1VJ7,2BE3


Conserved Protein Domain Family
RelA_SpoT
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smart00954: RelA_SpoT 
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Region found in RelA / SpoT proteins
The functions of Escherichia coli RelA and SpoT differ somewhat. RelA produces pppGpp (or ppGpp) from ATP and GTP (or GDP). SpoT degrades ppGpp, but may also act as a secondary ppGpp synthetase. The two proteins are strongly similar. In many species, a single homolog to SpoT and RelA appears reponsible for both ppGpp synthesis and ppGpp degradation. (p)ppGpp is a regulatory metabolite of the stringent response, but appears also to be involved in antibiotic biosynthesis in some species.
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Statistics
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PSSM-Id: 214934
Aligned: 292 rows
Threshold Bit Score: 47.5636
Created: 13-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1VJ7_A       240 GRPKHIYSIYRKMRDKk--------KRFDQIFDLIAIRCVMET---QSDVYAMVGYIHE-LWRP---MPGRFKDYIAAPK 304 Streptococcus d...
YP_511374     65 qRLKRRNTIIDKMRREp-------nMPLVAMHDIAGCRMVFNS---LDDLRAVRESMHGaRWRHsltHELDKYDYILRPK 134 Jannaschia sp. ...
YP_767706     76 aRPKRMPSIRRKL-REs-------dIHLDRMQDIGGCRAILDD---IKGVRSLLAEINE-GFPH---HDRRQWPYIDAPK 140 Rhizobium legum...
YP_001706002 235 GRIKKKNNNIELLRHFvk-----neMDLQELTHSHAFEIVLQS---IADCDRLVAALKen------fQVIQYQDHIRRPL 300 Acinetobacter b...
ZP_07663940   29 SRAKSQDTLLAKLRRRp-------yLQLNTIQDIAGVRIDADl--lLGEQTRLAREIAdh-----fgADQPAIHDLRDHP 94  Mycobacterium t...
YP_620722     65 QRLKRKPQIIRKLNRl--------sVRLTQLQDIGGCRIIVQKnsdVDRIHKYLIDKVnsqn--vftIDRTTDYRDLGRD 134 Burkholderia ce...
YP_454615     85 RRLKRLPTIIDKLTRDtldginkntMCVTRMQDIGGCRVIVDn---KEQSLRVNSSLEqsrt--lyiTKLSR-DYNINPK 158 Sodalis glossin...
NP_631018     71 ERRKRLPTILDKLKRHp-------tMSVTTMQDLGGCRVVFDTvaeVEELVSVLVDLPrsknrvkkvYNYLR-D-DPGPR 141 Streptomyces co...
NP_934758    107 SQQRAKQKIALELNNQ-----------PERITDLARATIVADd---VASLVSAYEALEret----riVK--VKNRFKNPG 166 Vibrio vulnific...
YP_001475242 110 SYARAQEKVTAKFNGD-----------ASQLTDLARATLVSNn---IHDLMQAYESLStqt----qvVQ--VKNRFASPK 169 Shewanella sedi...

1VJ7_A       305 ANGYQSIHTTVYGP---------KG-P----IEIQIRTKEMHQVAEYGVAAHWAYKKG 348 Streptococcus dysgalactiae subsp. equ...
YP_511374    135 STGYRGIHDVYEYKvnsvggvpwNGlK----VEIQYRTLPQHAWATAVEVADlitsnr 188 Jannaschia sp. CCS1
YP_767706    141 DDGYRSHHISFEFCprkkeqsvfAGrR----VEFQIRTRLQHSWATAVEAVSLFNGED 194 Rhizobium leguminosarum bv. viciae 3841
YP_001706002 301 PGGNQSLMIKLKGE----------KtT----LSLTIQTELMRKAARFGVVLGENAPQT 344 Acinetobacter baumannii SDF
ZP_07663940   95 HAGYRAVHVWLRLPag--------------rVEIQIRTILQSLWANFYELLADAYGRG 138 Mycobacterium tuberculosis SUMu001
YP_620722    135 YTGYRSLHVILKRGgv--------------hLELQIRSRIQHYWSESIERTSVIYGYH 178 Burkholderia cenocepacia AU 1054
YP_454615    159 KTGYRGIHRVYQCYgk-----rkEHdWkgftIELQLRTRLQHLWATTVEVVDLCEGKT 211 Sodalis glossinidius str. 'morsitans'
NP_631018    142 DSGYRCVHLVYEYGas-----kkE--YhglrIELQVRTRLQHAWATAVETMDLFSGSE 192 Streptomyces coelicolor A3(2)
NP_934758    167 ESGYRDLNLLVQLP----------KtN----LVAEVQLHLKAIADVKSGPEHDLYQQI 210 Vibrio vulnificus YJ016
YP_001475242 170 ESGYRDLNVLIRLP----------NsQ----MIAEVQLHLDEIAKIKSGAEHLVYEEA 213 Shewanella sediminis HAW-EB3
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