2WVR


Conserved Protein Domain Family
CDT1

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smart01075: CDT1 
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DNA replication factor CDT1 like
CDT1 is a component of the replication licensing system and promotes the loading of the mini-chromosome maintenance complex onto chromatin. Geminin is an inhibitor of CDT1 and prevents inappropriate re-initiation of replication on an already fired origin. This region of CDT1 binds to Geminin.
Statistics
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PSSM-Id: 215014
Aligned: 17 rows
Threshold Bit Score: 113.264
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2WVR_C        186 LPYKYQVLAEMFRSMDTIVGMLHNRSE-TPTF--AKVQRGVQDMMRRRFEERNVGQIKTVYPASYRFRQE---------- 252  human
XP_001659329  330 LPYKYRSLAELFKCIDTVCAMFYNRKE-QITF--KKLKPAVQRMARKNLYETHLAQIKTLFPDAFEFSQE---------- 396  yellow fever ...
XP_315335     347 LPFKYRSLLELFKCTDTVCSMLHNRKE-QITF--KKLKPAVQRMARKNFFESHLAQIYSLFPDAFTLSQE---------- 413  Anopheles gam...
NP_524878     318 LPYKYRHLLDVFKGLDSVVAMFHNRKE-TITF--KKLKPAVQRMLRKNFTETHLAQIKHIYPDAFIFSQV---------- 384  fruit fly
NP_585896     121 LPKSLQKLSRIFRVLETIQRFNAARGL-TTIF--IKSLRCIENLVKQRVGVADIERMYYIAPELFRFKK----------- 186  Encephalitozo...
NP_191031      46 LPERFEILEEFFNGLDTAIRLLKLKGS-STTY--ANICPKIEYLTNRIFSYDHLAQMKHIYPEAIELKR----------- 111  thale cress
XP_625807     242 LSEKYEYLIEIFQGLE-IVLRLLERRQ-KPFFypTFIKEQVENITKKTFSLDNLLRIVWISPQLISIRWC---------- 309  Cryptosporidi...
NP_180685     111 LPEKYENLGKFFEALDNSMLLSKLRGS-KPTF--SNISKQIEHLTERRFCYSHLAQIKHILPEAIEIKR----------- 176  thale cress
NP_594448      51 IPSIFDNLFNLFKVINTTYTFLYLRNSlTITF--PLLNSSVKQSLKKELTIGDLSQLREICPQIIELNYKslaslalein 128  Schizosacchar...
NP_595196      87 knESVLFLEKVFNAVDICVKFHLSINT-KPTF--VLLENKVSGLTKISLKITHLAQILTVWPESFAITP----------- 152  Schizosacchar...
2WVR_C        253 RSVPT-------F-------KDGTRrs-dYQLTIEPLL-------------------EQ--E--------------ADGA 282  human
XP_001659329  397 LT-KN-------Y-------GSATKne-yYQLIIKPNV-------------------EE--Kepakcdd-edanviRSAQ 438  yellow fever ...
XP_315335     414 MT-KN-------Y-------GSATKhe-tYQLVIRPNI-------------------AD--ApeeparkaaeddfiRTNT 456  Anopheles gam...
NP_524878     385 KTR-N-------F-------GSVSKad-yFQLIIAPNVeplpeqqqsekpqhftkinED--Dv-------------LASA 433  fruit fly
NP_585896     187 --ISI-------H-------HDGKEvd-tFVIYVDG-------------------------------------------- 205  Encephalitozo...
NP_191031     112 --VLK-------F-------VEDTCcm-kPRLHIKLN------------------------Td-------------AIVV 137  thale cress
XP_625807     310 EANKI-------NnsrlespKNTLNef-yDQCELEIIL-------------------NDgiNn-------------PLKR 349  Cryptosporidi...
NP_180685     177 --VLI-------H-------DETTCcm-kPDLHVTLN------------------------Ad-------------AVEY 202  thale cress
NP_594448     129 KNVYTdlnpelyT-------GSTVSqsseYVLVIELLE-------------------TQ--Er-------------SSKR 167  Schizosacchar...
NP_595196     153 --CFT-------I-------HQGKRva-tYELSYPRN------------------------------------------- 172  Schizosacchar...
2WVR_C        283 AP-QL--TASRLLQRRQIFSQKLVEHVKEHHKAFLASLSpamVVPEDQ-LTRWHPRFNVDEVPDIEPAALPQ 350  human
XP_001659329  439 NQ-SM--NPQVLIERYQKFNRILLARAKEAHEKFLLQLDppvIIEKHK-LTRWHPDFNLESCPDIELGDVPQ 506  yellow fever mosquito
XP_315335     457 KP-AV--NSQSLLERYQHFRRLLLERTKDAHQAFLQTLDpplNIDRSK-IVRWHVDFDLENCPDIEKAELPQ 524  Anopheles gambiae str...
NP_524878     434 QStSM--NPHVMTARMQRFQSLLLDRAMRAHDQFLRSQDp--PIIIEKaLTRWHPQFDLESCPEVELSPLPQ 501  fruit fly
NP_585896     206 --------------ETREFNERLEKHVKECHSEFLSRNG-----YAHD-GGRFHPGFDFEEVPLPRKPLFPE 257  Encephalitozoon cunic...
NP_191031     138 ED-TI--CGTKYMELRKVFHSKLVDFRKA------------------------HPK------DEIPKELLPE 176  thale cress
XP_625807     350 LS-HS--NINERVDIFRFILIEFTMIQQEMHLRQIMTKNmeiNTDILE-LKGWSSFFNIENCVEIPKAKLPR 417  Cryptosporidium parvu...
NP_180685     203 NDkSK--SESKKIALRKVFRARLADFVKAHPQgdevpeeplpepfnrrkpvensnvevkrvsslmeemasip 272  thale cress
NP_594448     168 RR-REgpTMKANIQRQKLDFNNLKKAIELRNQKFLQGIKe--YIKKCQ-LTELDPTQQLltqsrknqpvppd 235  Schizosaccharomyces p...
NP_595196     173 ----A--NLPEAFSRSIEFKRRLEKWLLEHCSEteipaqqlqalpslskntvnesslvrklnlekstsrelr 238  Schizosaccharomyces p...
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