Conserved Protein Domain Family
RRM_DME

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pfam15628: RRM_DME 
RRM in Demeter
This is a predicted RRM-fold domain present at the C-terminus of Demeter-like glycoslyases. These proteins are involved in DNA demethylation in plants where they catalyze removal of the 5mC base and subsequently cleave the backbone through lyase activity. Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic domain with ssDNA or regulatory RNA.
Statistics
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PSSM-Id: 373977
Aligned: 13 rows
Threshold Bit Score: 169.083
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_006836725 1819 GTVLIPCRTATRGSFPLNGTYFQVNEVFADHETSLNPIAVPRAWIWNLPRRIVYFGSAVPTIFRDRSIEEIQQCFWKGYV 1898
B8YIE8       1740 GTVLVPCRTAMRGSFPLNGTYFQVNEVFADHSSSHNPINIPREQLWNLHRRMVYFGTSVPTIFKGLTTEEIQHCFWRGFV 1819 Japanese rice
EFJ08215      354 GTLLIPCRTAMRGSFPLNGTYFQVNEVFADSETGNFPLNVSRSLLWNLHRKFVYFGTSVPAIFRGLTADEVQACFWKGYV 433 
XP_009394020 1724 GTLLIPCRTANRGSFPLNGTYFQVNEVFADHQSSHSPLVVPRRLLWNLPRRTVYFGTSIPTIFRGLTTDEIRFCFWRGFV 1803
XP_009379777 1747 GTILIPCRTAMRGSFPLNGTYFQVNEVFADHDTSCNPIDVPREWIWNLPRRTVYFGTSVPTIFKGLTTQEIQQCFWRGFV 1826
VDD06026     1289 GTILVPCRTAMRGSFPLNGTYFQVNEVFADHESSLTPIDVPRDWLWDLARRTVYFGTSIPSIFKGLSTETIQQCFWRGYV 1368
Q6K6Q6       1071 GTILIPCRTATRGNFPLNGTYFQDHEVFADHSSSRSPITIPRECIWNLDRCIVYFGSSIQSIMKGQTRQDIEDCYKKGYI 1150 Japanese rice
XP_002500051 1870 lTVMVPCRAAMNGKFPLHGTYFQTNEVFLDAETAVRPKLVAASELETLPTVSVYLGSSVASICRGMSRAEVASSFANRAV 1949
EFH61029      965 GTILIPCRTAMRGGFPLNGTYFQTNEVFADHGSSINPIEVPTQSIWDLRRRIAYFGSSVSSICKGLSVKEIEDNFQEGYV 1044
EEF34945     1600 GTILVPCRTAMRGRFPLNGTYFQVNEVFADHESSYNAIIVPRSSIWYLRRRIVYCGTSPNAIFKACSLKEIQENFWKGFI 1679
XP_010318462 1389 GTILIPCRTANRGSFPLNGTYFQINEVFADHESSLNPIPVARASIWNLRVTTLYCGTSVSSIVKGLSTMDIQKCFWKGFM 1468
XP_019075958 1290 GTLLIPCRTAMRGSFPLNGTYFQVNEVFADDESSRNPIIVRRTEIWNLPRRMAYFGTSATSIFRGLSIMEIQNCFWQGFI 1369
O49498        929 GTILIPCRTAMRGAFPLNGTYFQTNEVFADHETSLNPIVFRRELCKGLEKRALYCGSTVTSIFKLLDTRRIELCFWTGFL 1008 thale cress
XP_006836725 1899 CVRAFDRKYRCPRPLKHRLHAP 1920
B8YIE8       1820 CVRGFNMETRAPRPLCPHFHLA 1841 Japanese rice
EFJ08215      434 CVRGFDRKSRSPRPLAARLHIA 455 
XP_009394020 1804 CLRGIDRQTRAPKPLSPRLHLA 1825
XP_009379777 1827 CVRGFDQRTRAPKPLYARFHFP 1848
VDD06026     1369 CVRGFDRQTRAPRPLIARLHFP 1390
Q6K6Q6       1151 CVRGFDRNTRYPKPICAKLHAT 1172 Japanese rice
XP_002500051 1950 CVRSWEPHTGHPRPLPrwacpf 1971
EFH61029     1045 CVRGFDRENRKPKSLVKRLHCS 1066
EEF34945     1680 CVRGWDAKTGAPKPLAKRFHCP 1701
XP_010318462 1469 VVRGYDRKQRAPRPLHARFHRK 1490
XP_019075958 1370 CVRGFNRKTRAPKPLVRRLHIS 1391
O49498       1009 CLRAFDRKQRDPKELVRRLHTP 1030 thale cress
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