEG-TSFSDIYLSAR 258
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 247547209 486 VDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:PRK15185 259 MNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
499-530 4.01e-05

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 40.99  E-value: 4.01e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 247547209  499 TIKQVSDQVGFTThNYFFKVFKEVTGMTPQAY 530
Cdd:pfam00165  10 TIADIADELGFSR-SYFSRLFKKYTGVTPSQY 40
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
450-530 4.49e-05

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 45.30  E-value: 4.49e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 450 TLELAAGFIGLNASYLSRIFKDEtQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQA 529
Cdd:PRK09978 160 TLARIASELLMSPSLLKKKLREE-ETSYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFIYVFRNYYGMTPTE 238

                 .
gi 247547209 530 Y 530
Cdd:PRK09978 239 Y 239
PRK10161 PRK10161
phosphate response regulator transcription factor PhoB;
1-136 1.04e-04

phosphate response regulator transcription factor PhoB;


Pssm-ID: 182277 [Multi-domain]  Cd Length: 229  Bit Score: 43.94  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   1 MMYRVLLVDDEPLVRNDLRSLLDfrAHGFEICgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPA--V 78
Cdd:PRK10161   1 MARRILVVEDEAPIREMVCFVLE--QNGFQPV-EAEDYDSAVNQLNEPWPDLILLDWMLPGGSGIQFIKHLKRESMTrdI 77
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 247547209  79 QTIMLSSY-DDYDYVRDcLKNGSVDYLLKHRLDKDtLLAMLeKAVQAGKSSEAASEADE 136
Cdd:PRK10161  78 PVVMLTARgEEEDRVRG-LETGADDYITKPFSPKE-LVARI-KAVMRRISPMAVEEVIE 133
REC_RcNtrC-like cd19928
phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C ...
5-106 1.23e-04

phosphoacceptor receiver (REC) domain of Rhodobacter capsulatus nitrogen regulatory protein C (NtrC) and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include NtrC, also called nitrogen regulator I (NRI), from Rhodobacter capsulatus, Azospirillum brasilense, and Azorhizobium caulinodans. NtrC is part of the NtrB/NtrC two-component system that controls the expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381155 [Multi-domain]  Cd Length: 100  Bit Score: 41.34  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDFRAHGFEICGeaqSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:cd19928    1 ILVADDDRAIRTVLTQALGRAGYEVRTTG---NAATLWRWVEEGEGDLVITDVVMPDENGLDLIPRIKKARPDLPIIVMS 77
                         90       100
                 ....*....|....*....|..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd19928   78 AQNTLMTAVKAAERGAFEYLPK 99
REC_WspR-like cd17575
phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The ...
4-106 1.98e-04

phosphoacceptor receiver (REC) domain of WspR response regulator and similar proteins; The GGDEF response regulator WspR is part of the Wsp system that is homologous to chemotaxis systems and also includes the membrane-bound receptor protein WspA. In response to growth on surfaces, WspR is phosphorylated by the Wsp signal transduction complex and is activated, functioning as a diguanylate cyclase (DGC) that catalyzes c-di-GMP synthesis. WspR is a hybrid response regulator-diguanylate cyclase, containing an N-terminal REC domain and a C-terminal GGDEF domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381117 [Multi-domain]  Cd Length: 128  Bit Score: 41.24  E-value: 1.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLL-DFRAHGFEICgeaQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKqRYPA---VQ 79
Cdd:cd17575    2 MVLLVDDQAIIGEAVRRALaDEEDIDFHYC---SDPTEAIEVASQIKPTVILQDLVMPGVDGLTLVRFFR-ANPAtrdIP 77
                         90       100
                 ....*....|....*....|....*..
gi 247547209  80 TIMLSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:cd17575   78 IIVLSTKEEPEVKSEAFALGANDYLVK 104
PRK10296 PRK10296
DNA-binding transcriptional regulator ChbR; Provisional
459-534 2.47e-04

