Conserved Protein Domain Family
Alpha_Helical

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pfam18489: Alpha_Helical 
Alpha helical domain
This is the N-terminal domain found in putative tRNA-binding proteins found in archaea. Structural analysis from Pyrococcus horikoshii indicate that it is a helical domain where many conserved residues are found in the first three helices and are mainly located on the inverse side of the putative tRNA-binding site. A structural homology search suggested that this fold prefers to bind proteins/peptides.
Statistics
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PSSM-Id: 408282
Aligned: 13 rows
Threshold Bit Score: 179.101
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
WP_023992703       1 MWDTSNDYRLLVAEKSVELFLRTVEGANLKGKWNKKQALQSARKMTSEIQTLYYSYLEPSALVKTPQIDLLEEQARDIVE 80  Methanobact...
WP_013644019       1 MWDSSKDYRLRVLEKSVELFIKTAEGANLKGIWNKKKCLTSARSMLPEIQIMYFSYMEPAALAESPQVEDMKLKVKDIID 80  Methanobact...
WP_015849606       1 MWDTSNDYRLLVAEKAIELFLKTIEGAKFKGKWDKKRAVQLAKRMIPELQALRYSYLEPSELIETPQMKDLKEKVEGIIE 80  Thermococcu...
O27056             7 MWDTSKDYRLMVAVKAVDLFRRTLESGGFRGQWKKKPALQAAGEIERILQGLTYCYMEPEDLASSPEVMEIKGKVEEIVE 86  Methanother...
NZAGRC:Abm4_0404   1 MWDTSKDYRILIAIKSQELYLNTVQTGSFRGNWNKKAAIDEAKNMTSTFQSLKYSYLEGDNLTNTEDVSKLEENAERIIE 80 
agres:mru_0673     1 MWDTAKDYRILVAMHARELFLRTVQTGSFRGNWNKKATIEETKKMEADLKSLLYCYLEGDALANCEDVQKLEDKAGRIIE 80 
KZX12511           1 MWDSNKDYRLLIAQKSKDLFERTIESGSFRGRWNKKMAREIARNLNTDFQTLLYSYMEPKDMANSKDVEEIISKAHELIR 80 
WP_067259520       1 MWDTTKDYRLVLGQKTIDLFIRTVRGGSFRGRWNKKMALESATDMESDFQSLLYSYLDPQDLAETQEIVNLEEKANLVIR 80  Methanobrev...
KZX17296           1 MWDTDKDYRILIAQKALDLYNRTVNSGTLRGRWNKRMAIDTANSMSSDFQSLTYSYLDPADLAKSPEVKSLEDKYQLVIR 80 
WP_014026172       1 MSDTRSDYRLLVAEHAVSLLEGIVRGRRIPAPIDWEEAARLLREARGIVKRMRFSFMPATMLARSPDAKSLQEIAKRLVD 80  Pyrolobus f...
KSW11386           1 MSDTRSDYRILMAEHALGMLESIIKSKKLPLPVNWKKAQELHAQARSILMQMKYSFMPPTMLARSEEARKLQEISRQLAS 80 
imbp:Hbut_0362     1 MSDTRNDYRILVAEHAVSLLENIVRARRIPIPVNWHEVEALVSELRSLIVRIKYSFIPPTMLAGSEEVERVREYAGKLAK 80 
Q2NF72             4 IWDTSNDYRLKVAEKAIEDFIRVVEGSNLRGSWNKKKVRLIAKDMNPDIQTLYYSYISPDQLAKTPQVNNLLKSVDEIIE 83  Methanospha...
WP_023992703      81 ALGGDQWHRQFLELANREEKPKLEEALAKIKFFLNTIFGLKDRISLG 127 Methanobacterium sp. MB1
WP_013644019      81 ALGGDQWHVQFLNLVNKDEKEKLVESIAKMKFALNTISTVDERLKLG 127 Methanobacterium lacus
WP_015849606      81 ALGGEEWYVRFLELADRHEREKLEESIAKVRFFLNTIMNLDKRLALG 127 Thermococcus sibiricus
O27056            87 ALGGEDWSRRFLEEAPREEREKVEENIARVRFFLNTLGNLDRRLMLG 133 Methanothermobacter thermautotrophicus str. ...
NZAGRC:Abm4_0404  81 FLGGPEWNHKFMNAAPKDDKSKTEENIAKVKFFLDTILGLRNRLAYG 127
agres:mru_0673    81 FLGGEDWNHKFMQGAPKDEREKTEENIAKVRFFLDTILGLRNRFKFG 127
KZX12511          81 YLGGEDWYHIFLREAKKEDKEKTEESVAKVKFFLRTLLGLKDRLAHG 127
WP_067259520      81 YLGGDDWAHLFLEQTPKNDKEKSEEAIAKARFFLDTVLGLKKRILFG 127 Methanobrevibacter cuticularis
KZX17296          81 YLGGDDWNHEFLRQTPKNEKHKAEESIAKIRFFLRTISGLKDRLNFG 127
WP_014026172      81 VVLPREWVERL------RGDQRARMPIAEARYAIRTLYTLPARLALG 121 Pyrolobus fumarii
KSW11386          81 ILLPREWLERA------QLDQRARRVMADVKYAIRMLYGLPARLSLG 121
imbp:Hbut_0362    81 TLLSKE------RLAGAKLDSKTRMAIAEARYALRTLYGLGYRLSLG 121
Q2NF72            84 NLGGENYSKKFLSELNREEREKLELPLSKMKFFFNTIRGLPARLMLG 130 Methanosphaera stadtmanae DSM 3091
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