2C5S,1VBK,3G8Q,2DIR


Conserved Protein Domain Family
THUMP
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smart00981: THUMP 
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The THUMP domain is named after after thiouridine synthases, methylases and PSUSs.
The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets.
Links
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Statistics
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PSSM-Id: 214952
Aligned: 344 rows
Threshold Bit Score: 32.6323
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2C5S_A        94 ELEDIKKGALAAF--LqvkGDVKTFKI---T---VHRSY----KhFPMRTM---ELLPEIGGHILENTED-ITVDVHN-- 155 anthrax
YP_518309     70 TFEELFQQTKALp-wEewlPVDAEFPV---E---GKSIK----SkLFSVSDcqaIVKKAVVERLKDVYGI-S--WFKEtg 135 Desulfitobacter...
YP_001487180  69 TFDELFERTKA-IdwAaflPKNSTFPVigkS---VKSQL----AsVPDCQR---IVKKAIAQKLISSYNI-QSEWLEEtg 136 Bacillus pumilu...
YP_079515     69 TFDELFEKTKA-IdwSaylPEHASFPV---TgksVKSVL----AsVPDCQR---IVKKAIAEKLKSEYQT-QGEWLEEtg 136 Bacillus lichen...
ZP_07077289   88 TFDELFEKTLA-LpwDqllPMDAEFPV---E----GKSRnsklHsVPDVQS---IVKKAIVNQLADTYHR--SGHLPEtg 154 Lactobacillus p...
YP_804435     69 TFDDLFESVKA-LpwDeliPVDGAFPV---S----GKSKkstlFsVPDVQA---ITKKAVVEKLREVFHW--RNQFPEtg 135 Pediococcus pen...
YP_253382     67 TFDELFEKTKS-LpwEniiDKEGQFPV---Q----GRSVkstlYsVPDCQA---ITKKAIVERLKKAYDE--KGWLNEsg 133 Staphylococcus ...
YP_301389     67 TFDELFEKTKA-LpwEtliEQDGNFPV---Q----GRSVkstlFsVPDCQA---IVKKAIVERLRRAYQA--SGWLNEtg 133 Staphylococcus ...
ZP_02953466   69 SFEELFNKTVE-IdwSkyiPVDGKMHV---V----GKSVksklFsVPDCQS---IVKKAVVKSMSRSYGQ---DWFTEdg 134 Clostridium per...
NP_390099     69 TFDELFEKTKA-InwRsfiPENGKFPV---I----GKSVkstlAsVPDCQR---IVKKAIVEKLKLQSGKaN-DWIEEtg 136 Bacillus subtil...

2C5S_A       156 PDVNVRVEIRSGySYI 171 anthrax
YP_518309    136 PKYKIEVALLKDvVTL 151 Desulfitobacterium hafniense Y51
YP_001487180 137 PEYKIEVALLKDkAVL 152 Bacillus pumilus SAFR-032
YP_079515    137 PEYKIEVSLLKDkAVI 152 Bacillus licheniformis ATCC 14580
ZP_07077289  155 ALFPLEVAINKDhVLL 170 Lactobacillus plantarum subsp. plantarum ATCC 14917
YP_804435    136 AKYGLEVAIDKDhVMI 151 Pediococcus pentosaceus ATCC 25745
YP_253382    134 AKYPVEVAILKDnVLL 149 Staphylococcus haemolyticus JCSC1435
YP_301389    134 AKYPIEVAILKDnALL 149 Staphylococcus saprophyticus subsp. saprophyticus ATCC 15305
ZP_02953466  135 PVYKIEVGLLKDvVTL 150 Clostridium perfringens D str. JGS1721
NP_390099    137 AEYKVEISLLKDqALI 152 Bacillus subtilis subsp. subtilis str. 168
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