DNA-binding transcriptional regulator ChbR; Provisional


Pssm-ID: 182362 [Multi-domain]  Cd Length: 278  Bit Score: 43.21  E-value: 2.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 247547209 459 GLNASYLSRIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAYWNSL 534
Cdd:PRK10296 199 GKSQEYLTRATRRYYGKTPMQIINEIRINFAKKQLEMTNYSVTDIAFEAGYSSPSLFIKTFKKLTSFTPGSYRKKL 274
PRK10841 PRK10841
two-component system sensor histidine kinase RcsC;
4-73 2.76e-04

two-component system sensor histidine kinase RcsC;


Pssm-ID: 182772 [Multi-domain]  Cd Length: 924  Bit Score: 43.81  E-value: 2.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247547209   4 RVLLVDDEPLVR----NDLRSLldfrahGFEiCGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQ 73
Cdd:PRK10841 803 MILVVDDHPINRrllaDQLGSL------GYQ-CKTANDGVDALNVLSKNHIDIVLTDVNMPNMDGYRLTQRLRQ 869
REC_HP-RR-like cd17573
phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; ...
5-116 3.67e-04

phosphoacceptor receiver (REC) domain of orphan response regulator HP-RR and similar proteins; Helicobacter pylori response regulator hp1043 (HP-RR) is an orphan response regulator which is phosphorylation-independent and is essential for growth. HP-RR functions as a cell growth-associated regulator in the absence of post-translational modification. Members of this subfamily contain REC and DNA-binding output domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381115 [Multi-domain]  Cd Length: 110  Bit Score: 40.11  E-value: 3.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfrAHGFEicgeAQSAETALDmiGE-----QRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQ 79
Cdd:cd17573    1 ILLIEDDSTLGKEISKGLN--EKGYQ----ADVAESLKD--GEyyidiRNYDLVLVSDKLPDGNGLSIVSRIKEKHPSIV 72
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 247547209  80 TIMLSSYDDYDYVRDCLKNGSVDYLLKHRlDKDTLLA 116
Cdd:cd17573   73 VIVLSDNPKTEQEIEAFKEGADDYIAKPF-DFKVLVA 108
PRK10816 PRK10816
two-component system response regulator PhoP;
4-106 3.99e-04

two-component system response regulator PhoP;


Pssm-ID: 182755 [Multi-domain]  Cd Length: 223  Bit Score: 42.03  E-value: 3.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRslLDFRAHGFEIcGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIML 83
Cdd:PRK10816   2 RVLVVEDNALLRHHLK--VQLQDAGHQV-DAAEDAKEADYYLNEHLPDIAIVDLGLPDEDGLSLIRRWRSNDVSLPILVL 78
                         90       100
                 ....*....|....*....|...
gi 247547209  84 SSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:PRK10816  79 TARESWQDKVEVLSAGADDYVTK 101
PRK10840 PRK10840
transcriptional regulator RcsB; Provisional
5-84 5.43e-04

transcriptional regulator RcsB; Provisional


Pssm-ID: 182771 [Multi-domain]  Cd Length: 216  Bit Score: 41.74  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPG---MNGVDLNRTIKQRYPAVQTI 81
Cdd:PRK10840   6 VIIADDHPIVLFGIRKSLE-QIEWVNVVGEFEDSTALINNLPKLDAHVLITDLSMPGdkyGDGITLIKYIKRHFPSLSII 84

                 ...
gi 247547209  82 MLS 84
Cdd:PRK10840  85 VLT 87
PRK09935 PRK09935
fimbriae biosynthesis transcriptional regulator FimZ;
5-106 5.55e-04

fimbriae biosynthesis transcriptional regulator FimZ;


Pssm-ID: 182154 [Multi-domain]  Cd Length: 210  Bit Score: 41.40  E-value: 5.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   5 VLLVDDEPLVRNDLRSLLDfRAHGFEICGEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQRYPAVQTIMLS 84
Cdd:PRK09935   6 VIIMDTHPIIRMSIEVLLQ-KNSELQIVLKTDDYRITIDYLRTRPVDLIIMDIDLPGTDGFTFLKRIKQIQSTVKVLFLS 84
                         90       100
                 ....*....|....*....|..
gi 247547209  85 SYDDYDYVRDCLKNGSVDYLLK 106
Cdd:PRK09935  85 SKSECFYAGRAIQAGANGFVSK 106
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
460-538 6.23e-04

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 41.98  E-value: 6.23e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 247547209 460 LNASYLSRIFKDEtQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAYWNSLGDGK 538
Cdd:PRK15186 209 MSCSTLKRKLKQE-NTSFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSASYFTCVFKKHFKTTPSEFLAFLSSSR 286
ompR PRK09468
osmolarity response regulator; Provisional
2-140 1.16e-03

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 40.73  E-value: 1.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   2 MYRVLLVDDEPlvrnDLRSLLD--FRAHGFEIcgeaQSAETALDM---IGEQRPDVAILDVNMPGMNGVDLNRTIKQRYP 76
Cdd:PRK09468   5 NYKILVVDDDM----RLRALLEryLTEQGFQV----RSAANAEQMdrlLTRESFHLMVLDLMLPGEDGLSICRRLRSQNN 76
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 247547209  77 AVQTIMLSSY-DDYDYVRDcLKNGSVDYLLKhRLDKDTLLAMLeKAV---QAGKSSEAASEADESSHF 140
Cdd:PRK09468  77 PTPIIMLTAKgEEVDRIVG-LEIGADDYLPK-PFNPRELLARI-RAVlrrQAPELPGAPSQEEEVIAF 141
ftrA PRK09393
transcriptional activator FtrA; Provisional
467-530 2.15e-03

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 40.33  E-value: 2.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 247547209 467 RIFKDETQSTFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAY 530
Cdd:PRK09393 253 RRFEAATGMTPAEWLLRERLARARDLLESSALSIDQIAERAGFGSEESLRHHFRRRAATSPAAY 316
PRK09959 PRK09959
acid-sensing system histidine kinase EvgS;
5-74 2.19e-03

acid-sensing system histidine kinase EvgS;


Pssm-ID: 182169 [Multi-domain]  Cd Length: 1197  Bit Score: 40.87  E-value: 2.19e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209    5 VLLVDDEPLVRNDLRSLLDFRAHGFEicgEAQSAETALDMIGEQRPDVAILDVNMPGMNGVDLNRTIKQR 74
Cdd:PRK09959  961 ILIADDHPTNRLLLKRQLNLLGYDVD---EATDGVQALHKVSMQHYDLLITDVNMPNMDGFELTRKLREQ 1027
PRK10336 PRK10336
two-component system response regulator QseB;
4-106 3.65e-03

two-component system response regulator QseB;


Pssm-ID: 182387 [Multi-domain]  Cd Length: 219  Bit Score: 39.11  E-value: 3.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209   4 RVLLVDDEPLVRNDLRSLLDFRAHGFEICGEAQSAETALdmigEQRP-DVAILDVNMPGMNGVDLNRTIKQRYPAVQTIM 82
Cdd:PRK10336   2 RILLIEDDMLIGDGIKTGLSKMGFSVDWFTQGRQGKEAL----YSAPyDAVILDLTLPGMDGRDILREWREKGQREPVLI 77
                         90       100
                 ....*....|....*....|....
gi 247547209  83 LSSYDDYDYVRDCLKNGSVDYLLK 106
Cdd:PRK10336  78 LTARDALAERVEGLRLGADDYLCK 101
PRK15044 PRK15044
transcriptional regulator SirC; Provisional
455-534 8.49e-03

transcriptional regulator SirC; Provisional


Pssm-ID: 185004 [Multi-domain]  Cd Length: 295  Bit Score: 38.48  E-value: 8.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 247547209 455 AGFIGLNASYLSRIFKDETQStFSEYVNRVRVDAARRLLESGQYTIKQVSDQVGFTTHNYFFKVFKEVTGMTPQAYWNSL 534
Cdd:PRK15044 215 AGKLFMSVSSLKRKLAAEEVS-FSKIYLDARMNQAIKLLRMGAGNISQVATMCGYDTPSYFIAIFKRHFKITPLSFMRTM 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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